Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-X-C motif) receptor 2 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -7.6 | Displacement of [125I]IL8 from human CXCR2 expressed in HEK 293 by SPA | ChEMBL. | 17382543 |
IC50 (binding) | = 0.0095 uM | Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 membranes by SPA | ChEMBL. | 16297626 |
IC50 (binding) | = 0.0095 uM | Displacement of [125I]IL8 from human recombinant CXCR2 expressed in HEK293 membranes by SPA | ChEMBL. | 16297626 |
Log IC50 (binding) | = 7.6 | Displacement of [125I]IL8 from human CXCR2 expressed in HEK 293 by SPA | ChEMBL. | 17382543 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.