Detailed information for compound 353416

Basic information

Technical information
  • TDR Targets ID: 353416
  • Name: 2-amino-2-(2,3-difluorophenyl)acetic acid
  • MW: 187.143 | Formula: C8H7F2NO2
  • H donors: 2 H acceptors: 2 LogP: -1.5 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(c1cccc(c1F)F)C(=O)O
  • InChi: 1S/C8H7F2NO2/c9-5-3-1-2-4(6(5)10)7(11)8(12)13/h1-3,7H,11H2,(H,12,13)
  • InChiKey: DNWOZEQWCCXGRU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-azanyl-2-(2,3-difluorophenyl)ethanoic acid
  • 2-amino-2-(2,3-difluorophenyl)ethanoic acid
  • JRD-0494
  • 2,3-Difluoro-DL-phenylglycine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus calcium channel, voltage-dependent, alpha2/delta subunit 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus voltage dependent calcium channel subunit Get druggable targets OG5_133164 All targets in OG5_133164
Echinococcus multilocularis voltage dependent calcium channel subunit Get druggable targets OG5_133164 All targets in OG5_133164
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus voltage dependent calcium channel subunit calcium channel, voltage-dependent, alpha2/delta subunit 1 1103 aa 1025 aa 23.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0092 0.0141
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0204 0.0313
Echinococcus multilocularis transient receptor potential cation channel 0.0015 0.0092 0.0131
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0042 0.0064
Leishmania major short chain dehydrogenase-like protein 0.0015 0.0092 0.0116
Echinococcus multilocularis musashi 0.0027 0.0196 0.0279
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0092 0.0141
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0092 0.0075
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0042 0.0064
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0015 0.0092 0.0141
Loa Loa (eye worm) hypothetical protein 0.0089 0.076 0.1166
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.0141
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0042 0.0059
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0015 0.0092 0.0075
Brugia malayi Immunoglobulin I-set domain containing protein 0.0008 0.0028 0.0043
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0294 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0042 0.0064
Mycobacterium ulcerans ketoacyl reductase 0.0015 0.0092 0.0075
Echinococcus multilocularis 0.0007 0.0017 0.0024
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0012 0.0066 0.005
Trypanosoma cruzi short chain dehydrogenase, putative 0.0015 0.0092 0.0116
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0015 0.0092 0.0075
Entamoeba histolytica short chain dehydrogenase family protein 0.0015 0.0092 0.241
Toxoplasma gondii carbonyl reductase 1, putative 0.0015 0.0092 0.1703
Brugia malayi oxidoreductase 0.0015 0.0092 0.0141
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0083 0.0128
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0092 0.0141
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0141
Onchocerca volvulus 0.0027 0.0196 0.0444
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0015 0.0092 0.0141
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0015 0.0092 0.0075
Schistosoma mansoni cpg binding protein 0.0028 0.0204 0.0313
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0092 0.0075
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0015 0.0092 0.0116
Echinococcus granulosus lamin dm0 0.0027 0.0196 0.0301
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0459 1
Plasmodium falciparum steroid dehydrogenase, putative 0.0015 0.0092 0.241
Schistosoma mansoni hypothetical protein 0.0165 0.144 0.2209
Trypanosoma brucei short-chain dehydrogenase, putative 0.0015 0.0092 0.0116
Brugia malayi Cytochrome P450 family protein 0.0007 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0141
Echinococcus multilocularis carbonyl reductase 1 0.0015 0.0092 0.0131
Loa Loa (eye worm) CUTiclin family member 0.0008 0.0028 0.0043
Brugia malayi nuclear receptor NHR-88 0.001 0.0042 0.0064
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0325 1
Echinococcus granulosus cpg binding protein 0.0029 0.0218 0.0335
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0092 0.0116
Echinococcus granulosus hypothetical protein 0.0015 0.0092 0.0141
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0008 0.0028 0.0043
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0008 0.0028 0.0058
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0092 0.0075
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0092 0.0271
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.1218 0.1868
Mycobacterium ulcerans short-chain dehydrogenase 0.0015 0.0092 0.0075
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0042 0.0064
Onchocerca volvulus 0.0015 0.0092 0.0169
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0015 0.0092 0.0116
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0299 0.2657 0.4075
Loa Loa (eye worm) oxidoreductase 0.0015 0.0092 0.0141
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.0141
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0012 0.0066 0.0094
Echinococcus multilocularis lamin 0.0027 0.0196 0.0279
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0015 0.0092 0.1703
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0042 0.0064
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0015 0.0092 0.241
Loa Loa (eye worm) hypothetical protein 0.0012 0.0066 0.0101
Onchocerca volvulus 0.0027 0.0196 0.0444
Onchocerca volvulus 0.0428 0.3819 1
Echinococcus granulosus steroid dehydrogenase 0.0015 0.0092 0.0141
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0015 0.0092 0.0169
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0015 0.0092 0.241
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.1218 0.1733
Leishmania major quinonoid dihydropteridine reductase 0.0015 0.0092 0.0116
Echinococcus multilocularis conserved hypothetical protein 0.0015 0.0092 0.0131
Leishmania major short chain dehydrogenase, putative 0.0015 0.0092 0.0116
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0727 0.652 1
Trypanosoma cruzi amidase, putative 0.0012 0.0066 0.0076
Loa Loa (eye worm) dehydrogenase 0.0015 0.0092 0.0141
Mycobacterium ulcerans short chain dehydrogenase 0.1112 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0015 0.0092 0.0075
Brugia malayi von Willebrand factor type A domain containing protein 0.0008 0.0028 0.0043
Brugia malayi hypothetical protein 0.0015 0.0092 0.0141
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0092 0.0075
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0015 0.0092 0.1703
Brugia malayi von Willebrand factor type A domain containing protein 0.0008 0.0028 0.0043
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0092 0.0075
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.0141
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0015 0.0092 0.0169
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.0141
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0015 0.0092 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0015 0.0092 0.241
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0015 0.0092 0.0075
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.0141
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0092 0.0075
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0092 0.0116
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0092 0.0141
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0092 0.0271
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0042 0.0059
Brugia malayi Amidase family protein 0.0012 0.0066 0.0102
Echinococcus multilocularis Niemann Pick C1 protein 0.0299 0.2657 0.3779
Leishmania major hypothetical protein, conserved 0.0015 0.0092 0.0116
Onchocerca volvulus Sepiapterin reductase homolog 0.0015 0.0092 0.0169
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0015 0.0092 0.0141
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0325 0.6975
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.1703
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0141
Brugia malayi Cytochrome P450 family protein 0.0007 0.0017 0.0026
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0012 0.0066 0.005
Brugia malayi von Willebrand factor type A domain containing protein 0.0008 0.0028 0.0043
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0092 0.0271
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0092 0.0075
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0042 0.0064
Echinococcus multilocularis protein patched 0.0299 0.2657 0.3779
Leishmania major dehydrogenase-like protein 0.0015 0.0092 0.0116
Loa Loa (eye worm) oxidoreductase 0.0015 0.0092 0.0141
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0092 0.0075
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0092 0.0075
Schistosoma mansoni carbonyl reductase 0.0015 0.0092 0.0141
Schistosoma mansoni patched 1 0.0299 0.2657 0.4075
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0042 0.0059
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0042 0.0036
Trypanosoma brucei oxidoreductase-like protein 0.0015 0.0092 0.0116
Loa Loa (eye worm) hypothetical protein 0.0027 0.0196 0.0301
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0092 0.0075
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0042 0.0036
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0042 0.0064
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0092 0.0075
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0727 0.652 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0042 0.0064
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0042 0.0064
Trypanosoma brucei short-chain dehydrogenase, putative 0.0015 0.0092 0.0116
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0092 0.0075
Toxoplasma gondii oxidoreductase, putative 0.0015 0.0092 0.1703
Echinococcus granulosus hypothetical protein 0.0015 0.0092 0.0141
Schistosoma mansoni cpg binding protein 0.0029 0.0218 0.0335
Echinococcus multilocularis cpg binding protein 0.0029 0.0218 0.0311
Brugia malayi Cache domain containing protein 0.0089 0.076 0.1166
Leishmania major quinonoid dihydropteridine reductase 0.0015 0.0092 0.0116
Brugia malayi von Willebrand factor type A domain containing protein 0.0008 0.0028 0.0043
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0015 0.0092 0.0116
Mycobacterium ulcerans dehydrogenase 0.0015 0.0092 0.0075
Echinococcus multilocularis steroid dehydrogenase 0.0015 0.0092 0.0131
Loa Loa (eye worm) amidase 0.0012 0.0066 0.0102
Schistosoma mansoni lamin 0.0027 0.0196 0.0301
Mycobacterium ulcerans amidase 0.0012 0.0066 0.005
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0443 0.3959 0.5632
Onchocerca volvulus 0.0015 0.0092 0.0169
Onchocerca volvulus 0.0015 0.0092 0.0169
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0727 0.652 0.9275
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0325 0.1042
Brugia malayi amidase 0.0104 0.0888 0.1363
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0042 0.0064
Echinococcus multilocularis retinol dehydrogenase 13 0.0015 0.0092 0.0131
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0341 0.3034 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0042 0.0064
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0325 0.1042
Echinococcus multilocularis retinol dehydrogenase 11 0.0015 0.0092 0.0131
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0012 0.0066 0.0076
Loa Loa (eye worm) hypothetical protein 0.0727 0.652 1
Echinococcus granulosus fatty acid amide hydrolase 1 0.0104 0.0888 0.1363
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0092 0.0075
Echinococcus granulosus WW domain containing oxidoreductase 0.0015 0.0092 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0042 0.0064
Brugia malayi Amidase family protein 0.0012 0.0066 0.0102
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0294 0.0688
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0042 0.0064
Brugia malayi Dehydrogenases, short chain protein 30 0.0015 0.0092 0.0141
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0092 0.0141
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0015 0.0092 0.0116
Mycobacterium ulcerans amidase 0.0012 0.0066 0.005
Brugia malayi CXXC zinc finger family protein 0.0028 0.0204 0.0313
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0092 0.0141
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0043
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0196 0.0301
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0141
Loa Loa (eye worm) cytochrome P450 0.0007 0.0017 0.0026
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0092 0.0075
Mycobacterium ulcerans peptide amidase, GatA 0.0012 0.0066 0.005
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0015 0.0092 1
Leishmania major oxidoreductase-like protein 0.0015 0.0092 0.0116
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0015 0.0092 0.0169
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0015 0.0092 0.0075
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0012 0.0066 1
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0015 0.0092 0.0116
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0043
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0727 0.652 1
Brugia malayi von Willebrand factor type A domain containing protein 0.0008 0.0028 0.0043
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0092 0.0141
Loa Loa (eye worm) runx1 0.0054 0.0438 0.0672
Schistosoma mansoni carbonyl reductase 0.0015 0.0092 0.0141
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0358 0.0549
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0092 0.0141
Leishmania major short chain dehydrogenase, putative 0.0015 0.0092 0.0116
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0015 0.0092 0.0271
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0341 0.3034 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0042 0.0064
Echinococcus multilocularis carbonyl reductase 1 0.0015 0.0092 0.0131
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0141
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0015 0.0092 0.1703
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.1703
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0042 0.0064
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0016 0.0024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.0141
Schistosoma mansoni hypothetical protein 0.0008 0.0028 0.0043
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0092 0.0141
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0042 0.0064
Trypanosoma brucei short-chain dehydrogenase, putative 0.0015 0.0092 0.0116
Loa Loa (eye worm) CUTiclin-Like family member 0.0008 0.0028 0.0043
Brugia malayi hypothetical protein 0.0428 0.3819 0.5857
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0092 0.0141
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0294 1
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0015 0.0092 0.0075
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0015 0.0092 0.241
Echinococcus multilocularis Protein lozenge 0.0054 0.0438 0.0623
Loa Loa (eye worm) acetyltransferase 0.014 0.1218 0.1868
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0043
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.703 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0042 0.0064
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0196 0.0301
Mycobacterium tuberculosis Probable dehydrogenase 0.0015 0.0092 0.0075
Brugia malayi steroid hormone receptor 0.001 0.0042 0.0064
Brugia malayi putative amidase 0.0012 0.0066 0.0102
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0015 0.0092 0.0075
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.1703
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0042 0.0064
Mycobacterium ulcerans amidase 0.0012 0.0066 0.005
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0071 0.01
Brugia malayi dehydrogenases, short chain protein 2 0.0015 0.0092 0.0141
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0092 0.0141
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0015 0.0092 0.0075
Echinococcus granulosus FTZ F1 alpha 0.001 0.0042 0.0064
Echinococcus granulosus Niemann Pick C1 protein 0.0299 0.2657 0.4075
Brugia malayi von Willebrand factor type A domain containing protein 0.0008 0.0028 0.0043
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0092 0.0141
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0015 0.0092 0.0116
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0015 0.0092 0.0075
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.0141
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0064
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0042 0.0064
Loa Loa (eye worm) CYP4Cod1 0.0007 0.0017 0.0026
Loa Loa (eye worm) oxidoreductase 0.0015 0.0092 0.0141
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0092 0.0075
Echinococcus granulosus voltage dependent calcium channel subunit 0.0202 0.1775 0.2723
Mycobacterium tuberculosis Probable oxidoreductase 0.0015 0.0092 0.0075
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0092 0.0075
Mycobacterium ulcerans amidase 0.0012 0.0066 0.005
Onchocerca volvulus 0.0015 0.0092 0.0169
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0043
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0098 0.0834 0.128
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0043
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0064
Onchocerca volvulus 0.0015 0.0092 0.0169
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0092 0.0141
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0015 0.0092 0.0141
Leishmania major 3-keto-dihydrosphingosine reductase 0.0015 0.0092 0.0116
Mycobacterium tuberculosis Possible oxidoreductase 0.0015 0.0092 0.0075
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0064
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0015 0.0092 0.0116
Schistosoma mansoni lamin 0.0027 0.0196 0.0301
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0325 0.0499
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0042 0.0064
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0042 0.0064
Schistosoma mansoni nuclear hormone receptor 0.001 0.0042 0.0064
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0083 0.0128
Loa Loa (eye worm) hypothetical protein 0.0026 0.0192 0.0294
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0092 0.0075
Mycobacterium ulcerans short-chain dehydrogenase 0.0015 0.0092 0.0075
Brugia malayi Cytochrome P450 family protein 0.0045 0.0358 0.0549
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0015 0.0092 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0043
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0193 0.1701 0.2609
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0015 0.0092 0.0075
Loa Loa (eye worm) hypothetical protein 0.0428 0.3819 0.5857
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0012 0.0066 0.0094
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.1703
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0727 0.652 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0043
Loa Loa (eye worm) hypothetical protein 0.0428 0.3819 0.5857
Mycobacterium tuberculosis Probable oxidoreductase 0.0015 0.0092 0.0075
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0015 0.0092 0.0075
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0012 0.0066 0.005
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0092 0.0141
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0043
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0042 0.0064
Mycobacterium ulcerans carveol-like dehydrogenase 0.0015 0.0092 0.0075
Echinococcus granulosus collagen alpha 1VII chain 0.0008 0.0028 0.0043
Mycobacterium ulcerans ketoacyl reductase 0.0015 0.0092 0.0075
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0015 0.0092 0.0141
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0015 0.0092 0.0116
Onchocerca volvulus 0.0028 0.0204 0.0465
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0092 0.0075
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.1703
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0015 0.0092 0.0116
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0092 0.0075
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0092 0.0141
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0064
Echinococcus granulosus intermediate filament protein 0.0027 0.0196 0.0301
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0015 0.0092 0.0116
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0092 0.0075
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0012 0.0066 0.005
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0042 0.0064
Mycobacterium ulcerans oxidoreductase 0.0015 0.0092 0.0075
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0202 0.1775 0.2525
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0092 0.0271
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0015 0.0092 0.0075
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0299 0.2657 0.4075
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0042 0.0064
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0015 0.0092 0.0075
Echinococcus multilocularis carbonyl reductase 1 0.0015 0.0092 0.0131
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0092 0.0075
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0092 0.0075
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0064
Echinococcus granulosus fatty acid amide hydrolase 1 0.0012 0.0066 0.0102
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0092 0.0075
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0092 0.0271
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0042 0.0059
Brugia malayi ecdysteroid receptor 0.001 0.0042 0.0064
Echinococcus multilocularis protein dispatched 1 0.0299 0.2657 0.3779
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0092 0.2159
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0015 0.0092 0.0116
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.1183 0.1814
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0042 0.0059
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0727 0.652 1
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0015 0.0092 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0042 0.0064
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0042 0.0064
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0016 0.0024
Schistosoma mansoni amidase 0.0104 0.0888 0.1363
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0015 0.0092 0.0075
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0727 0.652 1
Mycobacterium ulcerans oxidoreductase 0.0015 0.0092 0.0075
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0015 0.0092 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0042 0.0064
Loa Loa (eye worm) hypothetical protein 0.0104 0.0888 0.1363
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0092 0.0141
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0016 0.0024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.0141
Schistosoma mansoni cytochrome P450 0.0007 0.0017 0.0026
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0015 0.0092 0.0131
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0042 0.0064
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0092 0.0141
Leishmania major hypothetical protein, conserved 0.0015 0.0092 0.0116
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0043
Echinococcus multilocularis retinol dehydrogenase 11 0.0015 0.0092 0.0131
Trypanosoma brucei short-chain dehydrogenase, putative 0.0015 0.0092 0.0116
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0064
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0031 0.0047
Echinococcus granulosus retinol dehydrogenase 11 0.0015 0.0092 0.0141
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0092 0.0075
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0092 0.0141
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0015 0.0092 0.0131
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.0141
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0042 0.0064
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0042 0.0059
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.003 0.0046
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0042 0.0064
Schistosoma mansoni fatty-acid amide hydrolase 0.0104 0.0888 0.1363
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0042 0.0059
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.3523 0.5011
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0031 0.0047
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0015 0.0092 0.0116
Brugia malayi Zona pellucida-like domain containing protein 0.0008 0.0028 0.0043
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0092 0.0075
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0015 0.0092 0.0141
Schistosoma mansoni hypothetical protein 0.0395 0.3523 0.5403
Entamoeba histolytica short chain dehydrogenase family protein 0.0015 0.0092 0.241
Loa Loa (eye worm) amidase 0.0012 0.0066 0.0102
Echinococcus granulosus carbonyl reductase 1 0.0015 0.0092 0.0141
Schistosoma mansoni coup transcription factor 0.001 0.0042 0.0064
Schistosoma mansoni fatty-acid amide hydrolase 0.0012 0.0066 0.0102
Loa Loa (eye worm) dehydrogenase 0.0015 0.0092 0.0141
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.0141
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0042 0.0064
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0043
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0043
Echinococcus granulosus oxidoreductase 0.0015 0.0092 0.0141
Trypanosoma brucei short-chain dehydrogenase, putative 0.0015 0.0092 0.0116
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.0012 0.0066 0.5
Schistosoma mansoni retinal dehydrogenase 0.0015 0.0092 0.0141
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.0017 0.0026
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0042 0.0064
Echinococcus granulosus dnaJ subfamily B 0.0395 0.3523 0.5403
Onchocerca volvulus 0.0015 0.0092 0.0169
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0042 0.0064
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0042 0.0064
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0485 0.0744
Leishmania major hypothetical protein, conserved 0.0015 0.0092 0.0116
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0012 0.0066 0.0102
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0092 0.0075
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0012 0.0066 0.129
Leishmania major short chain dehydrogenase/reductase, putative 0.0015 0.0092 0.0116
Mycobacterium ulcerans short-chain dehydrogenase 0.0015 0.0092 0.0075
Onchocerca volvulus 0.001 0.0042 0.0036
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0042 0.0064
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0015 0.0092 0.0116
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0012 0.0066 0.6571
Onchocerca volvulus 0.0015 0.0092 0.0169
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0012 0.0066 0.0102
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0012 0.0066 0.005
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0092 0.0141
Schistosoma mansoni lozenge 0.0054 0.0438 0.0672
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0092 0.0075
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0015 0.0092 0.0141
Onchocerca volvulus 0.0015 0.0092 0.0169
Echinococcus multilocularis oxidoreductase 0.0015 0.0092 0.0131
Mycobacterium ulcerans dehydrogenase/reductase 0.0015 0.0092 0.0075
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0092 0.0116
Leishmania major pteridine reductase 1 0.0015 0.0092 0.0116
Brugia malayi CHE-14 protein 0.0299 0.2657 0.4075
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0015 0.0092 0.0116
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0092 0.0141
Brugia malayi Zona pellucida-like domain containing protein 0.0008 0.0028 0.0043
Echinococcus granulosus carbonyl reductase 1 0.0015 0.0092 0.0141
Loa Loa (eye worm) hypothetical protein 0.0299 0.2657 0.4075
Echinococcus granulosus retinol dehydrogenase 11 0.0015 0.0092 0.0141
Echinococcus granulosus sterol regulatory element binding protein 0.0299 0.2657 0.4075
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0092 0.0075
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0092 0.0141
Schistosoma mansoni cpg binding protein 0.0029 0.0218 0.0335
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0092 0.0116
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0015 0.0092 0.0075
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0015 0.0092 0.0116
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0092 0.0075
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0015 0.0092 0.241
Echinococcus granulosus lamin 0.0027 0.0196 0.0301
Loa Loa (eye worm) oxidoreductase 0.0015 0.0092 0.0141
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.0141
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0012 0.0066 0.6571
Leishmania major quinonoid dihydropteridine reductase 0.0015 0.0092 0.0116
Mycobacterium ulcerans amidase 0.0012 0.0066 0.005
Brugia malayi Cytochrome P450 family protein 0.0007 0.0017 0.0026
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.0141
Plasmodium vivax steroid dehydrogenase, putative 0.0015 0.0092 0.2159
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0015 0.0092 0.0116
Trichomonas vaginalis steroid dehydrogenase, putative 0.0015 0.0092 0.0271
Loa Loa (eye worm) oxidoreductase 0.0015 0.0092 0.0141
Mycobacterium tuberculosis Possible oxidoreductase 0.0015 0.0092 0.0075
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0071 0.0108
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0141
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0092 0.0141
Onchocerca volvulus 0.0015 0.0092 0.0169
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0016 0.0022
Echinococcus granulosus Protein patched homolog 1 0.0299 0.2657 0.4075
Brugia malayi nuclear hormone receptor 0.001 0.0042 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0042 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0042 0.0064
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0012 0.0066 0.005
Echinococcus granulosus fatty acid amide hydrolase 1 0.0104 0.0888 0.1363
Loa Loa (eye worm) hypothetical protein 0.0013 0.0071 0.0108
Trypanosoma cruzi amidase, putative 0.0012 0.0066 0.0076
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0015 0.0092 0.0075
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0015 0.0092 0.0141
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0015 0.0092 0.0075
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0008 0.0028 0.004
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0015 0.0092 0.0141
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0196 0.0301
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.0141
Schistosoma mansoni carbonyl reductase 0.0015 0.0092 0.0141
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0015 0.0092 1
Echinococcus multilocularis carbonyl reductase 1 0.0015 0.0092 0.0131
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0092 0.0271
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.0141
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0727 0.652 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0031 0.0044
Echinococcus multilocularis lamin dm0 0.0027 0.0196 0.0279
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0092 0.0116
Entamoeba histolytica hypothetical protein, conserved 0.0015 0.0092 0.241
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0015 0.0092 0.241
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0042 0.0064
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0042 0.0064
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.0141
Leishmania major quinonoid dihydropteridine reductase 0.0015 0.0092 0.0116
Leishmania major short chain dehydrogenase/reductase, putative 0.0015 0.0092 0.0116
Schistosoma mansoni hypothetical protein 0.0165 0.144 0.2209
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0325 0.6975
Brugia malayi intermediate filament protein 0.0027 0.0196 0.0301
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0092 0.0141
Echinococcus multilocularis geminin 0.0165 0.144 0.2049
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0141
Mycobacterium ulcerans ketoacyl reductase 0.0015 0.0092 0.0075
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0141
Loa Loa (eye worm) hypothetical protein 0.001 0.0042 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0299 0.2657 0.8753
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0015 0.0092 0.0116
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.0141
Brugia malayi cytochrome P450 0.0007 0.0017 0.0026
Brugia malayi von Willebrand factor type A domain containing protein 0.0008 0.0028 0.0043
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0015 0.0092 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0042 0.0064
Loa Loa (eye worm) hypothetical protein 0.0012 0.0066 0.0101
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0092 0.0271
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0015 0.0092 0.0141
Mycobacterium tuberculosis Probable oxidoreductase 0.0015 0.0092 0.0075
Echinococcus granulosus voltage dependent calcium channel subunit 0.0443 0.3959 0.6072
Brugia malayi Dehydrogenases, short chain protein 2 0.0015 0.0092 0.0141
Brugia malayi hypothetical protein 0.0015 0.0092 0.0141
Mycobacterium ulcerans short-chain dehydrogenase 0.0015 0.0092 0.0075
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0015 0.0092 0.241
Loa Loa (eye worm) oxidoreductase 0.0015 0.0092 0.0141
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0015 0.0092 0.0075
Brugia malayi Retinol dehydrogenase 12 0.0015 0.0092 0.0141
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0141
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0042 0.0059
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0341 0.3034 1
Mycobacterium ulcerans short-chain type oxidoreductase 0.0015 0.0092 0.0075
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0015 0.0092 0.0116
Toxoplasma gondii oxidoreductase, putative 0.0015 0.0092 0.1703
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0015 0.0092 0.0271
Schistosoma mansoni thyroid hormone receptor 0.001 0.0042 0.0064
Mycobacterium tuberculosis Probable oxidoreductase 0.0015 0.0092 0.0075
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0008 0.0028 0.0043
Onchocerca volvulus 0.0015 0.0092 0.0169
Schistosoma mansoni hypothetical protein 0.0104 0.0894 0.1372
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0092 0.0075
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0008 0.0028 0.0251
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0042 0.0064
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0015 0.0092 0.0075
Entamoeba histolytica hypothetical protein, conserved 0.0015 0.0092 0.241
Loa Loa (eye worm) oxidoreductase 0.0015 0.0092 0.0141
Loa Loa (eye worm) oxidoreductase 0.0015 0.0092 0.0141
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.1218 0.1868
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0015 0.0092 0.0116
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0015 0.0092 0.0271
Leishmania major hypothetical protein, conserved 0.0015 0.0092 0.0116
Brugia malayi von Willebrand factor type A domain containing protein 0.0008 0.0028 0.0043
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0015 0.0092 0.0141
Mycobacterium ulcerans short chain dehydrogenase 0.0015 0.0092 0.0075
Echinococcus granulosus cytochrome P450 2K1 0.0007 0.0017 0.0026
Schistosoma mansoni hypothetical protein 0.0007 0.0017 0.0026
Echinococcus granulosus carbonyl reductase 1 0.0015 0.0092 0.0141
Leishmania major hypothetical protein, conserved 0.0012 0.0066 0.0076
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0015 0.0092 0.0131
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.0092 0.0141
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0016 0.0022
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0141
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0015 0.0092 0.0075
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0015 0.0092 0.0075
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0015 0.0092 0.0116
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0092 0.0116
Loa Loa (eye worm) oxidoreductase 0.0015 0.0092 0.0141
Schistosoma mansoni intermediate filament proteins 0.0027 0.0196 0.0301
Mycobacterium leprae Probable oxidoreductase 0.0015 0.0092 1
Echinococcus granulosus carbonyl reductase 1 0.0015 0.0092 0.0141
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0104 0.0888 0.1264
Leishmania major quinonoid dihydropteridine reductase 0.0015 0.0092 0.0116
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0008 0.0028 0.0043
Leishmania major quinonoid dihydropteridine reductase 0.0015 0.0092 0.0116
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0043
Toxoplasma gondii microneme protein MIC2 0.0008 0.0028 0.0251
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0015 0.0092 0.0116
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0043
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0104 0.0888 0.1264
Leishmania major quinonoid dihydropteridine reductase 0.0015 0.0092 0.0116
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0042 0.0036
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.0017 0.0026
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0015 0.0092 0.0141
Echinococcus granulosus geminin 0.0165 0.144 0.2209
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0015 0.0092 0.0131
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0015 0.0092 0.0131
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0727 0.652 0.6514
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0042 0.0064
Loa Loa (eye worm) hypothetical protein 0.0008 0.0028 0.0043
Brugia malayi dehydrogenases, short chain protein 9 0.0015 0.0092 0.0141
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0015 0.0092 0.0075
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0015 0.0092 0.0075
Onchocerca volvulus 0.0015 0.0092 0.0169
Onchocerca volvulus 0.0015 0.0092 0.0169
Echinococcus multilocularis sterol regulatory element binding protein 0.0299 0.2657 0.3779
Trypanosoma cruzi short chain dehydrogenase, putative 0.0015 0.0092 0.0116
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0042 0.0059
Echinococcus multilocularis steroid dehydrogenase 0.0015 0.0092 0.0131
Leishmania major hypothetical protein, conserved 0.0015 0.0092 0.0116
Entamoeba histolytica hypothetical protein 0.0015 0.0092 0.241
Schistosoma mansoni steroid dehydrogenase 0.0015 0.0092 0.0141
Schistosoma mansoni serine-rich repeat protein 0.0104 0.0894 0.1372
Brugia malayi von Willebrand Factor 0.0008 0.0028 0.0043
Brugia malayi hypothetical protein 0.0008 0.0028 0.0043
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0141
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0012 0.0066 0.144
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0341 0.3034 1
Onchocerca volvulus 0.0015 0.0092 0.0169
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0015 0.0092 0.0271
Schistosoma mansoni hypothetical protein 0.0008 0.0028 0.0043
Schistosoma mansoni short chain dehydrogenase 0.0015 0.0092 0.0141

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = -7.02 Displacement of [3H]L-leucine from alpha2delta containing calcium channel in murine brain ChEMBL. 16380257
Ki (binding) = 0.096 uM Displacement of [3H]L-leucine from alpha2delta containing calcium channel in murine brain ChEMBL. 16380257
Ki (binding) = 0.096 uM Displacement of [3H]L-leucine from alpha2delta containing calcium channel in murine brain ChEMBL. 16380257
Log Ki (binding) = -7.02 Displacement of [3H]L-leucine from alpha2delta containing calcium channel in murine brain ChEMBL. 16380257

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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