TDR Targets

Basic information

Technical information

TDR Targets ID: 353646
Name: 2-[2-(dimethylaminomethyl)phenoxy]-5-methylan iline
MW: 256.343 | Formula: C16H20N2O
H donors: 1 H acceptors: 0 LogP: 2.97 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CN(Cc1ccccc1Oc1ccc(cc1N)C)C
InChi: 1S/C16H20N2O/c1-12-8-9-16(14(17)10-12)19-15-7-5-4-6-13(15)11-18(2)3/h4-10H,11,17H2,1-3H3
InChiKey: DSAPXKWYVMTXKI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[2-(dimethylaminomethyl)phenoxy]-5-methyl-aniline
[2-(2-amino-4-methyl-phenoxy)benzyl]-dimethyl-amine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 2	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 3	Starlite/ChEMBL	References
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Treponema pallidum	sodium- and chloride- dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus granulosus	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	norepinephrine/norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Onchocerca volvulus		Get druggable targets OG5_128364	All targets in OG5_128364
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	solute carrier family 6 member 4	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	serotonin transporter b	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent noradrenaline transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus multilocularis	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_128364	All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 3	620 aa	579 aa	33.2 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 2	617 aa	638 aa	32.5 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 4	630 aa	574 aa	31.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.005	0.0293	0.0714
Echinococcus multilocularis	Niemann Pick C1 protein	0.0104	0.0942	0.0948
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0076	0.0128
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0107	0.0259
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.005	0.0293	0.0492
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0049	0.0283	0.0285
Loa Loa (eye worm)	serotonin transporter b	0.0292	0.3198	0.7781
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0293	0.0714
Toxoplasma gondii	isocitrate dehydrogenase	0.0049	0.0283	0.9651
Echinococcus multilocularis	sterol regulatory element binding protein	0.0044	0.0233	0.0234
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0219	0.2326	0.5659
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0293	0.0492
Onchocerca volvulus		0.0292	0.3198	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0293	0.0714
Echinococcus granulosus	geminin	0.0522	0.596	1
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0049	0.0283	1
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1245	0.303
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0105	0.0961	0.1613
Trichomonas vaginalis	set domain proteins, putative	0.0249	0.2689	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0353	0.0858
Schistosoma mansoni	hypothetical protein	0.0043	0.0213	0.0358
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.0293	0.0492
Echinococcus multilocularis	survival motor neuron protein 1	0.0244	0.2627	0.2645
Onchocerca volvulus		0.005	0.0293	0.0696
Brugia malayi	TAR-binding protein	0.0065	0.0484	0.1177
Echinococcus granulosus	serotonin transporter	0.0292	0.3198	0.5366
Toxoplasma gondii	isocitrate dehydrogenase	0.0049	0.0283	0.9651
Schistosoma mansoni	hypothetical protein	0.0522	0.596	1
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.005	0.0293	0.0295
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0266	0.0446
Brugia malayi	hypothetical protein	0.005	0.0293	0.0714
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0049	0.0283	0.0285
Schistosoma mansoni	hypothetical protein	0.0111	0.1029	0.1726
Onchocerca volvulus		0.005	0.0293	0.0696
Plasmodium falciparum	transporter, putative	0.005	0.0293	1
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0049	0.0283	0.9651
Toxoplasma gondii	hypothetical protein	0.005	0.0293	1
Brugia malayi	hypothetical protein	0.0111	0.1029	0.2503
Schistosoma mansoni	hypothetical protein	0.0043	0.0213	0.0358
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1245	0.303
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0293	0.0492
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0076	0.0128
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0266	0.0647
Plasmodium falciparum	amino acid transporter, putative	0.005	0.0293	1
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0484	0.0812
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0297	0.0722
Onchocerca volvulus		0.0249	0.2689	0.8368
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.0293	0.0295
Loa Loa (eye worm)	hypothetical protein	0.005	0.0293	0.0714
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0049	0.0283	1
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.0293	0.0714
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.005	0.0293	0.0492
Onchocerca volvulus	Huntingtin homolog	0.0129	0.1245	0.3745
Entamoeba histolytica	hypothetical protein	0.0111	0.1029	1
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0484	0.0812
Plasmodium vivax	amine transporter, putative	0.005	0.0293	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.0104	0.0942	0.2292
Plasmodium vivax	SET domain protein, putative	0.0031	0.0076	0.2581
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0062	0.0105
Echinococcus multilocularis	serotonin transporter	0.0292	0.3198	0.322
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0293	1
Brugia malayi	Isocitrate dehydrogenase	0.0049	0.0283	0.0689
Brugia malayi	isocitrate dehydrogenase	0.0049	0.0283	0.0689
Entamoeba histolytica	hypothetical protein	0.0111	0.1029	1
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.0293	0.0492
Loa Loa (eye worm)	norepinephrine transporter	0.0292	0.3198	0.7781
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0266	0.0446
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0266	0.0268
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0076	0.0128
Brugia malayi	MH2 domain containing protein	0.0368	0.411	1
Echinococcus granulosus	sterol regulatory element binding protein	0.0044	0.0233	0.039
Loa Loa (eye worm)	hypothetical protein	0.005	0.0293	0.0714
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.0293	0.0492
Echinococcus multilocularis	geminin	0.0522	0.596	0.6
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.005	0.0293	0.0492
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0292	0.3198	0.5366
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0107	0.0259
Echinococcus granulosus	survival motor neuron protein 1	0.0244	0.2627	0.4408
Echinococcus granulosus	sodium and chloride dependent glycine	0.005	0.0293	0.0492
Brugia malayi	hypothetical protein	0.0025	0.0001	0.0001
Echinococcus multilocularis	protein dispatched 1	0.0051	0.0308	0.031
Brugia malayi	hypothetical protein	0.0129	0.1245	0.303
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.0484	0.1177
Echinococcus multilocularis	expressed conserved protein	0.0097	0.0867	0.0872
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0049	0.0283	0.0475
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0266	0.0268
Schistosoma mansoni	hypothetical protein	0.0303	0.3335	0.5596
Echinococcus multilocularis	Niemann Pick C1 protein	0.0148	0.1475	0.1485
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0044	0.0233	0.0566
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0049	0.0283	0.0689
Onchocerca volvulus		0.005	0.0297	0.0706
Entamoeba histolytica	hypothetical protein	0.0111	0.1029	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.0484	0.1177
Echinococcus granulosus	Protein patched homolog 1	0.0044	0.0233	0.039
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0111	0.1029	0.1726
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0049	0.0283	0.9651
Schistosoma mansoni	hypothetical protein	0.0043	0.0213	0.0358
Echinococcus granulosus	expressed conserved protein	0.0097	0.0867	0.1454
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0292	0.3198	0.7781
Loa Loa (eye worm)	hypothetical protein	0.0244	0.2627	0.6391
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0001	0.0001
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0266	0.0446
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0111	0.1029	0.1036
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.005	0.0293	0.0714
Echinococcus granulosus	X box binding protein 1	0.0303	0.3335	0.5596
Echinococcus multilocularis	isocitrate dehydrogenase	0.0049	0.0283	0.0285
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.005	0.0293	0.5
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0076	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0292	0.3198	0.7781
Echinococcus multilocularis	sodium and chloride dependent glycine	0.005	0.0293	0.0295
Onchocerca volvulus		0.005	0.0293	0.0696
Echinococcus multilocularis	tar DNA binding protein	0.0065	0.0484	0.0487
Mycobacterium ulcerans	proteasome PrcA	0.086	1	0.5
Brugia malayi	Pre-SET motif family protein	0.0031	0.0076	0.0185
Plasmodium vivax	hypothetical protein, conserved	0.005	0.0293	1
Schistosoma mansoni	patched 1	0.0044	0.0233	0.039
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0049	0.0283	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0292	0.3198	0.7781
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0049	0.0283	0.0285
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0295	0.0718
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.086	1	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0076	0.2581
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0293	0.0714
Schistosoma mansoni	survival motor neuron protein	0.005	0.0297	0.0498
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0942	0.2292
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0854	0.9932	1
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0293	0.0492
Toxoplasma gondii	hypothetical protein	0.005	0.0293	1
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.005	0.0293	0.0295
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0049	0.0283	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.005	0.0293	0.0492
Loa Loa (eye worm)	hypothetical protein	0.005	0.0293	0.0714
Brugia malayi	RNA binding protein	0.0065	0.0484	0.1177
Brugia malayi	CHE-14 protein	0.0044	0.0233	0.0566
Onchocerca volvulus	Huntingtin homolog	0.0129	0.1245	0.3745
Loa Loa (eye worm)	hypothetical protein	0.005	0.0293	0.0714
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0292	0.3198	0.7781
Loa Loa (eye worm)	transcription factor SMAD2	0.0368	0.411	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.005	0.0293	0.0714
Loa Loa (eye worm)	hypothetical protein	0.0292	0.3198	0.7781
Schistosoma mansoni	hypothetical protein	0.005	0.0297	0.0498
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0049	0.0283	0.0475
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.0484	0.1177
Schistosoma mansoni	hypothetical protein	0.0034	0.0107	0.0179
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0293	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0076	0.0185
Schistosoma mansoni	hypothetical protein	0.0522	0.596	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.005	0.0293	0.0492
Schistosoma mansoni	sodium/chloride dependent transporter	0.005	0.0293	0.0492
Entamoeba histolytica	hypothetical protein	0.0111	0.1029	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.005	0.0293	0.0492
Echinococcus granulosus	Niemann Pick C1 protein	0.0104	0.0942	0.158
Echinococcus multilocularis	X box binding protein 1	0.0303	0.3335	0.3358
Schistosoma mansoni	hypothetical protein	0.0043	0.0213	0.0358
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.005	0.0293	0.0295
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0049	0.0283	1
Echinococcus granulosus	tar DNA binding protein	0.0065	0.0484	0.0812
Echinococcus granulosus	Niemann Pick C1 protein	0.0148	0.1475	0.2475
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0076	0.0128
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0266	0.0446
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0076	0.0128
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0266	0.0446
Brugia malayi	hypothetical protein	0.0244	0.2627	0.6391
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0293	1
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0049	0.0283	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0266	0.0647
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0076	0.0077
Treponema pallidum	sodium- and chloride- dependent transporter	0.0292	0.3198	0.5
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0233	0.0566
Loa Loa (eye worm)	RNA binding protein	0.0065	0.0484	0.1177
Loa Loa (eye worm)	hypothetical protein	0.005	0.0293	0.0714
Loa Loa (eye worm)	hypothetical protein	0.005	0.0295	0.0718
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.005	0.0293	0.0714
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0295	0.0718
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0295	0.0718
Echinococcus multilocularis	protein patched	0.0044	0.0233	0.0234
Schistosoma mansoni	sodium-dependent amino acid transporter	0.005	0.0293	0.0492
Schistosoma mansoni	transcription factor LCR-F1	0.0111	0.1029	0.1726
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0484	0.0812
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0484	0.0812
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.005	0.0293	0.0492
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.005	0.0293	1
Brugia malayi	Pre-SET motif family protein	0.0219	0.2326	0.5659
Schistosoma mansoni	sodium/chloride dependent transporter	0.0292	0.3198	0.5366
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0484	0.0812
Loa Loa (eye worm)	MH2 domain-containing protein	0.0368	0.411	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 100 nM	Inhibitory activity against DAT	ChEMBL.	16337793
IC50 (binding)	> 100 nM	Inhibitory activity against NET	ChEMBL.	16337793
IC50 (binding)	> 100 nM	Inhibitory activity against DAT	ChEMBL.	16337793
IC50 (binding)	> 100 nM	Inhibitory activity against NET	ChEMBL.	16337793
Ki (binding)	= 0.53 nM	Displacement of [3H]paroxetine from SERT	ChEMBL.	16337793
Ki (binding)	= 0.53 nM	Displacement of [3H]paroxetine from SERT	ChEMBL.	16337793

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL204199
PubChem: 10244152

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 353646