Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D5 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D1 | Starlite/ChEMBL | References |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | paired box 8 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Dopamine receptor protein 1 | Get druggable targets OG5_134111 | All targets in OG5_134111 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_134111 | All targets in OG5_134111 |
Brugia malayi | Pax transcription factor protein 2 | Get druggable targets OG5_139945 | All targets in OG5_139945 |
Loa Loa (eye worm) | pax transcription factor protein 2 | Get druggable targets OG5_139945 | All targets in OG5_139945 |
Onchocerca volvulus | Get druggable targets OG5_139945 | All targets in OG5_139945 | |
Schistosoma japonicum | 5-hydroxytryptamine receptor, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Schistosoma japonicum | 5-hydroxytryptamine receptor 1, putative | Get druggable targets OG5_132667 | All targets in OG5_132667 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1111 | 1 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1111 | 1 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1111 | 1 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1111 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1111 | 1 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1111 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1111 | 1 | 0.5 |
Brugia malayi | Dopamine receptor protein 1 | 0.0509 | 0.2657 | 0.2657 |
Loa Loa (eye worm) | hypothetical protein | 0.0457 | 0.2032 | 0.2032 |
Brugia malayi | CHE-14 protein | 0.0457 | 0.2032 | 0.2032 |
Onchocerca volvulus | 0.0291 | 0 | 0.5 | |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1111 | 1 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0521 | 0.281 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1111 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0521 | 0.281 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2657 | 0.2657 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0521 | 0.281 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0521 | 0.281 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0457 | 0.2032 | 0.2032 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (functional) | < 0.26 uM | PubChem BioAssay. SA5-Pax8: Cytotoxicity IOSE-T80 Measured in Cell-Based System Using Plate Reader - 7054-07_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
AC50 (functional) | < 0.26 uM | PubChem BioAssay. PAX8: PAX8-dependent cytotoxicity Measured in Cell-Based System Using Plate Reader - 7054-06_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Ki (binding) | Inhibition of binding to human D3 receptor expressed in HEK 293 cells by radioligand binding assay | ChEMBL. | 16420061 | |
Ki (binding) | Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay | ChEMBL. | 16420061 | |
Ki (binding) | Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay | ChEMBL. | 16420061 | |
Ki (binding) | Inhibition of binding to human D2L receptor expressed in HEK 293 cells by radioligand binding assay | ChEMBL. | 16420061 | |
Ki (binding) | 0 | Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay | ChEMBL. | 16420061 |
Ki (binding) | 0 | Inhibition of binding to human D2L receptor expressed in HEK 293 cells by radioligand binding assay | ChEMBL. | 16420061 |
Ki (binding) | 0 | Inhibition of binding to human D4 receptor expressed in HEK 293 cells by radioligand binding assay | ChEMBL. | 16420061 |
Ki (binding) | 0 | Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay | ChEMBL. | 16420061 |
Ki (binding) | 0 | Inhibition of binding to human D3 receptor expressed in HEK 293 cells by radioligand binding assay | ChEMBL. | 16420061 |
Ki (functional) | > 10 uM | Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay | ChEMBL. | 16420061 |
Ki (functional) | > 10 uM | Inhibition of binding to human D2L receptor expressed in HEK 293 cells by functional calcium assay | ChEMBL. | 16420061 |
Ki (functional) | > 10 uM | Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay | ChEMBL. | 16420061 |
Ki (functional) | > 10 uM | Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay | ChEMBL. | 16420061 |
Ki (functional) | > 10 uM | Inhibition of binding to human D2L receptor expressed in HEK 293 cells by functional calcium assay | ChEMBL. | 16420061 |
Ki (functional) | > 10 uM | Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay | ChEMBL. | 16420061 |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 84.9214 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.