Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable lipase LipE | 0.0042 | 0.0098 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0121 | 0.3562 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0098 | 0.0276 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0121 | 0.3562 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0098 | 0.0276 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0121 | 0.3562 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0121 | 0.3562 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0121 | 0.3562 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0121 | 0.3562 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0121 | 0.3562 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0098 | 0.0276 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0121 | 0.3562 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0042 | 0.0098 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0121 | 0.3562 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0121 | 0.3562 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0121 | 0.3562 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0042 | 0.0098 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0098 | 0.0276 |
Mycobacterium ulcerans | beta-lactamase | 0.0042 | 0.0098 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0098 | 0.0276 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0098 | 0.0276 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0121 | 0.3562 | 1 |
Onchocerca volvulus | 0.0042 | 0.0098 | 0.5 | |
Echinococcus granulosus | mitogen activated protein kinase | 0.0121 | 0.3562 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0121 | 0.3562 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0121 | 0.3562 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.0805 | 0.226 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0098 | 0.0276 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0121 | 0.3562 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.0805 | 0.226 |
Trypanosoma brucei | protein kinase, putative | 0.0121 | 0.3562 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0042 | 0.0098 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0098 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0098 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0098 | 0.0276 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0.0098 | 0.5 |
Brugia malayi | beta-lactamase | 0.0042 | 0.0098 | 0.0276 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0098 | 0.0276 |
Brugia malayi | MAP kinase sur-1 | 0.0121 | 0.3562 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0121 | 0.3562 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0121 | 0.3562 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0121 | 0.3562 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.0805 | 0.226 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0042 | 0.0098 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0098 | 0.0276 |
Onchocerca volvulus | 0.0042 | 0.0098 | 0.5 | |
Onchocerca volvulus | 0.0042 | 0.0098 | 0.5 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0098 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0098 | 0.0276 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0805 | 0.226 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ILS (functional) | = 5 % | Antitumor activity in the mice with intraperitoneal implanted L1210 lymphoid leukemia at the dose 19.1 and 26 mg/kg/day x 5 was determined as percentage increase in the life span as compared with control tumor bearers | ChEMBL. | 7452687 |
ILS (functional) | = 50 % | Antitumor activity in the mice with intraperitoneal implanted L1210 lymphoid leukemia at the dose 9.2 and 12.6 mg/kg/day x 5 was determined as percentage increase in the life span as compared with control tumor bearers | ChEMBL. | 7452687 |
Survival time (functional) | = 9 day | Antitumor activity in the mice with intraperitoneal implanted L1210 lymphoid leukemia at the dose 19.1 and 26 mg/kg/day x 5 was determined as Survival time in days; Range is 9-12 days | ChEMBL. | 7452687 |
Survival time (functional) | = 13 day | Antitumor activity in the mice with intraperitoneal implanted L1210 lymphoid leukemia at the dose 9.2 and 12.6 mg/kg/day x 5 was determined as Survival time in days; Range is 13-23 days | ChEMBL. | 7452687 |
Survivors (functional) | = 0 | Antitumor activity in the mice with intraperitoneal implanted L1210 lymphoid leukemia at the dose 9.2 and 12.6 mg/kg/day x 5 was determined and number of animals survived on 30 th day were reported; 0/6 | ChEMBL. | 7452687 |
Survivors (functional) | = 0 | Antitumor activity in the mice with intraperitoneal implanted L1210 lymphoid leukemia at the dose 19.1 and 26 mg/kg/day x 5 was determined and number of animals survived on 30 th day were reported; 0/8 | ChEMBL. | 7452687 |
T/C (functional) | = 10.5 | Antitumor activity in the mice with intraperitoneal implanted L1210 lymphoid leukemia at the dose of 19.1 and 26 mg/kg/day x 5 was determined as mean survival of treated group compared to untreated; 10.5/10 | ChEMBL. | 7452687 |
T/C (functional) | = 16.5 | Antitumor activity in the mice with intraperitoneal implanted L1210 lymphoid leukemia at the dose of 9.2 and 12.6 mg/kg/day x 5 was determined as mean survival of treated group compared to untreated; 16.5/11 | ChEMBL. | 7452687 |
Weight change (functional) | = -4.25 g mouse-1 | Antitumor activity in mice with intraperitoneal implanted L1210 lymphoid leukemia at the dose 19.1 and 26 mg/kg/day x 5 was determined as weight change (g/mouse) on 8th day | ChEMBL. | 7452687 |
Weight change (functional) | = -3.58 g mouse-1 | Antitumor activity in mice with intraperitoneal implanted L1210 lymphoid leukemia at the dose 9.2 and 12.6 mg/kg/day x 5 was determined as weight change (g/mouse) on 8th day | ChEMBL. | 7452687 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.