Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | microtubule-associated protein tau | 0.06 | 1 | 1 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.0182 | 0.2929 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0017 | 0.0148 | 0.0489 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative | 0.0025 | 0.028 | 0.0473 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.0182 | 0.2929 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0025 | 0.028 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-13 | 0.0025 | 0.028 | 0.0938 |
Onchocerca volvulus | 0.0025 | 0.028 | 0.5 | |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0025 | 0.028 | 0.0956 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0182 | 0.2929 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0182 | 0.2929 | 1 |
Schistosoma mansoni | fk506 binding protein | 0.0025 | 0.028 | 0.028 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0025 | 0.028 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0147 | 0.2348 | 0.2348 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0104 | 0.1612 | 0.5495 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0182 | 0.2929 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.028 | 0.028 |
Entamoeba histolytica | recQ family DNA helicase | 0.0009 | 0.0006 | 0.0019 |
Echinococcus multilocularis | 0.0025 | 0.028 | 0.0133 | |
Schistosoma mansoni | hypothetical protein | 0.0147 | 0.2348 | 0.2348 |
Brugia malayi | MH2 domain containing protein | 0.0104 | 0.1612 | 0.5264 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type (slyD) | 0.0025 | 0.028 | 0.0938 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0025 | 0.028 | 0.0473 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0025 | 0.028 | 0.5 |
Loa Loa (eye worm) | RecQ helicase | 0.0017 | 0.0148 | 0.0489 |
Trichomonas vaginalis | immunophilin, putative | 0.0182 | 0.2929 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.028 | 0.0473 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.0182 | 0.2929 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0157 | 0.2506 | 0.2393 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0182 | 0.2929 | 1 |
Leishmania major | fk506-binding protein 1-like protein | 0.0182 | 0.2929 | 1 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0009 | 0.0006 | 0.0006 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0182 | 0.2929 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0104 | 0.1612 | 0.5495 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0182 | 0.2929 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.028 | 0.0938 |
Loa Loa (eye worm) | FKBP5 protein | 0.0182 | 0.2929 | 1 |
Plasmodium vivax | peptidyl-prolyl cis-trans isomerase, putative | 0.0025 | 0.028 | 0.0956 |
Echinococcus multilocularis | geminin | 0.0147 | 0.2348 | 0.2232 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | 0.0025 | 0.028 | 0.0473 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0182 | 0.2929 | 1 |
Trypanosoma cruzi | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0025 | 0.028 | 0.0938 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.06 | 1 | 1 |
Trichomonas vaginalis | fk506 binding protein, putative | 0.0025 | 0.028 | 0.0473 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0025 | 0.028 | 0.0473 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0006 | 0.00000000041093 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0182 | 0.2929 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0017 | 0.0148 | 0.0148 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0025 | 0.028 | 0.0473 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0009 | 0.0006 | 0.0019 |
Echinococcus multilocularis | fk506 binding protein | 0.0182 | 0.2929 | 0.2822 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0148 | 0.0489 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.0182 | 0.2929 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0182 | 0.2929 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0025 | 0.028 | 0.0938 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-33 | 0.0025 | 0.028 | 0.0938 |
Schistosoma mansoni | immunophilin | 0.0182 | 0.2929 | 0.2929 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0182 | 0.2929 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase, putative | 0.0025 | 0.028 | 0.0473 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0025 | 0.028 | 0.0473 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 | 0.0025 | 0.028 | 0.0473 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0182 | 0.2929 | 0.2822 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.0182 | 0.2929 | 1 |
Leishmania major | FKBP-type peptidyl-prolyl cis-trans isomerase, putative | 0.0025 | 0.028 | 0.0473 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 | 0.0025 | 0.028 | 0.0473 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.2506 | 0.8554 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 | 0.0025 | 0.028 | 0.0473 |
Trypanosoma cruzi | macrophage infectivity potentiator, precursor, putative | 0.0025 | 0.028 | 0.0938 |
Onchocerca volvulus | 0.0025 | 0.028 | 0.5 | |
Echinococcus granulosus | FK506 binding protein 2 | 0.0025 | 0.028 | 0.0133 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-30 | 0.0025 | 0.028 | 0.0938 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0017 | 0.0148 | 0.5305 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0182 | 0.2929 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0157 | 0.2506 | 0.2393 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0017 | 0.0148 | 0.0489 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0182 | 0.2929 | 0.2822 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0025 | 0.028 | 0.5 |
Trypanosoma cruzi | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0025 | 0.028 | 0.0938 |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0025 | 0.028 | 1 |
Giardia lamblia | Hypothetical protein | 0.0025 | 0.028 | 0.0473 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0182 | 0.2929 | 0.2929 |
Schistosoma mansoni | immunophilin | 0.0182 | 0.2929 | 0.2929 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0025 | 0.028 | 0.0473 |
Trypanosoma brucei | macrophage infectivity potentiator, precursor, putative | 0.0025 | 0.028 | 0.0473 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0009 | 0.0006 | 0.0202 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0182 | 0.2929 | 1 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0025 | 0.028 | 1 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.0025 | 0.028 | 0.0938 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0025 | 0.028 | 0.0473 |
Trypanosoma brucei | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0025 | 0.028 | 0.0473 |
Echinococcus granulosus | geminin | 0.0147 | 0.2348 | 0.2232 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0182 | 0.2929 | 1 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0025 | 0.028 | 0.5 |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.0025 | 0.028 | 0.0133 |
Schistosoma mansoni | DNA helicase recq1 | 0.0017 | 0.0148 | 0.0148 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0025 | 0.028 | 0.0473 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0017 | 0.0148 | 0.5305 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0182 | 0.2929 | 0.2822 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.0182 | 0.2929 | 1 |
Echinococcus granulosus | FK506 binding protein 8 38 kDa | 0.0025 | 0.028 | 0.0133 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.0025 | 0.028 | 0.0956 |
Schistosoma mansoni | immunophilin | 0.0157 | 0.2506 | 0.2506 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0025 | 0.028 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0025 | 0.028 | 0.5 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0025 | 0.028 | 0.0473 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.0182 | 0.2929 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0017 | 0.0148 | 0.0507 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.0182 | 0.2929 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100 uM | Inhibition of 15-hLO | ChEMBL. | 16480270 |
IC50 (binding) | > 100 uM | Inhibition of 15-hLO | ChEMBL. | 16480270 |
IC50 (binding) | > 200 uM | Inhibition of 12-hLO | ChEMBL. | 16480270 |
IC50 (binding) | > 200 uM | Inhibition of 12-hLO | ChEMBL. | 16480270 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.