TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 510.36 | Formula: C23H16BrN3O4S
H donors: 2 H acceptors: 4 LogP: 3.39 Rotable bonds: 3
Rule of 5 violations (Lipinski): 2
SMILES: Brc1cccc(c1)Cn1c(=O)c(C2=NS(=O)(=O)c3c(N2)cccc3)c(c2c1cccc2)O
InChi: 1S/C23H16BrN3O4S/c24-15-7-5-6-14(12-15)13-27-18-10-3-1-8-16(18)21(28)20(23(27)29)22-25-17-9-2-4-11-19(17)32(30,31)26-22/h1-12,28H,13H2,(H,25,26)
InChiKey: XNYJQHGABNFQKM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Hepatitis C virus	Hepatitis C virus NS5B RNA-dependent RNA polymerase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei gambiense	DNA repair and recombination helicase protein PIF1, putative,DNA repair and recombination protein, mitochondrial precursor, puta	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania mexicana	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma congolense	DNA repair and recombination helicase protein PIF6	Get druggable targets OG5_128192	All targets in OG5_128192
Entamoeba histolytica	DNA repair and recombination protein, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania donovani	PIF1 helicase-like protein, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Schistosoma japonicum	ko:K01529 PIF1 5'-to-3' DNA helicase [EC:3.6.1.-], putative	Get druggable targets OG5_128192	All targets in OG5_128192
Candida albicans	DNA helicase	Get druggable targets OG5_128192	All targets in OG5_128192
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania donovani	PIF1 helicase-like protein, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Candida albicans	similar to PIF1 DNA helicase	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania infantum	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Candida albicans	similar to putative DNA helicase involved in repair and recombination of mitochondrial DNA that also plays a role in (nuclear) c	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei gambiense	DNA repair and recombination helicase protein PIF1, putative,DNA repair and recombination protein, mitochondrial precursor, puta	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania braziliensis	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Giardia lamblia	Rrm3p helicase	Get druggable targets OG5_128192	All targets in OG5_128192
Echinococcus granulosus	ATP dependent DNA helicase PIF1	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma congolense	DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania mexicana	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Entamoeba histolytica	hypothetical protein, conserved	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania infantum	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania braziliensis	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	Get druggable targets OG5_128192	All targets in OG5_128192

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.0314	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0059	0.1855
Entamoeba histolytica	cysteinyl-tRNA synthetase, putative	0.0089	0.013	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0071	0.2224
Schistosoma mansoni	hypothetical protein	0.004	0.005	0.1565
Loa Loa (eye worm)	cytochrome P450	0.0011	0.0002	0.0059
Schistosoma mansoni	cathepsin F (C01 family)	0.0053	0.0071	0.2224
Mycobacterium ulcerans	cysteinyl-tRNA synthetase	0.0089	0.013	0.0128
Echinococcus multilocularis	cathepsin L cysteine protease	0.0053	0.0071	0.0975
Trichomonas vaginalis	ABC transporter, putative	0.0024	0.0023	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0317	1
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0024	0.0023	0.071
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0159	0.5008
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.0032	0.102
Trypanosoma brucei	cysteinyl-tRNA synthetase, putative	0.0089	0.013	0.4095
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0028	0.085
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0028	0.1892
Onchocerca volvulus		0.0024	0.0023	0.0213
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0071	0.5257
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0012	0.0392
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0071	0.5257
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0027	0.0028	0.2191
Schistosoma mansoni	multidrug resistance protein	0.0024	0.0023	0.071
Plasmodium vivax	vivapain-3	0.0027	0.0028	0.1512
Schistosoma mansoni	cysteinyl-tRNA synthetase	0.0089	0.013	0.4095
Brugia malayi	Bloom's syndrome protein homolog	0.0024	0.0023	0.073
Entamoeba histolytica	hypothetical protein	0.004	0.005	0.3585
Onchocerca volvulus	Cathepsin L homolog	0.0053	0.0071	0.1808
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0071	0.5257
Echinococcus granulosus	cysteinyl tRNA synthetase	0.0089	0.013	0.4095
Echinococcus granulosus	multidrug resistance protein 1	0.0016	0.0011	0.0341
Plasmodium falciparum	cysteine--tRNA ligase	0.0089	0.013	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0053	0.0071	0.5257
Wolbachia endosymbiont of Brugia malayi	cysteinyl-tRNA synthetase	0.0089	0.013	0.5
Trichomonas vaginalis	ABC transporter, putative	0.0024	0.0023	0.1418
Plasmodium vivax	unspecified product	0.0027	0.0028	0.1512
Echinococcus granulosus	cathepsin L cysteine protease	0.0027	0.0028	0.0897
Echinococcus granulosus	cathepsin l1	0.0053	0.0071	0.2224
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.0314	1
Schistosoma mansoni	cathepsin s	0.0017	0.0012	0.0392
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.0314	1
Brugia malayi	multidrug resistance protein 3	0.0024	0.0023	0.071
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0024	0.0023	0.1418
Entamoeba histolytica	P-glycoprotein-2	0.0024	0.0023	0.1418
Trypanosoma cruzi	cruzipain precursor, putative	0.02	0.0314	0.9915
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0159	0.5008
Echinococcus multilocularis		0.0011	0.0002	0.0026
Trypanosoma brucei	cytochrome P450, putative	0.0029	0.0032	0.0976
Entamoeba histolytica	DNA repair and recombination protein, putative	0.0034	0.0039	0.2746
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0024	0.0023	0.1418
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0028	0.1892
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0028	0.1892
Brugia malayi	sodium-independent organic anion transporter family protein	0.0202	0.0317	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0317	1
Schistosoma mansoni	smdr2	0.0024	0.0023	0.071
Onchocerca volvulus		0.0053	0.0071	0.1808
Schistosoma mansoni	cytochrome P450	0.0011	0.0002	0.0059
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.0314	1
Onchocerca volvulus	Cathepsin L homolog	0.0053	0.0071	0.1808
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0024	0.0023	0.0311
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0071	0.5257
Trypanosoma cruzi	cruzipain precursor, putative	0.0017	0.0012	0.0335
Trichomonas vaginalis	ABC transporter, putative	0.0024	0.0023	0.1418
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0071	0.5257
Echinococcus granulosus	multidrug resistance protein 1	0.0024	0.0023	0.071
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0042	0.1319
Brugia malayi	hypothetical protein	0.002	0.0016	0.0508
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0016	0.0223
Plasmodium falciparum	LCCL domain-containing protein	0.002	0.0016	0.124
Loa Loa (eye worm)	hypothetical protein	0.012	0.0182	0.5742
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0071	0.5257
Giardia lamblia	Rrm3p helicase	0.0034	0.0039	0.3014
Brugia malayi	secreted modular calcium-binding protein 1	0.0106	0.0159	0.5008
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0028	0.1892
Toxoplasma gondii	cathepsin CPL	0.0053	0.0071	0.2224
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0012	0.0392
Schistosoma mansoni	lipoxygenase	0.002	0.0016	0.0508
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0011	0.0002	0.0059
Onchocerca volvulus		0.0202	0.0317	1
Loa Loa (eye worm)	RecQ helicase	0.0024	0.0023	0.073
Entamoeba histolytica	cysteine proteinase, putative	0.0053	0.0071	0.5257
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0071	0.5257
Onchocerca volvulus	Putative organic anion transporter	0.0202	0.0317	1
Loa Loa (eye worm)	agrin synaptic family protein	0.0106	0.0159	0.5008
Echinococcus multilocularis	ATP binding cassette sub family B	0.0023	0.0022	0.0306
Brugia malayi	cytochrome P450	0.0011	0.0002	0.0059
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0059	0.0813
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0024	0.0023	0.071
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0053	0.0071	0.2224
Schistosoma mansoni	rab6-interacting	0.002	0.0016	0.0508
Entamoeba histolytica	P-glycoprotein-2	0.0024	0.0023	0.1418
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0028	0.1892
Echinococcus granulosus	cathepsin L	0.0027	0.0028	0.0897
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0071	0.5257
Brugia malayi	Cathepsin L-like precursor	0.0053	0.0071	0.2224
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0042	0.1319
Echinococcus granulosus	Polycystic kidney disease protein	0.002	0.0016	0.0508
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0059	0.1855
Leishmania major	cysteinyl-tRNA synthetase, putative	0.0089	0.013	0.4095
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0059	0.1855
Trypanosoma cruzi	cytochrome P450, putative	0.0029	0.0032	0.0967
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0028	0.1892
Trypanosoma cruzi	cysteine peptidase, putative	0.02	0.0314	0.9915
Onchocerca volvulus		0.0106	0.0159	0.4742
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0053	0.0071	0.5431
Onchocerca volvulus		0.0053	0.0071	0.1808
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0016	0.0011	0.0482
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0028	0.0843
Echinococcus granulosus	ATP dependent DNA helicase PIF1	0.0034	0.0039	0.1234
Brugia malayi	Papain family cysteine protease containing protein	0.0053	0.0071	0.2224
Echinococcus multilocularis	cathepsin L	0.0027	0.0028	0.0393
Echinococcus granulosus	multidrug resistance protein 1	0.0024	0.0023	0.071
Trypanosoma cruzi	cytochrome P450, putative	0.0029	0.0032	0.0967
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0024	0.0023	0.0311
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0017	0.0012	0.0392
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0059	0.1855
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0071	0.5257
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0027	0.0028	0.0843
Trypanosoma cruzi	cysteine proteinase, putative	0.0027	0.0028	0.0843
Brugia malayi	prostaglandin transporter	0.0202	0.0317	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0071	0.5257
Entamoeba histolytica	P-glyco protein 6, putative	0.0024	0.0023	0.1418
Brugia malayi	Cathepsin L-like precursor	0.0053	0.0071	0.2224
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0024	0.0023	0.0311
Echinococcus multilocularis	cysteine protease	0.0053	0.0071	0.0975
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0071	0.5257
Loa Loa (eye worm)	cysteine protease	0.0053	0.0071	0.2224
Schistosoma mansoni	follistatin	0.0106	0.0159	0.5008
Schistosoma mansoni	rab6-interacting	0.002	0.0016	0.0508
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0005	0.0094
Leishmania major	p-glycoprotein	0.0024	0.0023	0.0661
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0028	0.1892
Echinococcus granulosus	RUN	0.002	0.0016	0.0508
Toxoplasma gondii	protease inhibitor PI2	0.0106	0.0159	0.5008
Mycobacterium tuberculosis	Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC	0.6074	1	1
Schistosoma mansoni	multidrug resistance protein	0.0024	0.0023	0.071
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0106	0.0159	0.5008
Brugia malayi	Cytochrome P450 family protein	0.0011	0.0002	0.0059
Brugia malayi	Papain family cysteine protease containing protein	0.0027	0.0028	0.0897
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0024	0.0023	0.071
Echinococcus multilocularis	cathepsin L cysteine protease	0.0053	0.0071	0.0975
Onchocerca volvulus		0.0202	0.0317	1
Plasmodium vivax	vivapain-1	0.0027	0.0028	0.1512
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0042	0.1319
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.0314	1
Brugia malayi	Papain family cysteine protease containing protein	0.0027	0.0028	0.0897
Echinococcus multilocularis	multidrug resistance protein 1	0.0016	0.0011	0.0149
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0024	0.0023	0.1418
Brugia malayi	Cathepsin L-like precursor	0.0053	0.0071	0.2224
Trypanosoma cruzi	cysteinyl-tRNA synthetase, putative	0.0089	0.013	0.406
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0028	0.085
Brugia malayi	SPARC precursor	0.0106	0.0159	0.5008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0071	0.5257
Schistosoma mansoni	hypothetical protein	0.0034	0.0039	0.1234
Echinococcus multilocularis	pol protein	0.0448	0.0723	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0024	0.0023	0.1418
Entamoeba histolytica	cysteine proteinase 2	0.0027	0.0028	0.1892
Echinococcus multilocularis	RUN	0.002	0.0016	0.0223
Trichomonas vaginalis	taga, putative	0.0024	0.0023	0.1418
Echinococcus multilocularis	cysteinyl tRNA synthetase	0.0089	0.013	0.1795
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.0314	1
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	0.0034	0.0039	0.0541
Leishmania major	cathepsin L-like protease	0.0053	0.0071	0.2197
Loa Loa (eye worm)	hypothetical protein	0.002	0.0016	0.0508
Echinococcus multilocularis	pol protein	0.0448	0.0723	1
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0034	0.0039	0.1192
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0106	0.0159	0.5008
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0012	0.0392
Trypanosoma cruzi	cysteine peptidase, putative	0.02	0.0314	0.9915
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.0314	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0053	0.0071	0.2224
Brugia malayi	Cathepsin L-like precursor	0.0053	0.0071	0.2224
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0059	0.1855
Echinococcus granulosus	multidrug resistance protein 1	0.0016	0.0011	0.0341
Onchocerca volvulus	Cathepsin F homolog	0.0053	0.0071	0.1808
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0024	0.0023	0.0661
Trypanosoma cruzi	cysteine peptidase, putative	0.0053	0.0071	0.2178
Treponema pallidum	cysteinyl-tRNA synthetase	0.0089	0.013	0.5
Entamoeba histolytica	P-glycoprotein-2, putative	0.0024	0.0023	0.1418
Loa Loa (eye worm)	doublecortin family protein	0.002	0.0016	0.0508
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0053	0.0071	0.0975
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0024	0.0023	0.071
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0023	0.071
Onchocerca volvulus		0.0053	0.0071	0.1808
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0053	0.0071	0.2224
Schistosoma mansoni	cathepsin F (C01 family)	0.0035	0.0042	0.1319
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0053	0.0071	0.5431
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0024	0.0023	0.071
Entamoeba histolytica	hypothetical protein	0.004	0.005	0.3585
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0053	0.0071	0.0975
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0024	0.0023	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0089	0.013	0.4095
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0027	0.0028	0.0897
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.0314	1
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0028	0.1892
Echinococcus multilocularis	Solute carrier organic anion transporter family	0.0202	0.0317	0.4384
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0028	0.1892
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0071	0.5257
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	0.0034	0.0039	0.1192
Trichomonas vaginalis	abcb9, putative	0.0024	0.0023	0.1418
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0024	0.0023	0.1418
Onchocerca volvulus		0.0089	0.013	0.3779
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0024	0.0023	0.0311
Onchocerca volvulus		0.0053	0.0071	0.1808
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0024	0.0023	0.071
Echinococcus granulosus	cathepsin l1	0.0035	0.0042	0.1319
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0014	0.0449
Toxoplasma gondii	transporter, major facilitator family protein	0.0202	0.0317	1
Plasmodium vivax	unspecified product	0.0017	0.0012	0.0172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0071	0.5257
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.005	0.0686
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0035	0.0042	0.1319
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0053	0.0071	0.5431
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0023	0.0022	0.0697
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0059	0.0813
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0016	0.0508
Schistosoma mansoni	lipoxygenase	0.0055	0.0074	0.2345
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0023	0.071
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0071	0.5257
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0005	0.0093
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0053	0.0071	0.5257
Loa Loa (eye worm)	fibroinase	0.0053	0.0071	0.2224
Plasmodium falciparum	cysteine--tRNA ligase	0.0089	0.013	1
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0055	0.0074	0.2345
Onchocerca volvulus	Putative organic anion transporter	0.0202	0.0317	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0042	0.1319
Onchocerca volvulus		0.0035	0.0042	0.0855
Echinococcus multilocularis	multidrug resistance protein 1	0.0024	0.0023	0.0311
Echinococcus granulosus	cysteine protease	0.0027	0.0028	0.0897
Onchocerca volvulus		0.0202	0.0317	1
Brugia malayi	ABC transporter family protein	0.0024	0.0023	0.071
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0024	0.0023	0.1418
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0016	0.001	0.0317
Echinococcus multilocularis	expressed protein	0.0106	0.0159	0.2196
Chlamydia trachomatis	cysteine--tRNA ligase	0.0089	0.013	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0017	0.0012	0.0392
Loa Loa (eye worm)	sodium-independent organic anion transporter	0.0202	0.0317	1
Brugia malayi	Cathepsin L-like precursor	0.0035	0.0042	0.1319
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0024	0.0023	0.1418
Entamoeba histolytica	cysteine proteinase, putative	0.0053	0.0071	0.5257
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.0032	0.102
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0053	0.0071	0.2224
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0028	0.1892
Echinococcus multilocularis	bloom syndrome protein	0.0024	0.0023	0.032
Trypanosoma cruzi	MFS transporter, putative	0.0202	0.0317	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0024	0.0023	0.1418
Brugia malayi	cathepsin L-like precursor	0.0035	0.0042	0.1319
Schistosoma mansoni	blooms syndrome DNA helicase	0.0019	0.0015	0.0468
Echinococcus granulosus	agrin	0.0106	0.0159	0.5008
Brugia malayi	hypothetical protein	0.002	0.0016	0.0508
Brugia malayi	Cytochrome P450 family protein	0.003	0.0033	0.1046
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	0.0034	0.0039	0.1182
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0024	0.0023	0.1418
Brugia malayi	Cytochrome P450 family protein	0.0029	0.0032	0.102
Plasmodium vivax	multidomain scavenger receptor, putative	0.002	0.0016	0.0479
Schistosoma mansoni	hypothetical protein	0.0011	0.0002	0.0059
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0024	0.0023	0.1418
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0024	0.0023	0.1418
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.005	0.1565
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0028	0.1892
Echinococcus multilocularis	follistatin	0.0106	0.0159	0.2196
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0317	1
Loa Loa (eye worm)	multidrug resistance protein 3	0.0024	0.0023	0.071
Onchocerca volvulus		0.0053	0.0071	0.1808
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0039	0.2746
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0024	0.0023	0.1418
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0034	0.0039	0.1182
Entamoeba histolytica	P-glycoprotein 5, putative	0.0024	0.0023	0.1418
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0106	0.0159	0.5008
Leishmania major	cathepsin L-like protease	0.0053	0.0071	0.2197
Onchocerca volvulus		0.0053	0.0071	0.1808
Echinococcus granulosus	follistatin	0.0106	0.0159	0.5008
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0059	0.1855
Leishmania major	cathepsin L-like protease	0.0053	0.0071	0.2197
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0034	0.0039	0.1182
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0024	0.0023	0.1418
Trypanosoma cruzi	cysteine peptidase, putative	0.02	0.0314	0.9915
Trypanosoma cruzi	cysteine protease, putative	0.0027	0.0028	0.0843
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0016	0.0508
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0034	0.0039	0.1192
Echinococcus multilocularis	pol protein	0.0448	0.0723	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0183	0.0286	0.9005
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0317	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0071	0.5257
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0028	0.1892
Loa Loa (eye worm)	cysteinyl tRNA synthetase 1	0.0089	0.013	0.4095
Echinococcus multilocularis	agrin	0.0106	0.0159	0.2196
Schistosoma mansoni	organic anion transporter	0.0202	0.0317	1
Leishmania major	cytochrome p450-like protein	0.0029	0.0032	0.0976
Brugia malayi	hypothetical protein	0.0202	0.0317	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0027	0.0028	0.0843
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0071	0.5257
Echinococcus multilocularis	cysteine protease	0.0053	0.0071	0.0975
Schistosoma mansoni	polycystin 1-related	0.002	0.0016	0.0508
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0012	0.0392
Schistosoma mansoni	agrin	0.0106	0.0159	0.5008
Leishmania major	cathepsin L-like protease	0.02	0.0314	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0071	0.5257
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0071	0.5257
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0024	0.0023	0.1418
Brugia malayi	hypothetical protein	0.0202	0.0317	1
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0317	1
Loa Loa (eye worm)	CYP4Cod1	0.0029	0.0032	0.102
Echinococcus multilocularis	multidrug resistance protein 1	0.0024	0.0023	0.0311
Loa Loa (eye worm)	hypothetical protein	0.002	0.0016	0.0508
Echinococcus granulosus	Solute carrier organic anion transporter family	0.0202	0.0317	1
Onchocerca volvulus		0.0053	0.0071	0.1808
Brugia malayi	cysteinyl tRNA synthetase protein 1	0.0089	0.013	0.4095
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0042	0.2962
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.0314	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0024	0.0023	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0159	0.5008
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0022	0.0697
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0012	0.0392
Trichomonas vaginalis	abcb9, putative	0.0024	0.0023	0.1418
Echinococcus granulosus	multidrug resistance protein 1	0.0024	0.0023	0.071
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0106	0.0159	0.5008
Brugia malayi	Cathepsin L-like precursor	0.0053	0.0071	0.2224
Entamoeba histolytica	hypothetical protein, conserved	0.0034	0.0039	0.2746
Leishmania major	cathepsin L-like protease	0.0053	0.0071	0.2197
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0028	0.1892
Schistosoma mansoni	organic anion transporter	0.0202	0.0317	1
Giardia lamblia	Cysteinyl-tRNA synthetase	0.0089	0.013	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0024	0.0023	0.071
Entamoeba histolytica	hypothetical protein	0.004	0.005	0.3585
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0317	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.0314	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0028	0.1892
Plasmodium vivax	cysteine--tRNA ligase, putative	0.0089	0.013	1
Schistosoma mansoni	loxhd1	0.002	0.0016	0.0508
Echinococcus multilocularis	Polycystic kidney disease protein	0.002	0.0016	0.0223
Brugia malayi	sodium-independent organic anion transporter family protein	0.0202	0.0317	1
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0028	0.1892
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0028	0.1892
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0024	0.0023	0.1418
Loa Loa (eye worm)	ctsf protein	0.0053	0.0071	0.2224
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0024	0.0023	0.1418
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0021	0.0018	0.1413
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0106	0.0159	0.5008
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.005	0.1565
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0071	0.5257
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.02	0.0314	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0035	0.0042	0.2962
Entamoeba histolytica	P-glycoprotein-1	0.0024	0.0023	0.1418
Leishmania major	cathepsin L-like protease	0.02	0.0314	1
Leishmania major	cathepsin L-like protease	0.0053	0.0071	0.2197
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0159	0.5008
Echinococcus multilocularis	organic anion transporting polypeptide 30B	0.0202	0.0317	0.4384
Entamoeba histolytica	hypothetical protein	0.004	0.005	0.3585
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0053	0.0071	0.5257
Brugia malayi	hypothetical protein	0.004	0.005	0.1565
Loa Loa (eye worm)	cytochrome P450 family protein	0.003	0.0033	0.1046
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0028	0.1892
Loa Loa (eye worm)	hypothetical protein	0.0202	0.0317	1
Entamoeba histolytica	cysteine protease, putative	0.0053	0.0071	0.5257
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0013	0.0005	0.0094
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0059	0.1855
Trichomonas vaginalis	abcb9, putative	0.0024	0.0023	0.1418
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0071	0.5257
Toxoplasma gondii	cysteine-tRNA synthetase (CysRS)	0.0089	0.013	0.4095
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0027	0.0028	0.0897
Brugia malayi	Cathepsin L-like precursor	0.0053	0.0071	0.2224
Echinococcus granulosus	leucyl tRNA synthetase	0.0089	0.013	0.4095
Brugia malayi	Kazal-type serine protease inhibitor domain containing protein	0.0106	0.0159	0.5008
Entamoeba histolytica	cysteine proteinase 1, putative	0.0027	0.0028	0.1892
Onchocerca volvulus		0.0202	0.0317	1
Plasmodium falciparum	multidrug resistance protein 1	0.0024	0.0023	0.1735
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0053	0.0071	0.5257
Schistosoma mansoni	hypothetical protein	0.002	0.0016	0.0508
Trypanosoma cruzi	cysteinyl-tRNA synthetase, putative	0.0089	0.013	0.406
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0024	0.0023	0.1418
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.0012	0.0335
Trichomonas vaginalis	cysteinyl-tRNA synthetase, putative	0.0089	0.013	1
Entamoeba histolytica	P-glycoprotein-5	0.0024	0.0023	0.1418
Mycobacterium ulcerans	cysteinyl-tRNA synthetase	0.6074	1	1
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0106	0.0159	0.5008
Toxoplasma gondii	Kazal-type serine protease inhibitor domain-containing protein	0.0106	0.0159	0.5008
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0027	0.0028	0.0897
Brugia malayi	Doublecortin family protein	0.002	0.0016	0.0508
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0024	0.0023	0.0311
Plasmodium vivax	vivapain-2	0.0053	0.0071	0.5035
Schistosoma mansoni	cathepsin F (C01 family)	0.0053	0.0071	0.2224
Echinococcus granulosus	bloom syndrome protein	0.0024	0.0023	0.073
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0055	0.0074	0.1028
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0016	0.0223
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	0.0034	0.0039	0.1192
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0028	0.1892
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0028	0.1892
Entamoeba histolytica	cysteine proteinase, putative	0.0035	0.0042	0.2962
Plasmodium vivax	vivapain-2	0.0053	0.0071	0.5035
Trichomonas vaginalis	DNA helicase recq, putative	0.0024	0.0023	0.1467
Onchocerca volvulus		0.0202	0.0317	1
Echinococcus multilocularis	pol protein	0.0448	0.0723	1
Schistosoma mansoni	cysteinyl-tRNA synthetase	0.0089	0.013	0.4095
Leishmania major	cysteine peptidase A (CPA)	0.0053	0.0071	0.2197
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0029	0.0032	0.003
Onchocerca volvulus	Putative organic anion transporter	0.0202	0.0317	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0158	0.0244	0.767
Brugia malayi	sodium-independent organic anion transporter family protein	0.0202	0.0317	1
Loa Loa (eye worm)	kazal-type serine protease inhibitor domain-containing protein	0.0106	0.0159	0.5008
Plasmodium vivax	multidrug resistance protein 1, putative	0.0024	0.0023	0.1017
Echinococcus granulosus	organic anion transporting polypeptide 30B	0.0202	0.0317	1
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0024	0.0023	0.0021
Brugia malayi	Cytochrome P450 family protein	0.0029	0.0032	0.102
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0024	0.0023	0.1418
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0024	0.0023	0.1418
Echinococcus granulosus	cytochrome P450 2K1	0.0011	0.0002	0.0059
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0024	0.0023	0.1418
Trichomonas vaginalis	DNA helicase recq1, putative	0.0024	0.0023	0.1467
Schistosoma mansoni	multidrug resistance protein	0.0024	0.0023	0.071
Trichomonas vaginalis	ABC transporter, putative	0.0024	0.0023	0.1418
Leishmania major	cathepsin L-like protease	0.02	0.0314	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 36 nM	Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay	ChEMBL.	16451063
IC50 (binding)	= 36 nM	Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay	ChEMBL.	16451063

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 351122