Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0185 | 1 | 1 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.0011 | 0.0247 | 0.0192 |
Onchocerca volvulus | 0.0011 | 0.0247 | 0.5 | |
Schistosoma mansoni | amine GPCR | 0.0011 | 0.0247 | 0.0192 |
Onchocerca volvulus | 0.0011 | 0.0247 | 0.5 | |
Echinococcus multilocularis | allatostatin A receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | biogenic amine receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | opsin-like receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | g protein coupled receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | serotonin receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | g protein coupled receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0011 | 0.0247 | 0.0192 |
Plasmodium falciparum | protein kinase, putative | 0.0008 | 0.0056 | 0.5 |
Echinococcus granulosus | 7tm_1 domain containing protein | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0185 | 1 | 1 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Onchocerca volvulus | 0.0011 | 0.0247 | 0.5 | |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | G-protein coupled receptor, putative | 0.0011 | 0.0247 | 0.0192 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0011 | 0.0247 | 0.5 |
Schistosoma mansoni | biogenic amine receptor | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | biogenic amine receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | alpha 1A adrenergic receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | G protein coupled receptor 139 | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | neuropeptide receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | serotonin receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | dro:myosuppressin receptor | 0.0011 | 0.0247 | 0.0192 |
Onchocerca volvulus | 0.0011 | 0.0247 | 0.5 | |
Schistosoma mansoni | neuropeptide receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.0011 | 0.0247 | 0.0192 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0185 | 1 | 1 |
Echinococcus granulosus | neuropeptide s receptor | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | serotonin receptor | 0.0011 | 0.0247 | 0.0192 |
Onchocerca volvulus | 0.0011 | 0.0247 | 0.5 | |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0185 | 1 | 1 |
Onchocerca volvulus | 0.0011 | 0.0247 | 0.5 | |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0011 | 0.0247 | 0.0192 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0185 | 1 | 1 |
Echinococcus granulosus | g protein coupled receptor | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | 7TM GPCR rhodopsin | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | neuropeptide receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | g-protein coupled receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | amine GPCR | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | neuropeptide FF receptor 2 | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | histamine h1 receptor | 0.0011 | 0.0247 | 0.0192 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0185 | 1 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | amine GPCR | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.0011 | 0.0247 | 0.0192 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0011 | 0.0247 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | neuropeptides capa receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | peptide allatostatin:somatostatin | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | g protein coupled receptor | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | adenoreceptor | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | opsin-like receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | somatostatin receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | neuropeptide receptor | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | g protein coupled receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Trypanosoma brucei | protein kinase, putative | 0.0185 | 1 | 1 |
Echinococcus granulosus | sex peptide receptor | 0.0011 | 0.0247 | 0.0192 |
Onchocerca volvulus | 0.0011 | 0.0247 | 0.5 | |
Echinococcus multilocularis | fmrfamide receptor | 0.0011 | 0.0247 | 0.0192 |
Onchocerca volvulus | 0.0011 | 0.0247 | 0.5 | |
Onchocerca volvulus | 0.0011 | 0.0247 | 0.5 | |
Echinococcus granulosus | g-protein coupled receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | opsin-like receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Onchocerca volvulus | 0.0011 | 0.0247 | 0.5 | |
Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | allatostatin A receptor | 0.0011 | 0.0247 | 0.0192 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0185 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | dro:myosuppressin receptor | 0.0011 | 0.0247 | 0.0192 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0185 | 1 | 0.5 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0011 | 0.0247 | 0.0192 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0185 | 1 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0185 | 1 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0011 | 0.0247 | 0.0192 |
Onchocerca volvulus | 0.0011 | 0.0247 | 0.5 | |
Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.0011 | 0.0247 | 0.0192 |
Onchocerca volvulus | 0.0011 | 0.0247 | 0.5 | |
Schistosoma mansoni | neuropeptide F-like receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0011 | 0.0247 | 0.0192 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0185 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0185 | 1 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.0011 | 0.0247 | 0.0192 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0185 | 1 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | orexin receptor type 2 | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | amine GPCR | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.0011 | 0.0247 | 0.0192 |
Onchocerca volvulus | 0.0011 | 0.0247 | 0.5 | |
Echinococcus multilocularis | g protein coupled receptor | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | neuropeptide receptor | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | amine GPCR | 0.0011 | 0.0247 | 0.0192 |
Onchocerca volvulus | 0.0011 | 0.0247 | 0.5 | |
Echinococcus multilocularis | somatostatin receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | fmrfamide receptor | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0247 | 0.0192 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0185 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0185 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0185 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0185 | 1 | 1 |
Echinococcus multilocularis | sex peptide receptor | 0.0011 | 0.0247 | 0.0192 |
Onchocerca volvulus | 0.0011 | 0.0247 | 0.5 | |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0011 | 0.0247 | 0.0192 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0185 | 1 | 1 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | myosin xvIII | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.0011 | 0.0247 | 0.0192 |
Schistosoma mansoni | neuropeptide receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.0011 | 0.0247 | 0.0192 |
Onchocerca volvulus | 0.0011 | 0.0247 | 0.5 | |
Giardia lamblia | Kinase, CMGC MAPK | 0.0185 | 1 | 0.5 |
Echinococcus granulosus | fmrfamide receptor | 0.0011 | 0.0247 | 0.0192 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0008 | 0.0056 | 1 |
Onchocerca volvulus | 0.0011 | 0.0247 | 0.5 | |
Echinococcus multilocularis | orexin receptor type 2 | 0.0011 | 0.0247 | 0.0192 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | neuropeptide receptor | 0.0011 | 0.0247 | 0.0192 |
Echinococcus granulosus | neuropeptide Y receptor | 0.0011 | 0.0247 | 0.0192 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -4.51 | Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement | ChEMBL. | 8568799 |
Ki (binding) | = 30800 nM | In vitro ability to displace [3H]-8-hydroxy-2-(di-n-propylamino) tetralin binding from 5-hydroxytryptamine 1A receptor site in rat brain hippocampus | ChEMBL. | 1535661 |
Ki (binding) | = 30800 nM | In vitro ability to displace [3H]-8-hydroxy-2-(di-n-propylamino) tetralin binding from 5-hydroxytryptamine 1A receptor site in rat brain hippocampus | ChEMBL. | 1535661 |
Log Ki (binding) | = 4.51 | Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabelled [3H]-8-OH-DPAT ligand displacement | ChEMBL. | 8568799 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.