TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 468.525 | Formula: C23H24N4O5S
H donors: 3 H acceptors: 5 LogP: 2.07 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CC(CCn1c(=O)c(C2=NS(=O)(=O)c3c(N2)cccc3)c(c2c1ccc(c2)NC(=O)C)O)C
InChi: 1S/C23H24N4O5S/c1-13(2)10-11-27-18-9-8-15(24-14(3)28)12-16(18)21(29)20(23(27)30)22-25-17-6-4-5-7-19(17)33(31,32)26-22/h4-9,12-13,29H,10-11H2,1-3H3,(H,24,28)(H,25,26)
InChiKey: XOBKPEXHDISODU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Hepatitis C virus	Hepatitis C virus NS5B RNA-dependent RNA polymerase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	Get druggable targets OG5_128192	All targets in OG5_128192
Entamoeba histolytica	hypothetical protein, conserved	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania braziliensis	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Candida albicans	DNA helicase	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania donovani	PIF1 helicase-like protein, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma congolense	DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania mexicana	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania braziliensis	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma congolense	DNA repair and recombination helicase protein PIF6	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania infantum	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_128192	All targets in OG5_128192
Giardia lamblia	Rrm3p helicase	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Candida albicans	similar to PIF1 DNA helicase	Get druggable targets OG5_128192	All targets in OG5_128192
Schistosoma japonicum	ko:K01529 PIF1 5'-to-3' DNA helicase [EC:3.6.1.-], putative	Get druggable targets OG5_128192	All targets in OG5_128192
Echinococcus granulosus	ATP dependent DNA helicase PIF1	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania mexicana	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	Get druggable targets OG5_128192	All targets in OG5_128192
Entamoeba histolytica	DNA repair and recombination protein, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	Get druggable targets OG5_128192	All targets in OG5_128192
Candida albicans	similar to putative DNA helicase involved in repair and recombination of mitochondrial DNA that also plays a role in (nuclear) c	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei gambiense	DNA repair and recombination helicase protein PIF1, putative,DNA repair and recombination protein, mitochondrial precursor, puta	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania donovani	PIF1 helicase-like protein, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Leishmania infantum	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	Get druggable targets OG5_128192	All targets in OG5_128192
Trypanosoma brucei gambiense	DNA repair and recombination helicase protein PIF1, putative,DNA repair and recombination protein, mitochondrial precursor, puta	Get druggable targets OG5_128192	All targets in OG5_128192

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.021	0.0178
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0017	0.0209	0.0177
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0308	0.1706
Brugia malayi	Bloom's syndrome protein homolog	0.0048	0.12	0.1664
Brugia malayi	MH2 domain containing protein	0.0128	0.3683	0.5201
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0028	0.0571	0.054
Leishmania major	DNA polymerase kappa, putative	0.0021	0.0327	0.0728
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0028	0.0571	0.3715
Schistosoma mansoni	ran	0.0023	0.0392	0.036
Schistosoma mansoni	hypothetical protein	0.0034	0.0733	0.0703
Leishmania major	eukaryotic initiation factor 4a, putative	0.0028	0.0571	0.2239
Leishmania major	DNA polymerase eta, putative	0.0048	0.1181	0.6028
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.1803	0.9881
Loa Loa (eye worm)	hypothetical protein	0.0022	0.037	0.0338
Schistosoma mansoni	DNA helicase recq5	0.002	0.0308	0.0276
Plasmodium vivax	RNA helicase-1, putative	0.0028	0.0571	0.7243
Brugia malayi	Ets-domain containing protein	0.0077	0.2108	0.2957
Schistosoma mansoni	rab6-interacting	0.0022	0.037	0.0338
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	0.0034	0.0733	0.0703
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0327	0.1904
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0034	0.0735	0.4075
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	0.0034	0.0733	0.5751
Entamoeba histolytica	hypothetical protein	0.0038	0.0886	1
Echinococcus granulosus	importin subunit beta 1	0.0031	0.0647	0.0617
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0068	0.1821	0.2549
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1351	0.1323
Brugia malayi	hypothetical protein	0.0038	0.0886	0.1217
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0017	0.021	0.0178
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0308	0.0392
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0023	0.0392	0.036
Echinococcus granulosus	dna polymerase kappa	0.0021	0.0327	0.0296
Echinococcus multilocularis	bloom syndrome protein	0.0048	0.12	0.1172
Brugia malayi	Doublecortin family protein	0.0022	0.037	0.0481
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0062	0.1611	0.1583
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0464	0.1567
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0028	0.0571	0.4213
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0327	0.1904
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0068	0.1821	0.1795
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0327	0.1904
Loa Loa (eye worm)	RecQ helicase	0.0048	0.12	0.1172
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.021	0.1163
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0733	0.4647
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0026	0.0492	0.2908
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0068	0.1821	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0031	0.0647	0.3587
Echinococcus multilocularis	RUN	0.0022	0.037	0.0338
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.002	0.0308	0.0276
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0023	0.0392	0.036
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0017	0.021	0.0178
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.002	0.0308	0.1214
Echinococcus granulosus	flap endonuclease 1	0.0028	0.0553	0.0523
Schistosoma mansoni	hypothetical protein	0.0329	1	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0308	0.0276
Loa Loa (eye worm)	flap endonuclease-1	0.0028	0.0553	0.0523
Trichomonas vaginalis	DNA helicase recq1, putative	0.0048	0.12	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0068	0.1821	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0327	0.1904
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.002	0.0308	0.0276
Giardia lamblia	Rrm3p helicase	0.0034	0.0733	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0392	0.1872
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0327	0.1904
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0327	0.1904
Leishmania major	eukaryotic initiation factor 4a, putative	0.0028	0.0571	0.2239
Entamoeba histolytica	recQ family helicase, putative	0.0026	0.0492	0.5554
Schistosoma mansoni	hypothetical protein	0.0017	0.0209	0.0177
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0077	0.2108	0.2082
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0571	0.054
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0021	0.0327	0.0296
Brugia malayi	isocitrate dehydrogenase	0.0017	0.021	0.0253
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0034	0.0733	0.3246
Entamoeba histolytica	hypothetical protein	0.0025	0.0464	0.5235
Schistosoma mansoni	hypothetical protein	0.0038	0.0886	0.0857
Schistosoma mansoni	aldehyde dehydrogenase	0.0068	0.1803	0.1777
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0034	0.0733	0.3246
Schistosoma mansoni	loxhd1	0.0022	0.037	0.0338
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0017	0.0209	0.0177
Plasmodium vivax	importin-beta 2, putative	0.0031	0.0647	0.8772
Entamoeba histolytica	hypothetical protein	0.0038	0.0886	1
Plasmodium falciparum	importin beta, putative	0.0031	0.0647	0.5423
Plasmodium falciparum	LCCL domain-containing protein	0.0022	0.037	0.1983
Trichomonas vaginalis	DNA helicase recq, putative	0.0026	0.0492	0.1891
Brugia malayi	ImpB/MucB/SamB family protein	0.0048	0.1181	0.1637
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0028	0.0571	0.054
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0017	0.0209	0.0177
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0327	0.1208
Brugia malayi	RNA, U transporter 1	0.0088	0.2429	0.3415
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0823	0.1126
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0464	0.1577
Onchocerca volvulus		0.0162	0.4746	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.0022	0.037	0.0338
Echinococcus granulosus	lipoxygenase domain containing protein	0.0022	0.037	0.0338
Entamoeba histolytica	hypothetical protein	0.0038	0.0886	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.1803	0.9881
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0068	0.1821	1
Schistosoma mansoni	hypothetical protein	0.0022	0.037	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0823	0.0793
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0023	0.0392	0.2171
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0647	0.0617
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.002	0.0308	0.0276
Trypanosoma cruzi	DNA polymerase eta, putative	0.0048	0.1181	1
Brugia malayi	Isocitrate dehydrogenase	0.0017	0.021	0.0253
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0053	0.1351	0.1879
Schistosoma mansoni	DNA helicase recq1	0.002	0.0308	0.0276
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0017	0.021	0.0178
Echinococcus multilocularis	Polycystic kidney disease protein	0.0022	0.037	0.0338
Trichomonas vaginalis	DNA helicase recq, putative	0.0048	0.12	1
Brugia malayi	hypothetical protein	0.0022	0.037	0.0481
Echinococcus granulosus	ATP dependent DNA helicase PIF1	0.0034	0.0733	0.0703
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0068	0.1803	0.9881
Echinococcus multilocularis	GA binding protein alpha chain	0.0077	0.2108	0.2082
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0021	0.0327	0.3691
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0068	0.1803	0.1777
Schistosoma mansoni	hypothetical protein	0.0017	0.0209	0.0177
Entamoeba histolytica	hypothetical protein, conserved	0.0034	0.0733	0.827
Brugia malayi	hypothetical protein	0.0162	0.4746	0.6716
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0028	0.0571	0.3715
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0886	0.0857
Loa Loa (eye worm)	fli-1 protein	0.0235	0.7051	0.7041
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.021	0.0178
Echinococcus granulosus	GPCR family 2	0.0017	0.0209	0.0177
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0327	0.1208
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0028	0.0571	0.4478
Schistosoma mansoni	hypothetical protein	0.0017	0.0209	0.0177
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0017	0.021	0.0791
Trichomonas vaginalis	ran, putative	0.0023	0.0392	0.0738
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.006	0.1551	0.1524
Brugia malayi	eukaryotic initiation factor 4A	0.0028	0.0571	0.0767
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0034	0.0733	0.5386
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1756	0.1729
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0028	0.0571	0.054
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0327	0.1904
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0022	0.037	0.0338
Schistosoma mansoni	ets-related	0.0235	0.7051	0.7041
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0327	0.0728
Loa Loa (eye worm)	hypothetical protein	0.0022	0.037	0.0338
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0028	0.0571	0.6185
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0308	0.1706
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0034	0.0733	0.5386
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.002	0.0308	0.0276
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0053	0.1351	0.1323
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0017	0.0209	0.0177
Plasmodium vivax	multidomain scavenger receptor, putative	0.0022	0.037	0.3208
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0023	0.0392	0.1872
Echinococcus multilocularis	isocitrate dehydrogenase	0.0017	0.021	0.0178
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0068	0.1803	0.989
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0647	0.4935
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0023	0.0392	0.2515
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0017	0.0209	0.0252
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.0327	0.0728
Schistosoma mansoni	flap endonuclease-1	0.0025	0.0469	0.0438
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0023	0.0392	0.036
Echinococcus multilocularis	dna polymerase eta	0.0048	0.1181	0.1153
Echinococcus multilocularis	GPCR, family 2	0.0017	0.0209	0.0177
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0028	0.0571	0.2789
Giardia lamblia	Flap structure-specific endonuclease	0.0028	0.0553	0.5773
Trichomonas vaginalis	flap endonuclease-1, putative	0.0028	0.0553	0.2589
Leishmania major	GTP-binding protein, putative	0.0023	0.0392	0.1128
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0028	0.0553	0.4047
Echinococcus granulosus	Polycystic kidney disease protein	0.0022	0.037	0.0338
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0327	0.1208
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0021	0.0327	0.0296
Toxoplasma gondii	isocitrate dehydrogenase	0.0017	0.021	0.1163
Loa Loa (eye worm)	hypothetical protein	0.0147	0.4302	0.4283
Echinococcus granulosus	GA binding protein alpha chain	0.0077	0.2108	0.2082
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0327	0.1904
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0886	0.0857
Echinococcus granulosus	RUN	0.0022	0.037	0.0338
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0464	0.1567
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0327	0.1904
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0327	0.042
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0327	0.1904
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0327	0.1904
Loa Loa (eye worm)	MH2 domain-containing protein	0.0128	0.3683	0.3662
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0068	0.1803	0.989
Plasmodium falciparum	flap endonuclease 1	0.0028	0.0553	0.4261
Entamoeba histolytica	DNA repair and recombination protein, putative	0.0034	0.0733	0.827
Echinococcus multilocularis	snurportin 1	0.0329	1	1
Schistosoma mansoni	polycystin 1-related	0.0022	0.037	0.0338
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0068	0.1821	0.1795
Plasmodium vivax	flap endonuclease 1, putative	0.0028	0.0553	0.6892
Giardia lamblia	DINP protein human, muc B family	0.0021	0.0327	0.0458
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0327	0.1208
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0026	0.0492	0.3469
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.002	0.0308	0.0276
Schistosoma mansoni	importin beta-1	0.0031	0.0647	0.0617
Echinococcus multilocularis	importin subunit beta 1	0.0031	0.0647	0.0617
Brugia malayi	hypothetical protein	0.0022	0.037	0.0481
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0028	0.0571	0.0459
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0329	1	1
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0028	0.0571	0.2239
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0327	0.1904
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0032	0.0696	0.3858
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	0.0034	0.0733	0.5386
Brugia malayi	Latrophilin receptor protein 2	0.0017	0.0209	0.0252
Loa Loa (eye worm)	hypothetical protein	0.0162	0.4746	0.4729
Brugia malayi	Ets-domain containing protein	0.0077	0.2108	0.2957
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0028	0.0553	0.3067
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0043	0.1016	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1181	0.1153
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0028	0.0571	0.054
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0062	0.1611	0.1583
Entamoeba histolytica	Flap nuclease, putative	0.0028	0.0553	0.6242
Trypanosoma cruzi	DNA polymerase eta, putative	0.0034	0.0735	0.5406
Schistosoma mansoni	DNA polymerase eta	0.0048	0.1181	0.1153
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0028	0.0571	0.6439
Trypanosoma brucei	importin beta-1 subunit, putative	0.0031	0.0647	0.4935
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0068	0.1803	0.1777
Trypanosoma brucei	DNA polymerase eta, putative	0.0048	0.1181	1
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0028	0.0571	0.2789
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0327	0.1904
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.021	0.0178
Schistosoma mansoni	hypothetical protein	0.0017	0.0209	0.0177
Entamoeba histolytica	Ran family GTPase	0.0023	0.0392	0.4419
Schistosoma mansoni	hypothetical protein	0.0036	0.0823	0.0793
Brugia malayi	Fli-1 protein	0.0235	0.7051	1
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0308	0.0392
Schistosoma mansoni	rab6-interacting	0.0022	0.037	0.0338
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0023	0.0392	0.1974
Loa Loa (eye worm)	doublecortin family protein	0.0022	0.037	0.0338
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0068	0.1821	1
Echinococcus multilocularis	flap endonuclease 1	0.0028	0.0553	0.0523
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0021	0.0327	0.0296
Loa Loa (eye worm)	transcription factor SMAD2	0.0128	0.3683	0.3662
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0464	0.2617
Toxoplasma gondii	aldehyde dehydrogenase	0.0068	0.1803	1
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0028	0.0571	0.054
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0886	0.0857
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0464	0.1567
Echinococcus granulosus	dna polymerase eta	0.0048	0.1181	0.1153
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0023	0.0392	0.3649
Schistosoma mansoni	blooms syndrome DNA helicase	0.0038	0.088	0.0851
Echinococcus multilocularis	dna polymerase kappa	0.0021	0.0327	0.0296
Brugia malayi	Importin beta-1 subunit	0.0031	0.0647	0.0876
Schistosoma mansoni	gabp alpha	0.0077	0.2108	0.2082
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	0.0034	0.0733	0.5751
Brugia malayi	Flap endonuclease-1	0.0028	0.0553	0.0742
Schistosoma mansoni	lipoxygenase	0.0022	0.037	0.0338
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0017	0.0209	0.0177
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0026	0.0492	0.1753
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0023	0.0392	0.2256
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0028	0.0553	0.2131
Schistosoma mansoni	aldehyde dehydrogenase	0.0068	0.1803	0.1777
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0023	0.0392	0.0512
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0028	0.0553	0.3535
Entamoeba histolytica	hypothetical protein	0.0038	0.0886	1
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0028	0.0571	0.3164
Schistosoma mansoni	lipoxygenase	0.0062	0.1611	0.1583
Echinococcus granulosus	bloom syndrome protein	0.0048	0.12	0.1172
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0209	0.0177
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0068	0.1821	0.1795
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0017	0.021	0.0178
Trypanosoma brucei	unspecified product	0.0021	0.0327	0.1904
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0021	0.0327	0.0296
Leishmania major	DNA polymerase eta, putative	0.0034	0.0735	0.3259
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0028	0.0571	0.2789
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0028	0.0571	0.054
Treponema pallidum	ATP-dependent RNA helicase	0.0028	0.0571	0.5
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0053	0.1351	0.1879
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.021	0.0791
Schistosoma mansoni	ran	0.0023	0.0392	0.036
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0022	0.037	0.0338
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0021	0.0327	0.0296
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.0327	0.0728
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0033	0.0708	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 10000 nM	Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay	ChEMBL.	16451063
IC50 (binding)	> 10000 nM	Inhibitory activity against HCV delta 21 NS5B RNA polymerase by SPA assay	ChEMBL.	16451063

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 351448