Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | calcium channel, voltage-dependent, alpha2/delta subunit 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | voltage dependent calcium channel subunit | Get druggable targets OG5_133164 | All targets in OG5_133164 |
Echinococcus granulosus | voltage dependent calcium channel subunit | Get druggable targets OG5_133164 | All targets in OG5_133164 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | voltage dependent calcium channel subunit | calcium channel, voltage-dependent, alpha2/delta subunit 1 | 1103 aa | 1025 aa | 23.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.13 | 1 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0949 | 0.6806 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0949 | 0.6806 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.13 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0949 | 0.6806 | 1 |
Brugia malayi | thymidylate synthase | 0.0817 | 0.5607 | 0.7649 |
Schistosoma mansoni | dihydrofolate reductase | 0.0949 | 0.6806 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0949 | 0.6806 | 0.5 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.0443 | 0.2201 | 0.3234 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0949 | 0.6806 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0389 | 0.1704 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.13 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0817 | 0.5607 | 0.8238 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.13 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.0949 | 0.6806 | 1 |
Onchocerca volvulus | 0.0817 | 0.5607 | 0.5 | |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0817 | 0.5607 | 0.7649 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.13 | 1 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0817 | 0.5607 | 0.8238 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0949 | 0.6806 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0949 | 0.6806 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0949 | 0.6806 | 1 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.0443 | 0.2201 | 0.3234 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -6.5 | Displacement of [3H]L-leucine from alpha2delta containing calcium channel in murine brain | ChEMBL. | 16380257 |
Ki (binding) | = 320 nM | Displacement of [3H]L-leucine from alpha2delta containing calcium channel in murine brain | ChEMBL. | 16380257 |
Ki (binding) | = 320 nM | Displacement of [3H]L-leucine from alpha2delta containing calcium channel in murine brain | ChEMBL. | 16380257 |
Log Ki (binding) | = -6.5 | Displacement of [3H]L-leucine from alpha2delta containing calcium channel in murine brain | ChEMBL. | 16380257 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.