TDR Targets

Basic information

Technical information

TDR Targets ID: 351039
Name: 4-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydro xymethyl)oxan-2-yl]oxybenzaldehyde
MW: 284.262 | Formula: C13H16O7
H donors: 4 H acceptors: 5 LogP: -0.78 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1O[C@@H](Oc2ccc(cc2)C=O)[C@@H]([C@@H]([C@@H]1O)O)O
InChi: 1S/C13H16O7/c14-5-7-1-3-8(4-2-7)19-13-12(18)11(17)10(16)9(6-15)20-13/h1-5,9-13,15-18H,6H2/t9-,10-,11-,12-,13-/m1/s1
InChiKey: OLZAGZCCJJBKNZ-SYLRKERUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxybenzaldehyde
4-[[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]benzaldehyde
4-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxybenzaldehyde

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0537	0.1174
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0074	0.0074
Onchocerca volvulus		0.009	0.2762	0.3394
Loa Loa (eye worm)	acetylcholinesterase 1	0.0082	0.2502	0.2502
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.0009	0.0074	0.0074
Brugia malayi	Carboxylesterase family protein	0.0082	0.2502	0.3024
Loa Loa (eye worm)	hypothetical protein	0.009	0.2762	0.2762
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0066	0.1955	0.2363
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0222	0.0222
Schistosoma mansoni	hypothetical protein	0.009	0.2762	0.2762
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0066	0.1955	0.1955
Loa Loa (eye worm)	carboxylesterase	0.0014	0.0222	0.0222
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2902	1
Echinococcus granulosus	roundabout 2	0.0009	0.0074	0.0074
Schistosoma mansoni	acetylcholinesterase	0.0014	0.0222	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0222	0.0222
Brugia malayi	Trypsin family protein	0.009	0.2762	0.3338
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0222	0.0222
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0465	0.0562
Schistosoma mansoni	neuroglian	0.0009	0.0074	0.0074
Brugia malayi	Carboxylesterase family protein	0.0014	0.0222	0.0269
Schistosoma mansoni	cercarial elastase (S01 family)	0.009	0.2762	0.2762
Mycobacterium ulcerans	hypothetical protein	0.009	0.2762	1
Echinococcus granulosus	contactin	0.0009	0.0074	0.0074
Onchocerca volvulus		0.0014	0.0222	0.0187
Echinococcus multilocularis	neuroglian	0.0009	0.0074	0.0074
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0094	0.2902	0.2902
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0009	0.0074	0.009
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0718	0.0718
Loa Loa (eye worm)	hypothetical protein	0.009	0.2762	0.2762
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0009	0.0074	0.009
Onchocerca volvulus		0.0014	0.0222	0.0187
Schistosoma mansoni	ran	0.0021	0.0465	0.0465
Brugia malayi	Prion-like-	0.0009	0.0074	0.009
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0009	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0222	0.0222
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0465	0.0465
Schistosoma mansoni	cercarial elastase (S01 family)	0.009	0.2762	0.2762
Loa Loa (eye worm)	hypothetical protein	0.009	0.2762	0.2762
Schistosoma mansoni	cercarial elastase (S01 family)	0.009	0.2762	0.2762
Echinococcus granulosus	BC026374 protein S09 family	0.0014	0.0222	0.0222
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0066	0.1955	0.6116
Plasmodium falciparum	importin beta, putative	0.0029	0.0718	1
Brugia malayi	Trypsin family protein	0.009	0.2762	0.3338
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0009	0.0074	0.009
Onchocerca volvulus		0.009	0.2762	0.3394
Loa Loa (eye worm)	trypsin family protein	0.009	0.2762	0.2762
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0094	0.2902	1
Brugia malayi	Trypsin-like protease protein 5	0.009	0.2762	0.3338
Echinococcus granulosus	lachesin	0.0009	0.0074	0.0074
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0009	0.0074	0.0074
Schistosoma mansoni	titin	0.0009	0.0074	0.0074
Brugia malayi	Trypsin family protein	0.009	0.2762	0.3338
Echinococcus granulosus	carboxylesterase 5A	0.0082	0.2502	0.2502
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.1955	0.6116
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.009	0.2762	0.2762
Schistosoma mansoni	importin beta-1	0.0029	0.0718	0.0718
Echinococcus granulosus	glycoprotein Antigen 5	0.009	0.2762	0.2762
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0465	0.0465
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0009	0.0074	0.0074
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.1315	0.4077
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0718	0.1039
Onchocerca volvulus		0.0014	0.0222	0.0187
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0014	0.0222	0.0222
Schistosoma mansoni	septate junction protein	0.0009	0.0074	0.0074
Echinococcus multilocularis	tyrosine protein kinase otk	0.0009	0.0074	0.0074
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.009	0.2762	0.2762
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0537	0.0295
Echinococcus granulosus	roundabout 2	0.0017	0.0315	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0074	0.0074
Schistosoma mansoni	cercarial elastase (S01 family)	0.009	0.2762	0.2762
Echinococcus multilocularis	transcription factor Dp 1	0.0038	0.103	0.103
Brugia malayi	RNA, U transporter 1	0.0081	0.2487	0.3006
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0009	0.0074	0.009
Echinococcus granulosus	transcription factor Dp 1	0.0038	0.103	0.103
Loa Loa (eye worm)	carboxylesterase	0.0082	0.2502	0.2502
Echinococcus multilocularis	neuroligin	0.0014	0.0222	0.0222
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0718	1
Echinococcus multilocularis	acetylcholinesterase	0.0082	0.2502	0.2502
Schistosoma mansoni	cercarial elastase (S01 family)	0.009	0.2762	0.2762
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0074	0.0074
Echinococcus multilocularis	snurportin 1	0.0306	1	1
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2902	1
Brugia malayi	hypothetical protein	0.009	0.2762	0.3338
Loa Loa (eye worm)	hypothetical protein	0.009	0.2762	0.2762
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.001	0.0085	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0074	0.0074
Onchocerca volvulus		0.009	0.2762	0.3394
Onchocerca volvulus		0.024	0.7807	0.9763
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0082	0.2502	0.2502
Schistosoma mansoni	cell adhesion molecule	0.0009	0.0074	0.0074
Echinococcus multilocularis	lachesin	0.0009	0.0074	0.0074
Brugia malayi	Trypsin family protein	0.009	0.2762	0.3338
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0222	0.0222
Entamoeba histolytica	hypothetical protein	0.0023	0.0537	0.0295
Brugia malayi	Carboxylesterase family protein	0.0082	0.2502	0.3024
Schistosoma mansoni	cercarial elastase (S01 family)	0.009	0.2762	0.2762
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0014	0.0222	0.5
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.009	0.2762	0.2762
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0074	0.0074
Echinococcus granulosus	peroxidasin	0.0009	0.0074	0.0074
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0014	0.0222	0.5
Brugia malayi	Peroxidasin	0.0009	0.0074	0.009
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0012	0.0177	0.0177
Echinococcus granulosus	neuroglian	0.0011	0.0139	0.0139
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0009	0.0074	0.0074
Echinococcus multilocularis	roundabout 2	0.0009	0.0074	0.0074
Brugia malayi	hypothetical protein	0.0014	0.0222	0.0269
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0009	0.0074	0.0074
Brugia malayi	Carboxylesterase family protein	0.0014	0.0222	0.0269
Echinococcus multilocularis	roundabout 2	0.0009	0.0074	0.0074
Echinococcus multilocularis	peroxidasin	0.0009	0.0074	0.0074
Schistosoma mansoni	serine/threonine protein kinase	0.0094	0.2902	0.2902
Echinococcus granulosus	tyrosine protein kinase otk	0.0009	0.0074	0.0074
Schistosoma mansoni	hypothetical protein	0.009	0.2762	0.2762
Brugia malayi	Carboxylesterase family protein	0.0014	0.0222	0.0269
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2902	1
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.009	0.2762	0.2762
Echinococcus granulosus	acetylcholinesterase	0.0082	0.2502	0.2502
Schistosoma mansoni	nephrin	0.0009	0.0074	0.0074
Echinococcus multilocularis	transmembrane protease serine 3	0.009	0.2762	0.2762
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.1315	0.4077
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0315	0.0315
Trypanosoma brucei	polo-like protein kinase	0.0094	0.2902	1
Echinococcus multilocularis	carboxylesterase 5A	0.0082	0.2502	0.2502
Trypanosoma cruzi	polo-like protein kinase, putative	0.0094	0.2902	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0014	0.0222	0.5
Loa Loa (eye worm)	hypothetical protein	0.0082	0.2502	0.2502
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0718	1
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0014	0.0222	0.0222
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0718	0.1039
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0066	0.1955	0.6116
Schistosoma mansoni	cercarial elastase (S01 family)	0.009	0.2762	0.2762
Loa Loa (eye worm)	hypothetical protein	0.0082	0.2502	0.2502
Loa Loa (eye worm)	hypothetical protein	0.009	0.2762	0.2762
Schistosoma mansoni	cercarial elastase (S01 family)	0.009	0.2762	0.2762
Giardia lamblia	Kinase, PLK	0.0094	0.2902	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0009	0.0074	0.009
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0537	0.0295
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.009	0.2762	0.2762
Onchocerca volvulus		0.009	0.2762	0.3394
Trichomonas vaginalis	ran, putative	0.0021	0.0465	0.0905
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2902	1
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0094	0.2902	0.2902
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0537	0.1174
Echinococcus granulosus	neuroglian	0.0009	0.0074	0.0074
Trypanosoma cruzi	polo-like protein kinase, putative	0.0094	0.2902	1
Schistosoma mansoni	hypothetical protein	0.0306	1	1
Echinococcus granulosus	para nitrobenzyl esterase	0.0014	0.0222	0.0222
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2902	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.009	0.2762	0.2762
Loa Loa (eye worm)	carboxylesterase	0.0014	0.0222	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0074	0.0074
Echinococcus multilocularis	enteropeptidase	0.009	0.2762	0.2762
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0009	0.0074	0.009
Echinococcus multilocularis	roundabout 2	0.0017	0.0315	0.0315
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0009	0.0074	0.009
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.1955	0.6116
Echinococcus granulosus	enteropeptidase	0.009	0.2762	0.2762
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0009	0.0074	0.009
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0718	0.0718
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0009	0.0074	0.0074
Echinococcus granulosus	twitchin	0.0012	0.0149	0.0149
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0094	0.2902	0.2902
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0222	0.0222
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.009	0.2762	0.2762
Echinococcus granulosus	acetylcholinesterase	0.0082	0.2502	0.2502
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0014	0.0222	0.0222
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0465	0.0465
Schistosoma mansoni	cercarial elastase (S01 family)	0.009	0.2762	0.2762
Echinococcus multilocularis	neuroglian	0.0011	0.0139	0.0139
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0094	0.2902	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0014	0.0222	0.0222
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0014	0.0222	0.0222
Loa Loa (eye worm)	hypothetical protein	0.009	0.2762	0.2762
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0066	0.1955	0.6116
Onchocerca volvulus	Tyrosine kinase homolog	0.0246	0.7995	1
Echinococcus multilocularis	glycoprotein Antigen 5	0.009	0.2762	0.2762
Schistosoma mansoni	gliotactin	0.0014	0.0222	0.0222
Brugia malayi	Importin beta-1 subunit	0.0029	0.0718	0.0868
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0009	0.0074	0.009
Schistosoma mansoni	cell adhesion molecule	0.0009	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0177	0.0177
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0306	1	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.2762	0.2762
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0254	0.8274	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0009	0.0074	0.0074
Schistosoma mansoni	cell adhesion molecule	0.0012	0.0177	0.0177
Schistosoma mansoni	cercarial elastase (S01 family)	0.009	0.2762	0.2762
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2902	1
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0066	0.1955	0.1955
Schistosoma mansoni	nephrin	0.0011	0.0139	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0222	0.0222
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.009	0.2762	0.2762
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0094	0.2902	0.357
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.009	0.2762	0.2762
Schistosoma mansoni	ran	0.0021	0.0465	0.0465
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0074	0.0074
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.009	0.2762	0.2762
Onchocerca volvulus		0.0014	0.0222	0.0187
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0718	0.0718
Echinococcus granulosus	roundabout 2	0.0009	0.0074	0.0074
Echinococcus multilocularis	acetylcholinesterase	0.0082	0.2502	0.2502
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.009	0.2762	0.2762
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0254	0.8274	0.8274
Onchocerca volvulus		0.009	0.2762	0.3394
Onchocerca volvulus		0.0014	0.0222	0.0187
Schistosoma mansoni	septate junction protein	0.0009	0.0074	0.0074
Schistosoma mansoni	cell adhesion molecule	0.0009	0.0074	0.0074
Echinococcus multilocularis	para nitrobenzyl esterase	0.0014	0.0222	0.0222
Echinococcus multilocularis	hemicentin 1	0.0009	0.0074	0.0074
Onchocerca volvulus		0.009	0.2762	0.3394
Echinococcus multilocularis	hemicentin 1	0.0009	0.0074	0.0074
Echinococcus multilocularis	Mastin	0.009	0.2762	0.2762
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0074	0.0074
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0066	0.1955	0.1955
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0315	0.0315
Brugia malayi	Carboxylesterase family protein	0.0014	0.0222	0.0269
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0009	0.0074	0.0074
Echinococcus granulosus	hemicentin 1	0.0009	0.0074	0.0074
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.009	0.2762	0.2762
Echinococcus granulosus	Mastin	0.009	0.2762	0.2762
Brugia malayi	serine/threonine-protein kinase plk-2	0.0094	0.2902	0.3507
Schistosoma mansoni	BC026374 protein (S09 family)	0.0014	0.0222	0.0222
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.009	0.2762	0.3338
Schistosoma mansoni	kinase	0.0048	0.1356	0.1356
Trichomonas vaginalis	CAMK family protein kinase	0.0094	0.2902	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0009	0.0074	0.0074
Schistosoma mansoni	tyrosine kinase	0.0011	0.0124	0.0124
Echinococcus granulosus	neuroligin	0.0014	0.0222	0.0222
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0537	0.1174
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0014	0.0222	0.0222
Schistosoma mansoni	cercarial elastase (S01 family)	0.009	0.2762	0.2762
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0014	0.0222	0.0222
Schistosoma mansoni	roundabout	0.0009	0.0074	0.0074
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0066	0.1955	0.1955
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0009	0.0074	0.0074
Echinococcus granulosus	transmembrane protease serine 3	0.009	0.2762	0.2762

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)		Inhibition of Electrophorus electricus AChE upto 500 uM by Ellman's method	ChEMBL.	17574306
Activity (binding)		Inhibition of horse serum BuChE upto 500 uM by Ellman's method	ChEMBL.	17574306
IC50 (binding)	= 2.54 mM	Inhibition of mushroom tyrosinase assessed as 3,4-dihydroxy-L-phenylalanine oxidation	ChEMBL.	18996693
IC50 (binding)	> 1000 uM	Inhibitory activity against SSADH	ChEMBL.	16290145
IC50 (binding)	> 1000 uM	Inhibitory activity against GABAT	ChEMBL.	16290145
IC50 (binding)	> 1000 uM	Inhibitory activity against SSADH	ChEMBL.	16290145
IC50 (binding)	> 1000 uM	Inhibitory activity against GABAT	ChEMBL.	16290145
Inhibition (binding)		Inhibition of mushroom tyrosinase at 200 uM	ChEMBL.	19800229
Inhibition (binding)	= 10 %	Inhibition of mushroom tyrosinase assessed as 3,4-dihydroxy-L-phenylalanine oxidation at 0.1 mM	ChEMBL.	18996693
Inhibition (binding)	= 24.835 %	Inhibition of Torpedo california AChE at 1 mM by Ellman's method	ChEMBL.	19726199

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL201358
PubChem: 12896796

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 351039