TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 438.364 | Formula: C19H20F6N2O3
H donors: 1 H acceptors: 3 LogP: 4.94 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1cn(c(n1)C(CC)C)c1ccc(cc1)C(C(F)(F)F)(C(F)(F)F)O
InChi: 1S/C19H20F6N2O3/c1-4-11(3)15-26-14(16(28)30-5-2)10-27(15)13-8-6-12(7-9-13)17(29,18(20,21)22)19(23,24)25/h6-11,29H,4-5H2,1-3H3
InChiKey: OWVMBSXXEMJSDK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	malonyl-CoA decarboxylase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania donovani	malonyl-coa decarboxylase-like protein	Get druggable targets OG5_131397	All targets in OG5_131397
Wolbachia endosymbiont of Brugia malayi	malonyl-CoA decarboxylase	Get druggable targets OG5_131397	All targets in OG5_131397
Trypanosoma congolense	malonyl-CoA decarboxylase, mitochondrial precursor, putative	Get druggable targets OG5_131397	All targets in OG5_131397
Trypanosoma brucei	malonyl-CoA decarboxylase, mitochondrial precursor, putative	Get druggable targets OG5_131397	All targets in OG5_131397
Leishmania infantum	malonyl-coa decarboxylase-like protein	Get druggable targets OG5_131397	All targets in OG5_131397
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131397	All targets in OG5_131397
Leishmania major	malonyl-coa decarboxylase-like protein	Get druggable targets OG5_131397	All targets in OG5_131397
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	Get druggable targets OG5_131397	All targets in OG5_131397
Leishmania braziliensis	malonyl-coa decarboxylase-like protein	Get druggable targets OG5_131397	All targets in OG5_131397
Leishmania mexicana	malonyl-coa decarboxylase-like protein	Get druggable targets OG5_131397	All targets in OG5_131397
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	Get druggable targets OG5_131397	All targets in OG5_131397
Brugia malayi	putative malonyl-CoA decarboxylase	Get druggable targets OG5_131397	All targets in OG5_131397
Trypanosoma brucei gambiense	malonyl-CoA decarboxylase, mitochondrial precursor, putative	Get druggable targets OG5_131397	All targets in OG5_131397

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0014	0.0054	0.0026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.1132	0.2538
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.1132	0.2538
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0013	0.0045	0.0092
Brugia malayi	PHD-finger family protein	0.0012	0.0013	0.0013
Schistosoma mansoni	chromobox protein	0.0012	0.0018	0.0022
Echinococcus multilocularis	peregrin	0.0031	0.0396	0.0467
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0053	0.0859	0.2173
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0364	0.0754
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0227	0.0487
Echinococcus granulosus	cathepsin l1	0.0018	0.0132	0.0156
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0669	0.1387
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0158	0.2977	0.2977
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0132	0.0132
Onchocerca volvulus		0.0018	0.0132	0.0273
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0157	0.0325
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.01	0.1806	0.2132
Echinococcus granulosus	snurportin 1	0.0323	0.632	0.746
Brugia malayi	M-phase phosphoprotein, mpp8	0.0012	0.0018	0.0018
Echinococcus granulosus	geminin	0.0178	0.3378	0.3988
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0312	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0606	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0018
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0386	0.0386
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.1132	0.2538
Schistosoma mansoni	transcription factor btf3	0.0037	0.0519	0.0613
Echinococcus multilocularis	lamin	0.0028	0.0349	0.0412
Loa Loa (eye worm)	helicase	0.0012	0.0018	0.0018
Echinococcus granulosus	mitogen activated protein kinase	0.0053	0.0859	0.1014
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.1132	0.2538
Schistosoma mansoni	hypothetical protein	0.0031	0.0396	0.0467
Leishmania major	hypothetical protein, conserved	0.0026	0.0312	0.0822
Brugia malayi	CHD4 protein	0.0014	0.0053	0.0053
Trypanosoma cruzi	cruzipain precursor, putative	0.0067	0.1132	0.2901
Schistosoma mansoni	hypothetical protein	0.0323	0.632	0.746
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0012	0.0018	0.0038
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0157	0.0325
Onchocerca volvulus		0.0018	0.0132	0.0273
Brugia malayi	hypothetical protein	0.0026	0.0312	0.0312
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0424	0.05
Brugia malayi	intermediate filament protein	0.0028	0.0349	0.0349
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.1132	0.2901
Brugia malayi	hypothetical protein	0.0092	0.1649	0.1649
Echinococcus granulosus	lamin	0.0028	0.0349	0.0412
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0132	0.0273
Echinococcus multilocularis	Chromobox protein 3	0.0012	0.0018	0.0022
Echinococcus multilocularis	chromobox protein 2	0.0012	0.0018	0.0022
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0053	0.0859	0.2265
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0132	0.0273
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0053	0.0062
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0018	0.0132	0.0156
Trypanosoma cruzi	cysteine peptidase, putative	0.0018	0.0132	0.0233
Echinococcus granulosus	cathepsin l1	0.0012	0.0014	0.0017
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.01	0.1806	0.2132
Plasmodium vivax	hypothetical protein, conserved	0.0012	0.0018	0.0352
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0013	0.0045	0.0045
Echinococcus granulosus	transcription factor btf3	0.0037	0.0519	0.0613
Loa Loa (eye worm)	hypothetical protein	0.0504	1	1
Plasmodium vivax	hypothetical protein, conserved	0.0012	0.0018	0.0352
Mycobacterium leprae	Possible regulatory protein	0.0013	0.0045	0.5
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0859	0.1781
Brugia malayi	PAS domain containing protein	0.0051	0.081	0.081
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0018	0.0038
Onchocerca volvulus		0.0013	0.0045	0.0092
Echinococcus multilocularis	mitogen activated protein kinase	0.0053	0.0859	0.1014
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0053	0.0859	0.2173
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0132	0.0273
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0012	0.0016	0.0301
Echinococcus multilocularis	cysteine protease	0.0018	0.0132	0.0156
Loa Loa (eye worm)	jmjC domain-containing protein	0.0039	0.0561	0.0561
Plasmodium vivax	vivapain-2	0.0018	0.0132	0.2539
Loa Loa (eye worm)	hypothetical protein	0.003	0.0389	0.0389
Brugia malayi	Pre-SET motif family protein	0.0032	0.0424	0.0424
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0053	0.0859	0.2265
Echinococcus granulosus	single minded 2	0.0038	0.0541	0.0639
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0015	0.0082	0.0171
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0198	0.3793	1
Onchocerca volvulus		0.0028	0.0349	0.0724
Entamoeba histolytica	hypothetical protein	0.0012	0.0018	0.0352
Trypanosoma cruzi	transcription factor btf3, putative	0.0037	0.0519	0.1266
Brugia malayi	chromobox protein homolog 3	0.0041	0.0606	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0396	0.0396
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0132	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0014	0.0014
Echinococcus multilocularis	snurportin 1	0.0323	0.632	0.746
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0132	0.0273
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0061	0.1014	0.2587
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0018
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0012	0.0011	0.0013
Schistosoma mansoni	cpg binding protein	0.0032	0.0421	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0018
Brugia malayi	hypothetical protein	0.0017	0.0122	0.0122
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0132	0.0273
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0045	0.0092
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0013	0.0045	0.0092
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0018	0.0038
Brugia malayi	SET domain containing protein	0.0014	0.0055	0.0055
Onchocerca volvulus		0.0018	0.0132	0.0273
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0014	0.0054	0.0026
Echinococcus granulosus	chromobox protein 1	0.0073	0.1257	0.1484
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0053	0.0062
Onchocerca volvulus		0.0018	0.0132	0.0273
Brugia malayi	Valyl-tRNA synthetase	0.0012	0.0018	0.0018
Leishmania major	cathepsin L-like protease	0.0018	0.0132	0.0348
Leishmania major	GTP-binding protein, putative	0.0022	0.0227	0.0598
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0132	0.0156
Onchocerca volvulus		0.0012	0.0014	0.0029
Schistosoma mansoni	hypothetical protein	0.0429	0.8471	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1649	0.1649
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0424	0.4434
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0312	0.0238
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0016	0.0019
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0031	0.0396	0.0467
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0859	0.1014
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.1132	0.2538
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0219	0.4214	0.4214
Schistosoma mansoni	eyes absent homolog	0.0092	0.1649	0.1947
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0053	0.0859	0.1773
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0132	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0171	0.3245	0.3245
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0157	0.0325
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0312	0.3261
Echinococcus multilocularis	transfer RNA-Lys	0.0038	0.0541	0.0639
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0018	0.0352
Brugia malayi	Pre-SET motif family protein	0.0219	0.4214	0.4214
Plasmodium falciparum	heterochromatin protein 1	0.0012	0.0018	0.0352
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0349	0.0349
Echinococcus granulosus	importin subunit beta 1	0.003	0.0389	0.0459
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0013	0.0045	1
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.0273	0.0566
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0039	0.0561	0.0662
Echinococcus granulosus	cpg binding protein	0.0032	0.0421	0.0497
Brugia malayi	Associated with TFs and helicases family protein	0.0012	0.0018	0.0018
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0039	0.0561	0.0662
Onchocerca volvulus		0.0018	0.0132	0.0273
Schistosoma mansoni	single-minded	0.0051	0.081	0.0956
Toxoplasma gondii	NAC domain-containing protein	0.0037	0.0519	0.5431
Trichomonas vaginalis	ran, putative	0.0022	0.0227	0.047
Mycobacterium ulcerans	putative regulatory protein	0.0038	0.0541	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0013
Leishmania major	protein kinase, putative	0.0014	0.0054	0.0143
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0013	0.0045	0.0118
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0273	0.0566
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0014	0.0014
Echinococcus multilocularis	musashi	0.0028	0.0349	0.0412
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0132	0.0273
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0018	0.0132	0.2539
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0044	0.0666	0.0786
Onchocerca volvulus		0.0032	0.0427	0.0884
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0019	0.0153	0.0181
Leishmania major	protein kinase, putative	0.0014	0.0054	0.0143
Entamoeba histolytica	hypothetical protein	0.0025	0.0273	0.5257
Schistosoma mansoni	hypothetical protein	0.0178	0.3378	0.3988
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0132	0.0273
Echinococcus multilocularis	cysteine protease	0.0018	0.0132	0.0156
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0424	0.05
Trichomonas vaginalis	chromobox protein, putative	0.0012	0.0018	0.0038
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0312	0.0713
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0014	0.0053	0.0063
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0012	0.0018	0.0022
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0012	0.0018	0.0191
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0014	0.0029
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0065	0.1094	0.1292
Echinococcus granulosus	lysine specific demethylase 5A	0.0039	0.0561	0.0662
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0132	0.0132
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0312	0.6004
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0012	0.0011	0.0013
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0312	0.0713
Trypanosoma cruzi	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0198	0.3793	1
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0014	0.0054	0.0026
Onchocerca volvulus		0.0018	0.0132	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1649	0.1649
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0132	0.0156
Brugia malayi	hypothetical protein	0.0171	0.3245	0.3245
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0669	0.1387
Trichomonas vaginalis	chromobox protein, putative	0.0012	0.0018	0.0038
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0053	0.0859	0.0859
Trichomonas vaginalis	Heterochromatin protein, putative	0.0012	0.0018	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0042	0.0042
Schistosoma mansoni	hypothetical protein	0.0054	0.0875	0.1033
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0227	0.0268
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0092	0.0192
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0227	0.0487
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0013	0.0045	0.0092
Brugia malayi	CXXC zinc finger family protein	0.003	0.0386	0.0386
Schistosoma mansoni	cpg binding protein	0.003	0.0386	0.0456
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0031	0.0396	0.0467
Brugia malayi	Importin beta-1 subunit	0.003	0.0389	0.0389
Onchocerca volvulus		0.0028	0.0349	0.0724
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.1132	0.2538
Loa Loa (eye worm)	heterochromatin protein 1	0.0073	0.1257	0.1257
Loa Loa (eye worm)	CHromoDomain protein family member	0.0014	0.0053	0.0053
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0227	0.0268
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0013	0.0045	0.0053
Brugia malayi	F/Y-rich N-terminus family protein	0.002	0.0188	0.0188
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0227	0.0227
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0083	0.0083
Trichomonas vaginalis	hypothetical protein	0.0012	0.0018	0.0038
Onchocerca volvulus		0.0012	0.0018	0.0038
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0157	0.0325
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0312	0.6004
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0045	0.0092
Brugia malayi	hypoxia-induced factor 1	0.0158	0.2977	0.2977
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0859	0.1781
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0132	0.0273
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0519	0.1076
Plasmodium falciparum	importin beta, putative	0.003	0.0389	0.749
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0132	0.0273
Schistosoma mansoni	hypothetical protein	0.0178	0.3378	0.3988
Schistosoma mansoni	chromobox protein	0.0073	0.1257	0.1484
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.0956	1
Plasmodium vivax	heterochromatin protein 1, putative	0.0012	0.0018	0.0352
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0018	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0519	0.1076
Plasmodium falciparum	basic transcription factor 3b, putative	0.0037	0.0519	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0045	0.0045
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0323	0.632	0.632
Schistosoma mansoni	ran	0.0022	0.0227	0.0268
Echinococcus multilocularis	Chromo domain	0.0012	0.0018	0.0022
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0132	0.0273
Trypanosoma brucei	malonyl-CoA decarboxylase, mitochondrial precursor, putative	0.0198	0.3793	1
Leishmania major	cathepsin L-like protease	0.0067	0.1132	0.2985
Onchocerca volvulus		0.0249	0.4825	1
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0859	0.1781
Trichomonas vaginalis	CMGC family protein kinase	0.0053	0.0859	0.1781
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0132	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0424	0.0424
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0157	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0349	0.0349
Trichomonas vaginalis	set domain proteins, putative	0.0249	0.4825	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0018	0.0132	0.0156
Loa Loa (eye worm)	cysteine protease	0.0018	0.0132	0.0132
Brugia malayi	bHLH-PAS transcription factor	0.0038	0.0541	0.0541
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0132	0.0273
Trichomonas vaginalis	guanylate cyclase, putative	0.0013	0.0045	0.0092
Plasmodium falciparum	phd finger protein, putative	0.0031	0.0396	0.7621
Trypanosoma brucei	transcription factor BTF3, putative	0.0037	0.0519	0.0819
Echinococcus multilocularis	transcription factor btf3	0.0037	0.0519	0.0613
Toxoplasma gondii	PHD-finger domain-containing protein	0.0031	0.0396	0.4139
Echinococcus multilocularis	lysine specific demethylase 5A	0.0037	0.0526	0.0621
Loa Loa (eye worm)	PHD-finger family protein	0.0031	0.0396	0.0396
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0022	0.0227	0.4373
Loa Loa (eye worm)	ctsf protein	0.0018	0.0132	0.0132
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0132	0.0273
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0018	0.0132	0.2539
Echinococcus multilocularis	cathepsin L cysteine protease	0.0018	0.0132	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0018
Brugia malayi	hypothetical protein	0.0012	0.0018	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0018	0.0038
Leishmania major	cathepsin L-like protease	0.0018	0.0132	0.0348
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0053	0.0859	0.2173
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0018	0.0132	0.0273
Wolbachia endosymbiont of Brugia malayi	malonyl-CoA decarboxylase	0.0504	1	0.5
Trypanosoma brucei	protein kinase, putative	0.0053	0.0859	0.1773
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0018	0.0132	0.0156
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.1257	0.2605
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0132	0.0273
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0364	0.0754
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0014	0.0014
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0132	0.0273
Trichomonas vaginalis	chromobox protein, putative	0.0012	0.0018	0.0038
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.1132	0.2901
Leishmania major	importin beta-1 subunit, putative	0.0025	0.0273	0.072
Entamoeba histolytica	cysteine protease, putative	0.0018	0.0132	0.2539
Brugia malayi	PHD-finger family protein	0.0031	0.0396	0.0396
Echinococcus granulosus	jumonji domain containing protein	0.0043	0.0638	0.0754
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0014	0.0054	0.0026
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0014	0.0014
Trypanosoma cruzi	major cysteine proteinase, putative	0.0053	0.0842	0.2127
Entamoeba histolytica	hypothetical protein	0.0012	0.0018	0.0352
Schistosoma mansoni	hypothetical protein	0.0012	0.0016	0.0019
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0132	0.0156
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0011	0	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0132	0.0273
Schistosoma mansoni	chromobox protein	0.0012	0.0018	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0018	0.0038
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0053	0.0859	0.1014
Entamoeba histolytica	Ran family GTPase	0.0022	0.0227	0.4373
Schistosoma mansoni	importin beta-1	0.003	0.0389	0.0459
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0424	0.05
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.1257	0.2605
Echinococcus multilocularis	chromobox protein 1	0.0073	0.1257	0.1484
Plasmodium vivax	hypothetical protein, conserved	0.0012	0.0016	0.0301
Plasmodium vivax	hypothetical protein, conserved	0.0031	0.0396	0.7621
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0018	0.0132	0.2539
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0389	0.0454
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0018	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0339	0.0339
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0012	0.0018	0.0022
Trichomonas vaginalis	guanylate cyclase, putative	0.0013	0.0045	0.0092
Plasmodium vivax	importin-beta 2, putative	0.003	0.0389	0.749
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0606	0.1256
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0424	0.05
Brugia malayi	MAP kinase sur-1	0.0053	0.0859	0.0859
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0014	0.0014
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0227	0.0227
Trichomonas vaginalis	adenylate cyclase, putative	0.0013	0.0045	0.0092
Onchocerca volvulus		0.0018	0.0132	0.0273
Onchocerca volvulus		0.0012	0.0018	0.0038
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.0013	0.0045	0.0053
Echinococcus multilocularis	dnaJ subfamily B	0.0429	0.8471	1
Echinococcus granulosus	dnaJ subfamily B	0.0429	0.8471	1
Schistosoma mansoni	chromobox protein-related (chromobox 1) (heterochromatin 1)	0.0012	0.0018	0.0022
Brugia malayi	Bromodomain containing protein	0.0031	0.0396	0.0396
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0022	0.0227	0.2375
Leishmania major	cathepsin L-like protease	0.0067	0.1132	0.2985
Brugia malayi	jmjC domain containing protein	0.0039	0.0561	0.0561
Echinococcus granulosus	peregrin	0.0031	0.0396	0.0467
Brugia malayi	cathepsin L-like precursor	0.0012	0.0014	0.0014
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0045	0.0092
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0132	0.0273
Brugia malayi	Heterochromatin protein 1	0.0073	0.1257	0.1257
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0606	0.1256
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0018	0.0132	0.0132
Echinococcus multilocularis	chromobox protein 1	0.0073	0.1257	0.1484
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0132	0.0132
Onchocerca volvulus	Cathepsin L homolog	0.0018	0.0132	0.0273
Leishmania major	cathepsin L-like protease	0.0018	0.0132	0.0348
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0424	0.05
Onchocerca volvulus		0.003	0.0386	0.0801
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0012	0.0018	0.0018
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0389	0.0454
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.0273	0.0566
Echinococcus granulosus	intermediate filament protein	0.0028	0.0349	0.0412
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0013	0.0045	0.0053
Loa Loa (eye worm)	fibroinase	0.0018	0.0132	0.0132
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0132	0.0273
Leishmania major	cathepsin L-like protease	0.0018	0.0132	0.0348
Onchocerca volvulus		0.0044	0.0666	0.1381
Schistosoma mansoni	cpg binding protein	0.0032	0.0421	0.0497
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0018	0.0352
Plasmodium vivax	SET domain protein, putative	0.0032	0.0424	0.8164
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0018	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0018	0.0038
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0132	0.0132
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0012	0.0018	0.0191
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0132	0.0132
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0132	0.0132
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0349	0.0349
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0012	0.0018	0.0022
Echinococcus multilocularis	jumonji domain containing protein	0.0043	0.0638	0.0754
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0427	0.0427
Echinococcus multilocularis	lamin dm0	0.0028	0.0349	0.0412
Leishmania major	cathepsin L-like protease	0.0067	0.1132	0.2985
Trichomonas vaginalis	conserved hypothetical protein	0.0037	0.0519	0.1076
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0012	0.0014	0.0014
Brugia malayi	RNA, U transporter 1	0.0086	0.1519	0.1519
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0014	0.0053	0.0063
Giardia lamblia	PHD finger protein 15	0.0031	0.0396	0.2668
Echinococcus granulosus	mitogen activated protein kinase 3	0.0053	0.0859	0.1014
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0019	0.0157	0.0325
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.1132	0.2538
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0132	0.0273
Entamoeba histolytica	transcription factor BTF3, putative	0.0037	0.0519	1
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0132	0.0132
Leishmania major	cathepsin L-like protease	0.0018	0.0132	0.0348
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0013	0.0045	0.0092
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.0083	0.0083
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.1132	0.2538
Toxoplasma gondii	cathepsin CPL	0.0018	0.0132	0.1379
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0018	0.0038
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.1132	0.2538
Schistosoma mansoni	ran	0.0022	0.0227	0.0268
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0157	0.0325
Echinococcus granulosus	Chromobox protein 3	0.0012	0.0018	0.0022
Schistosoma mansoni	chromobox protein	0.0073	0.1257	0.1484
Giardia lamblia	Kinase, CMGC MAPK	0.0053	0.0859	1
Leishmania major	malonyl-coa decarboxylase-like protein	0.0198	0.3793	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0132	0.0273
Leishmania major	cysteine peptidase A (CPA)	0.0018	0.0132	0.0348
Schistosoma mansoni	jumonji domain containing protein	0.0079	0.1389	0.1639
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0132	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0053	0.0053
Onchocerca volvulus	Cathepsin F homolog	0.0018	0.0132	0.0273
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0053	0.0859	0.8987
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0389	0.0459
Schistosoma mansoni	lamin	0.0028	0.0349	0.0412
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0424	0.05
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0044	0.0669	0.1387
Entamoeba histolytica	cysteine proteinase, putative	0.0012	0.0014	0.0272
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0838	0.0838
Brugia malayi	beta-NAC-like protein	0.0037	0.0519	0.0519
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0014	0.0053	0.0063
Schistosoma mansoni	aryl hydrocarbon receptor	0.0051	0.081	0.0956
Echinococcus granulosus	chromobox protein 2	0.0012	0.0018	0.0022
Onchocerca volvulus		0.0038	0.0541	0.1122
Schistosoma mansoni	hypothetical protein	0.0012	0.0018	0.0022
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.1132	0.2538
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0018	0.0038
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0016	0.0019
Brugia malayi	Protein cec-1.	0.0012	0.0018	0.0018
Onchocerca volvulus	Alhambra homolog	0.0031	0.0396	0.082
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0132	0.2539
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0067	0.1132	0.2538
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0022	0.0227	0.4373
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0018	0.0132	0.0273
Brugia malayi	jmjC domain containing protein	0.01	0.1806	0.1806
Echinococcus granulosus	aryl hydrocarbon receptor	0.0013	0.0045	0.0053
Schistosoma mansoni	lamin	0.0028	0.0349	0.0412
Entamoeba histolytica	hypothetical protein	0.0012	0.0018	0.0352
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0012	0.0018	0.0352
Plasmodium vivax	basic transcription factor 3b, putative	0.0037	0.0519	1
Leishmania major	basic transcription factor 3a, putative	0.0037	0.0519	0.1369
Echinococcus multilocularis	geminin	0.0178	0.3378	0.3988
Loa Loa (eye worm)	jmjC domain-containing protein	0.0063	0.1056	0.1056
Plasmodium vivax	vivapain-2	0.0018	0.0132	0.2539
Loa Loa (eye worm)	ICD-1 protein	0.0037	0.0519	0.0519
Trypanosoma cruzi	cysteine peptidase, putative	0.0067	0.1132	0.2901
Toxoplasma gondii	PHD-finger domain-containing protein	0.0031	0.0396	0.4139
Toxoplasma gondii	'chromo' (CHRromatin Organization MOdifier) domain-containing protein	0.0012	0.0018	0.0191
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0387	0.0457
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0132	0.2539
Trichomonas vaginalis	adenylate cyclase, type VII, putative	0.0013	0.0045	0.0092
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0014	0.0029
Trypanosoma cruzi	transcription factor btf3, putative	0.0037	0.0519	0.1266
Schistosoma mansoni	cathepsin F (C01 family)	0.0012	0.0014	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0018
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0312	0.6004
Echinococcus granulosus	Chromo domain	0.0012	0.0018	0.0022
Echinococcus granulosus	chromobox protein 1	0.0073	0.1257	0.1484
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0132	0.0273
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0019	0.0157	0.0325
Echinococcus granulosus	lamin dm0	0.0028	0.0349	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0018	0.0018
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0053	0.0859	0.2173
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0018	0.0352
Echinococcus granulosus	PHD finger protein rhinoceros	0.0031	0.0396	0.0467
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0389	0.4068
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0132	0.0132
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0132	0.0132
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0132	0.0273
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0016	0.0092	0.0192
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0012	0.0018	0.0022
Entamoeba histolytica	hypothetical protein	0.0037	0.0519	1
Echinococcus multilocularis	cpg binding protein	0.0032	0.0421	0.0497
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0012	0.0018	0.0352
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0349	0.0349
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.0273	0.0609
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0606	0.1256
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0349	0.0412

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.5	Inhibition of human recombinant MCD	ChEMBL.	17482825
IC50 (binding)	= 0.318 uM	Inhibition of human recombinant MCD	ChEMBL.	17482825
IC50 (binding)	= 0.318 uM	Inhibition of human recombinant MCD	ChEMBL.	17482825
IC50 (binding)	= 318 uM	Inhibitory activity against recombinant human MCD MBP fusion protein	ChEMBL.	16257202
IC50 (binding)	= 318 uM	Inhibitory activity against recombinant human MCD MBP fusion protein	ChEMBL.	16257202
Log IC50 (binding)	= 0.5	Inhibition of human recombinant MCD	ChEMBL.	17482825

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL202205

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 352534