Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opiate receptor-like 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | opiate receptor-like 1 | 370 aa | 349 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0283 | 0.022 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0283 | 0.022 | 0.0225 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0283 | 0.022 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0283 | 0.022 | 0.0225 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0283 | 0.022 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.022 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.5944 | 0.9534 | 0.9775 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0283 | 0.022 | 0.0225 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0283 | 0.022 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0283 | 0.022 | 0.0225 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0283 | 0.022 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0283 | 0.022 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0283 | 0.022 | 0.0225 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0283 | 0.022 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0283 | 0.022 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0283 | 0.022 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.022 | 0.0225 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0283 | 0.022 | 0.0225 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0283 | 0.022 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.022 | 0.0225 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0283 | 0.022 | 0.0225 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0283 | 0.022 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0283 | 0.022 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0283 | 0.022 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0283 | 0.022 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0283 | 0.022 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.022 | 0.0225 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0283 | 0.022 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0283 | 0.022 | 0.0225 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0283 | 0.022 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.6077 | 0.9754 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0283 | 0.022 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0283 | 0.022 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0283 | 0.022 | 0.0225 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0283 | 0.022 | 0.0225 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0283 | 0.022 | 0.0225 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0283 | 0.022 | 0.0225 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0283 | 0.022 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0283 | 0.022 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0283 | 0.022 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.022 | 0.0225 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0283 | 0.022 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.022 | 0.0225 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0283 | 0.022 | 1 |
Brugia malayi | nuclear hormone receptor | 0.6077 | 0.9754 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0283 | 0.022 | 0.0225 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0283 | 0.022 | 0.0225 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0283 | 0.022 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0283 | 0.022 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0283 | 0.022 | 0.0225 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0283 | 0.022 | 0.0225 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0283 | 0.022 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0283 | 0.022 | 1 |
Brugia malayi | steroid hormone receptor | 0.0283 | 0.022 | 0.0225 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0283 | 0.022 | 0.0225 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0283 | 0.022 | 0.0225 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0283 | 0.022 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0283 | 0.022 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.022 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.022 | 0.0225 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0283 | 0.022 | 0.0225 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0283 | 0.022 | 0.0225 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0283 | 0.022 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0283 | 0.022 | 0.0225 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0283 | 0.022 | 0.0225 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0283 | 0.022 | 0.0225 |
Schistosoma mansoni | nuclear hormone receptor | 0.0283 | 0.022 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0283 | 0.022 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0283 | 0.022 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0283 | 0.022 | 0.0225 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1000 nM | Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells | ChEMBL. | 16451050 |
IC50 (binding) | > 1000 nM | Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells | ChEMBL. | 16451050 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.