Detailed information for compound 351304

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 447.485 | Formula: C19H17N3O6S2
  • H donors: 2 H acceptors: 6 LogP: 0.58 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1c(C2=NS(=O)(=O)c3c(N2)cccc3)c(=O)n(c2c1cccc2)CCS(=O)(=O)C
  • InChi: 1S/C19H17N3O6S2/c1-29(25,26)11-10-22-14-8-4-2-6-12(14)17(23)16(19(22)24)18-20-13-7-3-5-9-15(13)30(27,28)21-18/h2-9,23H,10-11H2,1H3,(H,20,21)
  • InChiKey: MXMQBGGWAJATKJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Hepatitis C virus Hepatitis C virus NS5B RNA-dependent RNA polymerase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis ATP dependent DNA helicase PIF1 Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania mexicana PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania donovani PIF1 helicase-like protein, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma brucei gambiense DNA repair and recombination helicase protein PIF1, putative,DNA repair and recombination protein, mitochondrial precursor, puta Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma congolense DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128192 All targets in OG5_128192
Entamoeba histolytica DNA repair and recombination protein, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma brucei gambiense DNA repair and recombination helicase protein PIF1, putative,DNA repair and recombination protein, mitochondrial precursor, puta Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania donovani PIF1 helicase-like protein, putative Get druggable targets OG5_128192 All targets in OG5_128192
Schistosoma mansoni hypothetical protein Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma congolense DNA repair and recombination helicase protein PIF6 Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania infantum PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Candida albicans similar to putative DNA helicase involved in repair and recombination of mitochondrial DNA that also plays a role in (nuclear) c Get druggable targets OG5_128192 All targets in OG5_128192
Entamoeba histolytica hypothetical protein, conserved Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania braziliensis PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative Get druggable targets OG5_128192 All targets in OG5_128192
Echinococcus granulosus ATP dependent DNA helicase PIF1 Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 Get druggable targets OG5_128192 All targets in OG5_128192
Giardia lamblia Rrm3p helicase Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania infantum PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Candida albicans DNA helicase Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania mexicana PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Schistosoma japonicum ko:K01529 PIF1 5'-to-3' DNA helicase [EC:3.6.1.-], putative Get druggable targets OG5_128192 All targets in OG5_128192
Candida albicans similar to PIF1 DNA helicase Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania braziliensis PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0074 0.1617 0.1658
Onchocerca volvulus Matrilysin homolog 0.0054 0.1084 0.2004
Onchocerca volvulus 0.0026 0.0364 0.0386
Schistosoma mansoni cpg binding protein 0.0029 0.045 0.0284
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0592 0.0483
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0034 0.0561 0.0422
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0592 0.0615
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0055 0.1131 0.0977
Loa Loa (eye worm) hypothetical protein 0.0035 0.0592 0.0666
Loa Loa (eye worm) hypothetical protein 0.0013 0.0012 0.0014
Schistosoma mansoni lamin 0.0026 0.0364 0.0197
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0592 0.0483
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0171 0.0161
Brugia malayi beta-lactamase family protein 0.0035 0.0592 0.0615
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0171 0.0161
Loa Loa (eye worm) hypothetical protein 0.0082 0.1812 0.2037
Toxoplasma gondii endonuclease IV APN 0.0074 0.1617 0.1162
Loa Loa (eye worm) hypothetical protein 0.0026 0.0364 0.041
Schistosoma mansoni integrin alpha-ps 0.0034 0.0584 0.0421
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0054 0.1084 0.0929
Brugia malayi beta-lactamase 0.0035 0.0592 0.0615
Onchocerca volvulus 0.0035 0.0592 0.0898
Schistosoma mansoni hypothetical protein 0.0164 0.3958 0.3853
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0127 0.3009 0.2888
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0034 0.0561 0.0576
Onchocerca volvulus 0.0035 0.0592 0.0898
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.1131 0.112
Echinococcus multilocularis dihydrofolate reductase 0.0353 0.8896 0.8894
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0171 0.0161
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0373 0.9412 1
Echinococcus granulosus integrin alpha 3 0.0113 0.2641 0.2632
Loa Loa (eye worm) hypothetical protein 0.0054 0.1084 0.1219
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0592 0.0666
Onchocerca volvulus Matrix metalloproteinase homolog 0.0119 0.2789 0.5837
Echinococcus multilocularis integrin alpha ps 0.0066 0.1413 0.1402
Mycobacterium ulcerans lipase LipD 0.0035 0.0592 0.0483
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0055 0.1131 0.112
Loa Loa (eye worm) hypothetical protein 0.0054 0.1084 0.1219
Loa Loa (eye worm) hypothetical protein 0.0116 0.2712 0.3049
Echinococcus multilocularis integrin alpha ps 0.0066 0.1413 0.1402
Loa Loa (eye worm) hypothetical protein 0.0034 0.0584 0.0657
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0019 0.0193 0.0163
Echinococcus granulosus lamin dm0 0.0026 0.0364 0.0352
Loa Loa (eye worm) hypothetical protein 0.0019 0.0193 0.0216
Mycobacterium tuberculosis Hypothetical protein 0.009 0.2043 0.2145
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.1056 0.0526
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0373 0.9412 1
Schistosoma mansoni hypothetical protein 0.0034 0.0561 0.0397
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0561 0.2084
Mycobacterium ulcerans beta-lactamase 0.0035 0.0592 0.0483
Echinococcus multilocularis thymidylate synthase 0.019 0.4641 0.4635
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0171 0.0161
Echinococcus multilocularis integrin alpha 3 0.0113 0.2641 0.2632
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0592 0.0483
Mycobacterium ulcerans hypothetical protein 0.0019 0.0193 0.0025
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0034 0.0561 0.0549
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0049 0.0055
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.009 0.2043 0.2025
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.019 0.4641 0.5112
Brugia malayi thymidylate synthase 0.019 0.4641 0.5191
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0409 0.0459
Echinococcus granulosus lamin 0.0026 0.0364 0.0352
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0055 0.1131 0.11
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0353 0.8896 1
Loa Loa (eye worm) matrixin family protein 0.013 0.3069 0.345
Mycobacterium ulcerans endonuclease IV 0.0074 0.1617 0.1658
Mycobacterium ulcerans hydrolase 0.0065 0.1389 0.1397
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0171 0.0161
Mycobacterium ulcerans epimerase 0.0019 0.0193 0.0025
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0353 0.8896 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0592 0.0429
Giardia lamblia Rrm3p helicase 0.0034 0.0561 1
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0195 0.4775 0.4768
Brugia malayi Matrixin family protein 0.0054 0.1084 0.1171
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0592 0.0483
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0592 0.0483
Loa Loa (eye worm) hypothetical protein 0.0019 0.0171 0.0192
Brugia malayi hypothetical protein 0.009 0.2043 0.2254
Brugia malayi Matrixin family protein 0.0054 0.1084 0.1171
Entamoeba histolytica hypothetical protein, conserved 0.0034 0.0561 1
Schistosoma mansoni cpg binding protein 0.0029 0.045 0.0284
Schistosoma mansoni hypothetical protein 0.0395 1 1
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0074 0.1617 0.1162
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0019 0.0193 0.0025
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0195 0.4775 0.4768
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0373 0.9412 1
Brugia malayi Hemopexin family protein 0.0076 0.1669 0.1832
Brugia malayi Matrixin family protein 0.0054 0.1084 0.1171
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.1131 0.11
Echinococcus multilocularis dna polymerase eta 0.0019 0.0171 0.0159
Schistosoma mansoni cpg binding protein 0.0028 0.0409 0.0242
Brugia malayi Dihydrofolate reductase 0.0353 0.8896 1
Loa Loa (eye worm) dihydrofolate reductase 0.0353 0.8896 1
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0364 0.0357
Loa Loa (eye worm) hypothetical protein 0.0035 0.0592 0.0666
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0592 0.0459
Loa Loa (eye worm) hypothetical protein 0.0112 0.2601 0.2924
Echinococcus granulosus integrin alpha ps 0.0066 0.1413 0.1402
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0034 0.0561 0.0549
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0171 0.0161
Entamoeba histolytica DNA repair and recombination protein, putative 0.0034 0.0561 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0171 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0171 0.0161
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0171 0.0161
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.5486 0.6091
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0592 0.0609
Loa Loa (eye worm) beta-lactamase 0.0035 0.0592 0.0666
Schistosoma mansoni hypothetical protein 0.0032 0.0513 0.0348
Mycobacterium ulcerans thymidylate synthase 0.019 0.4641 0.5124
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0592 0.2251
Schistosoma mansoni lamin 0.0026 0.0364 0.0197
Brugia malayi Matrixin family protein 0.013 0.3069 0.3414
Loa Loa (eye worm) integrin alpha pat-2 0.0228 0.5629 0.6328
Brugia malayi Integrin alpha pat-2 precursor 0.0148 0.3541 0.3947
Mycobacterium tuberculosis Conserved protein 0.0035 0.0592 0.0483
Mycobacterium ulcerans hypothetical protein 0.0035 0.0592 0.0483
Echinococcus multilocularis dnaJ subfamily B 0.0395 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0171 0.0161
Mycobacterium leprae Probable lipase LipE 0.0035 0.0592 0.0459
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0592 0.0483
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0112 0.2601 0.2886
Loa Loa (eye worm) hypothetical protein 0.0035 0.0592 0.0666
Onchocerca volvulus 0.0026 0.0364 0.0386
Mycobacterium tuberculosis Conserved protein 0.0035 0.0592 0.0483
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0592 0.2251
Schistosoma mansoni hypothetical protein 0.0164 0.3958 0.3853
Echinococcus multilocularis lamin 0.0026 0.0364 0.0352
Mycobacterium tuberculosis Conserved protein 0.0035 0.0592 0.0483
Onchocerca volvulus 0.0035 0.0592 0.0898
Schistosoma mansoni intermediate filament proteins 0.0026 0.0364 0.0197
Echinococcus granulosus thymidylate synthase 0.019 0.4641 0.4635
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0364 0.041
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0065 0.1389 0.1516
Loa Loa (eye worm) matrix metalloproteinase 0.0054 0.1084 0.1219
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0171 0.0159
Schistosoma mansoni integrin alpha-ps 0.0066 0.1413 0.1264
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0074 0.1617 0.1773
Loa Loa (eye worm) hypothetical protein 0.0065 0.1389 0.1562
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0592 0.0429
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0592 0.0581
Brugia malayi beta-lactamase family protein 0.0035 0.0592 0.0615
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0171 0.0161
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0592 0.0483
Echinococcus multilocularis lamin dm0 0.0026 0.0364 0.0352
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0034 0.0561 0.0422
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0592 0.0456
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.019 0.4641 0.5124
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0592 0.2251
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0592 0.0581
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0592 0.2251
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0034 0.0561 0.0422
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0592 0.0483
Loa Loa (eye worm) hypothetical protein 0.0074 0.1617 0.1818
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0074 0.1617 0.1637
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0055 0.1131 0.11
Onchocerca volvulus 0.0054 0.1084 0.2004
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0055 0.1131 0.1039
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0171 0.0161
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0373 0.9412 1
Schistosoma mansoni integrin alpha 0.0148 0.3541 0.3429
Chlamydia trachomatis dihydrofolate reductase 0.0353 0.8896 1
Schistosoma mansoni dihydrofolate reductase 0.0353 0.8896 0.8877
Echinococcus multilocularis geminin 0.0164 0.3958 0.395
Onchocerca volvulus Matrilysin homolog 0.0119 0.2789 0.5837
Loa Loa (eye worm) hypothetical protein 0.0032 0.0513 0.0577
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0592 0.0483
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0171 0.0161
Leishmania major hypothetical protein, conserved 0.0035 0.0592 0.0456
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0171 0.0159
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0065 0.1389 0.1397
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0034 0.0561 0.0576
Echinococcus multilocularis musashi 0.0026 0.0364 0.0352
Echinococcus granulosus intermediate filament protein 0.0026 0.0364 0.0352
Mycobacterium leprae PROBABLE HYDROLASE 0.0065 0.1389 0.1375
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0373 0.9412 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0364 0.041
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0592 0.2251
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.1034 0.1162
Loa Loa (eye worm) hypothetical protein 0.0035 0.0592 0.0666
Schistosoma mansoni hypothetical protein 0.0076 0.1669 0.1524
Echinococcus granulosus cpg binding protein 0.0029 0.045 0.0438
Brugia malayi intermediate filament protein 0.0026 0.0364 0.0357
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0353 0.8896 1
Onchocerca volvulus 0.0028 0.0409 0.0485
Loa Loa (eye worm) hypothetical protein 0.0026 0.0352 0.0396
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0171 0.0161
Loa Loa (eye worm) matrixin family protein 0.0119 0.2789 0.3136
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1221 0.1068
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0373 0.9412 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.1084 0.1219
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0171 0.0138
Trichomonas vaginalis esterase, putative 0.0035 0.0592 0.2251
Trypanosoma brucei unspecified product 0.0019 0.0171 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.009 0.2043 1
Onchocerca volvulus 0.0076 0.1669 0.3319
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0171 0.0159
Brugia malayi dihydrofolate reductase family protein 0.0353 0.8896 1
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0034 0.0561 0.0422
Echinococcus granulosus dna polymerase eta 0.0019 0.0171 0.0159
Echinococcus granulosus integrin alpha ps 0.0032 0.0513 0.0501
Loa Loa (eye worm) hypothetical protein 0.0035 0.0592 0.0666
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0193 0.0025
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.1131 0.1224
Onchocerca volvulus 0.019 0.4641 1
Echinococcus granulosus dihydrofolate reductase 0.0353 0.8896 0.8894
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.019 0.4641 0.4548
Echinococcus multilocularis integrin alpha ps 0.0032 0.0513 0.0501
Loa Loa (eye worm) thymidylate synthase 0.019 0.4641 0.5218
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0171 0.0138
Echinococcus granulosus geminin 0.0164 0.3958 0.395
Echinococcus multilocularis cpg binding protein 0.0029 0.045 0.0438
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0034 0.0561 0.0422
Echinococcus granulosus dna polymerase kappa 0.0019 0.0171 0.0159
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0171 0.0192
Brugia malayi CXXC zinc finger family protein 0.0028 0.0409 0.0407
Loa Loa (eye worm) hypothetical protein 0.0035 0.0592 0.0666
Brugia malayi Matrixin family protein 0.0054 0.1084 0.1171
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0592 0.0456

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2322 nM Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay ChEMBL. 16451063
IC50 (binding) = 2322 nM Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay ChEMBL. 16451063

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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