Detailed information for compound 352274

Basic information

Technical information
  • TDR Targets ID: 352274
  • Name: (5Z)-3-amino-5-[(4-fluorophenyl)methylidene]- 2-sulfanylidene-1,3-thiazolidin-4-one
  • MW: 254.304 | Formula: C10H7FN2OS2
  • H donors: 1 H acceptors: 1 LogP: 2.33 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: NN1C(=S)S/C(=C\c2ccc(cc2)F)/C1=O
  • InChi: 1S/C10H7FN2OS2/c11-7-3-1-6(2-4-7)5-8-9(14)13(12)10(15)16-8/h1-5H,12H2/b8-5-
  • InChiKey: JCUKYKFMRIBKTJ-YVMONPNESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5Z)-3-amino-5-[(4-fluorophenyl)methylene]-2-thioxo-thiazolidin-4-one
  • (5Z)-3-amino-5-[(4-fluorophenyl)methylene]-2-thioxo-4-thiazolidinone
  • (5Z)-3-azanyl-5-[(4-fluorophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
  • (5Z)-3-amino-5-(4-fluorobenzylidene)-2-thioxo-thiazolidin-4-one
  • 3-amino-5-[(4-fluorophenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
  • 3-amino-5-[(4-fluorophenyl)methylene]-2-thioxo-thiazolidin-4-one
  • 3-amino-5-[(4-fluorophenyl)methylene]-2-thioxo-4-thiazolidinone
  • 3-amino-5-(4-fluorobenzylidene)-2-thioxo-thiazolidin-4-one
  • ZINC04882756

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Hepatitis C virus Hepatitis C virus NS5B RNA-dependent RNA polymerase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania braziliensis PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma congolense DNA repair and recombination helicase protein PIF6 Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania donovani PIF1 helicase-like protein, putative Get druggable targets OG5_128192 All targets in OG5_128192
Candida albicans similar to PIF1 DNA helicase Get druggable targets OG5_128192 All targets in OG5_128192
Entamoeba histolytica DNA repair and recombination protein, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania infantum PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma congolense DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania braziliensis PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128192 All targets in OG5_128192
Schistosoma mansoni hypothetical protein Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania mexicana PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania mexicana PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Echinococcus granulosus ATP dependent DNA helicase PIF1 Get druggable targets OG5_128192 All targets in OG5_128192
Schistosoma japonicum ko:K01529 PIF1 5'-to-3' DNA helicase [EC:3.6.1.-], putative Get druggable targets OG5_128192 All targets in OG5_128192
Entamoeba histolytica hypothetical protein, conserved Get druggable targets OG5_128192 All targets in OG5_128192
Echinococcus multilocularis ATP dependent DNA helicase PIF1 Get druggable targets OG5_128192 All targets in OG5_128192
Giardia lamblia Rrm3p helicase Get druggable targets OG5_128192 All targets in OG5_128192
Candida albicans similar to putative DNA helicase involved in repair and recombination of mitochondrial DNA that also plays a role in (nuclear) c Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania donovani PIF1 helicase-like protein, putative Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania infantum PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma brucei gambiense DNA repair and recombination helicase protein PIF1, putative,DNA repair and recombination protein, mitochondrial precursor, puta Get druggable targets OG5_128192 All targets in OG5_128192
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma brucei gambiense DNA repair and recombination helicase protein PIF1, putative,DNA repair and recombination protein, mitochondrial precursor, puta Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative Get druggable targets OG5_128192 All targets in OG5_128192
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 Get druggable targets OG5_128192 All targets in OG5_128192
Candida albicans DNA helicase Get druggable targets OG5_128192 All targets in OG5_128192
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0122 0.0144
Loa Loa (eye worm) hypothetical protein 0.0037 0.1874 0.221
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0037 0.1874 0.221
Giardia lamblia Rrm3p helicase 0.0034 0.163 0.486
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.2654 0.2654
Schistosoma mansoni thyroid hormone receptor 0.001 0.0122 0.0122
Echinococcus granulosus glycine receptor subunit alpha 1 0.0037 0.1874 0.1874
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0034 0.163 0.486
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0122 0.0122
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0555 0.0654
Loa Loa (eye worm) hypothetical protein 0.001 0.0122 0.0144
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0122 0.0122
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0593 0.0699
Schistosoma mansoni neurotransmitter gated ion channel 0.0017 0.0593 0.0593
Echinococcus multilocularis GPCR, family 2 0.0017 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0129 0.7723 0.9107
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.2138 0.7408
Loa Loa (eye worm) hypothetical protein 0.0017 0.0593 0.0699
Brugia malayi excitatory GABA receptor EXP-1A 0.0037 0.1874 0.221
Onchocerca volvulus 0.0037 0.1874 0.2305
Schistosoma mansoni nAChR subunit 0.0037 0.1874 0.1874
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0037 0.1874 0.1874
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.2654 0.8337
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0037 0.1874 0.221
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.2654 0.313
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0122 0.0144
Loa Loa (eye worm) hypothetical protein 0.0017 0.0593 0.0699
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0122 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0122 0.0144
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0037 0.1874 0.221
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0037 0.1874 0.1874
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.3052 1
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0034 0.163 0.486
Entamoeba histolytica hypothetical protein 0.002 0.0777 0.0919
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0122 0.0122
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0037 0.1874 0.1874
Schistosoma mansoni hypothetical protein 0.0017 0.0555 0.0555
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0037 0.1874 0.1874
Loa Loa (eye worm) hypothetical protein 0.0037 0.1874 0.221
Loa Loa (eye worm) hypothetical protein 0.002 0.0777 0.0916
Loa Loa (eye worm) hypothetical protein 0.0017 0.0593 0.0699
Loa Loa (eye worm) ACC-1 protein 0.0037 0.1874 0.221
Brugia malayi Cation transporter family protein 0.0037 0.1874 0.221
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0122 0.0122
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.3052 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0122 0.0144
Echinococcus multilocularis nAChR subunit 0.0037 0.1874 0.1874
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0034 0.163 0.4052
Entamoeba histolytica hypothetical protein 0.0035 0.1726 0.8473
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0017 0.0593 0.0593
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0593 0.0699
Brugia malayi hypothetical protein 0.0017 0.0593 0.0699
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.2138 0.2138
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.163 0.486
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0122 0.0144
Brugia malayi MAP kinase sur-1 0.005 0.2654 0.313
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0037 0.1874 0.1874
Loa Loa (eye worm) hypothetical protein 0.002 0.0777 0.0916
Loa Loa (eye worm) hypothetical protein 0.002 0.0777 0.0916
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.1874 0.221
Loa Loa (eye worm) hypothetical protein 0.001 0.0122 0.0144
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0122 0.0144
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.2813 0.3316
Brugia malayi ecdysteroid receptor 0.001 0.0122 0.0144
Trichomonas vaginalis CMGC family protein kinase 0.005 0.2654 1
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0122 0.0122
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0122 0.0122
Brugia malayi hypothetical protein 0.0017 0.0593 0.0699
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.002 0.0777 0.0916
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0037 0.1874 0.221
Loa Loa (eye worm) hypothetical protein 0.002 0.0777 0.0916
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0122 0.0144
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0037 0.1874 0.221
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0662 0.078
Loa Loa (eye worm) hypothetical protein 0.0037 0.1874 0.221
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0017 0.0593 0.0699
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0122 0.0122
Schistosoma mansoni coup transcription factor 0.001 0.0122 0.0122
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.3052 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0122 0.0144
Schistosoma mansoni nAChR subunit 0.0017 0.0593 0.0593
Onchocerca volvulus 0.0037 0.1874 0.2305
Loa Loa (eye worm) hypothetical protein 0.0017 0.0555 0.0654
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0122 0.0122
Schistosoma mansoni hypothetical protein 0.0165 1 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0017 0.0593 0.0593
Loa Loa (eye worm) hypothetical protein 0.001 0.0122 0.0144
Loa Loa (eye worm) hypothetical protein 0.0037 0.1874 0.221
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0122 0.0122
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.2138 0.7408
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0122 0.0144
Loa Loa (eye worm) hypothetical protein 0.0037 0.1874 0.221
Schistosoma mansoni hypothetical protein 0.0017 0.0555 0.0555
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0037 0.1874 0.1874
Trichomonas vaginalis CMGC family protein kinase 0.005 0.2654 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0017 0.0593 0.0593
Onchocerca volvulus 0.0017 0.0593 0.0619
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0122 0.0144
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.6896 0.8132
Loa Loa (eye worm) hypothetical protein 0.0037 0.1874 0.221
Onchocerca volvulus 0.0017 0.0593 0.0619
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.2844 0.3353
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0037 0.1874 0.221
Schistosoma mansoni nAChR subunit 0.0037 0.1874 0.1874
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0017 0.0593 0.0593
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0037 0.1874 0.1874
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0122 0.0122
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0037 0.1874 0.221
Loa Loa (eye worm) hypothetical protein 0.002 0.0777 0.0916
Brugia malayi nuclear hormone receptor 0.001 0.0122 0.0144
Loa Loa (eye worm) hypothetical protein 0.0017 0.0593 0.0699
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0037 0.1874 0.221
Echinococcus granulosus nAChR subunit 0.0037 0.1874 0.1874
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0034 0.163 0.163
Schistosoma mansoni nAChR subunit 0.0037 0.1874 0.1874
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0122 0.0122
Onchocerca volvulus 0.0037 0.1874 0.2305
Entamoeba histolytica hypothetical protein 0.0035 0.1726 0.8473
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0017 0.0593 0.0593
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.1918 0.6304
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.2654 1
Brugia malayi nuclear receptor NHR-88 0.001 0.0122 0.0144
Loa Loa (eye worm) hypothetical protein 0.0017 0.0593 0.0699
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0122 0.0122
Loa Loa (eye worm) ACC-1 protein 0.0037 0.1874 0.221
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0037 0.1874 0.1874
Loa Loa (eye worm) hypothetical protein 0.002 0.0777 0.0916
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0122 0.0144
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.8229 0.8229
Loa Loa (eye worm) hypothetical protein 0.0037 0.1874 0.221
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.002 0.0777 0.0777
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0122 0.0122
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.3052 0.3052
Echinococcus granulosus glycine receptor subunit beta 0.0037 0.1874 0.1874
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.2654 1
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0034 0.163 0.486
Brugia malayi hypothetical protein 0.0017 0.0593 0.0699
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.2654 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0122 0.0144
Loa Loa (eye worm) hypothetical protein 0.0017 0.0593 0.0699
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.8481 0.8481
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0037 0.1874 0.1874
Schistosoma mansoni nAChR subunit 0.0037 0.1874 0.1874
Onchocerca volvulus 0.0037 0.1874 0.2305
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0017 0.0593 0.0699
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0034 0.163 0.4052
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.2138 0.7408
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0122 0.0144
Loa Loa (eye worm) hypothetical protein 0.001 0.0122 0.0144
Schistosoma mansoni nAChR subunit 0.0017 0.0593 0.0593
Loa Loa (eye worm) hypothetical protein 0.001 0.0122 0.0144
Loa Loa (eye worm) hypothetical protein 0.001 0.0122 0.0144
Entamoeba histolytica DNA repair and recombination protein, putative 0.0034 0.163 0.771
Loa Loa (eye worm) hypothetical protein 0.0037 0.1874 0.221
Trichomonas vaginalis CMGC family protein kinase 0.005 0.2654 1
Brugia malayi MH2 domain containing protein 0.0116 0.6896 0.8132
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0122 0.0122
Schistosoma mansoni serine/threonine protein kinase 0.005 0.2654 0.2654
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0037 0.1874 0.1874
Loa Loa (eye worm) hypothetical protein 0.0037 0.1874 0.221
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0037 0.1874 0.1874
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0122 0.0122
Echinococcus granulosus mitogen activated protein kinase 0.005 0.2654 0.2654
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0662 0.0662
Loa Loa (eye worm) acetyltransferase 0.0141 0.8481 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0662 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.1874 0.221
Loa Loa (eye worm) hypothetical protein 0.0017 0.0593 0.0699
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0017 0.0593 0.0699
Loa Loa (eye worm) hypothetical protein 0.0017 0.0593 0.0699
Echinococcus granulosus FTZ F1 alpha 0.001 0.0122 0.0122
Schistosoma mansoni hypothetical protein 0.0017 0.0555 0.0555
Loa Loa (eye worm) hypothetical protein 0.0036 0.1784 0.2104
Echinococcus multilocularis nAChR subunit 0.002 0.0777 0.0777
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0017 0.0593 0.0593
Loa Loa (eye worm) hypothetical protein 0.0037 0.1874 0.221
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0122 0.0144
Brugia malayi hypothetical protein 0.0017 0.0593 0.0699
Echinococcus granulosus glycine receptor subunit beta 0.0037 0.1874 0.1874
Schistosoma mansoni hypothetical protein 0.0036 0.1784 0.1784
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.2654 0.2654
Schistosoma mansoni acetylcholine receptor-related 0.0017 0.0593 0.0593
Onchocerca volvulus 0.002 0.0777 0.0861
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0122 0.0122
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.8481 0.8481
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0034 0.163 0.486
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0662 0.078
Echinococcus multilocularis glycine receptor subunit beta 0.0037 0.1874 0.1874
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0034 0.163 0.163
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0555 0.0555
Loa Loa (eye worm) LGC-31 protein 0.0037 0.1874 0.221
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0122 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0122 0.0144
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0555 0.0555
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0122 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0122 0.0144
Giardia lamblia Kinase, CMGC MAPK 0.005 0.2654 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0037 0.1874 0.221
Loa Loa (eye worm) hypothetical protein 0.002 0.0777 0.0916
Onchocerca volvulus 0.0037 0.1874 0.2305
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.1726 0.1726
Schistosoma mansoni hypothetical protein 0.0017 0.0555 0.0555
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0017 0.0593 0.0699
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0017 0.0593 0.0699
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0122 0.0144
Loa Loa (eye worm) hypothetical protein 0.0129 0.7723 0.9107
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.3052 0.3052
Loa Loa (eye worm) hypothetical protein 0.002 0.0777 0.0916
Schistosoma mansoni ap endonuclease 0.0018 0.0662 0.0662
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0037 0.1874 0.1874
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0122 0.0122
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0037 0.1874 0.1874
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0122 0.0122
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.1918 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.1726 0.1726
Loa Loa (eye worm) hypothetical protein 0.0017 0.0593 0.0699
Loa Loa (eye worm) hypothetical protein 0.001 0.0122 0.0144
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0037 0.1874 0.1874
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0037 0.1874 0.221
Schistosoma mansoni hypothetical protein 0.0165 1 1
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0037 0.1874 0.1874
Echinococcus multilocularis glycine receptor subunit beta 0.0037 0.1874 0.1874
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.3052 0.3599
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0122 0.0144
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0034 0.163 0.486
Loa Loa (eye worm) hypothetical protein 0.0037 0.1874 0.221
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0662 0.5
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0037 0.1874 0.221
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0017 0.0593 0.0699
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0555 0.0654
Loa Loa (eye worm) hypothetical protein 0.0037 0.1874 0.221
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0037 0.1874 0.221
Loa Loa (eye worm) hypothetical protein 0.0017 0.0593 0.0699
Schistosoma mansoni ap endonuclease 0.0018 0.0662 0.0662
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0662 0.0662
Loa Loa (eye worm) hypothetical protein 0.002 0.0777 0.0916
Onchocerca volvulus Huntingtin homolog 0.0129 0.7723 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.2844 0.3353
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0037 0.1874 0.1874
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.6896 0.8132
Onchocerca volvulus Huntingtin homolog 0.0129 0.7723 1
Echinococcus granulosus GPCR family 2 0.0017 0.0555 0.0555
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0122 0.0144
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0037 0.1874 0.1874
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0037 0.1874 0.1874
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.1918 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0122 0.0122
Brugia malayi Cation transporter family protein 0.0037 0.1874 0.221
Brugia malayi steroid hormone receptor 0.001 0.0122 0.0144
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0037 0.1874 0.1874
Schistosoma mansoni hypothetical protein 0.0034 0.163 0.163
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.1874 0.221
Onchocerca volvulus Putative nachr subunit 0.0037 0.1874 0.2305
Echinococcus multilocularis geminin 0.0165 1 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0037 0.1874 0.1874
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0777 0.0916
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0122 0.0122
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.002 0.0777 0.0777
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0037 0.1874 0.221
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0122 0.0122
Schistosoma mansoni acetylcholine receptor subunit beta 0.0017 0.0593 0.0593
Loa Loa (eye worm) hypothetical protein 0.0017 0.0593 0.0699
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0122 0.0122
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0122 0.0122
Trypanosoma brucei protein kinase, putative 0.005 0.2654 1
Brugia malayi Cation transporter family protein 0.0037 0.1874 0.221
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.2654 0.2654
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0037 0.1874 0.1874
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0037 0.1874 0.221
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.1874 0.221
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.3052 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0122 0.0144
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.2138 0.7408
Trichomonas vaginalis CMGC family protein kinase 0.005 0.2654 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.1874 0.221
Echinococcus granulosus nAChR subunit 0.002 0.0777 0.0777
Brugia malayi hypothetical protein 0.0129 0.7723 0.9107
Loa Loa (eye worm) hypothetical protein 0.0037 0.1874 0.221
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0122 0.0122
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0037 0.1874 0.221
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0122 0.0144
Loa Loa (eye worm) hypothetical protein 0.0037 0.1874 0.221
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.2654 1
Onchocerca volvulus 0.002 0.0777 0.0861
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0122 0.0122
Schistosoma mansoni hypothetical protein 0.0035 0.1726 0.1726
Schistosoma mansoni nAChR subunit 0.0037 0.1874 0.1874
Schistosoma mansoni nAChR subunit 0.0037 0.1874 0.1874
Brugia malayi hypothetical protein 0.0035 0.1726 0.2035
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.8481 1
Schistosoma mansoni neurotransmitter gated ion channel 0.002 0.0777 0.0777
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0555 0.0654
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.1784 0.2104
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.002 0.0777 0.0916
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0122 0.0144
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.2654 0.8337
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0122 0.0122
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.1874 0.221
Entamoeba histolytica hypothetical protein, conserved 0.0034 0.163 0.771
Loa Loa (eye worm) hypothetical protein 0.0037 0.1874 0.221
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0037 0.1874 0.221
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.2844 0.3353
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.2138 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0037 0.1874 0.1874
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.2654 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0555 0.0555
Loa Loa (eye worm) acetylcholine receptor protein 0.0017 0.0593 0.0699
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.2844 0.3353
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0037 0.1874 0.1874
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.3052 0.3052
Loa Loa (eye worm) hypothetical protein 0.0037 0.1874 0.221
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0037 0.1874 0.221
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.002 0.0777 0.0916
Entamoeba histolytica hypothetical protein 0.0035 0.1726 0.8473
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0037 0.1874 0.221
Loa Loa (eye worm) hypothetical protein 0.0017 0.0593 0.0699
Onchocerca volvulus 0.0037 0.1874 0.2305
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0037 0.1874 0.1874
Loa Loa (eye worm) hypothetical protein 0.001 0.0122 0.0144
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0037 0.1874 0.1874
Loa Loa (eye worm) hypothetical protein 0.0037 0.1874 0.221
Entamoeba histolytica hypothetical protein 0.0035 0.1726 0.8473
Onchocerca volvulus 0.0017 0.0593 0.0619
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.2654 1
Loa Loa (eye worm) GABA receptor subunit 0.002 0.0777 0.0916
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0017 0.0593 0.0699
Brugia malayi hypothetical protein 0.0017 0.0593 0.0699
Echinococcus granulosus glycine receptor subunit alpha 1 0.0037 0.1874 0.1874
Schistosoma mansoni nuclear hormone receptor 0.001 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0017 0.0593 0.0699
Loa Loa (eye worm) hypothetical protein 0.0017 0.0593 0.0699
Schistosoma mansoni nAChR subunit 0.0037 0.1874 0.1874

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7 uM Inhibitory activity against HCV delta 21 NS5b RNA polymerase ChEMBL. 16451069
IC50 (binding) = 7 uM Inhibitory activity against HCV delta 21 NS5b RNA polymerase ChEMBL. 16451069

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.