Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosylhomocysteinase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | putative S-adenosyl-L-homocysteine hydrolase SahH | 0.0156 | 0.2623 | 0.5 |
Mycobacterium tuberculosis | Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) | 0.0156 | 0.2623 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.3108 | 0.285 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0156 | 0.2623 | 0.2347 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0546 | 1 | 1 |
Brugia malayi | Endonuclease/Exonuclease/phosphatase family protein | 0.0381 | 0.6871 | 0.6871 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0099 | 0.155 | 0.1198 |
Plasmodium vivax | adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative | 0.0156 | 0.2623 | 1 |
Echinococcus granulosus | adenosylhomocysteinase | 0.0156 | 0.2623 | 0.2316 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.3108 | 0.285 |
Entamoeba histolytica | adenosylhomocysteinase, putative | 0.0156 | 0.2623 | 0.2316 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.04 | 0.004 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.1498 | 0.1179 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0156 | 0.2623 | 0.2487 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0103 | 0.1624 | 0.131 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0103 | 0.1624 | 0.1275 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0681 | 0.0681 |
Echinococcus multilocularis | adenosylhomocysteinase | 0.0156 | 0.2623 | 0.2316 |
Trypanosoma cruzi | S-adenosylhomocysteine hydrolase, putative | 0.0156 | 0.2623 | 0.2487 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0316 | 0.5649 | 0.5468 |
Loa Loa (eye worm) | endonuclease/Exonuclease/phosphatase | 0.0375 | 0.6763 | 0.6704 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0181 | 0.0181 |
Trypanosoma brucei | S-adenosylhomocysteine hydrolase, putative | 0.0156 | 0.2623 | 0.2487 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0546 | 1 | 1 |
Leishmania major | S-adenosylhomocysteine hydrolase | 0.0156 | 0.2623 | 0.2487 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0546 | 1 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0546 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.04 | 0.004 |
Echinococcus multilocularis | geminin | 0.0182 | 0.3108 | 0.2821 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0156 | 0.2623 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.1498 | 0.1179 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0361 | 0.0361 |
Mycobacterium ulcerans | S-adenosyl-L-homocysteine hydrolase | 0.0156 | 0.2623 | 0.5 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.1498 | 0.1179 |
Loa Loa (eye worm) | adenosylhomocysteinase | 0.0156 | 0.2623 | 0.2487 |
Echinococcus multilocularis | traf and tnf receptor associated protein | 0.0381 | 0.6871 | 0.6741 |
Trichomonas vaginalis | adenosylhomocysteinase, putative | 0.0156 | 0.2623 | 1 |
Toxoplasma gondii | S-Adenosyl homocysteine hydrolase | 0.0156 | 0.2623 | 0.3769 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0546 | 1 | 1 |
Toxoplasma gondii | endonuclease/exonuclease/phosphatase family protein | 0.037 | 0.6661 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0546 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0039 | 0.04 | 0.04 |
Plasmodium falciparum | adenosylhomocysteinase | 0.0156 | 0.2623 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0361 | 0.0183 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0546 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0681 | 0.0509 |
Echinococcus granulosus | traf and tnf receptor associated protein | 0.0381 | 0.6871 | 0.6741 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0546 | 1 | 1 |
Schistosoma mansoni | adenosylhomocysteinase | 0.0097 | 0.1498 | 0.1179 |
Brugia malayi | Adenosylhomocysteinase | 0.0156 | 0.2623 | 0.2623 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0681 | 0.0681 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0546 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0681 | 0.0509 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0316 | 0.5649 | 0.5468 |
Echinococcus granulosus | geminin | 0.0182 | 0.3108 | 0.2821 |
Toxoplasma gondii | adenosylhomocysteinase, putative | 0.0156 | 0.2623 | 0.3769 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 1.2 ug ml-1 | Cytotoxicity against HEL cells | ChEMBL. | 16480257 |
CC50 (functional) | = 1.2 ug ml-1 | Cytotoxicity against HEL cells | ChEMBL. | 16480257 |
EC50 (functional) | = 11 ug ml-1 | Antiviral activity against TK+ VZV OKA in human embryonic lung cells | ChEMBL. | 16480257 |
EC50 (functional) | = 17 ug ml-1 | Antiviral activity against TK- VZV 07/10 in human embryonic lung cells | ChEMBL. | 16480257 |
EC50 (functional) | > 20 ug ml-1 | Antiviral activity against Cytomegalovirus AD169 in human embryonic lung cells | ChEMBL. | 16480257 |
EC50 (functional) | > 20 ug ml-1 | Antiviral activity against Cytomegalovirus Davis in human embryonic lung cells | ChEMBL. | 16480257 |
Ki (binding) | = 17 uM | Inhibitory activity against AdoHcy Hydrolase | ChEMBL. | 16480257 |
Ki (binding) | = 17 uM | Inhibitory activity against AdoHcy Hydrolase | ChEMBL. | 16480257 |
MCC (functional) | = 100 ug ml-1 | Cytotoxicity as determined by alteration in the cell morphology of HEL cells | ChEMBL. | 16480257 |
MCC (functional) | = 100 ug ml-1 | Cytotoxicity as determined by alteration in the cell morphology of HEL cells | ChEMBL. | 16480257 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.