Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.00245365 | 0.00348256 | 0.0116502 |
Onchocerca volvulus | 0.00239872 | 0.00295973 | 0.014866 | |
Loa Loa (eye worm) | hypothetical protein | 0.0052471 | 0.0300699 | 0.0476169 |
Schistosoma mansoni | Lamin B receptor (ERG24) | 0.00469627 | 0.0248272 | 0.0830546 |
Toxoplasma gondii | aurora kinase | 0.00547426 | 0.0322319 | 0.107826 |
Brugia malayi | serine/threonine kinase 12 | 0.00547426 | 0.0322319 | 0.107826 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.00547426 | 0.0322319 | 0.107826 |
Leishmania major | sterol C-24 reductase, putative | 0.00469627 | 0.0248272 | 0.0785855 |
Loa Loa (eye worm) | AUR protein kinase | 0.00547426 | 0.0322319 | 0.0510405 |
Entamoeba histolytica | protein kinase domain containing protein | 0.00547426 | 0.0322319 | 0.107826 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0334951 | 0.298926 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.00695813 | 0.0463549 | 0.0463549 |
Brugia malayi | Probable DNA topoisomerase II | 0.0334951 | 0.298926 | 1 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.00695813 | 0.0463549 | 0.155071 |
Trichomonas vaginalis | adenylate cyclase, type VII, putative | 0.00245365 | 0.00348256 | 0.0116502 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.017834 | 0.149868 | 0.149868 |
Loa Loa (eye worm) | hypothetical protein | 0.0139601 | 0.112998 | 0.178937 |
Leishmania major | PAS-domain containing phosphoglycerate kinase, putative | 0.00245365 | 0.00348256 | 0.0110234 |
Mycobacterium ulcerans | proteasome PrcA | 0.107155 | 1 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.00249839 | 0.00390836 | 0.0123711 |
Echinococcus multilocularis | aurora kinase A | 0.00547426 | 0.0322319 | 0.107826 |
Trichomonas vaginalis | AGC family protein kinase | 0.00547426 | 0.0322319 | 0.107826 |
Trichomonas vaginalis | conserved hypothetical protein | 0.00245365 | 0.00348256 | 0.0116502 |
Loa Loa (eye worm) | AUR protein kinase | 0.00547426 | 0.0322319 | 0.0510405 |
Trypanosoma cruzi | sterol C-24 reductase, putative | 0.00469627 | 0.0248272 | 0.0785855 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.023006 | 0.199094 | 1 |
Echinococcus multilocularis | lamin b receptor | 0.00469627 | 0.0248272 | 0.0830546 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.00245365 | 0.00348256 | 0.0116502 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.00245365 | 0.00348256 | 0.0116502 |
Leishmania major | hypothetical protein, conserved | 0.00995147 | 0.0748447 | 0.236906 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.00995147 | 0.0748447 | 0.236906 |
Entamoeba histolytica | protein kinase, putative | 0.00547426 | 0.0322319 | 0.107826 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.00547426 | 0.0322319 | 0.107826 |
Schistosoma mansoni | hypothetical protein | 0.00239872 | 0.00295973 | 0.00990121 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.017834 | 0.149868 | 0.501354 |
Brugia malayi | PAS domain containing protein | 0.00944121 | 0.0699882 | 0.234132 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0352812 | 0.315926 | 1 |
Echinococcus granulosus | lamin b receptor | 0.00469627 | 0.0248272 | 0.0830546 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.00249839 | 0.00390836 | 0.0123711 |
Trichomonas vaginalis | adenylate and guanylate cyclases, putative | 0.00245365 | 0.00348256 | 0.0116502 |
Loa Loa (eye worm) | hypothetical protein | 0.0226944 | 0.196128 | 0.310576 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.023006 | 0.199094 | 1 |
Trichomonas vaginalis | adenylate cyclase, putative | 0.00245365 | 0.00348256 | 0.0116502 |
Leishmania major | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.00995147 | 0.0748447 | 0.236906 |
Loa Loa (eye worm) | hypothetical protein | 0.0316744 | 0.281597 | 0.44592 |
Trichomonas vaginalis | conserved hypothetical protein | 0.00245365 | 0.00348256 | 0.0116502 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.00249839 | 0.00390836 | 0.0123711 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0314074 | 0.279056 | 0.883295 |
Brugia malayi | serine/threonine protein kinase 6 | 0.00547426 | 0.0322319 | 0.107826 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.00401785 | 0.0183702 | 0.0614539 |
Loa Loa (eye worm) | hypothetical protein | 0.0226944 | 0.196128 | 0.310576 |
Trypanosoma cruzi | Emopamil binding protein, putative | 0.00995147 | 0.0748447 | 0.236906 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0070332 | 0.0470694 | 0.0470694 |
Echinococcus granulosus | single minded 2 | 0.00698757 | 0.0466351 | 0.156009 |
Trichomonas vaginalis | guanylate cyclase, putative | 0.00245365 | 0.00348256 | 0.0116502 |
Echinococcus multilocularis | Aryl hydrocarbon receptor nuclear | 0.00245365 | 0.00348256 | 0.0116502 |
Loa Loa (eye worm) | AUR protein kinase | 0.00547426 | 0.0322319 | 0.0510405 |
Loa Loa (eye worm) | matrixin family protein | 0.00409044 | 0.0190611 | 0.030184 |
Onchocerca volvulus | 0.00245365 | 0.00348256 | 0.0174921 | |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0334951 | 0.298926 | 1 |
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.00245365 | 0.00348256 | 0.0116502 |
Trypanosoma brucei | aurora B kinase | 0.00547426 | 0.0322319 | 0.102024 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0314074 | 0.279056 | 0.883295 |
Leishmania major | protein kinase, putative | 0.00547426 | 0.0322319 | 0.102024 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0160479 | 0.132868 | 0.88657 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.00547426 | 0.0322319 | 0.107826 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.017834 | 0.149868 | 1 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.00547426 | 0.0322319 | 0.107826 |
Loa Loa (eye worm) | hypothetical protein | 0.0052471 | 0.0300699 | 0.0476169 |
Trichomonas vaginalis | AGC family protein kinase | 0.00547426 | 0.0322319 | 0.107826 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.00695813 | 0.0463549 | 0.309305 |
Loa Loa (eye worm) | hypothetical protein | 0.0052471 | 0.0300699 | 0.0476169 |
Trypanosoma cruzi | STE group serine/threonine-protein kinase, putative | 0.00249839 | 0.00390836 | 0.0123711 |
Mycobacterium ulcerans | putative regulatory protein | 0.00698757 | 0.0466351 | 0.0466351 |
Loa Loa (eye worm) | hypothetical protein | 0.0139601 | 0.112998 | 0.178937 |
Mycobacterium leprae | probable proteasome (alpha subunit) PrcA | 0.107155 | 1 | 1 |
Echinococcus granulosus | aurora kinase A | 0.00547426 | 0.0322319 | 0.107826 |
Trichomonas vaginalis | conserved hypothetical protein | 0.00245365 | 0.00348256 | 0.0116502 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0314074 | 0.279056 | 0.883295 |
Brugia malayi | hypoxia-induced factor 1 | 0.0292207 | 0.258244 | 0.863905 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.00695813 | 0.0463549 | 0.309305 |
Brugia malayi | Hemopexin family protein | 0.00239872 | 0.00295973 | 0.00990121 |
Trypanosoma cruzi | sterol C-24 reductase, putative | 0.00469627 | 0.0248272 | 0.0785855 |
Entamoeba histolytica | protein kinase , putative | 0.00547426 | 0.0322319 | 0.107826 |
Trypanosoma cruzi | C-14 sterol reductase, putative | 0.00469627 | 0.0248272 | 0.0785855 |
Onchocerca volvulus | 0.00698757 | 0.0466351 | 0.234237 | |
Mycobacterium leprae | Possible regulatory protein | 0.00245365 | 0.00348256 | 0.00348256 |
Trichomonas vaginalis | soluble guanylate cyclase gcy, putative | 0.00245365 | 0.00348256 | 0.0116502 |
Brugia malayi | hypothetical protein | 0.0316744 | 0.281597 | 0.942028 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.017834 | 0.149868 | 0.501354 |
Giardia lamblia | DNA topoisomerase II | 0.0318098 | 0.282886 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.00375216 | 0.0158414 | 0.0795677 |
Loa Loa (eye worm) | matrixin family protein | 0.00375216 | 0.0158414 | 0.0250856 |
Trichomonas vaginalis | AGC family protein kinase | 0.00547426 | 0.0322319 | 0.107826 |
Schistosoma mansoni | serine/threonine protein kinase | 0.00547426 | 0.0322319 | 0.107826 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.00245365 | 0.00348256 | 0.00551478 |
Brugia malayi | bHLH-PAS transcription factor | 0.00698757 | 0.0466351 | 0.156009 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0334951 | 0.298926 | 1 |
Giardia lamblia | Aurora kinase | 0.00547426 | 0.0322319 | 0.11394 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.00615088 | 0.0386717 | 0.129369 |
Trypanosoma cruzi | aurora B kinase, putative | 0.00547426 | 0.0322319 | 0.102024 |
Leishmania major | C-14 sterol reductase, putative | 0.00469627 | 0.0248272 | 0.0785855 |
Schistosoma mansoni | DNA topoisomerase II | 0.0334951 | 0.298926 | 1 |
Leishmania major | protein kinase, putative | 0.00249839 | 0.00390836 | 0.0123711 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.00245365 | 0.00348256 | 0.0110234 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.00615088 | 0.0386717 | 0.129369 |
Trypanosoma cruzi | C-14 sterol reductase, putative | 0.00469627 | 0.0248272 | 0.0785855 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.00547426 | 0.0322319 | 0.107826 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0334951 | 0.298926 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0352812 | 0.315926 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0352812 | 0.315926 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0684373 | 0.631496 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0334951 | 0.298926 | 0.473362 |
Schistosoma mansoni | protein kinase | 0.00547426 | 0.0322319 | 0.107826 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.00245365 | 0.00348256 | 0.0116502 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.017834 | 0.149868 | 1 |
Trypanosoma cruzi | PAS-domain containing phosphoglycerate kinase, putative | 0.00245365 | 0.00348256 | 0.0110234 |
Entamoeba histolytica | protein kinase, putative | 0.00547426 | 0.0322319 | 0.107826 |
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.00995147 | 0.0748447 | 0.236906 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.00695813 | 0.0463549 | 0.309305 |
Trichomonas vaginalis | AGC family protein kinase | 0.00547426 | 0.0322319 | 0.107826 |
Trypanosoma cruzi | 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative | 0.00995147 | 0.0748447 | 0.236906 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.00695813 | 0.0463549 | 0.309305 |
Schistosoma mansoni | single-minded | 0.00944121 | 0.0699882 | 0.234132 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0334951 | 0.298926 | 1 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.00547426 | 0.0322319 | 0.107826 |
Trypanosoma brucei | C-14 sterol reductase, putative | 0.00469627 | 0.0248272 | 0.0785855 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0292207 | 0.258244 | 0.40894 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.017834 | 0.149868 | 0.108545 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0314074 | 0.279056 | 0.883295 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.00695813 | 0.0463549 | 0.155071 |
Onchocerca volvulus | Matrilysin homolog | 0.00375216 | 0.0158414 | 0.0795677 |
Chlamydia trachomatis | two component regulatory system sensor histidine kinase | 0.00413895 | 0.0195228 | 0.130267 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0334951 | 0.298926 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0334951 | 0.298926 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00245365 | 0.00348256 | 0.00551478 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0334951 | 0.298926 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.00695813 | 0.0463549 | 0.155071 |
Leishmania major | protein kinase, putative | 0.00249839 | 0.00390836 | 0.0123711 |
Echinococcus multilocularis | transfer RNA-Lys | 0.00698757 | 0.0466351 | 0.156009 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.023006 | 0.199094 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.00547426 | 0.0322319 | 0.107826 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.00547426 | 0.0322319 | 0.107826 |
Leishmania major | DNA topoisomerase ii | 0.0314074 | 0.279056 | 0.883295 |
Echinococcus granulosus | Aryl hydrocarbon receptor nuclear | 0.00245365 | 0.00348256 | 0.0116502 |
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.107155 | 1 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0334951 | 0.298926 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.017834 | 0.149868 | 1 |
Onchocerca volvulus | 0.00995147 | 0.0748447 | 0.375927 | |
Brugia malayi | Matrixin family protein | 0.00409044 | 0.0190611 | 0.0637652 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0352812 | 0.315926 | 1 |
Trypanosoma brucei | Emopamil binding protein, putative | 0.00995147 | 0.0748447 | 0.236906 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.00944121 | 0.0699882 | 0.234132 |
Plasmodium falciparum | DNA gyrase subunit B | 0.017834 | 0.149868 | 0.501354 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 16392829 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.