Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | steroid sulfatase (microsomal), isozyme S | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | hypothetical protein | Get druggable targets OG5_130476 | All targets in OG5_130476 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium ulcerans | arylsulfatase AtsB | steroid sulfatase (microsomal), isozyme S | 583 aa | 470 aa | 23.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1975 | 0.2112 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.018 | 0.3289 | 0.3519 |
Mycobacterium tuberculosis | Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) | 0.0249 | 0.6059 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.018 | 0.3289 | 0.3519 |
Loa Loa (eye worm) | S-methyl-5'-thioadenosine phosphorylase MTAP | 0.0331 | 0.9348 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.018 | 0.3289 | 0.3519 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.018 | 0.3289 | 0.5 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0331 | 0.9348 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.018 | 0.3289 | 0.3519 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.018 | 0.3289 | 0.3519 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.018 | 0.3289 | 0.3519 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0331 | 0.9348 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.018 | 0.3289 | 0.3519 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.018 | 0.3289 | 0.5 |
Echinococcus granulosus | methylthioadenosine phosphorylase | 0.0331 | 0.9348 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.018 | 0.3289 | 0.3519 |
Echinococcus multilocularis | methylthioadenosine phosphorylase | 0.0331 | 0.9348 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.018 | 0.3289 | 0.3519 |
Trypanosoma cruzi | methylthioadenosine phosphorylase, putative | 0.0331 | 0.9348 | 0.5 |
Schistosoma mansoni | methylthioadenosine phosphorylase | 0.0331 | 0.9348 | 1 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.018 | 0.3289 | 0.5 |
Leishmania major | methylthioadenosine phosphorylase, putative | 0.0331 | 0.9348 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.018 | 0.3289 | 0.3519 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.018 | 0.3289 | 0.3519 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.018 | 0.3289 | 0.3519 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.018 | 0.3289 | 0.3519 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.018 | 0.3289 | 0.3519 |
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | 0.0331 | 0.9348 | 0.5 |
Brugia malayi | MTAP | 0.0331 | 0.9348 | 0.9029 |
Mycobacterium ulcerans | 5'-methylthioadenosine phosphorylase | 0.0331 | 0.9348 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.018 | 0.3289 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 13 uM | Inhibitory activity againist Estrone sulfatase from MCF-7 cells (placental microsomes) | ChEMBL. | 11992772 |
IC50 (binding) | = 13 uM | Inhibitory activity againist Estrone sulfatase from MCF-7 cells (placental microsomes) | ChEMBL. | 11992772 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.