Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | dihydrofolate reductase | 0.1207 | 0.0978 | 0.0969 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 1.2004 | 1 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.1207 | 0.0978 | 0.0969 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 1.1543 | 0.9615 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 1.1543 | 0.9615 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1207 | 0.0978 | 0.0969 |
Trichomonas vaginalis | conserved hypothetical protein | 0.5491 | 0.4558 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1207 | 0.0978 | 0.5 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0166 | 0.0108 | 0.0112 |
Mycobacterium leprae | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) | 0.0098 | 0.0051 | 0.0053 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0166 | 0.0108 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.1207 | 0.0978 | 0.0969 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 1.2004 | 1 | 1 |
Onchocerca volvulus | 1.1543 | 0.9615 | 1 | |
Onchocerca volvulus | Putative folylpolyglutamate synthase | 0.0098 | 0.0051 | 0.0053 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1207 | 0.0978 | 0.0969 |
Brugia malayi | thymidylate synthase | 1.1543 | 0.9615 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1207 | 0.0978 | 0.0969 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0166 | 0.0108 | 0.0112 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1207 | 0.0978 | 0.1017 |
Brugia malayi | hypothetical protein | 0.5491 | 0.4558 | 0.4712 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 1.2004 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 1.1543 | 0.9615 | 1 |
Echinococcus granulosus | thymidylate synthase | 1.1543 | 0.9615 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 1.2004 | 1 | 1 |
Mycobacterium ulcerans | folylpolyglutamate synthase protein FolC | 0.0098 | 0.0051 | 0.0053 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 1.2004 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1207 | 0.0978 | 0.1017 |
Treponema pallidum | folylpolyglutamate synthetase (folC) | 0.0098 | 0.0051 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 1.1543 | 0.9615 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.5491 | 0.4558 | 0.453 |
Echinococcus multilocularis | thymidylate synthase | 1.1543 | 0.9615 | 1 |
Mycobacterium tuberculosis | Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) | 0.0098 | 0.0051 | 0.0053 |
Mycobacterium ulcerans | thymidylate synthase | 1.1543 | 0.9615 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1207 | 0.0978 | 0.1017 |
Mycobacterium tuberculosis | Hypothetical protein | 0.5491 | 0.4558 | 0.4741 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.1 uM | In vitro inhibition of endothelin binding to endothelin A receptor in rat heart ventricles was measured using a 125-I labelled ET-1 competition assay | ChEMBL. | 10890162 |
IC50 (binding) | = 15 uM | In vitro inhibition of [125-I] labelled ET-1 endothelin binding to Endothelin B receptor in rat cerebellum | ChEMBL. | 10890162 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.