Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Hepatitis C virus | Hepatitis C virus NS5B RNA-dependent RNA polymerase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0112 | 0.1234 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0323 | 1 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0112 | 0.1234 | 0.1234 |
Loa Loa (eye worm) | glutathione reductase | 0.0323 | 1 | 0.5 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0323 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0112 | 0.1234 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0112 | 0.1234 | 0.5 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0112 | 0.1234 | 0.5 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0112 | 0.1234 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0323 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0112 | 0.1234 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0323 | 1 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0112 | 0.1234 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0323 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0323 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0323 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0112 | 0.1234 | 0.5 |
Treponema pallidum | NADH oxidase | 0.0112 | 0.1234 | 0.5 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0323 | 1 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0323 | 1 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0323 | 1 | 1 |
Leishmania major | trypanothione reductase | 0.0323 | 1 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0112 | 0.1234 | 0.5 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0323 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0323 | 1 | 1 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0112 | 0.1234 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.75 uM | Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase | ChEMBL. | 16274990 |
IC50 (binding) | = 0.75 uM | Displacement of [alpha-32P]GTP from recombinant HCV NS5B RNA dependent RNA polymerase | ChEMBL. | 16274990 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.