Detailed information for compound 35315

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 465.498 | Formula: C24H25F2N7O
  • H donors: 1 H acceptors: 4 LogP: 2.67 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C(=O)N)c2c(n1)n(C)c1c2ncnc1N1CCN(CC1)CCc1ccc(c(c1)F)F
  • InChi: 1S/C24H25F2N7O/c1-14-11-16(22(27)34)19-20-21(31(2)23(19)30-14)24(29-13-28-20)33-9-7-32(8-10-33)6-5-15-3-4-17(25)18(26)12-15/h3-4,11-13H,5-10H2,1-2H3,(H2,27,34)
  • InChiKey: KFCQYUZRWULLQM-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 1A Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL References
Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia Multidrug resistance-associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette protein Get druggable targets OG5_126561 All targets in OG5_126561
Brugia malayi multidrug resistance related protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis multidrug resistance associated protein 4 Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ATP-binding cassette protein subfamily C, member 2, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei p-glycoprotein Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei gambiense multidrug resistance-associated protein, putative,p-glycoprotein Get druggable targets OG5_126561 All targets in OG5_126561
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei multidrug resistance protein E Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily C, member 6, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus multidrug resistance associated protein 4 Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense multidrug resistance protein E,p-glycoprotein Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major pentamidine resistance protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Cryptosporidium hominis SI:dZ52I16.4 (novel ABC transporter similar to human multidrug-resistance proteins (MRP)) Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum pentamidine resistance protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans similar to vacuolar membrane ATP-dependant transporter, metal resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Giardia lamblia ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Giardia lamblia Multidrug resistance-associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Giardia lamblia Multidrug resistance-associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia MRP-like ABC transporter Get druggable targets OG5_126561 All targets in OG5_126561
Babesia bovis ABC transporter family protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K05674 ATP-binding cassette, subfamily C (CFTR/MRP), member 10, putative Get druggable targets OG5_126561 All targets in OG5_126561
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05667 ATP-binding cassette, subfamily C (CFTR/MRP), member 3, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Multidrug resistance-associated protein 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma cruzi multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans vacuolar ABC transporter similar to multiple drug resistance-associated protein Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma congolense multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily C, member 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Babesia bovis ABC transporter family protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Canalicular multispecific organic anion transporter 2, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma cruzi multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) multidrug resistance-associated protein Get druggable targets OG5_126561 All targets in OG5_126561
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Babesia bovis ABC transporter, ATP-binding protein domain containing protein Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Babesia bovis ABC transporter family protein Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Multidrug resistance-associated protein 4, putative Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana p-glycoprotein e, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans similar to vacuolar membrane ATP-dependant transporter, metal resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance associated protein 7 Get druggable targets OG5_126561 All targets in OG5_126561
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania donovani pentamidine resistance protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica multidrug resistance protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi multidrug resistance protein E, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana ATP-binding cassette protein subfamily C, member 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma congolense multidrug resistance protein A Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Brugia malayi ABC transporter transmembrane region family protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance-associated protein 4, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium parvum ABC ATpase (2 ABC domains) with 10 transmembrane domains, adjacent duplicated gene Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance-associated protein 4, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana p-glycoprotein-like protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Neospora caninum hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein e, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans vacuolar ABC transporter similar to multiple drug resistance-associated protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana multidrug resistance protein, copy 1-like protein Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ATP-binding cassette protein subfamily C, member 5, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance-associated protein 7, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ABC transporter transmembrane region family protein Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis multidrug resistance associated protein 7 Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.2368 0.2803
Brugia malayi multidrug resistance protein 3 0.0017 0.039 0.0461
Toxoplasma gondii thioredoxin reductase 0.0125 0.8447 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0043 0.2368 0.2803
Leishmania major p-glycoprotein e 0.0021 0.0719 0.0852
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0043 0.2368 1
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0021 0.0719 0.0852
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0017 0.039 0.0461
Trichomonas vaginalis abcb9, putative 0.0017 0.039 0.1645
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0043 0.2368 0.2803
Leishmania major ABC-thiol transporter 0.0021 0.0719 0.0852
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0017 0.039 0.1645
Trichomonas vaginalis glutathione reductase, putative 0.0043 0.2368 1
Trichomonas vaginalis ABC transporter, putative 0.0017 0.039 0.1645
Entamoeba histolytica P-glycoprotein-2 0.0017 0.039 0.5416
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0021 0.0719 0.0852
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0043 0.2368 0.2803
Leishmania major cytochrome p450-like protein 0.0015 0.0251 0.0297
Trypanosoma brucei multidrug resistance protein E 0.0021 0.0719 0.0852
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0021 0.0719 0.0852
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0043 0.2368 0.2803
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0043 0.2368 0.2803
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0017 0.039 0.1645
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0017 0.039 0.1645
Trichomonas vaginalis mercuric reductase, putative 0.0043 0.2368 1
Schistosoma mansoni smdr2 0.0017 0.039 0.039
Loa Loa (eye worm) hypothetical protein 0.0017 0.039 0.0461
Trichomonas vaginalis ABC transporter, putative 0.0017 0.039 0.1645
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0719 0.0852
Schistosoma mansoni multidrug resistance protein 0.0017 0.039 0.039
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0017 0.039 0.1645
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0043 0.2368 0.2803
Brugia malayi multidrug resistance related protein 1 0.0021 0.0719 0.0852
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0251 0.0297
Echinococcus multilocularis multidrug resistance protein 1 0.0017 0.039 0.0461
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0043 0.2368 0.2803
Trichomonas vaginalis abcb9, putative 0.0017 0.039 0.1645
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0043 0.2368 0.2803
Entamoeba histolytica P-glycoprotein-1 0.0017 0.039 0.5416
Brugia malayi Thioredoxin reductase 0.0125 0.8447 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0017 0.039 0.1645
Echinococcus multilocularis multidrug resistance associated protein 1 0.0021 0.0719 0.0852
Entamoeba histolytica P-glycoprotein-2 0.0017 0.039 0.5416
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0017 0.039 0.1645
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0043 0.2368 0.2803
Entamoeba histolytica P-glycoprotein-5 0.0017 0.039 0.5416
Trypanosoma brucei trypanothione reductase 0.0125 0.8447 1
Schistosoma mansoni multidrug resistance protein 0.0021 0.0719 0.0719
Echinococcus multilocularis multidrug resistance protein 1 0.0017 0.039 0.0461
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0017 0.039 0.1645
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0043 0.2368 1
Trypanosoma brucei p-glycoprotein 0.0021 0.0719 0.0852
Leishmania major p-glycoprotein 0.0017 0.039 0.0461
Entamoeba histolytica multidrug resistance protein, putative 0.0021 0.0719 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0017 0.039 0.0461
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0021 0.0719 0.0852
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0043 0.2368 0.2803
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0043 0.2368 0.2368
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0017 0.039 0.0461
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.2368 0.2803
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0251 0.0297
Leishmania major pentamidine resistance protein 1 0.0021 0.0719 0.0852
Giardia lamblia ABC transporter, putative 0.0021 0.0719 0.3038
Trypanosoma cruzi multidrug resistance protein E, putative 0.0021 0.0719 0.0852
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0015 0.0251 0.106
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.2368 0.2803
Entamoeba histolytica P-glycoprotein 5, putative 0.0017 0.039 0.5416
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0719 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0043 0.2368 0.2803
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0017 0.039 0.1645
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0021 0.0719 0.0852
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0017 0.039 0.1645
Plasmodium falciparum glutathione reductase 0.0043 0.2368 0.2803
Plasmodium falciparum thioredoxin reductase 0.0125 0.8447 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0017 0.039 0.0461
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0017 0.039 0.1645
Entamoeba histolytica hypothetical protein 0.0021 0.0719 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0043 0.2368 0.2803
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0043 0.2368 0.2803
Echinococcus granulosus multidrug resistance associated protein 4 0.0013 0.0126 0.0149
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0251 0.0297
Echinococcus granulosus thioredoxin glutathione reductase 0.0125 0.8447 1
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0017 0.039 0.0461
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0017 0.039 0.0461
Trypanosoma cruzi trypanothione reductase, putative 0.0125 0.8447 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0021 0.0719 0.3038
Giardia lamblia Multidrug resistance-associated protein 1 0.0021 0.0699 0.2951
Trichomonas vaginalis ABC transporter, putative 0.0017 0.039 0.1645
Giardia lamblia MRP-like ABC transporter 0.0021 0.0719 0.3038
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0043 0.2368 1
Trichomonas vaginalis taga, putative 0.0017 0.039 0.1645
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.2368 0.2803
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0017 0.039 0.0461
Giardia lamblia NADH oxidase lateral transfer candidate 0.0043 0.2368 1
Echinococcus granulosus multidrug resistance associated protein 7 0.0021 0.0719 0.0852
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0251 0.0297
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0043 0.2368 0.2803
Echinococcus multilocularis ATP binding cassette sub family B 0.0016 0.0369 0.0437
Schistosoma mansoni multidrug resistance protein 0.0017 0.039 0.039
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0021 0.0719 0.0852
Loa Loa (eye worm) glutathione reductase 0.0125 0.8447 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0032 0.1512 0.179
Brugia malayi ABC transporter transmembrane region family protein 0.0021 0.0719 0.0852
Trichomonas vaginalis abcb9, putative 0.0017 0.039 0.1645
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0017 0.039 0.1645
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0021 0.0719 0.0852
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0251 0.0297
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0017 0.039 0.1645
Schistosoma mansoni multidrug resistance protein 0.0017 0.039 0.039
Brugia malayi ABC transporter family protein 0.0017 0.039 0.0461
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.2368 0.2803
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0017 0.039 0.0461
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0043 0.2368 0.2803
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.039 0.0461
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0043 0.2368 0.2803
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0043 0.2368 1
Leishmania major trypanothione reductase 0.0125 0.8447 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0017 0.039 0.1645
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0017 0.039 0.0461
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0043 0.2368 0.2803
Trypanosoma cruzi hypothetical protein 0.0013 0.0126 0.0149
Entamoeba histolytica ABC transporter, putative 0.0021 0.0719 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0017 0.039 0.1645
Giardia lamblia Multidrug resistance-associated protein 1 0.0021 0.0719 0.3038
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0017 0.039 0.1645
Plasmodium vivax glutathione reductase, putative 0.0125 0.8447 1
Plasmodium falciparum glutathione reductase 0.0125 0.8447 1
Treponema pallidum NADH oxidase 0.0043 0.2368 1
Echinococcus granulosus multidrug resistance associated protein 1 0.0021 0.0719 0.0852
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0043 0.2368 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0017 0.039 0.1645
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.2368 0.2803
Entamoeba histolytica P-glyco protein 6, putative 0.0017 0.039 0.5416
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0017 0.039 0.0461
Loa Loa (eye worm) hypothetical protein 0.0016 0.0369 0.0437
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0125 0.8447 1
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0017 0.039 0.0461
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0021 0.0719 0.0852
Schistosoma mansoni multidrug resistance protein 0.0021 0.0719 0.0719
Loa Loa (eye worm) multidrug resistance protein 3 0.0017 0.039 0.0461
Brugia malayi glutathione reductase 0.0125 0.8447 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0043 0.2368 0.2803
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.039 0.0461
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0017 0.039 0.0461
Plasmodium falciparum thioredoxin reductase 0.0043 0.2368 0.2803
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0032 0.1512 0.179
Onchocerca volvulus 0.0017 0.039 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0719 0.0852
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0017 0.039 0.1645
Entamoeba histolytica P-glycoprotein-2, putative 0.0017 0.039 0.5416
Brugia malayi Cytochrome P450 family protein 0.0015 0.0251 0.0297
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0043 0.2368 1
Plasmodium vivax multidrug resistance protein 1, putative 0.0017 0.039 0.0461
Schistosoma mansoni multidrug resistance protein 0.0021 0.0719 0.0719
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0251 0.0297
Trichomonas vaginalis ABC transporter, putative 0.0017 0.039 0.1645
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0017 0.039 0.1645
Plasmodium vivax thioredoxin reductase, putative 0.0125 0.8447 1
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0016 0.0369 0.0437
Plasmodium falciparum multidrug resistance protein 1 0.0017 0.039 0.0461
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0043 0.2368 0.2803
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0017 0.039 0.1645
Echinococcus multilocularis thioredoxin glutathione reductase 0.0125 0.8447 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0699 0.0827
Mycobacterium tuberculosis Probable oxidoreductase 0.0043 0.2368 0.2803
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0719 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0043 0.2368 0.2803
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0017 0.039 0.0461
Echinococcus multilocularis multidrug resistance associated protein 4 0.0013 0.0126 0.0149
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0017 0.039 0.1645
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0043 0.2368 1
Schistosoma mansoni multidrug resistance protein 0.0021 0.0719 0.0719
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0017 0.039 0.1645
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0719 1
Loa Loa (eye worm) multidrug resistance-associated protein 0.0013 0.0147 0.0174
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0719 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0043 0.2368 0.2803
Loa Loa (eye worm) thioredoxin reductase 0.0125 0.8447 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0043 0.2368 0.2803
Echinococcus multilocularis multidrug resistance associated protein 7 0.0021 0.0719 0.0852
Brugia malayi Cytochrome P450 family protein 0.0015 0.0251 0.0297
Toxoplasma gondii NADPH-glutathione reductase 0.0043 0.2368 0.2803
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0017 0.039 0.1645
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.039 0.0461
Loa Loa (eye worm) hypothetical protein 0.0017 0.039 0.0461
Loa Loa (eye worm) hypothetical protein 0.0021 0.0719 0.0852
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0017 0.039 0.0461
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0021 0.0719 0.0852
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0017 0.039 0.1645

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.067 uM Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assay ChEMBL. 14998324
IC50 (binding) = 0.067 uM Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assay ChEMBL. 14998324
IC50 (ADMET) = 0.21 uM Inhibitory activity against cytochrome P450 3A4 ChEMBL. 14998324
IC50 (ADMET) = 0.21 uM Inhibitory activity against cytochrome P450 3A4 ChEMBL. 14998324
IC50 (binding) = 0.223 uM In vitro inhibitory activity of the compound against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in accumulation assay ChEMBL. 14998324
IC50 (binding) = 0.223 uM In vitro inhibitory activity of the compound against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in accumulation assay ChEMBL. 14998324
IC50 (binding) > 10 uM Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assay ChEMBL. 14998324
IC50 (binding) > 10 uM Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assay ChEMBL. 14998324

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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