Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0164 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.6742 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0097 | 0.5479 | 0.8127 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0097 | 0.5479 | 0.5479 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.6742 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0097 | 0.5479 | 0.5479 |
Brugia malayi | hypothetical protein | 0.0035 | 0.1313 | 0.1948 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.6742 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0091 | 0.5131 | 0.7611 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.5168 | 0.7666 |
Echinococcus multilocularis | geminin | 0.0164 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0024 | 0.0612 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1313 | 0.5 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0612 | 0.0908 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1313 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.1313 | 0.1313 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0024 | 0.0612 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0612 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1313 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.1313 | 0.1313 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0612 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0024 | 0.0612 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.1313 | 0.1313 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1313 | 0.1313 |
Leishmania major | hypothetical protein, conserved | 0.0024 | 0.0612 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0612 | 0.0908 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0.0612 | 1 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0031 | 0.0046 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0024 | 0.0612 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1313 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 13.3 % | Inhibition of HBeAg release aganist HBV in HepG2 2.2.15 cell line at 0.1 umol/mL | ChEMBL. | 16364643 |
Activity (functional) | = 18.1 % | Inhibition of HBsAg release against HBV in HepG2 2.2.15 cell line at 0.1 umol/mL | ChEMBL. | 16364643 |
Activity (functional) | = 19.5 % | Inhibition of HBeAg release against HBV in HepG2 2.2.15 cell line at 0.2 umol/mL | ChEMBL. | 16364643 |
Activity (functional) | >= 25 % | Cytotoxicity against HepG2 2.2.15 cell line at 0.4 umol/mL by MTT assay | ChEMBL. | 16364643 |
Activity (functional) | >= 25 % | Cytotoxicity against HepG2 2.2.15 cell line at 0.4 umol/mL by MTT assay | ChEMBL. | 16364643 |
Activity (functional) | = 31.6 % | Inhibition of HBsAg release against HBV in HepG2 2.2.15 cell line at 0.2 umol/mL | ChEMBL. | 16364643 |
IC50 (functional) | > 40 uM | Antiproliferative activity against human KB cells after 3 days by SRB assay | ChEMBL. | 26865176 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.