TDR Targets

Basic information

Technical information

TDR Targets ID: 353248
Name: 2-N,7-N-bis(furan-2-ylmethyl)-9H-fluorene-2,7 -disulfonamide
MW: 484.545 | Formula: C23H20N2O6S2
H donors: 2 H acceptors: 4 LogP: 2.67 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=S(=O)(c1ccc2c(c1)Cc1c2ccc(c1)S(=O)(=O)NCc1ccco1)NCc1ccco1
InChi: 1S/C23H20N2O6S2/c26-32(27,24-14-18-3-1-9-30-18)20-5-7-22-16(12-20)11-17-13-21(6-8-23(17)22)33(28,29)25-15-19-4-2-10-31-19/h1-10,12-13,24-25H,11,14-15H2
InChiKey: HWWHZSNJWALPOF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N2,N7-bis(2-furylmethyl)-9H-fluorene-2,7-disulfonamide
N2,N7-bis(furan-2-ylmethyl)-9H-fluorene-2,7-disulfonamide
N,N'-bis(2-furfuryl)-9H-fluorene-2,7-disulfonamide
N,N'-bis(furan-2-ylmethyl)-9H-fluorene-2,7-disulfonamide
N,N'-bis(2-furylmethyl)-9H-fluorene-2,7-disulfonamide
ZINC00626002
9H-Fluorene-2,7-disulfonic acid bis-[(furan-2-ylmethyl)-amide]
BAS 00313385

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Plasmodium falciparum	cysteine proteinase falcipain 2a	Starlite/ChEMBL	References
Plasmodium falciparum	cysteine proteinase falcipain 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium vivax	vivapain-3	cysteine proteinase falcipain 3	492 aa	498 aa	50.2 %
Plasmodium vivax	vivapain-3	cysteine proteinase falcipain 2a	484 aa	497 aa	45.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0024	0.0047
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0126	0.038
Echinococcus granulosus	inositol monophosphatase 1	0.004	0.0132	0.0227
Loa Loa (eye worm)	hypothetical protein	0.0022	0.003	0.0058
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.0211	0.0765
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0036	0.0106	0.0384
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	0.003	0.0059
Loa Loa (eye worm)	thioredoxin reductase	0.0103	0.0491	0.0953
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0126	0.1059
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.0211	0.0765
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0022	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0126	0.0244
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0059	0.0765
Entamoeba histolytica	cysteine proteinase, putative	0.0028	0.0061	0.0143
Loa Loa (eye worm)	fibroinase	0.0054	0.0211	0.0409
Schistosoma mansoni	lipoxygenase	0.0021	0.0024	0.0042
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.0061	0.0221
Brugia malayi	hypothetical protein	0.0051	0.0194	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0086	0.0166
Schistosoma mansoni	intermediate filament proteins	0.0059	0.0237	0.041
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.003	0.0059
Brugia malayi	Raf kinase	0.0888	0.4999	1
Giardia lamblia	Thymidine kinase	0.0498	0.2759	1
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0061	0.0143
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0054	0.0211	0.0691
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0126	0.1644
Schistosoma mansoni	diacylglycerol kinase theta	0.0032	0.0086	0.0148
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.0022	0.0079
Echinococcus granulosus	Rac GTPase activating protein 1	0.0032	0.0086	0.0148
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0036	0.0106	0.1385
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.003	0.0051
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.0322	0.2308
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.003	0.003
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0211	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0231	0.0448
Schistosoma mansoni	thyroid hormone receptor	0.0148	0.0752	0.1299
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0036	0.0106	0.0384
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0059	0.0212
Mycobacterium tuberculosis	Probable reductase	0.0234	0.1247	0.8925
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	0.003	0.0059
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0211	0.0422
Trypanosoma cruzi	thymidine kinase, putative	0.0498	0.2759	1
Schistosoma mansoni	inositol monophosphatase	0.004	0.0132	0.0227
Toxoplasma gondii	ABC1 family protein	0.0039	0.0126	0.1644
Schistosoma mansoni	rab6-interacting	0.0021	0.0024	0.0042
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0032	0.0086	0.0166
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0126	0.0142
Plasmodium falciparum	thioredoxin reductase	0.0103	0.0491	0.6421
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0126	0.0624	0.0624
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0028	0.0061	0.0143
Echinococcus granulosus	protein kinase c eta type	0.0032	0.0086	0.0148
Echinococcus granulosus	cathepsin l1	0.0036	0.0109	0.0188
Schistosoma mansoni	cathepsin F (C01 family)	0.0054	0.0211	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0086	0.0166
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0022	0.0079
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0059	0.0765
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0212	0.0424
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0028	0.0061	0.0221
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0151	0.0765	0.2774
Echinococcus granulosus	protein kinase c epsilon type	0.0032	0.0086	0.0148
Leishmania major	cathepsin L-like protease	0.0054	0.0211	0.0765
Echinococcus multilocularis	lamin dm0	0.0059	0.0237	0.0237
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.006	0.0245	0.0245
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.0126	0.09
Echinococcus multilocularis	myotubularin protein 13	0.0032	0.0086	0.0086
Onchocerca volvulus		0.0032	0.0086	0.0846
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.003	0.0051
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.003	0.0058
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0211	0.0422
Onchocerca volvulus		0.0054	0.0211	0.257
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.025	0.1334	0.9546
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.0132	0.0401
Onchocerca volvulus		0.0032	0.0086	0.0846
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0126	0.1059
Trichomonas vaginalis	esterase, putative	0.0039	0.0126	0.038
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0261	0.1397	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0022	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0064	0.0124
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.006	0.0244	0.1745
Brugia malayi	beta-lactamase	0.0039	0.0126	0.0252
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0109	0.0318
Echinococcus multilocularis	thymidine kinase	0.1026	0.5792	0.5792
Brugia malayi	diacylglycerol kinase	0.0032	0.0086	0.0172
Trypanosoma brucei	trypanothione reductase	0.0103	0.0491	0.1781
Leishmania major	cathepsin L-like protease	0.0054	0.0211	0.0765
Plasmodium vivax	vivapain-3	0.0028	0.0061	0.0797
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0126	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0086	0.0166
Trypanosoma cruzi	cysteine peptidase, putative	0.0028	0.0061	0.0221
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.003	0.003
Brugia malayi	cathepsin L-like precursor	0.0036	0.0109	0.0218
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0018	0.0004	0.0008
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0101	0.0201
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0109	0.0218
Trypanosoma cruzi	thymidine kinase, putative	0.0498	0.2759	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0126	0.038
Echinococcus multilocularis	thymidylate synthase	0.0107	0.0515	0.0515
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0022	0.0156
Leishmania major	hypothetical protein, conserved	0.0039	0.0126	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0211
Onchocerca volvulus	Huntingtin homolog	0.0148	0.0751	1
Echinococcus multilocularis	geminin	0.0205	0.1076	0.1076
Echinococcus granulosus	RUN	0.0021	0.0024	0.0042
Toxoplasma gondii	LsmAD domain-containing protein	0.0027	0.0059	0.0765
Echinococcus multilocularis	cathepsin L cysteine protease	0.0054	0.0211	0.0211
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0036	0.0106	0.0384
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0036	0.0106	0.0183
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0022	0.0079
Schistosoma mansoni	polycystin 1-related	0.0021	0.0024	0.0042
Trypanosoma cruzi	cysteine proteinase, putative	0.0028	0.0061	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0022	0.003	0.0058
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.004	0.0132	0.1719
Plasmodium vivax	unspecified product	0.0028	0.0061	0.0797
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0004	0.0008
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.0126	0.09
Brugia malayi	Papain family cysteine protease containing protein	0.0028	0.0061	0.0122
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0036	0.0106	0.1385
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0028	0.0061	0.0105
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0126	0.0624	0.1078
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0036	0.0106	0.1385
Schistosoma mansoni	inositol monophosphatase	0.004	0.0132	0.0227
Schistosoma mansoni	lipoxygenase	0.006	0.0245	0.0424
Brugia malayi	Doublecortin family protein	0.0021	0.0024	0.0049
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0022	0.0079
Trichomonas vaginalis	thymidine kinase, putative	0.0498	0.2759	1
Echinococcus granulosus	cysteine protease	0.0028	0.0061	0.0105
Leishmania major	cysteine peptidase A (CPA)	0.0054	0.0211	0.0765
Toxoplasma gondii	NADPH-glutathione reductase	0.0036	0.0106	0.1385
Echinococcus granulosus	raf serine:threonine protein kinase	0.092	0.5183	0.8949
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0061	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0059	0.0114
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0126	0.038
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0751	0.1456
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0036	0.0106	0.0858
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0032	0.0086	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0004	0.0008
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0022	0.0079
Echinococcus multilocularis	dihydrofolate reductase	0.0044	0.0152	0.0152
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0211	0.0691
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0158	0.0497
Brugia malayi	photoreceptor-specific nuclear receptor	0.0022	0.003	0.0059
Toxoplasma gondii	cathepsin CPL	0.0054	0.0211	0.2758
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0086	0.0166
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.006	0.0244	0.0883
Echinococcus multilocularis	dna polymerase eta	0.0021	0.0022	0.0022
Schistosoma mansoni	cpg binding protein	0.0035	0.0101	0.0174
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0024	0.0042
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0158	0.0572
Trypanosoma cruzi	trypanothione reductase, putative	0.0103	0.0491	0.1781
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.003	0.0051
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.006	0.0244	0.0883
Leishmania major	hypothetical protein, conserved	0.0027	0.0059	0.0212
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.0322	0.0322
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.0211	0.0691
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.003	0.0051
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0054	0.0211	0.0691
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0173	0.0892	0.3234
Onchocerca volvulus	Protein ultraspiracle homolog	0.0022	0.003	0.0073
Schistosoma mansoni	cathepsin F (C01 family)	0.0054	0.0211	0.0364
Schistosoma mansoni	ap endonuclease	0.006	0.0244	0.0421
Entamoeba histolytica	cysteine proteinase 2	0.0028	0.0061	0.0143
Schistosoma mansoni	unc-13 (munc13)	0.0032	0.0086	0.0148
Loa Loa (eye worm)	thymidylate synthase	0.0107	0.0515	0.0999
Chlamydia trachomatis	dihydrofolate reductase	0.0044	0.0152	1
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0032	0.0086	0.0148
Trypanosoma brucei	thymidine kinase	0.0498	0.2759	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0018	0.0004	0.0014
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.0211	0.0765
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0212	0.0411
Echinococcus granulosus	Thymidine kinase 2 mitochondrial	0.1026	0.5792	1
Schistosoma mansoni	hypothetical protein	0.0108	0.052	0.0899
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0192	0.1004	0.7186
Echinococcus multilocularis	dnaJ subfamily B	0.0494	0.2736	0.2736
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.0211	0.0765
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0086	0.0148
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0032	0.0086	0.0166
Mycobacterium ulcerans	thymidylate synthase	0.0107	0.0515	0.5023
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0004	0.0008
Leishmania major	cathepsin L-like protease	0.0054	0.0211	0.0765
Loa Loa (eye worm)	raf kinase	0.0916	0.5158	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0086	0.0166
Plasmodium vivax	multidomain scavenger receptor, putative	0.0021	0.0024	0.0319
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0211	0.0691
Echinococcus multilocularis	protein kinase c eta type	0.0032	0.0086	0.0086
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	0.003	0.0059
Plasmodium vivax	glutathione reductase, putative	0.0103	0.0491	0.6421
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.003	0.0059
Onchocerca volvulus		0.0035	0.0101	0.105
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0022	0.0079
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.006	0.0244	0.0421
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0021	0.0022	0.0038
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0107	0.0515	0.3687
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0045	0.0158	0.0273
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0148	0.0752	0.0752
Brugia malayi	thymidylate synthase	0.0107	0.0515	0.1031
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0061	0.0143
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0036	0.0106	0.0759
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.0211	0.0691
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.003	0.0051
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0036	0.0106	0.0384
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.003	0.0051
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0103	0.0495	0.0495
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0054	0.0211	0.0409
Entamoeba histolytica	diacylglycerol kinase, putative	0.0032	0.0086	0.0234
Echinococcus granulosus	N chimaerin	0.0032	0.0086	0.0148
Brugia malayi	Papain family cysteine protease containing protein	0.0054	0.0211	0.0422
Echinococcus granulosus	thymidine kinase	0.1026	0.5792	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0126	0.0379
Echinococcus multilocularis	protein kinase c iota type	0.0032	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0028	0.0061	0.0143
Leishmania major	cathepsin L-like protease	0.0054	0.0211	0.0765
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0044	0.0152	0.1324
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0036	0.0106	0.0384
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0061	0.0143
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0022	0.0079
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.006	0.0244	0.0883
Loa Loa (eye worm)	cysteine protease	0.0054	0.0211	0.0409
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.154	0.266
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0032	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0158	0.0497
Onchocerca volvulus		0.0054	0.0211	0.257
Leishmania major	cathepsin L-like protease	0.0054	0.0211	0.0765
Leishmania major	mitochondrial DNA polymerase beta	0.0365	0.1995	0.7229
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0036	0.0106	0.0858
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0051	0.0196	0.071
Schistosoma mansoni	protein kinase C mu	0.0032	0.0086	0.0148
Brugia malayi	Pleckstrin Homology Domain	0.0032	0.0086	0.0172
Leishmania major	DNA polymerase kappa, putative	0.0021	0.0022	0.0079
Brugia malayi	exodeoxyribonuclease III family protein	0.006	0.0244	0.0488
Echinococcus granulosus	cpg binding protein	0.0037	0.0112	0.0193
Schistosoma mansoni	hypothetical protein	0.0126	0.0624	0.1078
Trichomonas vaginalis	mercuric reductase, putative	0.0036	0.0106	0.0308
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0062	0.026	0.0943
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	0.003	0.0059
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0086	0.0148
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.003	0.0051
Echinococcus multilocularis	cysteine protease	0.0054	0.0211	0.0211
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0126	0.0142
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.003	0.0058
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.0322	0.1169
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.006	0.0244	0.0244
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0032	0.0086	0.0086
Echinococcus multilocularis	protein kinase c epsilon type	0.0032	0.0086	0.0086
Brugia malayi	hypothetical protein	0.0286	0.154	0.3081
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0132	0.0477
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	0.003	0.0059
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.006	0.0244	0.3185
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0211	0.0691
Echinococcus granulosus	thymidine kinase	0.1026	0.5792	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0211	0.0691
Entamoeba histolytica	cysteine proteinase, putative	0.0028	0.0061	0.0143
Entamoeba histolytica	hypothetical protein	0.0039	0.0126	0.0379
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0036	0.0106	0.0384
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0026	0.0052	0.0104
Onchocerca volvulus		0.0039	0.0126	0.1396
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0211	0.0691
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0211	0.0691
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0126	0.09
Schistosoma mansoni	dihydrofolate reductase	0.0044	0.0152	0.0262
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0018	0.0004	0.0008
Toxoplasma gondii	hypothetical protein	0.0059	0.0239	0.3125
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0211	0.0422
Trypanosoma cruzi	cruzipain precursor, putative	0.0018	0.0004	0.0014
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.004	0.0132	0.0401
Brugia malayi	nuclear hormone receptor	0.0022	0.003	0.0059
Onchocerca volvulus		0.0054	0.0211	0.257
Onchocerca volvulus		0.0059	0.0237	0.2934
Schistosoma mansoni	hypothetical protein	0.0205	0.1076	0.1858
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0044	0.0152	0.0344
Onchocerca volvulus		0.0054	0.0211	0.257
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0158	0.0273
Onchocerca volvulus	Bile acid receptor homolog	0.0022	0.003	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0022	0.003	0.0058
Echinococcus multilocularis	thymidine kinase	0.1026	0.5792	0.5792
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0032	0.0086	0.0172
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0054	0.0211	0.0409
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0045	0.0158	0.0572
Schistosoma mansoni	atypical protein kinase C	0.0032	0.0086	0.0148
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0036	0.0106	0.0212
Loa Loa (eye worm)	glutathione reductase	0.0103	0.0491	0.0953
Echinococcus multilocularis	cpg binding protein	0.0037	0.0112	0.0112
Schistosoma mansoni	diacylglycerol kinase theta	0.0032	0.0086	0.0148
Entamoeba histolytica	thymidine kinase, putative	0.0498	0.2759	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0032	0.0086	0.0166
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0322	0.0557
Brugia malayi	Intermediate filament tail domain containing protein	0.0059	0.0237	0.0475
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.003	0.0059
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	0.003	0.0059
Entamoeba histolytica	cysteine protease, putative	0.0054	0.0211	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0058	0.0112
Treponema pallidum	exodeoxyribonuclease (exoA)	0.006	0.0244	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0234	0.1247	0.8925
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0194	0.0627
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0086	0.0166
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0211	0.0691
Brugia malayi	beta-lactamase family protein	0.0039	0.0126	0.0252
Loa Loa (eye worm)	doublecortin family protein	0.0021	0.0024	0.0047
Giardia lamblia	Deoxynucleoside kinase	0.0376	0.2062	0.7453
Plasmodium falciparum	LCCL domain-containing protein	0.0021	0.0024	0.0319
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0022	0.0044
Brugia malayi	Steroid receptor seven-up type 2	0.0022	0.003	0.0059
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0036	0.0106	0.0858
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0054	0.0211	0.0364
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0028	0.0064	0.0064
Leishmania major	cathepsin L-like protease	0.0054	0.0211	0.0765
Echinococcus granulosus	thymidylate synthase	0.0107	0.0515	0.0889
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0028	0.0061	0.0105
Echinococcus granulosus	thioredoxin glutathione reductase	0.0103	0.0495	0.0855
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.003	0.0051
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0126	0.09
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0236	0.0472
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0061	0.0143
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0036	0.0109	0.0218
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0036	0.0106	0.0308
Echinococcus granulosus	cathepsin l1	0.0054	0.0211	0.0364
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0103	0.0491	0.3517
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.004	0.0132	0.1118
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.003	0.0059
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0054	0.0211	0.2758
Brugia malayi	Thioredoxin reductase	0.0103	0.0491	0.0983
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0051	0.0194	0.0701
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0021	0.0022	0.0022
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0045	0.0158	0.0273
Plasmodium vivax	thioredoxin reductase, putative	0.0103	0.0491	0.6421
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0751	0.1456
Schistosoma mansoni	hypothetical protein	0.0037	0.0114	0.0197
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0234	0.1247	0.8925
Brugia malayi	cytoplasmic intermediate filament protein	0.0031	0.0082	0.0163
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.003	0.0058
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.0196	0.071
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0032	0.0086	0.0086
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0126	0.0456
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0126	0.1059
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.003	0.0059
Schistosoma mansoni	ap endonuclease	0.006	0.0244	0.0421
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.003	0.003
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0036	0.0106	0.0384
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0126	0.09
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0045	0.0158	0.0497
Onchocerca volvulus	Huntingtin homolog	0.0148	0.0751	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0126	0.0379
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0032	0.0086	0.0086
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.0022	0.0156
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0036	0.0106	0.0384
Plasmodium vivax	vivapain-1	0.0028	0.0061	0.0797
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0107	0.0515	0.3161
Schistosoma mansoni	lamin	0.0059	0.0237	0.041
Brugia malayi	glutathione reductase	0.0103	0.0491	0.0983
Leishmania major	cathepsin L-like protease	0.0054	0.0211	0.0765
Loa Loa (eye worm)	hypothetical protein	0.0022	0.003	0.0058
Entamoeba histolytica	diacylglycerol kinase, putative	0.0032	0.0086	0.0234
Leishmania major	trypanothione reductase	0.0103	0.0491	0.1781
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0132	0.0477
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0054	0.0211	0.0364
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0036	0.0106	0.0384
Echinococcus granulosus	Diacylglycerol kinase theta	0.0032	0.0086	0.0148
Echinococcus multilocularis	lamin	0.0059	0.0237	0.0237
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0022	0.0079
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0126	0.0217
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0022	0.0079
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0173	0.0892	0.3234
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.0211	0.0765
Echinococcus granulosus	cathepsin L cysteine protease	0.0028	0.0061	0.0105
Entamoeba histolytica	cysteine proteinase, putative	0.0028	0.0061	0.0143
Schistosoma mansoni	unc-13 (munc13)	0.0034	0.0098	0.0169
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.0211	0.0765
Echinococcus granulosus	dnaJ subfamily B	0.0494	0.2736	0.4724
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0322	0.3061
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0061	0.0143
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0126	0.0244
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.003	0.0051
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0211	0.0691
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0211	0.0691
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	0.003	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0286	0.154	0.2987
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0126	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0086	0.0166
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0211	0.0691
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0045	0.0158	0.0497
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0045	0.0158	0.0497
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0151	0.0765	0.2774
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0022	0.0079
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.003	0.0058
Echinococcus granulosus	Protein kinase C brain isozyme	0.0032	0.0086	0.0148
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.006	0.0244	0.0811
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.003	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0212	0.0411
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0211	0.0691
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0234	0.1247	0.8925
Schistosoma mansoni	thymidine kinase	0.1026	0.5792	1
Schistosoma mansoni	protein kinase C mu	0.0032	0.0086	0.0148
Entamoeba histolytica	cysteine proteinase, putative	0.0028	0.0061	0.0143
Loa Loa (eye worm)	inositol-1	0.004	0.0132	0.0255
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.0211	0.0765
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0109	0.0318
Brugia malayi	hypothetical protein	0.0018	0.0003	0.0006
Schistosoma mansoni	loxhd1	0.0021	0.0024	0.0042
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0151	0.0765	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0126	0.0244
Trichomonas vaginalis	inositol monophosphatase, putative	0.004	0.0132	0.0401
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.003	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0058	0.0112
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0021	0.0022	0.0042
Entamoeba histolytica	cysteine proteinase 1, putative	0.0028	0.0061	0.0143
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0158	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0022	0.003	0.0058
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0158	0.0572
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.003	0.003
Brugia malayi	Papain family cysteine protease containing protein	0.0028	0.0061	0.0122
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0126	0.038
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.0126	0.09
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.0211	0.0765
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0322	0.3061
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.003	0.0051
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0044	0.0152	0.1086
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0024	0.0024
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0086	0.0148
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.006	0.0245	0.0424
Echinococcus granulosus	lamin dm0	0.0059	0.0237	0.041
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.003	0.0051
Brugia malayi	ecdysteroid receptor	0.0022	0.003	0.0059
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.0126	0.09
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.0211	0.0765
Onchocerca volvulus		0.0036	0.0109	0.1162
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0126	0.0244
Echinococcus multilocularis	RUN	0.0021	0.0024	0.0024
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0045	0.0158	0.0572
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0028	0.0061	0.0797
Onchocerca volvulus		0.0039	0.0126	0.1396
Echinococcus granulosus	dna polymerase kappa	0.0021	0.0022	0.0038
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0021	0.0022	0.0038
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0211	0.0422
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	0.003	0.0051
Onchocerca volvulus		0.0022	0.003	0.0073
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.003	0.0051
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.006	0.0244	0.0883
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0054	0.0211	0.2758
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0211	0.0422
Schistosoma mansoni	hypothetical protein	0.0205	0.1076	0.1858
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.003	0.003
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0036	0.0106	0.0384
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.006	0.0244	0.226
Onchocerca volvulus		0.0054	0.0211	0.257
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0151	0.0765	1
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0026	0.0052	0.0104
Toxoplasma gondii	diacylglycerol kinase, putative	0.0032	0.0086	0.1121
Schistosoma mansoni	hypothetical protein	0.0039	0.0126	0.0217
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0211	0.0691
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.004	0.0132	0.1857
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0036	0.0106	0.0384
Entamoeba histolytica	hypothetical protein	0.0032	0.0086	0.0234
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0237	0.046
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0211	0.0691
Plasmodium vivax	vivapain-2	0.0054	0.0211	0.2758
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0061	0.0143
Echinococcus multilocularis	dna polymerase kappa	0.0021	0.0022	0.0022
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0126	0.0456
Echinococcus granulosus	ubiquitin specific protease 41	0.0045	0.0158	0.0273
Schistosoma mansoni	hypothetical protein	0.0058	0.0236	0.0407
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0051	0.0196	0.071
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.0211	0.257
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0036	0.0106	0.0106
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.0126	0.09
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0054	0.0211	0.2758
Echinococcus granulosus	unc 13 munc13	0.0032	0.0086	0.0148
Schistosoma mansoni	hypothetical protein	0.0494	0.2736	0.4724
Echinococcus multilocularis	Polycystic kidney disease protein	0.0021	0.0024	0.0024
Mycobacterium tuberculosis	Probable oxidoreductase	0.0261	0.1397	1
Brugia malayi	C1-like domain containing protein	0.0032	0.0086	0.0172
Entamoeba histolytica	hypothetical protein	0.0039	0.0126	0.0379
Echinococcus granulosus	dna polymerase eta	0.0021	0.0022	0.0038
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0132	0.0477
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.003	0.003
Brugia malayi	Dihydrofolate reductase	0.0044	0.0152	0.0304
Brugia malayi	hypothetical protein	0.0027	0.0059	0.0117
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.003	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0086	0.0166
Brugia malayi	Protein kinase c protein 2	0.0032	0.0086	0.0172
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0322	0.3061
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0036	0.0106	0.0384
Schistosoma mansoni	lamin	0.0059	0.0237	0.041
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0522	0.2896	0.5615
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0022	0.0079
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0045	0.0158	0.0273
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0045	0.0158	0.0158
Mycobacterium tuberculosis	Probable dehydrogenase	0.0234	0.1247	0.8925
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0022	0.0079
Onchocerca volvulus		0.0107	0.0515	0.6758
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.0324	0.0559
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0126	0.0126
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0234	0.1247	0.8925
Echinococcus multilocularis	cysteine protease	0.0054	0.0211	0.0211
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0211	0.0691
Brugia malayi	Cathepsin L-like precursor	0.0054	0.0211	0.0422
Schistosoma mansoni	cathepsin F (C01 family)	0.0036	0.0109	0.0188
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.0211	0.0765
Echinococcus multilocularis	inositol monophosphatase 1	0.004	0.0132	0.0132
Loa Loa (eye worm)	intermediate filament protein	0.0059	0.0237	0.046
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0028	0.0061	0.0105
Onchocerca volvulus		0.0039	0.0126	0.1396
Echinococcus multilocularis	raf serine:threonine protein kinase	0.092	0.5183	0.5183
Plasmodium falciparum	glutathione reductase	0.0103	0.0491	0.6421
Brugia malayi	nuclear receptor NHR-88	0.0022	0.003	0.0059
Mycobacterium ulcerans	lipase LipD	0.0039	0.0126	0.1059
Onchocerca volvulus		0.0058	0.0236	0.2912
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0236	0.0407
Echinococcus multilocularis	N chimaerin	0.0032	0.0086	0.0086
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0032	0.0086	0.0166
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0126	0.0244
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0036	0.0106	0.0384
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.0211	0.0765
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0126	0.0244
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.003	0.0051
Trichomonas vaginalis	glutathione reductase, putative	0.0036	0.0106	0.0308
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0059	0.0212
Brugia malayi	steroid hormone receptor	0.0022	0.003	0.0059
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0059	0.0237	0.046
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0322	0.0557
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0126	0.0217
Trypanosoma cruzi	cysteine protease, putative	0.0028	0.0061	0.0221
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0032	0.0086	0.0148
Brugia malayi	Ras association domain family 1 isoform A	0.0032	0.0086	0.0172
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0036	0.0106	0.1385
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0151	0.0765	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0036	0.0106	0.0384
Trypanosoma brucei	unspecified product	0.0021	0.0022	0.0079
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.0126	0.09
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.003	0.003
Plasmodium falciparum	thioredoxin reductase	0.0036	0.0106	0.1385
Brugia malayi	hypothetical protein	0.0039	0.0126	0.0251
Echinococcus granulosus	lamin	0.0059	0.0237	0.041
Onchocerca volvulus	Cathepsin F homolog	0.0054	0.0211	0.257
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0211	0.0691
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0109	0.0218
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0054	0.0211	0.0211
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0036	0.0106	0.1385
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0004	0.0008
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0211	0.0691
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0022	0.003	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0022	0.003	0.0058
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0365	0.1995	0.7229
Mycobacterium tuberculosis	Hypothetical protein	0.0051	0.0194	0.1385
Onchocerca volvulus		0.0059	0.0237	0.2934
Toxoplasma gondii	thioredoxin reductase	0.0103	0.0491	0.6421
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.006	0.0244	1
Brugia malayi	beta-lactamase family protein	0.0039	0.0126	0.0252
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.003	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0086	0.0166
Echinococcus granulosus	dihydrofolate reductase	0.0044	0.0152	0.0262
Brugia malayi	RhoGAP domain containing protein	0.0032	0.0086	0.0172
Echinococcus multilocularis	ubiquitin specific protease 41	0.0045	0.0158	0.0158
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.0132	0.0477
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.1995	0.7229
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0126	0.0244
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0059	0.0765
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0024	0.0042
Trichomonas vaginalis	ap endonuclease, putative	0.006	0.0244	0.0811
Trichomonas vaginalis	ap endonuclease, putative	0.006	0.0244	0.0811
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.154	0.154
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.006	0.0244	0.0473
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0261	0.1397	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0054	0.0211	0.0211
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.0279	0.3641
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0107	0.0515	0.0889
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0126	0.0244
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.0126	0.09
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0158	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0086	0.0166
Brugia malayi	hypothetical protein	0.0021	0.0024	0.0049
Brugia malayi	protein kinase C3,putative	0.0032	0.0086	0.0172
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0114	0.0228
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.0211	0.257
Schistosoma mansoni	thyroid hormone receptor	0.0148	0.0752	0.1299
Plasmodium vivax	unspecified product	0.0018	0.0004	0.0051
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.006	0.0244	0.0811
Leishmania major	cathepsin L-like protease	0.0054	0.0211	0.0765
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0211	0.0691
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.0211	0.0765
Echinococcus granulosus	protein kinase c iota type	0.0032	0.0086	0.0148
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0126	0.0456
Brugia malayi	Protein kinase domain containing protein	0.0032	0.0086	0.0172
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.0211	0.0765
Echinococcus granulosus	cathepsin L	0.0028	0.0061	0.0105
Schistosoma mansoni	rab6-interacting	0.0021	0.0024	0.0042
Schistosoma mansoni	protein kinase C	0.0032	0.0086	0.0148
Brugia malayi	hypothetical protein	0.0148	0.0751	0.1502
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.0132	0.0401
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0022	0.0079
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0032	0.0086	0.0086
Loa Loa (eye worm)	ctsf protein	0.0054	0.0211	0.0409
Schistosoma mansoni	hypothetical protein	0.0032	0.0086	0.0148
Brugia malayi	Inositol-1	0.004	0.0132	0.0263
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0211	0.0691
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0031	0.0082	0.0158
Trypanosoma cruzi	cruzipain precursor, putative	0.0054	0.0211	0.0765
Brugia malayi	dihydrofolate reductase family protein	0.0044	0.0152	0.0304
Schistosoma mansoni	hypothetical protein	0.0021	0.0024	0.0042
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0086	0.0148
Trypanosoma cruzi	cysteine proteinase, putative	0.0028	0.0061	0.0221
Toxoplasma gondii	exonuclease III APE	0.006	0.0244	0.3185
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0061	0.0143
Brugia malayi	RhoGEF domain containing protein	0.0032	0.0086	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0022	0.003	0.0058
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0032	0.0086	0.0166
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0109	0.0318
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0036	0.0106	0.0384
Plasmodium vivax	vivapain-2	0.0054	0.0211	0.2758
Trichomonas vaginalis	thymidine kinase, putative	0.0498	0.2759	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	0.003	0.0059
Leishmania major	DNA polymerase eta, putative	0.0021	0.0022	0.0079
Onchocerca volvulus		0.0054	0.0211	0.257
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0061	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0114	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0022	0.0042
Trichomonas vaginalis	thymidine kinase, putative	0.0498	0.2759	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.003	0.0058
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.0322	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0086	0.0166
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.006	0.0244	0.3185
Onchocerca volvulus		0.0032	0.0086	0.0846
Brugia malayi	RhoGAP domain containing protein	0.0032	0.0086	0.0172
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0126	0.1059
Brugia malayi	diacylglycerol kinase	0.0032	0.0086	0.0172
Echinococcus multilocularis	unc 13 (munc13)	0.0032	0.0086	0.0086
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0173	0.0892	0.3234
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0032	0.0086	0.0148
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0061	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0086	0.0166
Leishmania major	thymidine kinase, putative	0.0498	0.2759	1
Plasmodium falciparum	glutathione reductase	0.0036	0.0106	0.1385
Echinococcus multilocularis	cathepsin L	0.0028	0.0061	0.0061
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0059	0.0212
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0211	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0211
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0086	0.0148
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0028	0.0064	0.011
Echinococcus multilocularis	musashi	0.0059	0.0237	0.0237
Schistosoma mansoni	cpg binding protein	0.0037	0.0112	0.0193
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.0211	0.0765
Onchocerca volvulus		0.0054	0.0211	0.257
Schistosoma mansoni	coup transcription factor	0.0022	0.003	0.0051
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.003	0.0051
Trypanosoma cruzi	DNA polymerase eta, putative	0.0021	0.0022	0.0079
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0021	0.0022	0.0038
Mycobacterium ulcerans	hypothetical protein	0.0192	0.1004	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0126	0.038
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.003	0.0058
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0126	0.0252
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.003	0.0059
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0024	0.0024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0211	0.0691
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0061	0.0143
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0061	0.0143
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0126	0.0217
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0045	0.0158	0.0316
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0024	0.0047
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0151	0.0765	0.2774
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0036	0.0106	0.0384
Brugia malayi	hypothetical protein	0.0021	0.0024	0.0049
Schistosoma mansoni	serine/threonine protein kinase	0.092	0.5183	0.8949
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0022	0.0079
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0212	0.0424
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0036	0.0109	0.0394
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0032	0.0086	0.0166
Schistosoma mansoni	DNA polymerase eta	0.0021	0.0022	0.0038
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.003	0.003
Echinococcus multilocularis	transfer RNA-Ile	0.1026	0.5792	0.5792
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0036	0.0108	0.0769
Entamoeba histolytica	cysteine protease, putative	0.0028	0.0061	0.0143
Schistosoma mansoni	vav2	0.0032	0.0086	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0022	0.003	0.0058
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0022	0.0079
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.003	0.0051
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0028	0.0061	0.0221
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.1995	0.7229
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0036	0.0106	0.0183
Brugia malayi	cathepsin F-like cysteine proteinase	0.0018	0.0004	0.0008
Loa Loa (eye worm)	dihydrofolate reductase	0.0044	0.0152	0.0294
Echinococcus granulosus	geminin	0.0205	0.1076	0.1858
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0022	0.0044
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0032	0.0086	0.0166
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.0211	0.0691
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0022	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0109	0.0211
Echinococcus granulosus	Polycystic kidney disease protein	0.0021	0.0024	0.0042
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0032	0.0086	0.0086
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0051	0.0196	0.071
Echinococcus multilocularis	cathepsin L cysteine protease	0.0054	0.0211	0.0211
Schistosoma mansoni	cathepsin s	0.0018	0.0004	0.0007
Brugia malayi	Variant SH3 domain containing protein	0.0032	0.0086	0.0172
Brugia malayi	protein kinase C II.	0.0032	0.0086	0.0172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.0211	0.0691
Brugia malayi	intermediate filament protein	0.0059	0.0237	0.0475
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.003	0.0058
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0032	0.0086	0.0148
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0036	0.0106	0.0384
Schistosoma mansoni	rac gtpase activating protein	0.0032	0.0086	0.0148
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.0322	0.4213
Trypanosoma brucei	DNA polymerase eta, putative	0.0021	0.0022	0.0079
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0126	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0211	0.0409
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0101	0.0195
Echinococcus granulosus	myotubularin protein 13	0.0032	0.0086	0.0148
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.0211	0.0765
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0234	0.1247	0.8836
Echinococcus granulosus	intermediate filament protein	0.0059	0.0237	0.041
Schistosoma mansoni	cpg binding protein	0.0037	0.0112	0.0193
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0261	0.1397	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.4 uM	Inhibition of falcipain2	ChEMBL.	16509575
IC50 (binding)	= 1.4 uM	Inhibition of falcipain2	ChEMBL.	16509575
IC50 (binding)	= 11.4 uM	Inhibition of falcipain3	ChEMBL.	16509575
IC50 (binding)	= 11.4 uM	Inhibition of falcipain3	ChEMBL.	16509575

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL381093
PubChem: 980900

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 353248