Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opiate receptor-like 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | opiate receptor-like 1 | 370 aa | 349 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0203 | 0.1838 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.052 | 1 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.052 | 1 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.052 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0203 | 0.1838 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0132 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.052 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0203 | 0.1838 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0203 | 0.1838 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0203 | 0.1838 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.052 | 1 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.052 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.052 | 1 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.052 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.052 | 1 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.052 | 1 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0203 | 0.1838 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.052 | 1 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.052 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0203 | 0.1838 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0203 | 0.1838 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0203 | 0.1838 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.052 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0132 | 0 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0203 | 0.1838 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.052 | 1 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0203 | 0.1838 | 0.5 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0203 | 0.1838 | 0.1838 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 50 nM | Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells | ChEMBL. | 16451050 |
IC50 (binding) | = 50 nM | Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells | ChEMBL. | 16451050 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.