Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Hepatitis C virus | Hepatitis C virus NS5B RNA-dependent RNA polymerase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 381 nM | Inhibition of HCV RNA replication in Huh7 cells | ChEMBL. | 16451063 |
EC50 (functional) | = 381 nM | Inhibition of HCV RNA replication in Huh7 cells | ChEMBL. | 16451063 |
EC90 (functional) | = 2073 nM | Inhibition of HCV RNA replication in Huh7 cells | ChEMBL. | 16451063 |
EC90 (functional) | = 2073 nM | Inhibition of HCV RNA replication in Huh7 cells | ChEMBL. | 16451063 |
IC50 (binding) | = 340 nM | Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay | ChEMBL. | 16451063 |
IC50 (binding) | = 340 nM | Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay | ChEMBL. | 16451063 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.