Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | poly (ADP-ribose) polymerase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | folylpolyglutamate synthase, putative | 0.0097 | 0.0256 | 0.0007 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0883 | 0.335 | 0.3863 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0095 | 0.0249 | 0.006 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0146 | 0.0447 | 0.0515 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2573 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2235 | 0.8671 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.0393 | 0.0294 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2573 | 1 | 1 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0095 | 0.0249 | 0.019 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.2235 | 0.8671 | 1 |
Brugia malayi | hypothetical protein | 0.1063 | 0.4059 | 0.4524 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0146 | 0.0447 | 0.0515 |
Treponema pallidum | folylpolyglutamate synthetase (folC) | 0.0097 | 0.0256 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0883 | 0.335 | 0.3802 |
Mycobacterium leprae | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) | 0.0097 | 0.0256 | 0.0295 |
Brugia malayi | FolC bifunctional protein | 0.0097 | 0.0256 | 0.0009 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.018 | 0.0583 | 0.0336 |
Mycobacterium ulcerans | folylpolyglutamate synthase protein FolC | 0.0097 | 0.0256 | 0.0295 |
Loa Loa (eye worm) | FolC protein | 0.0097 | 0.0256 | 0.0133 |
Brugia malayi | dihydrofolate reductase family protein | 0.0883 | 0.335 | 0.3682 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0883 | 0.335 | 0.3863 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0883 | 0.335 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2573 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0146 | 0.0447 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1063 | 0.4059 | 1 |
Echinococcus multilocularis | folylpolyglutamate synthase, mitochondrial | 0.0097 | 0.0256 | 0.0261 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0174 | 0.0557 | 0.0548 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.2235 | 0.8671 | 1 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0174 | 0.0557 | 0.5 |
Echinococcus multilocularis | folylpolyglutamate synthase, mitochondrial | 0.0097 | 0.0256 | 0.0261 |
Brugia malayi | WGR domain containing protein | 0.0174 | 0.0557 | 0.0365 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1063 | 0.4059 | 0.4681 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.1063 | 0.4059 | 0.3907 |
Trypanosoma cruzi | folylpolyglutamate synthetase | 0.0097 | 0.0256 | 0.0007 |
Echinococcus granulosus | folylpolyglutamate synthase mitochondrial | 0.0097 | 0.0256 | 0.0198 |
Echinococcus multilocularis | thymidylate synthase | 0.2235 | 0.8671 | 1 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0174 | 0.0557 | 0.0609 |
Onchocerca volvulus | 0.2235 | 0.8671 | 1 | |
Mycobacterium ulcerans | thymidylate synthase | 0.2235 | 0.8671 | 1 |
Mycobacterium tuberculosis | Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) | 0.0097 | 0.0256 | 0.0295 |
Echinococcus granulosus | folylpolyglutamate synthase, mitochondrial | 0.0097 | 0.0256 | 0.0198 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2573 | 1 | 1 |
Schistosoma mansoni | folylpolyglutamate synthase | 0.0097 | 0.0256 | 0.0068 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0174 | 0.0557 | 0.0423 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0249 | 0.0124 |
Brugia malayi | thymidylate synthase | 0.2235 | 0.8671 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2573 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0883 | 0.335 | 0.372 |
Loa Loa (eye worm) | thymidylate synthase | 0.2235 | 0.8671 | 1 |
Onchocerca volvulus | Putative folylpolyglutamate synthase | 0.0097 | 0.0256 | 0.0295 |
Brugia malayi | Dihydrofolate reductase | 0.0883 | 0.335 | 0.3682 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0883 | 0.335 | 0.3863 |
Echinococcus granulosus | thymidylate synthase | 0.2235 | 0.8671 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0883 | 0.335 | 0.3761 |
Trypanosoma cruzi | folylpolyglutamate synthase, putative | 0.0097 | 0.0256 | 0.0007 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0095 | 0.0249 | 0.0253 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0883 | 0.335 | 0.3842 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.