TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 483.512 | Formula: C29H25NO6
H donors: 0 H acceptors: 3 LogP: 5.56 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)c1c(OCCN2CCCCC2)c2ccccc2c2c1c1C(=O)c3ccccc3C(=O)c1o2
InChi: 1S/C29H25NO6/c1-34-29(33)23-21-22-24(31)17-9-3-4-10-18(17)25(32)28(22)36-27(21)20-12-6-5-11-19(20)26(23)35-16-15-30-13-7-2-8-14-30/h3-6,9-12H,2,7-8,13-16H2,1H3
InChiKey: KSKXCLMAVSEKHS-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	References
Homo sapiens	fibroblast growth factor receptor 1	Starlite/ChEMBL	References
Homo sapiens	platelet-derived growth factor receptor, beta polypeptide	Starlite/ChEMBL	References
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR002048,Calcium-binding EF-hand;IPR001245,Tyrosine protein kinase;IPR000719,Protein kinase;IPR011009,Protein kinase-like,domai	Get druggable targets OG5_128769	All targets in OG5_128769
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma japonicum	Fibroblast growth factor receptor precursor, putative	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128769	All targets in OG5_128769
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	Get druggable targets OG5_128769	All targets in OG5_128769
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	fibroblast growth factor receptor 4	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_128769	All targets in OG5_128769
Echinococcus granulosus	fibroblast growth factor receptor 4	Get druggable targets OG5_128769	All targets in OG5_128769
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	Get druggable targets OG5_128769	All targets in OG5_128769
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_128769	All targets in OG5_128769

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Immunoglobulin	0.0037	0.0459	0.0459
Echinococcus granulosus	roundabout 2	0.0053	0.087	0.087
Schistosoma mansoni	tyrosine kinase	0.01	0.2028	0.3321
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.01	0.2028	0.2028
Onchocerca volvulus	Huntingtin homolog	0.0112	0.2324	0.5008
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.2583	0.4231
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0215	0.486	1
Brugia malayi	hypothetical protein	0.0112	0.2324	0.465
Echinococcus multilocularis	histone acetyltransferase MYST2	0.005	0.0784	0.0784
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0267	0.6158	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0089	0.1743	0.1743
Echinococcus granulosus	histone acetyltransferase MYST2	0.005	0.0784	0.0784
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2931	0.6011
Schistosoma mansoni	cell adhesion molecule	0.0044	0.064	0.1048
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0172	0.3802	0.3802
Echinococcus granulosus	epidermal growth factor receptor	0.01	0.2028	0.2028
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0131	0.2782	0.5
Giardia lamblia	Fructose-bisphosphate aldolase	0.0267	0.6158	0.5
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0215	0.486	1
Brugia malayi	RNA binding protein	0.0123	0.2583	0.5196
Loa Loa (eye worm)	TAR-binding protein	0.0123	0.2583	0.5292
Loa Loa (eye worm)	hypothetical protein	0.005	0.0784	0.1572
Brugia malayi	Protein kinase domain containing protein	0.0061	0.106	0.1982
Schistosoma mansoni	sex comb on midleg homolog	0.0044	0.0635	0.104
Brugia malayi	RNA recognition motif domain containing protein	0.0123	0.2583	0.5196
Echinococcus granulosus	defective proboscis extension response	0.0037	0.0459	0.0459
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0033	0.0369	0.0369
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0021	0.0067	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2324	0.4757
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0267	0.6158	0.5
Loa Loa (eye worm)	hypothetical protein	0.0137	0.2931	0.6011
Echinococcus multilocularis	roundabout 2	0.0053	0.087	0.087
Brugia malayi	MH2 domain containing protein	0.0109	0.2254	0.4501
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0037	0.0459	0.0459
Loa Loa (eye worm)	RNA binding protein	0.0123	0.2583	0.5292
Loa Loa (eye worm)	TK protein kinase	0.0133	0.2833	0.5809
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0267	0.6158	0.5
Echinococcus granulosus	twitchin	0.0046	0.0689	0.0689
Schistosoma mansoni	tyrosine kinase	0.0123	0.2603	0.4263
Brugia malayi	Fibronectin type III domain containing protein	0.0037	0.0459	0.0715
Brugia malayi	Bromodomain containing protein	0.0035	0.0423	0.0638
Brugia malayi	Bromodomain containing protein	0.0069	0.1251	0.2386
Echinococcus multilocularis	epidermal growth factor receptor	0.01	0.2028	0.2028
Echinococcus multilocularis	neuropeptide s receptor	0.0423	1	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0424	0.0828
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0044	0.064	0.064
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0123	0.2583	0.5292
Loa Loa (eye worm)	hypothetical protein	0.0053	0.087	0.175
Treponema pallidum	fructose-bisphosphate aldolase	0.0267	0.6158	0.5
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0131	0.2782	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0183	0.4084	0.4084
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0459	0.09
Schistosoma mansoni	tyrosine kinase	0.0096	0.1921	0.3146
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0267	0.6158	0.5
Schistosoma mansoni	tyrosine kinase	0.01	0.2028	0.3321
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0267	0.6158	0.5
Echinococcus multilocularis		0.0056	0.0934	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0478	0.0939
Onchocerca volvulus	Tyrosine kinase homolog	0.018	0.4008	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.0061	0.106	0.2143
Brugia malayi	Furin-like cysteine rich region family protein	0.0183	0.4084	0.8363
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0459	0.09
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.1743	0.2854
Echinococcus multilocularis	neuroglian	0.0046	0.0689	0.0689
Schistosoma mansoni	tyrosine kinase	0.0061	0.106	0.1736
Schistosoma mansoni	hypothetical protein	0.0265	0.6106	1
Echinococcus multilocularis	tar DNA binding protein	0.0123	0.2583	0.2583
Echinococcus granulosus	insulin receptor	0.0061	0.106	0.106
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0123	0.2603	0.2603
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0123	0.2603	0.2603
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.005	0.0784	0.0784
Loa Loa (eye worm)	mbt repeat family protein	0.0044	0.0635	0.1264
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0044	0.0635	0.0635
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0172	0.3802	0.3802
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0183	0.4084	0.8396
Echinococcus multilocularis	neuropeptide receptor A26	0.0423	1	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.064	0.1274
Schistosoma mansoni	tyrosine kinase	0.0183	0.4084	0.669
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0267	0.6158	0.5
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0037	0.0459	0.0752
Loa Loa (eye worm)	MH2 domain-containing protein	0.0109	0.2254	0.4611
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.2583	0.4231
Echinococcus granulosus	polycomb protein SCMH1	0.0044	0.0635	0.0635
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0089	0.1743	0.3423
Onchocerca volvulus		0.0167	0.3671	0.9
Echinococcus multilocularis	insulin receptor	0.0061	0.106	0.106
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0267	0.6158	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.1743	0.2854
Schistosoma mansoni	vesicular amine transporter	0.0037	0.0459	0.0752
Echinococcus multilocularis	muscleblind protein 1	0.0137	0.2931	0.2931
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0061	0.106	0.106
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0635	0.1264
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0459	0.09
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0021	0.0067	0.011
Echinococcus multilocularis	polycomb protein SCMH1	0.0044	0.0635	0.0635
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.005	0.0784	0.0784
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0521	0.1028
Brugia malayi	TAR-binding protein	0.0123	0.2583	0.5196
Schistosoma mansoni	tyrosine kinase	0.0061	0.106	0.1736
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0061	0.106	0.106
Echinococcus granulosus	neuroglian	0.0046	0.0689	0.0689
Schistosoma mansoni	hypothetical protein	0.0019	0.0024	0.0039
Echinococcus granulosus	SAM and MBT domain containing protein	0.0044	0.0635	0.0635
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0055	0.0906	0.0906
Schistosoma mansoni	nephrin	0.0046	0.0689	0.1129
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0133	0.2833	0.5723
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0037	0.0459	0.0752
Brugia malayi	Muscleblind-like protein	0.0137	0.2931	0.593
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0089	0.1743	0.1743
Echinococcus granulosus	neuropeptide receptor A26	0.0423	1	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0267	0.6158	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.2583	0.4231
Brugia malayi	hypothetical protein	0.0037	0.0459	0.0715
Echinococcus granulosus	fetal alzheimer antigen falz	0.0021	0.0067	0.0067
Brugia malayi	mbt repeat family protein	0.0044	0.0635	0.1086
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0131	0.2782	0.5
Echinococcus granulosus	muscleblind protein	0.0137	0.2931	0.2931
Schistosoma mansoni	tyrosine kinase	0.0096	0.1921	0.3146
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0123	0.2603	0.2603
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0459	0.09
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0089	0.1743	0.1743
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0267	0.6158	0.5
Schistosoma mansoni	tyrosine kinase	0.0096	0.1921	0.3146
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0089	0.1743	0.1743
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.2583	0.4231
Schistosoma mansoni	myelin transcription factor 1 myt1	0.005	0.0784	0.1284
Brugia malayi	mbt repeat family protein	0.0044	0.0635	0.1086
Loa Loa (eye worm)	transcription factor SMAD2	0.0109	0.2254	0.4611
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0037	0.0459	0.0715
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0044	0.0635	0.104
Loa Loa (eye worm)	hypothetical protein	0.0053	0.087	0.175
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.1743	0.2854
Loa Loa (eye worm)	hypothetical protein	0.0065	0.1155	0.2339
Schistosoma mansoni	tar DNA-binding protein	0.0123	0.2583	0.4231
Echinococcus granulosus	tar DNA binding protein	0.0123	0.2583	0.2583
Schistosoma mansoni	bromodomain containing protein	0.0058	0.0987	0.1616
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0055	0.0906	0.0906
Loa Loa (eye worm)	hypothetical protein	0.0112	0.2324	0.4757
Schistosoma mansoni	sex comb on midleg homolog	0.0044	0.0635	0.104
Onchocerca volvulus	Huntingtin homolog	0.0112	0.2324	0.5008
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0459	0.09
Echinococcus granulosus	epidermal growth factor receptor	0.0183	0.4084	0.4084
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0459	0.09
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.005	0.0784	0.14
Loa Loa (eye worm)	MBCTL1	0.005	0.0784	0.1572
Echinococcus multilocularis	muscleblind protein	0.0137	0.2931	0.2931
Echinococcus multilocularis	Immunoglobulin	0.0037	0.0459	0.0459
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0267	0.6158	0.5
Schistosoma mansoni	tyrosine kinase	0.0021	0.0076	0.0124
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0123	0.2603	0.2603
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0089	0.1743	0.3554
Echinococcus granulosus	Immunoglobulin	0.0037	0.0459	0.0459
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0033	0.0369	0.0369

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	0	Intracellular inhibition of autophosphorylation of EGFR in A431 cells	ChEMBL.	16321529
Activity (functional)	0	Inhibition of HUVEC tube formation at 10 uM	ChEMBL.	16321529
Activity (functional)	0	Inhibition of blood vessel formation by CAM assay at 50 ug	ChEMBL.	16321529
Activity (functional)	0	Inhibition of ERK1 phosphorylation in EGF-treated A431 cells at 1 uM	ChEMBL.	16321529
Activity (functional)	0	Inhibition of ERK2 phosphorylation in EGF-treated A431 cells at 1 uM	ChEMBL.	16321529
Activity (functional)	0	Inhibition of MEK1 phosphorylation in EGF-treated A431 cells at 1 uM	ChEMBL.	16321529
Activity (functional)	0	Inhibition of MEK2 phosphorylation in EGF-treated A431 cells at 1 uM	ChEMBL.	16321529
IC50 (binding)	= 2.8 uM	Inhibitory activity against EGFR kinase	ChEMBL.	16321529
IC50 (binding)	= 2.8 uM	Inhibitory activity against EGFR kinase	ChEMBL.	16321529
IC50 (functional)	= 4.3 uM	Cytotoxicity against lung cancer A431 cell line	ChEMBL.	16321529
IC50 (functional)	= 4.3 uM	Cytotoxicity against lung cancer A431 cell line	ChEMBL.	16321529
IC50 (binding)	= 4.6 uM	Inhibitory activity against VEGFR2 kinase	ChEMBL.	16321529
IC50 (binding)	= 4.6 uM	Inhibitory activity against VEGFR2 kinase	ChEMBL.	16321529
IC50 (binding)	= 5.5 uM	Inhibitory activity against PDGFRbeta kinase	ChEMBL.	16321529
IC50 (binding)	= 5.5 uM	Inhibitory activity against PDGFRbeta kinase	ChEMBL.	16321529
IC50 (binding)	= 7.1 uM	Inhibitory activity against FGFR1 kinase	ChEMBL.	16321529
IC50 (binding)	= 7.1 uM	Inhibitory activity against FGFR1 kinase	ChEMBL.	16321529
Inhibition (binding)	= 79.1 %	Inhibitory activity against FGFR1 kinase at 20 uM	ChEMBL.	16321529
Inhibition (binding)	= 79.1 %	Inhibitory activity against FGFR1 kinase at 20 uM	ChEMBL.	16321529
Inhibition (binding)	= 81.7 %	Inhibitory activity against VEGFR2 kinase at 20 uM	ChEMBL.	16321529
Inhibition (binding)	= 81.7 %	Inhibitory activity against VEGFR2 kinase at 20 uM	ChEMBL.	16321529
Inhibition (binding)	= 84.3 %	Inhibitory activity against EGFR kinase at 20 uM	ChEMBL.	16321529
Inhibition (binding)	= 84.3 %	Inhibitory activity against EGFR kinase at 20 uM	ChEMBL.	16321529
Inhibition (binding)	= 89.8 %	Inhibitory activity against PDGFRbeta kinase at 20 uM	ChEMBL.	16321529
Inhibition (binding)	= 89.8 %	Inhibitory activity against PDGFRbeta kinase at 20 uM	ChEMBL.	16321529

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	16321529

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL200976
PubChem: 11569258

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 351251