Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | potassium voltage-gated channel, subfamily H (eag-related), member 2 | Starlite/ChEMBL | References |
Homo sapiens | tachykinin receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0045 | 0.3249 | 0.484 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0013 | 0.0372 | 0.0554 |
Echinococcus multilocularis | equilibrative nucleoside transporter 3 | 0.0083 | 0.6714 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0372 | 0.0554 |
Onchocerca volvulus | Equilibrative nucleoside transporter, putative homolog | 0.0083 | 0.6714 | 0.5 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.0083 | 0.6714 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.2983 | 0.4443 |
Schistosoma mansoni | protein kinase | 0.0014 | 0.0504 | 0.0504 |
Echinococcus multilocularis | equilibrative nucleoside transporter 3 | 0.0068 | 0.5409 | 0.8056 |
Echinococcus multilocularis | equilibrative nucleoside transporter protein | 0.0083 | 0.6714 | 1 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.0014 | 0.0504 | 0.075 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0045 | 0.3249 | 0.3249 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.3621 | 0.3621 |
Entamoeba histolytica | nucleoside transporter, putative | 0.0083 | 0.6714 | 1 |
Brugia malayi | hypothetical protein | 0.0083 | 0.6714 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0119 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.6714 | 1 |
Trypanosoma brucei | exopolyphosphatase | 0.0119 | 1 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.004 | 0.2862 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0013 | 0.0372 | 0.0372 |
Echinococcus granulosus | voltage gated potassium channel | 0.0013 | 0.0372 | 0.0372 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.0083 | 0.6714 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0119 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0013 | 0.0372 | 0.0554 |
Trypanosoma cruzi | acidocalcisomal exopolyphosphatase, putative | 0.0119 | 1 | 1 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.0014 | 0.0504 | 0.075 |
Onchocerca volvulus | Equilibrative nucleoside transporter, putative homolog | 0.0083 | 0.6714 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0372 | 0.0372 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.0014 | 0.0504 | 0.075 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.6714 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2714 | 0.4043 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.0083 | 0.6714 | 1 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.0014 | 0.0504 | 0.075 |
Toxoplasma gondii | hypothetical protein | 0.0119 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0504 | 0.075 |
Echinococcus granulosus | equilibrative nucleoside transporter 3 | 0.0083 | 0.6714 | 0.6714 |
Leishmania major | acidocalcisomal exopolyphosphatase, putative | 0.0119 | 1 | 1 |
Echinococcus granulosus | equilibrative nucleoside transporter | 0.0083 | 0.6714 | 0.6714 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0045 | 0.3249 | 0.484 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.0014 | 0.0504 | 0.075 |
Trypanosoma cruzi | exopolyphosphatase | 0.0119 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0504 | 0.075 |
Trichomonas vaginalis | equilibrative nucleoside transporter, putative | 0.0083 | 0.6714 | 1 |
Giardia lamblia | Hypothetical protein | 0.0083 | 0.6714 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0042 | 0.2983 | 0.4443 |
Schistosoma mansoni | equilibrative nucleoside transporter | 0.0014 | 0.0504 | 0.0504 |
Brugia malayi | Nucleoside transporter family protein | 0.0083 | 0.6714 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.6714 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0049 | 0.3621 | 0.3621 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0013 | 0.0372 | 0.0554 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0045 | 0.3249 | 0.484 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0013 | 0.0372 | 0.0372 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.48 nM | Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cells | ChEMBL. | 16384700 |
IC50 (binding) | = 0.48 nM | Displacement of [125I]-labelled substance P from the cloned human NK1 receptor expressed in CHO cells | ChEMBL. | 16384700 |
Inhibition (functional) | = 29 % | Inhibition of GR73632-induced foot-tapping in gerbils after 24 h at 3 mg/kg, iv | ChEMBL. | 16384700 |
Ki (binding) | = 947 nM | Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cells | ChEMBL. | 16384700 |
Ki (binding) | = 947 nM | Displacement of labelled MK-499 from cloned channel hERG expressed in HEK cells | ChEMBL. | 16384700 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.