Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0187 | 0.1522 | 0.5123 | |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0105 | 0.0768 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0105 | 0.0768 | 0.2509 |
Schistosoma mansoni | kinase | 0.0054 | 0.0291 | 0.0291 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1522 | 0.1522 |
Brugia malayi | hypothetical protein | 0.0187 | 0.1522 | 0.1522 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0105 | 0.0768 | 0.0768 |
Brugia malayi | Trypsin family protein | 0.0344 | 0.297 | 0.297 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0025 | 0.003 | 0.003 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0187 | 0.1522 | 0.1522 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0187 | 0.1522 | 0.1522 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0025 | 0.003 | 0.003 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0187 | 0.1522 | 0.1522 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0025 | 0.003 | 0.003 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0856 | 0.7682 | 0.7682 |
Onchocerca volvulus | 0.0025 | 0.003 | 0.0102 | |
Trichomonas vaginalis | CAMK family protein kinase | 0.0105 | 0.0768 | 0.2509 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0286 | 0.0286 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1522 | 0.1522 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.003 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.003 | 0.003 |
Brugia malayi | Carboxylesterase family protein | 0.0187 | 0.1522 | 0.1522 |
Onchocerca volvulus | 0.0187 | 0.1522 | 0.5123 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0025 | 0.003 | 0.003 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0187 | 0.1522 | 0.1522 |
Echinococcus granulosus | acetylcholinesterase | 0.1108 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1522 | 0.1522 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0187 | 0.1522 | 0.6371 |
Onchocerca volvulus | 0.0187 | 0.1522 | 0.5123 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1108 | 1 | 1 |
Echinococcus multilocularis | enteropeptidase | 0.0025 | 0.003 | 0.003 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0025 | 0.003 | 0.003 |
Onchocerca volvulus | 0.0344 | 0.297 | 1 | |
Brugia malayi | Trypsin family protein | 0.0025 | 0.003 | 0.003 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0105 | 0.0768 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0025 | 0.003 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 0.297 | 0.297 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0286 | 0.0286 |
Echinococcus multilocularis | neuroligin | 0.0187 | 0.1522 | 0.1522 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0187 | 0.1522 | 0.1522 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1108 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0187 | 0.1522 | 0.1522 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0286 | 0.0286 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0025 | 0.003 | 0.003 |
Brugia malayi | Carboxylesterase family protein | 0.1108 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0025 | 0.003 | 0.003 |
Echinococcus granulosus | Mastin | 0.0025 | 0.003 | 0.003 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.0025 | 0.003 | 0.003 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0187 | 0.1522 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0264 | 0.223 | 1 |
Onchocerca volvulus | 0.0264 | 0.223 | 0.7509 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0025 | 0.003 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1522 | 0.1522 |
Echinococcus multilocularis | Mastin | 0.0025 | 0.003 | 0.003 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0187 | 0.1522 | 0.6371 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.003 | 0.003 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0232 | 0.1935 | 0.1935 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0105 | 0.0768 | 0.5 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0104 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0025 | 0.003 | 0.003 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0105 | 0.0768 | 0.2509 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0104 | 0.0104 |
Onchocerca volvulus | 0.0319 | 0.2738 | 0.9218 | |
Brugia malayi | Trypsin-like protease protein 5 | 0.0025 | 0.003 | 0.003 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.0025 | 0.003 | 0.003 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0167 | 0.0167 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0105 | 0.0768 | 0.2509 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0104 | 0.0104 |
Echinococcus granulosus | acetylcholinesterase | 0.1108 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1108 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1108 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1108 | 1 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0105 | 0.0768 | 0.0768 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.003 | 0.003 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0286 | 0.0286 |
Echinococcus multilocularis | acetylcholinesterase | 0.1108 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0025 | 0.003 | 0.003 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0187 | 0.1522 | 0.5 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0104 | 0.0104 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0105 | 0.0768 | 0.2509 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0105 | 0.0768 | 0.2509 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0187 | 0.1522 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0025 | 0.003 | 0.003 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0167 | 0.0167 |
Brugia malayi | Carboxylesterase family protein | 0.0187 | 0.1522 | 0.1522 |
Onchocerca volvulus | 0.0187 | 0.1522 | 0.5123 | |
Echinococcus granulosus | neuroligin | 0.0187 | 0.1522 | 0.1522 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0286 | 0.0286 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0025 | 0.003 | 0.003 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0025 | 0.003 | 0.003 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0025 | 0.003 | 0.003 |
Onchocerca volvulus | 0.0025 | 0.003 | 0.0102 | |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0025 | 0.003 | 0.003 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0187 | 0.1522 | 0.1522 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0344 | 0.297 | 0.297 |
Loa Loa (eye worm) | carboxylesterase | 0.0187 | 0.1522 | 0.1522 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.003 | 0.003 |
Echinococcus granulosus | enteropeptidase | 0.0025 | 0.003 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1522 | 0.1522 |
Onchocerca volvulus | 0.0187 | 0.1522 | 0.5123 | |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.003 | 0.003 |
Brugia malayi | Pre-SET motif family protein | 0.0232 | 0.1935 | 0.1935 |
Brugia malayi | Trypsin family protein | 0.0025 | 0.003 | 0.003 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0104 | 0.0104 |
Trypanosoma brucei | polo-like protein kinase | 0.0105 | 0.0768 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0105 | 0.0768 | 0.0768 |
Loa Loa (eye worm) | carboxylesterase | 0.1108 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0167 | 0.0167 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0104 | 0.0104 |
Brugia malayi | hypothetical protein | 0.0025 | 0.003 | 0.003 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0187 | 0.1522 | 0.1522 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0187 | 0.1522 | 0.1522 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0025 | 0.003 | 0.003 |
Giardia lamblia | Kinase, PLK | 0.0105 | 0.0768 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0187 | 0.1522 | 0.1522 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0105 | 0.0768 | 0.0768 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1522 | 0.1522 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0187 | 0.1522 | 0.1522 |
Onchocerca volvulus | 0.0033 | 0.0104 | 0.0352 | |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0104 | 0.0104 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0105 | 0.0768 | 0.2509 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0344 | 0.297 | 0.297 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0105 | 0.0768 | 0.0768 |
Loa Loa (eye worm) | hypothetical protein | 0.0344 | 0.297 | 0.297 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0187 | 0.1522 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.003 | 0.003 |
Loa Loa (eye worm) | trypsin family protein | 0.0025 | 0.003 | 0.003 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0187 | 0.1522 | 0.1522 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0105 | 0.0768 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0025 | 0.003 | 0.003 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0105 | 0.0768 | 0.2585 |
Echinococcus granulosus | carboxylesterase 5A | 0.1108 | 1 | 1 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0025 | 0.003 | 0.003 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.0025 | 0.003 | 0.003 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0104 | 0.0104 |
Onchocerca volvulus | 0.0025 | 0.003 | 0.0102 | |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0093 | 0.0093 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0286 | 0.0286 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0286 | 0.0286 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0167 | 0.0167 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0104 | 0.0104 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0104 | 0.0104 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.1522 | 0.1522 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.0025 | 0.003 | 0.003 |
Schistosoma mansoni | gliotactin | 0.0187 | 0.1522 | 0.1522 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.0025 | 0.003 | 0.003 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1108 | 1 | 1 |
Onchocerca volvulus | 0.0025 | 0.003 | 0.0102 | |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0104 | 0.5 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.0025 | 0.003 | 0.003 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0286 | 0.0286 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.0025 | 0.003 | 0.003 |
Onchocerca volvulus | 0.0025 | 0.003 | 0.0102 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0187 | 0.1522 | 0.1522 |
Brugia malayi | Carboxylesterase family protein | 0.0187 | 0.1522 | 0.1522 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.0025 | 0.003 | 0.003 |
Brugia malayi | Carboxylesterase family protein | 0.0187 | 0.1522 | 0.1522 |
Brugia malayi | hypothetical protein | 0.004 | 0.0167 | 0.0167 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0286 | 0.0286 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.039 uM | Inhibitory activity against thrombin | ChEMBL. | 16290930 |
IC50 (binding) | = 0.34 uM | Inhibitory activity against trypsin | ChEMBL. | 16290930 |
Ratio IC50 (binding) | = 8.7 | Selectivity ratio of thrombin over trypsin | ChEMBL. | 16290930 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.