Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.015 | 0.0251 | 0.3871 |
Schistosoma mansoni | gliotactin | 0.0858 | 0.1652 | 0.1652 |
Onchocerca volvulus | 0.0858 | 0.1652 | 1 | |
Loa Loa (eye worm) | carboxylesterase | 0.0858 | 0.1652 | 0.1652 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0035 | 0.0023 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 0.1652 | 0.1652 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0858 | 0.1652 | 0.1652 |
Schistosoma mansoni | lamin | 0.0028 | 0.0011 | 0.0011 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0045 | 0.0043 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0167 | 0.0284 | 0.1348 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0858 | 0.1652 | 0.1652 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0316 | 0.058 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 0.1652 | 0.1652 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0082 | 0.0117 | 0.0117 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0045 | 0.0043 | 0.0043 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0081 | 0.0062 |
Onchocerca volvulus | 0.0858 | 0.1652 | 1 | |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0011 | 0.0011 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.5078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0011 | 0.0011 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.0306 | 0.0306 |
Loa Loa (eye worm) | hypothetical protein | 0.5078 | 1 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0041 | 0.0036 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0316 | 0.058 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0081 | 0.0062 |
Loa Loa (eye worm) | acetyltransferase | 0.0153 | 0.0257 | 0.0257 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.0081 | 0.0081 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0316 | 0.058 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0035 | 0.0023 | 0.0023 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0035 | 0.0023 | 0.0023 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0858 | 0.1652 | 0.1652 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0064 | 0.0081 | 0.0062 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.015 | 0.0251 | 0.3871 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0858 | 0.1652 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0035 | 0.0023 | 0.0023 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0082 | 0.0117 | 0.0117 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0035 | 0.0023 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 0.1652 | 0.1652 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0064 | 0.0081 | 0.0081 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0035 | 0.0023 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 0.1652 | 0.1652 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0858 | 0.1652 | 0.1652 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0194 | 0.0338 | 0.0338 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0054 | 0.0062 | 0.0358 |
Echinococcus granulosus | neuroligin | 0.0858 | 0.1652 | 0.1652 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0064 | 0.0081 | 0.0081 |
Brugia malayi | Cytochrome P450 family protein | 0.0051 | 0.0056 | 0.0056 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0011 | 0.0011 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0858 | 0.1652 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0194 | 0.0338 | 0.0338 |
Echinococcus granulosus | carboxylesterase 5A | 0.5078 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0858 | 0.1652 | 0.1652 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.015 | 0.0251 | 0.3398 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0153 | 0.0257 | 0.0257 |
Schistosoma mansoni | lipoxygenase | 0.0058 | 0.007 | 0.007 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0858 | 0.1652 | 1 |
Echinococcus multilocularis | geminin | 0.0178 | 0.0306 | 0.0306 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0011 | 0.0011 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0011 | 0.0011 |
Brugia malayi | Carboxylesterase family protein | 0.5078 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0858 | 0.1652 | 0.1652 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 0.1652 | 0.1652 |
Onchocerca volvulus | 0.0858 | 0.1652 | 1 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.5078 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0011 | 0.0011 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0858 | 0.1652 | 0.1652 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0041 | 0.0036 | 0.5 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0148 | 0.0248 | 0.0248 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0011 | 0.0011 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0011 | 0.0011 |
Brugia malayi | hypothetical protein | 0.0858 | 0.1652 | 0.1652 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0858 | 0.1652 | 0.1652 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0858 | 0.1652 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0058 | 0.007 | 0.007 |
Schistosoma mansoni | acetylcholinesterase | 0.0858 | 0.1652 | 0.1652 |
Echinococcus granulosus | acetylcholinesterase | 0.5078 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.5078 | 1 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0058 | 0.007 | 0.007 |
Onchocerca volvulus | 0.0858 | 0.1652 | 1 | |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 0.0081 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0858 | 0.1652 | 0.1652 |
Schistosoma mansoni | hypothetical protein | 0.0178 | 0.0306 | 0.0306 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0153 | 0.0257 | 0.0257 |
Toxoplasma gondii | hypothetical protein | 0.0051 | 0.0055 | 0.3222 |
Mycobacterium ulcerans | hypothetical protein | 0.0167 | 0.0284 | 0.1348 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0858 | 0.1652 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0011 | 0.0011 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0081 | 0.0062 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0035 | 0.0023 | 0.0023 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0059 | 0.0071 | 0.5 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0035 | 0.0023 | 0.0023 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0858 | 0.1652 | 0.1652 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0194 | 0.0338 | 0.0338 |
Echinococcus multilocularis | acetylcholinesterase | 0.5078 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.001 | 0.001 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.0081 | 0.0081 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0858 | 0.1652 | 0.1652 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0316 | 0.058 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0858 | 0.1652 | 0.1652 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0041 | 0.0036 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0858 | 0.1652 | 0.1652 |
Onchocerca volvulus | 0.0858 | 0.1652 | 1 | |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0011 | 0.0011 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0035 | 0.0023 | 0.0023 |
Schistosoma mansoni | lamin | 0.0028 | 0.0011 | 0.0011 |
Echinococcus multilocularis | neuroligin | 0.0858 | 0.1652 | 0.1652 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.5078 | 1 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0153 | 0.0257 | 0.0257 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 0.1652 | 0.1652 |
Loa Loa (eye worm) | carboxylesterase | 0.5078 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0178 | 0.0306 | 0.0306 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0858 | 0.1652 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0858 | 0.1652 | 0.1652 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0082 | 0.0117 | 0.0117 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0858 | 0.1652 | 0.1652 |
Loa Loa (eye worm) | hypothetical protein | 0.5078 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.5078 | 1 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0035 | 0.0023 | 0.0023 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0051 | 0.0056 | 0.0056 |
Chlamydia trachomatis | glutamine binding protein | 0.0059 | 0.0071 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0035 | 0.0023 | 0.0023 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0011 | 0.0011 |
Brugia malayi | Carboxylesterase family protein | 0.0858 | 0.1652 | 0.1652 |
Loa Loa (eye worm) | carboxylesterase | 0.0858 | 0.1652 | 0.1652 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0059 | 0.0071 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0059 | 0.0071 | 0.5 |
Echinococcus granulosus | lamin | 0.0028 | 0.0011 | 0.0011 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 14.9 uM | Cytotoxicity against human Hep2 cells infected with RSV Long strain | ChEMBL. | 16368233 |
CC50 (functional) | = 14.9 uM | Cytotoxicity against human Hep2 cells infected with RSV Long strain | ChEMBL. | 16368233 |
EC50 (functional) | = 0.015 uM | Antiviral activity against RSV Long strain in human Hep2 cells | ChEMBL. | 16368233 |
Ratio CC50/EC50 (functional) | = 993 | Therapeutic index (CC50/EC50) for RSV infected Hep2 cells | ChEMBL. | 16368233 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.