Detailed information for compound 351429

Basic information

Technical information
  • TDR Targets ID: 351429
  • Name: 1-propyl-2,3,4,4a,5,7,8,9,10,10a-decahydroben zo[g]quinolin-6-one
  • MW: 247.376 | Formula: C16H25NO
  • H donors: 0 H acceptors: 1 LogP: 2.49 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN1CCCC2C1CC1=C(C2)C(=O)CCC1
  • InChi: 1S/C16H25NO/c1-2-8-17-9-4-6-13-10-14-12(11-15(13)17)5-3-7-16(14)18/h13,15H,2-11H2,1H3
  • InChiKey: QLIKRYHBUISCTR-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.009
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0027 0.0307 0.3528
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.0068 0.0783
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0207 0.2376
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0118 0.1375
Echinococcus granulosus bloom syndrome protein 0.0052 0.0871 0.0871
Brugia malayi hypothetical protein 0.0041 0.0632 0.1074
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0016 0.0068 0.0783
Echinococcus granulosus importin subunit beta 1 0.0033 0.045 0.045
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0068 0.0797
Leishmania major short chain dehydrogenase, putative 0.0016 0.0068 0.0271
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.2491 0.9905
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0207 0.0567
Echinococcus multilocularis retinol dehydrogenase 11 0.0016 0.0068 0.0068
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0118 0.0118
Echinococcus multilocularis dna polymerase eta 0.0051 0.0856 0.0856
Leishmania major quinonoid dihydropteridine reductase 0.0016 0.0068 0.0271
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0018 0.0118 0.0205
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.045 0.4935
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.2491 0.3234
Trypanosoma brucei unspecified product 0.0022 0.0207 0.1904
Echinococcus granulosus hypothetical protein 0.0016 0.0068 0.0068
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.0068 0.0783
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.009
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0027 0.0307 0.0307
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0118 0.0502
Schistosoma mansoni rab6-interacting 0.006 0.1055 0.1317
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0192 0.0192
Echinococcus multilocularis carbonyl reductase 1 0.0016 0.0068 0.0068
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0018 0.0118 0.0205
Loa Loa (eye worm) oxidoreductase 0.0016 0.0068 0.009
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.003 0.0379 0.4424
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0986 0.1747
Leishmania major hypothetical protein, conserved 0.0016 0.0068 0.0271
Loa Loa (eye worm) hypothetical protein 0.0033 0.045 0.0595
Onchocerca volvulus 0.0016 0.0068 0.0191
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0027 0.0307 0.0307
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0016 0.0068 0.0797
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0192 0.0236
Loa Loa (eye worm) oxidoreductase 0.0016 0.0068 0.009
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0068 0.0797
Echinococcus granulosus GA binding protein alpha chain 0.0083 0.1561 0.1561
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0018 0.0118 0.0205
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0018 0.0118 0.0205
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0016 0.0068 0.0191
Onchocerca volvulus 0.0016 0.0068 0.0191
Schistosoma mansoni inositol monophosphatase 0.0037 0.0537 0.0625
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0125 0.2514 0.3265
Echinococcus granulosus GPCR family 2 0.0018 0.0117 0.0117
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0018 0.0118 0.0205
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0207 0.2417
Echinococcus granulosus dna polymerase eta 0.0051 0.0856 0.0856
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0018 0.0118 0.0205
Onchocerca volvulus 0.0016 0.0068 0.0191
Leishmania major GTP-binding protein, putative 0.0024 0.0256 0.1018
Echinococcus granulosus snurportin 1 0.0352 0.756 0.756
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0016 0.0068 0.0797
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0068 0.0797
Trypanosoma brucei short-chain dehydrogenase, putative 0.0016 0.0068 0.0174
Schistosoma mansoni lipoxygenase 0.0123 0.245 0.318
Onchocerca volvulus 0.006 0.1055 0.2958
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0811 0.0992
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0192 0.1256
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0192 0.0192
Leishmania major quinonoid dihydropteridine reductase 0.0016 0.0068 0.0271
Loa Loa (eye worm) RecQ helicase 0.0052 0.0871 0.1152
Onchocerca volvulus 0.006 0.1055 0.2958
Loa Loa (eye worm) fli-1 protein 0.0251 0.5318 0.7035
Entamoeba histolytica hypothetical protein 0.0027 0.0311 0.4306
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0256 0.2515
Trypanosoma cruzi short chain dehydrogenase, putative 0.0016 0.0068 0.0797
Echinococcus multilocularis oxidoreductase 0.0016 0.0068 0.0068
Plasmodium vivax multidomain scavenger receptor, putative 0.006 0.1055 1
Echinococcus granulosus flap endonuclease 1 0.003 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.009
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0016 0.0068 0.0191
Schistosoma mansoni hypothetical protein 0.0018 0.0117 0.0065
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0207 0.2417
Echinococcus multilocularis bloom syndrome protein 0.0052 0.0871 0.0871
Trichomonas vaginalis ran, putative 0.0024 0.0256 0.2939
Echinococcus granulosus retinol dehydrogenase 11 0.0016 0.0068 0.0068
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0192 0.0192
Schistosoma mansoni hypothetical protein 0.0018 0.0117 0.0065
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0537 0.0537
Brugia malayi Ets-domain containing protein 0.0083 0.1561 0.2843
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0018 0.0118 0.0205
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0071 0.1293 0.171
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0125 0.2514 1
Leishmania major cytochrome p450-like protein 0.0018 0.0118 0.0471
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0018 0.0118 0.0205
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0028 0.0332 0.3469
Mycobacterium leprae putative cytochrome p450 0.0018 0.0118 0.2628
Onchocerca volvulus 0.0016 0.0068 0.0191
Trypanosoma brucei DNA polymerase eta, putative 0.0051 0.0856 1
Loa Loa (eye worm) dehydrogenase 0.0016 0.0068 0.009
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0016 0.0068 0.0797
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0018 0.0118 0.0205
Echinococcus multilocularis retinol dehydrogenase 13 0.0016 0.0068 0.0068
Entamoeba histolytica recQ family helicase, putative 0.0028 0.0332 0.4687
Schistosoma mansoni ran 0.0024 0.0256 0.0251
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0517 0.1852
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0016 0.0068 0.0797
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0045 0.073 0.671
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0027 0.0307 0.3588
Onchocerca volvulus 0.0173 0.3566 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0207 0.2376
Onchocerca volvulus 0.0016 0.0068 0.0191
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.045 0.1563
Echinococcus multilocularis retinol dehydrogenase 11 0.0016 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.009
Loa Loa (eye worm) flap endonuclease-1 0.003 0.0379 0.0501
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0018 0.0118 0.0205
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0083 0.1561 0.2064
Echinococcus multilocularis importin subunit beta 1 0.0033 0.045 0.045
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0256 0.0256
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0117 0.0093
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0016 0.0068 0.0068
Brugia malayi hypoxia-induced factor 1 0.0152 0.3108 0.5791
Echinococcus multilocularis snurportin 1 0.0352 0.756 0.756
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.0068 0.0783
Leishmania major quinonoid dihydropteridine reductase 0.0016 0.0068 0.0271
Plasmodium falciparum LCCL domain-containing protein 0.006 0.1055 1
Trypanosoma brucei oxidoreductase-like protein 0.0016 0.0068 0.0174
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.009
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0018 0.0118 0.0205
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0118 0.0502
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0207 0.0185
Loa Loa (eye worm) hypothetical protein 0.0157 0.3228 0.427
Trypanosoma brucei short-chain dehydrogenase, putative 0.0016 0.0068 0.0174
Onchocerca volvulus 0.0016 0.0068 0.0191
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0207 0.0567
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0018 0.0118 0.0205
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0256 0.0256
Echinococcus multilocularis neuropeptide receptor A26 0.0461 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0207 0.1904
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0537 0.6015
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0118 0.0118
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0207 0.1904
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0016 0.0068 0.0797
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0016 0.0068 0.0174
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0487 0.1729
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0517 0.6038
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0018 0.0118 0.0205
Trypanosoma cruzi short chain dehydrogenase, putative 0.0016 0.0068 0.0797
Schistosoma mansoni blooms syndrome DNA helicase 0.0041 0.0628 0.0747
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0018 0.0118 0.0205
Plasmodium vivax RNA helicase-1, putative 0.0027 0.0307 0.2421
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0018 0.0118 0.0205
Mycobacterium leprae Conserved hypothetical protein 0.0018 0.0118 0.2628
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0207 0.1904
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0256 0.2989
Loa Loa (eye worm) hypoxia-induced factor 1 0.0152 0.3108 0.4111
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0311 0.3571
Onchocerca volvulus 0.0016 0.0068 0.0191
Onchocerca volvulus 0.0016 0.0068 0.0191
Leishmania major quinonoid dihydropteridine reductase 0.0016 0.0068 0.0271
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0016 0.0068 0.1514
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0018 0.0118 0.0205
Echinococcus granulosus single minded 2 0.0036 0.0526 0.0526
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0125 0.2514 1
Leishmania major quinonoid dihydropteridine reductase 0.0016 0.0068 0.0271
Leishmania major hypothetical protein, conserved 0.0016 0.0068 0.0271
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0537 0.6163
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0632 0.0632
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0016 0.0068 0.0797
Onchocerca volvulus 0.0016 0.0068 0.0191
Echinococcus multilocularis lipoxygenase domain containing protein 0.006 0.1055 0.1055
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0117 0.0117
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0118 0.0118
Loa Loa (eye worm) doublecortin family protein 0.006 0.1055 0.1395
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0016 0.0068 0.0783
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0526 0.1874
Plasmodium falciparum eukaryotic initiation factor 4A 0.0027 0.0307 0.2421
Leishmania major quinonoid dihydropteridine reductase 0.0016 0.0068 0.0271
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0018 0.0118 0.0205
Mycobacterium leprae Probable oxidoreductase 0.0016 0.0068 0.1514
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0068 0.0797
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0207 0.246
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0016 0.0068 0.0797
Schistosoma mansoni hypothetical protein 0.0039 0.0584 0.0688
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0124 0.2491 0.9908
Loa Loa (eye worm) oxidoreductase 0.0016 0.0068 0.009
Echinococcus granulosus eukaryotic initiation factor 4A 0.0027 0.0307 0.0307
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0537 1
Loa Loa (eye worm) dehydrogenase 0.0016 0.0068 0.009
Leishmania major 3-keto-dihydrosphingosine reductase 0.0016 0.0068 0.0271
Echinococcus multilocularis transient receptor potential cation channel 0.0016 0.0068 0.0068
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0192 0.399
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0125 0.2514 1
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0027 0.0307 0.0319
Echinococcus granulosus steroid dehydrogenase 0.0016 0.0068 0.0068
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0027 0.0307 0.4238
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0207 0.0274
Schistosoma mansoni DNA helicase recq5 0.0021 0.0192 0.0165
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0118 0.0791
Leishmania major dehydrogenase-like protein 0.0016 0.0068 0.0271
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0118 0.1375
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.009
Onchocerca volvulus 0.0036 0.0526 0.1476
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0027 0.0307 0.7694
Echinococcus granulosus neuropeptide receptor A26 0.0461 1 1
Schistosoma mansoni polycystin 1-related 0.006 0.1055 0.1317
Loa Loa (eye worm) oxidoreductase 0.0016 0.0068 0.009
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0027 0.0307 0.0861
Loa Loa (eye worm) oxidoreductase 0.0016 0.0068 0.009
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0018 0.0118 0.0205
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0028 0.0332 0.1322
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0016 0.0068 0.0797
Leishmania major DNA polymerase eta, putative 0.0051 0.0856 0.3405
Echinococcus granulosus carbonyl reductase 1 0.0016 0.0068 0.0068
Trypanosoma brucei short-chain dehydrogenase, putative 0.0016 0.0068 0.0174
Echinococcus multilocularis conserved hypothetical protein 0.0016 0.0068 0.0068
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0027 0.0307 0.3588
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0027 0.0307 0.0307
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0018 0.0118 0.0205
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.003 0.0379 0.1282
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0311 0.3571
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0537 0.6268
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0537 0.6163
Brugia malayi Cytochrome P450 family protein 0.0018 0.0118 0.0096
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0125 0.2514 0.4659
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0118 0.0157
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0018 0.0118 0.0205
Schistosoma mansoni rab6-interacting 0.006 0.1055 0.1317
Brugia malayi Cytochrome P450 family protein 0.0057 0.0978 0.1734
Brugia malayi Bloom's syndrome protein homolog 0.0052 0.0871 0.1529
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0018 0.0118 0.0205
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0537 0.6268
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0018 0.0118 0.0205
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0117 0.0093
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0986 0.1747
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0118 0.0204
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0207 0.0207
Entamoeba histolytica hypothetical protein 0.0041 0.0632 1
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0016 0.0068 0.0797
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0207 0.0185
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.2491 0.9905
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.2491 0.9905
Brugia malayi Inositol-1 0.0037 0.0537 0.0892
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.045 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0016 0.0068 0.1514
Entamoeba histolytica Flap nuclease, putative 0.003 0.0379 0.5509
Schistosoma mansoni DNA helicase recq1 0.0021 0.0192 0.0165
Echinococcus multilocularis GPCR, family 2 0.0018 0.0117 0.0117
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.0068 0.0783
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.0068 0.0783
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0016 0.0068 0.0068
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0118 0.1383
Schistosoma mansoni single-minded 0.0049 0.0811 0.0992
Loa Loa (eye worm) hypothetical protein 0.0051 0.0856 0.1132
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0584 0.0982
Schistosoma mansoni gabp alpha 0.0083 0.1561 0.1992
Leishmania major eukaryotic initiation factor 4a, putative 0.0027 0.0307 0.1222
Loa Loa (eye worm) hypothetical protein 0.006 0.1055 0.1395
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0207 0.0567
Schistosoma mansoni hypothetical protein 0.0352 0.756 1
Brugia malayi Importin beta-1 subunit 0.0033 0.045 0.0727
Leishmania major eukaryotic initiation factor 4a, putative 0.0027 0.0307 0.1222
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0311 0.3632
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0118 0.0157
Echinococcus multilocularis carbonyl reductase 1 0.0016 0.0068 0.0068
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0118 0.0207
Brugia malayi hypothetical protein 0.0173 0.3566 0.6663
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0125 0.2514 0.2514
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0231 0.4862 0.4862
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0016 0.0068 0.1514
Brugia malayi Flap endonuclease-1 0.003 0.0379 0.0592
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0027 0.0307 0.3528
Loa Loa (eye worm) hypothetical protein 0.006 0.1055 0.1395
Echinococcus multilocularis steroid dehydrogenase 0.0016 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.009
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.2758 0.3648
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.003 0.0379 0.4047
Leishmania major hypothetical protein, conserved 0.0016 0.0068 0.0271
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0207 0.1904
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0068 0.0797
Schistosoma mansoni loxhd1 0.006 0.1055 0.1317
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0027 0.0307 0.3528
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0016 0.0068 0.0797
Brugia malayi Doublecortin family protein 0.006 0.1055 0.188
Leishmania major pteridine reductase 1 0.0016 0.0068 0.0271
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0016 0.0068 0.009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.009
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0986 0.1304
Loa Loa (eye worm) hypothetical protein 0.0018 0.0117 0.0155
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0016 0.0068 0.0068
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0537 0.0537
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0013 0 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0016 0.0068 0.0797
Trichomonas vaginalis DNA helicase recq1, putative 0.0052 0.0871 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0118 0.1383
Echinococcus granulosus WW domain containing oxidoreductase 0.0016 0.0068 0.0068
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0018 0.0118 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0207 0.1904
Leishmania major short chain dehydrogenase/reductase, putative 0.0016 0.0068 0.0271
Loa Loa (eye worm) inositol-1 0.0037 0.0537 0.071
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0117 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0207 0.1904
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0632 0.0753
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0035 0.0496 0.434
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0256 0.1902
Schistosoma mansoni hypothetical protein 0.0041 0.0632 0.0753
Echinococcus multilocularis steroid dehydrogenase 0.0016 0.0068 0.0068
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0537 0.2134
Plasmodium falciparum importin beta, putative 0.0033 0.045 0.3868
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0118 0.0471
Leishmania major importin beta-1 subunit, putative 0.0027 0.0311 0.1237
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0118 0.0157
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0118 0.0156
Treponema pallidum ATP-dependent RNA helicase 0.0027 0.0307 0.5
Echinococcus granulosus oxidoreductase 0.0016 0.0068 0.0068
Echinococcus granulosus hypothetical protein 0.0016 0.0068 0.0068
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0117 0.0155
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0016 0.0068 0.0797
Loa Loa (eye worm) oxidoreductase 0.0016 0.0068 0.009
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0256 0.0339
Leishmania major short chain dehydrogenase-like protein 0.0016 0.0068 0.0271
Trichomonas vaginalis flap endonuclease-1, putative 0.003 0.0379 0.435
Plasmodium vivax flap endonuclease 1, putative 0.003 0.0379 0.3147
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0018 0.0118 0.0205
Schistosoma mansoni DNA polymerase eta 0.0051 0.0856 0.1052
Schistosoma mansoni ets-related 0.0251 0.5318 0.7008
Brugia malayi Cytochrome P450 family protein 0.0018 0.0118 0.0096
Brugia malayi Fli-1 protein 0.0251 0.5318 1
Brugia malayi RNA, U transporter 1 0.0094 0.1805 0.3308
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0018 0.0118 0.0205
Onchocerca volvulus 0.0016 0.0068 0.0191
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0192 0.0236
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0207 0.1904
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0016 0.0068 0.0068
Giardia lamblia DINP protein human, muc B family 0.0022 0.0207 0.4467
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0207 0.1904
Echinococcus multilocularis lipoxygenase domain containing protein 0.006 0.1055 0.1055
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.011 0.2161 0.2859
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0118 0.0118
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0118 0.0118
Brugia malayi PAS domain containing protein 0.0049 0.0811 0.1416
Loa Loa (eye worm) cytochrome P450 family protein 0.0057 0.0978 0.1294
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0018 0.0118 0.0205
Leishmania major hypothetical protein, conserved 0.0016 0.0068 0.0271
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0118 0.0468
Brugia malayi hypothetical protein 0.006 0.1055 0.188
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0018 0.0118 0.0205
Toxoplasma gondii aldehyde dehydrogenase 0.0124 0.2491 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.0068 0.0783
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0231 0.4862 0.4862
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0027 0.0307 0.0319
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0526 0.0526
Echinococcus granulosus retinol dehydrogenase 11 0.0016 0.0068 0.0068
Entamoeba histolytica hypothetical protein 0.0041 0.0632 1
Brugia malayi MH2 domain containing protein 0.0136 0.2758 0.5123
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0016 0.0068 0.0174
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0016 0.0068 0.0797
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0537 0.1915
Trypanosoma brucei cytochrome P450, putative 0.0018 0.0118 0.08
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0018 0.0118 0.0205
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0256 0.2989
Onchocerca volvulus 0.0016 0.0068 0.0191
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0016 0.0068 0.0174
Loa Loa (eye worm) hypothetical protein 0.0021 0.0192 0.0254
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0018 0.0118 0.0205
Leishmania major flap endonuclease-1 (FEN-1), putative 0.003 0.0379 0.1506
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0207 0.1904
Brugia malayi Cytochrome P450 family protein 0.0018 0.0118 0.0096
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0016 0.0068 0.0191
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.2758 0.3648
Leishmania major quinonoid dihydropteridine reductase 0.0016 0.0068 0.0271
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0118 0.0118
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0207 0.0823
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0118 0.0204
Onchocerca volvulus Sepiapterin reductase homolog 0.0016 0.0068 0.0191
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0057 0.0986 0.1304
Echinococcus multilocularis 0.0018 0.0118 0.0118
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0018 0.0118 0.0205
Loa Loa (eye worm) hypothetical protein 0.0165 0.3393 0.4488
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0207 0.1904
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0027 0.0307 0.0977
Loa Loa (eye worm) oxidoreductase 0.0016 0.0068 0.009
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0256 0.6045
Plasmodium vivax importin-beta 2, putative 0.0033 0.045 0.3868
Echinococcus multilocularis GA binding protein alpha chain 0.0083 0.1561 0.1561
Onchocerca volvulus 0.0016 0.0068 0.0191
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0016 0.0068 0.0174
Echinococcus granulosus lipoxygenase domain containing protein 0.006 0.1055 0.1055
Schistosoma mansoni ran 0.0024 0.0256 0.0251
Brugia malayi ImpB/MucB/SamB family protein 0.0051 0.0856 0.1501
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.009
Echinococcus multilocularis RUN 0.006 0.1055 0.1055
Echinococcus multilocularis neuropeptide s receptor 0.0461 1 1
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0207 0.0264
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0068 0.0797
Trichomonas vaginalis steroid dehydrogenase, putative 0.0016 0.0068 0.0783
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0018 0.0118 0.0205
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0016 0.0068 0.0068
Echinococcus granulosus carbonyl reductase 1 0.0016 0.0068 0.0068
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0018 0.0118 0.0205
Trypanosoma brucei short-chain dehydrogenase, putative 0.0016 0.0068 0.0174
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0124 0.2491 0.2491
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0207 0.1904
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.0068 0.0783
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0018 0.0118 0.0205
Schistosoma mansoni hypothetical protein 0.0018 0.0118 0.0067
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0018 0.0118 0.0205
Schistosoma mansoni inositol monophosphatase 0.0037 0.0537 0.0625
Loa Loa (eye worm) hypothetical protein 0.0039 0.0584 0.0772
Echinococcus multilocularis carbonyl reductase 1 0.0016 0.0068 0.0068
Brugia malayi cytochrome P450 0.0018 0.0118 0.0096
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0016 0.0068 0.0797
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0537 0.6163
Brugia malayi Ets-domain containing protein 0.0083 0.1561 0.2843
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0207 0.0207
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0016 0.0068 0.0783
Leishmania major short chain dehydrogenase/reductase, putative 0.0016 0.0068 0.0271
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0018 0.0118 0.0205
Schistosoma mansoni cytochrome P450 0.0018 0.0118 0.0067
Echinococcus multilocularis flap endonuclease 1 0.003 0.0379 0.0379
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0124 0.2491 0.9905
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0027 0.0307 0.0986
Echinococcus granulosus dna polymerase kappa 0.0022 0.0207 0.0207
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0118 0.1383
Echinococcus granulosus RUN 0.006 0.1055 0.1055
Entamoeba histolytica Ran family GTPase 0.0024 0.0256 0.333
Echinococcus granulosus carbonyl reductase 1 0.0016 0.0068 0.0068
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0526 0.0873
Leishmania major DNA polymerase eta, putative 0.0036 0.0517 0.2056
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0207 0.2417
Trypanosoma brucei short-chain dehydrogenase, putative 0.0016 0.0068 0.0174
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0016 0.0068 0.0068
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0537 0.8308
Schistosoma mansoni importin beta-1 0.0033 0.045 0.051
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0311 0.3571
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0018 0.0118 0.0205
Echinococcus multilocularis carbonyl reductase 1 0.0016 0.0068 0.0068
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0207 0.2417
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0118 0.1383
Leishmania major hypothetical protein, conserved 0.0016 0.0068 0.0271
Schistosoma mansoni hypothetical protein 0.0018 0.0117 0.0065
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0018 0.0118 0.0205
Loa Loa (eye worm) hypothetical protein 0.0016 0.0068 0.009
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0118 0.0791
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0018 0.0118 0.0205
Loa Loa (eye worm) oxidoreductase 0.0016 0.0068 0.009
Entamoeba histolytica hypothetical protein 0.0041 0.0632 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0207 0.0567
Loa Loa (eye worm) cytochrome P450 0.0018 0.0118 0.0157
Echinococcus multilocularis Polycystic kidney disease protein 0.006 0.1055 0.1055
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.0856 1
Schistosoma mansoni hypothetical protein 0.0018 0.0117 0.0065
Brugia malayi hypothetical protein 0.006 0.1055 0.188
Giardia lamblia Flap structure-specific endonuclease 0.003 0.0379 1
Leishmania major DNA polymerase kappa, putative 0.0022 0.0207 0.0823
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0117 0.0117
Entamoeba histolytica hypothetical protein 0.0041 0.0632 1
Echinococcus granulosus carbonyl reductase 1 0.0016 0.0068 0.0068
Echinococcus granulosus Polycystic kidney disease protein 0.006 0.1055 0.1055
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0018 0.0118 0.0205
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0016 0.0068 0.0783
Loa Loa (eye worm) hypothetical protein 0.0173 0.3566 0.4717
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0118 0.0202
Trichomonas vaginalis DNA helicase recq, putative 0.0028 0.0332 0.3818
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0018 0.0118 0.0205
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.2491 0.3234
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0016 0.0068 0.0068
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.045 0.4935
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0537 0.1933
Leishmania major short chain dehydrogenase, putative 0.0016 0.0068 0.0271
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0016 0.0068 0.1514
Echinococcus granulosus lipoxygenase domain containing protein 0.006 0.1055 0.1055
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0192 0.0511
Onchocerca volvulus 0.0016 0.0068 0.0191
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0256 0.0358
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0016 0.0068 0.0797
Leishmania major cytochrome p450-like protein 0.0018 0.0118 0.0471
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0118 0.0066
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0256 0.0775
Loa Loa (eye worm) oxidoreductase 0.0016 0.0068 0.009
Brugia malayi hypothetical protein 0.0165 0.3393 0.6333
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0352 0.756 1
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0027 0.0307 0.3154
Schistosoma mansoni lipoxygenase 0.0231 0.4862 0.6399
Plasmodium falciparum flap endonuclease 1 0.003 0.0379 0.3147
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0124 0.2491 0.2491
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0125 0.2514 0.2514
Loa Loa (eye worm) hypothetical protein 0.0027 0.0307 0.0406
Brugia malayi eukaryotic initiation factor 4A 0.0027 0.0307 0.0455
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0118 0.0118
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0192 0.0511
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0192 0.0254
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0028 0.0332 0.3883
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0016 0.0068 0.1514
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0192 0.0192
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0118 0.0094
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0256 0.1902
Schistosoma mansoni hypothetical protein 0.006 0.1055 0.1317
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0207 0.1904
Trichomonas vaginalis DNA helicase recq, putative 0.0052 0.0871 1
Leishmania major cytochrome p450-like protein 0.0018 0.0118 0.0471
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0016 0.0068 0.0174
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0118 0.08
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.045 0.1576
Brugia malayi isocitrate dehydrogenase 0.0018 0.0118 0.0094
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0018 0.0118 0.0205
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0632 0.0632
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0207 0.1904
Trypanosoma cruzi cytochrome P450, putative 0.0018 0.0118 0.1383
Schistosoma mansoni flap endonuclease-1 0.0027 0.0315 0.0329
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0125 0.2514 1
Leishmania major oxidoreductase-like protein 0.0016 0.0068 0.0271

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Effect on striatal dopamine release in rat at 1umol/kg, sc ChEMBL. 16480286
Activity (binding) = -19 % Displacement of [3H]nemonapride from human dopamine D4 receptor at 50nM ChEMBL. 16480286
Activity (binding) = -19 % Displacement of [3H]nemonapride from human dopamine D4 receptor at 50nM ChEMBL. 16480286
Activity (binding) = -4 % Displacement of [3H]nemonapride from human dopamine D4 receptor at 50nM ChEMBL. 16480286
Activity (binding) = -4 % Displacement of [3H]nemonapride from human dopamine D4 receptor at 50nM ChEMBL. 16480286
Activity (binding) = -1 % Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum membrane at 100nM ChEMBL. 16480286
Activity (binding) = -1 % Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum membrane at 100nM ChEMBL. 16480286
Activity (binding) = 3 % Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum membrane at 100nM ChEMBL. 16480286
Activity (binding) = 3 % Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum membrane at 100nM ChEMBL. 16480286
Activity (binding) = 7 % Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum membrane at 100nM ChEMBL. 16480286
Activity (binding) = 7 % Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum membrane at 100nM ChEMBL. 16480286
Activity (binding) = 15 % Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum membrane at 100nM ChEMBL. 16480286
Activity (binding) = 15 % Displacement of [3H]spiperone from dopamine D2 receptor in rat corpus striatum membrane at 100nM ChEMBL. 16480286
Activity (functional) = 20 % Decrease in striatal dopamine levels in rat at 1 nmol/kg, sc ChEMBL. 16480286
Activity (functional) = 20 % Decrease in striatal dopamine levels in rat at 3 nmol/kg, sc ChEMBL. 16480286
Activity (functional) = 20 % Decrease in striatal dopamine levels in rat at 10 nmol/kg, sc ChEMBL. 16480286
Activity (binding) = 23 % Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells at 50nM ChEMBL. 16480286
Activity (binding) = 23 % Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells at 50nM ChEMBL. 16480286
Activity (binding) = 28 % Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells at 50nM ChEMBL. 16480286
Activity (binding) = 28 % Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells at 50nM ChEMBL. 16480286
Activity (functional) = 45 % Decrease in striatal dopamine levels in rat at 3 nmol/kg, po ChEMBL. 16480286
Activity (functional) = 60 % Decrease in striatal dopamine levels in rat at 10 nmol/kg, po ChEMBL. 16480286

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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