TDR Targets

Basic information

Technical information

TDR Targets ID: 350617
Name: 1,3-bis(3-chlorophenyl)-5-phenylimidazolidine -2,4-dione
MW: 397.254 | Formula: C21H14Cl2N2O2
H donors: 0 H acceptors: 2 LogP: 5.39 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cccc(c1)N1C(=O)N(C(C1=O)c1ccccc1)c1cccc(c1)Cl
InChi: 1S/C21H14Cl2N2O2/c22-15-8-4-10-17(12-15)24-19(14-6-2-1-3-7-14)20(26)25(21(24)27)18-11-5-9-16(23)13-18/h1-13,19H
InChiKey: FWYLGZWGRACSJW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1,3-bis(3-chlorophenyl)-5-phenyl-imidazolidine-2,4-dione
1,3-bis(3-chlorophenyl)-5-phenyl-hydantoin

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cannabinoid receptor 1 (brain)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0023	0.0053	1
Brugia malayi	beta-lactamase family protein	0.0035	0.0212	0.0212
Trypanosoma cruzi	PAB1-binding protein , putative	0.0052	0.042	0.1142
Trichomonas vaginalis	ran, putative	0.0021	0.0026	0.1234
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.057	0.057
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0212	1
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0799	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.057	0.057
Onchocerca volvulus		0.0035	0.0212	0.5
Echinococcus multilocularis	dihydrofolate reductase	0.0799	1	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.057	0.057
Echinococcus granulosus	snurportin 1	0.0302	0.3633	0.3633
Trypanosoma cruzi	PAB1-binding protein , putative	0.0052	0.042	0.1142
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0212	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0345	0.0345
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0302	0.3633	0.3633
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0306	0.3675	1
Trichomonas vaginalis	esterase, putative	0.0035	0.0212	1
Plasmodium falciparum	importin beta, putative	0.0028	0.0122	0.0332
Brugia malayi	Importin beta-1 subunit	0.0028	0.0122	0.0122
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0212	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0026	0.0071
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.057	0.057
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0026	0.0071
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0212	0.0212
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0212	0.0212
Onchocerca volvulus		0.0035	0.0212	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0212	1
Brugia malayi	hypothetical protein	0.0052	0.042	0.042
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0212	0.0212
Trypanosoma brucei	PAB1-binding protein , putative	0.0052	0.042	0.1142
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0345	0.0345
Schistosoma mansoni	hypothetical protein	0.0302	0.3633	0.3633
Plasmodium falciparum	ataxin-2 like protein, putative	0.0052	0.042	0.1142
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0053	0.2515
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0023	0.0055	0.0055
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0212	0.0212
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0053	0.0145
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0306	0.3675	1
Echinococcus multilocularis	snurportin 1	0.0302	0.3633	0.3633
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.057	0.057
Loa Loa (eye worm)	dihydrofolate reductase	0.0799	1	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.1262	0.1262
Entamoeba histolytica	Ran family GTPase	0.0021	0.0026	0.4909
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0026	0.0026
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0212	0.0212
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0345	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0212	0.0212
Schistosoma mansoni	dihydrofolate reductase	0.0799	1	1
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0306	0.3675	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0226	0.2654	0.2654
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0212	0.0212
Schistosoma mansoni	ran	0.0021	0.0026	0.0026
Leishmania major	hypothetical protein, conserved	0.0035	0.0212	0.0578
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0	0.5
Brugia malayi	RNA, U transporter 1	0.0081	0.0791	0.0791
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0212	0.0212
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0212	0.0212
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0122	0.0332
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0345	0.0345
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0026	0.0071
Brugia malayi	beta-lactamase	0.0035	0.0212	0.0212
Onchocerca volvulus		0.0035	0.0212	0.5
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0345	0.0345
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0212	0.0212
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0799	1	1
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0799	1	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0053	0.2515
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.1262	0.1262
Plasmodium vivax	ataxin-2 like protein, putative	0.0052	0.042	0.1142
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0345	0.0345
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0212	1
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0212	0.0578
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0026	0.0071
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.057	0.057
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0122	0.0332
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0306	0.3675	1
Brugia malayi	beta-lactamase family protein	0.0035	0.0212	0.0212
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.057	0.057
Leishmania major	GTP-binding protein, putative	0.0021	0.0026	0.0071
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0122	0.0332
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0053	0.2515
Toxoplasma gondii	ABC1 family protein	0.0035	0.0212	0.0578
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0212	0.0212
Schistosoma mansoni	importin beta-1	0.0028	0.0122	0.0122
Brugia malayi	Dihydrofolate reductase	0.0799	1	1
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0306	0.3675	1
Echinococcus granulosus	tar DNA binding protein	0.0063	0.057	0.057
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0212	0.0212
Toxoplasma gondii	LsmAD domain-containing protein	0.0052	0.042	0.1142
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0023	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0122	0.0122
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0026	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0345	0.0345
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0	0.5
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0212	0.0212
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0026	0.0071
Brugia malayi	TAR-binding protein	0.0063	0.057	0.057
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0212	0.0578
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0212	0.0212
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0212	0.0578
Loa Loa (eye worm)	RNA binding protein	0.0063	0.057	0.057
Chlamydia trachomatis	dihydrofolate reductase	0.0799	1	0.5
Echinococcus granulosus	dihydrofolate reductase	0.0799	1	1
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0212	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0052	0.042	0.042
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0212	0.0578
Plasmodium falciparum	ataxin-2 like protein, putative	0.0052	0.042	0.1142
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0212	0.0212
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0053	0.0145
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0212	0.0212
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0212	0.0212
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.057	0.057
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0122	0.0332
Brugia malayi	MH2 domain containing protein	0.0117	0.1262	0.1262
Brugia malayi	hypothetical protein	0.0033	0.0186	0.0186
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0026	0.0026
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0306	0.3675	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0212	0.0212
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0212	0.0212
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0345	0.0345
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0212	0.0212
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0122	0.0122
Mycobacterium ulcerans	lipase LipD	0.0035	0.0212	0.0212
Schistosoma mansoni	hypothetical protein	0.0023	0.0055	0.0055
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0212	0.0212
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0026	0.0026
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0212	0.0212
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0212	0.0212
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0212	0.0212
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0345	0.0345
Schistosoma mansoni	ran	0.0021	0.0026	0.0026
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0122	0.0122
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.057	0.057
Brugia malayi	RNA binding protein	0.0063	0.057	0.057
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0026	0.0071
Leishmania major	hypothetical protein, conserved	0.0052	0.042	0.1142
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0212	0.0212

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 32.1 %	Displacement of [3H]CP-55,940 from human CB2 receptor expressed in CHO cells at 10 uM	ChEMBL.	16451053
Activity (binding)	= 32.1 %	Displacement of [3H]CP-55,940 from human CB2 receptor expressed in CHO cells at 10 uM	ChEMBL.	16451053
Activity (binding)	= 76 %	Displacement of [3H]SR141716A from human CB1 receptor expressed in CHO cells at 10 uM	ChEMBL.	16451053
Activity (binding)	= 76 %	Displacement of [3H]SR141716A from human CB1 receptor expressed in CHO cells at 10 uM	ChEMBL.	16451053
EC50 (functional)	= 936 nM	Potency at human CB1 receptor in a [35S]GTPgammaS functional assay	ChEMBL.	16451053
EC50 (functional)	= 936 nM	Potency at human CB1 receptor in a [35S]GTPgammaS functional assay	ChEMBL.	16451053
Emax (functional)	= -50.9 %	Maximum stimulation at human CB1 receptor by [35S]GTPgammaS assay compared to the basal level	ChEMBL.	16451053
Emax (functional)	= -50.9 %	Maximum stimulation at human CB1 receptor by [35S]GTPgammaS assay compared to the basal level	ChEMBL.	16451053
Inhibition (binding)	< 10 %	Inhibition of FAAH in rat brain homogenates at 10 uM	ChEMBL.	16451053
Inhibition (binding)	< 10 %	Inhibition of FAAH in rat brain homogenates at 10 uM	ChEMBL.	16451053
Ki (binding)	= 2110 nM	Displacement of [3H]SR141716A from human CB1 receptor	ChEMBL.	16451053
Ki (binding)	= 2110 nM	Displacement of [3H]SR141716A from human CB1 receptor	ChEMBL.	16451053

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL201291
PubChem: 11560329

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 350617