Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0228 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0228 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0228 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0228 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0228 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0228 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0228 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0228 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0228 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0228 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0228 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0228 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0228 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0228 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0228 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0228 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0228 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0228 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0228 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0228 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0228 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0228 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0228 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0228 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0228 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0228 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0228 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0228 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0228 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0228 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0228 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0228 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0228 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0228 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0228 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0228 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0228 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0228 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0228 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0228 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0228 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0228 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0228 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0228 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0228 | 0.5 | 0.5 | |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0228 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0228 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0228 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0228 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0228 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0228 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0228 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0228 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0228 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0228 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0228 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0228 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0228 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0228 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0228 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0228 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0228 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 34 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HeLa cells at 0.01 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 34 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HeLa cells at 0.01 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 46 % | Displacement of [3H]ZM241385 from recombinant human adenosine A2A receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 46 % | Displacement of [3H]ZM241385 from recombinant human adenosine A2A receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 86 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 86 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Ki (binding) | = 7.4 | Binding affinity to recombinant human adenosine A2A receptor | ChEMBL. | 16392813 |
Ki (binding) | = 7.95 | Binding affinity to recombinant human adenosine A2B receptor | ChEMBL. | 16392813 |
Log Ki (binding) | = 7.4 | Binding affinity to recombinant human adenosine A2A receptor | ChEMBL. | 16392813 |
Log Ki (binding) | = 7.95 | Binding affinity to recombinant human adenosine A2B receptor | ChEMBL. | 16392813 |
Ratio Ki (binding) | = 3.5 | Selectivity for human adenosine A2B over human adenosine A2A receptor | ChEMBL. | 16392813 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.