Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0284 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0284 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0284 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0284 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0284 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0284 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0284 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0284 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0284 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0284 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0284 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0284 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0284 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0284 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0284 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0284 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.6109 | 0.9749 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0284 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0284 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0284 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0284 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0284 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.5975 | 0.9524 | 0.977 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0284 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.6109 | 0.9749 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0284 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0284 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0284 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0284 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0284 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0284 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0284 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0284 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0284 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 22 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HeLa cells at 0.01 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 22 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HeLa cells at 0.01 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 52 % | Displacement of [3H]ZM241385 from recombinant human adenosine A2A receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 52 % | Displacement of [3H]ZM241385 from recombinant human adenosine A2A receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 80 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Inhibition (binding) | = 80 % | Displacement of [3H]DPCPX from recombinant human adenosine A2B receptor expressed in HEK293 cells at 0.1 uM | ChEMBL. | 16392813 |
Ki (binding) | = 7.7 | Binding affinity to recombinant human adenosine A2A receptor | ChEMBL. | 16392813 |
Ki (binding) | = 7.92 | Binding affinity to recombinant human adenosine A2B receptor | ChEMBL. | 16392813 |
Log Ki (binding) | = 7.7 | Binding affinity to recombinant human adenosine A2A receptor | ChEMBL. | 16392813 |
Log Ki (binding) | = 7.92 | Binding affinity to recombinant human adenosine A2B receptor | ChEMBL. | 16392813 |
Ratio Ki (binding) | = 1.7 | Selectivity for human adenosine A2B over human adenosine A2A receptor | ChEMBL. | 16392813 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.