Detailed information for compound 354002

Basic information

Technical information
  • TDR Targets ID: 354002
  • Name: 3-(1,3-benzodioxole-5-carbonylamino)-N-propan -2-yl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5 -carboxamide
  • MW: 357.364 | Formula: C17H19N5O4
  • H donors: 3 H acceptors: 3 LogP: 0.73 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(NC(=O)N1Cc2c(C1)c([nH]n2)NC(=O)c1ccc2c(c1)OCO2)C
  • InChi: 1S/C17H19N5O4/c1-9(2)18-17(24)22-6-11-12(7-22)20-21-15(11)19-16(23)10-3-4-13-14(5-10)26-8-25-13/h3-5,9H,6-8H2,1-2H3,(H,18,24)(H2,19,20,21,23)
  • InChiKey: IQQAPAMUKYXXIQ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 3-(1,3-benzodioxole-5-carbonylamino)-N-isopropyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxamide
  • 3-[[1,3-benzodioxol-5-yl(oxo)methyl]amino]-N-isopropyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxamide
  • 3-(1,3-benzodioxol-5-ylcarbonylamino)-N-propan-2-yl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxamide
  • N-isopropyl-3-(piperonyloylamino)-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxamide
  • 3-(1,3-benzodioxole-5-carbonylamino)-N-propan-2-yl-4,6-dihydro-1H-pyrrolo[3,4-d]pyrazole-5-carboxamide
  • 3-(1,3-benzodioxole-5-carbonylamino)-N-isopropyl-4,6-dihydro-1H-pyrrolo[3,4-d]pyrazole-5-carboxamide
  • 3-[(1,3-benzodioxol-5-yl-oxomethyl)amino]-N-isopropyl-4,6-dihydro-1H-pyrrolo[3,4-d]pyrazole-5-carboxamide
  • 3-(1,3-benzodioxol-5-ylcarbonylamino)-N-propan-2-yl-4,6-dihydro-1H-pyrrolo[3,4-d]pyrazole-5-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin A2 References
Homo sapiens cyclin A1 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 References
Homo sapiens aurora kinase A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely B-type cyclin similar to S. cerevisiae CLB4 (YLR210W) and CLB3 (YDL155W) involved in G1/S transition Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis mitotic cyclin-CYC2 Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia G2/mitotic-specific cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei mitotic cyclin 6 Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense cyclin 6,mitotic cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Cyclin, N-terminal domain containing protein Get druggable targets OG5_126649 All targets in OG5_126649
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania mexicana cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma mansoni cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania braziliensis cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely G2 B-type cyclin similar to S. cerevisiae CLB1 (YPR119W) which is involved in mitotic induction Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126649 All targets in OG5_126649
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum cyclin Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis cyclin A, putative Get druggable targets OG5_126649 All targets in OG5_126649
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin B Get druggable targets OG5_126649 All targets in OG5_126649
Trichomonas vaginalis cyclins, putative Get druggable targets OG5_126649 All targets in OG5_126649
Leishmania infantum CYC2-like cyclin, putative,cyclin 6, putative Get druggable targets OG5_126649 All targets in OG5_126649
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense Cyclin, N-terminal domain/Cyclin, C-terminal domain containing protein, putative Get druggable targets OG5_126649 All targets in OG5_126649
Trypanosoma cruzi CYC2-like cyclin, putative Get druggable targets OG5_126649 All targets in OG5_126649
Schistosoma japonicum ko:K05868 cyclin B, putative Get druggable targets OG5_126649 All targets in OG5_126649
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.009 0.0089 1
Schistosoma mansoni dihydroorotate dehydrogenase 0.4348 1 1
Trypanosoma cruzi CYC2-like cyclin, putative 0.009 0.0089 0.0087
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.4348 1 0.5
Trypanosoma brucei mitotic cyclin 6 0.009 0.0089 0.0087
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.1698 0.3832 1
Brugia malayi serine/threonine kinase 12 0.0069 0.004 0.0037
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0069 0.004 0.0097
Trypanosoma cruzi cyclin, putative 0.009 0.0089 0.0087
Echinococcus granulosus aurora kinase A 0.0069 0.004 0.0097
Loa Loa (eye worm) hypothetical protein 0.0052 0.0002 0.024
Trichomonas vaginalis cyclins, putative 0.0062 0.0023 0.0054
Trichomonas vaginalis AGC family protein kinase 0.0069 0.004 0.0097
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0069 0.004 0.0097
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0069 0.004 0.0097
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0069 0.004 0.0097
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.0089 0.0087
Trichomonas vaginalis cyclin B, putative 0.009 0.0089 0.0227
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.4348 1 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0003 0.029
Trypanosoma brucei aurora B kinase 0.0069 0.004 0.0037
Trichomonas vaginalis AGC family protein kinase 0.0069 0.004 0.0097
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1698 0.3832 1
Trichomonas vaginalis cyclin B, putative 0.009 0.0089 0.0227
Trichomonas vaginalis cyclins, putative 0.009 0.0089 0.0227
Leishmania major protein kinase, putative 0.0069 0.004 0.0037
Trichomonas vaginalis cyclins, putative 0.009 0.0089 0.0227
Trypanosoma cruzi cyclin, putative 0.009 0.0089 0.0087
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1698 0.3832 1
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.0003 0.029
Plasmodium falciparum dihydroorotate dehydrogenase 0.4348 1 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0089 1
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.004 0.0037
Echinococcus granulosus cyclin B 0.009 0.0089 0.0227
Trichomonas vaginalis cyclin A, putative 0.009 0.0089 0.0227
Trypanosoma cruzi cyclin 6, putative 0.009 0.0089 0.0087
Trypanosoma cruzi aurora B kinase, putative 0.0069 0.004 0.0037
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0003 0.029
Entamoeba histolytica protein kinase , putative 0.0069 0.004 0.0097
Leishmania major cyclin 0.009 0.0089 0.0087
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.4348 1 0.5
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.4348 1 1
Loa Loa (eye worm) AUR protein kinase 0.0069 0.004 0.4459
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.4348 1 1
Giardia lamblia G2/mitotic-specific cyclin B 0.009 0.0089 1
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.4348 1 0.5
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1698 0.3832 1
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.4348 1 1
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0069 0.004 0.0097
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.1698 0.3832 1
Schistosoma mansoni protein kinase 0.0069 0.004 0.0037
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.1698 0.3832 0.383
Onchocerca volvulus 0.009 0.0089 0.5
Toxoplasma gondii aurora kinase 0.0069 0.004 0.0037
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.1698 0.3832 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1698 0.3832 1
Schistosoma mansoni cyclin B 0.009 0.0089 0.0087
Brugia malayi serine/threonine-protein kinase 6 0.0069 0.004 0.0037
Entamoeba histolytica cyclin, putative 0.009 0.0089 0.0227
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.009 0.0089 0.0087
Entamoeba histolytica protein kinase, putative 0.0069 0.004 0.0097
Echinococcus multilocularis aurora kinase A 0.0069 0.004 0.0097
Trichomonas vaginalis AGC family protein kinase 0.0069 0.004 0.0097
Loa Loa (eye worm) AUR protein kinase 0.0069 0.004 0.4459
Brugia malayi Cyclin, N-terminal domain containing protein 0.009 0.0089 0.0087
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1698 0.3832 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.1698 0.3832 1
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0069 0.004 0.0037
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.4348 1 1
Trichomonas vaginalis cyclin B, putative 0.009 0.0089 0.0227
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.1698 0.3832 1
Trichomonas vaginalis cyclins, putative 0.009 0.0089 0.0227
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.4348 1 0.5
Echinococcus multilocularis cyclin B 0.009 0.0089 0.0227
Entamoeba histolytica protein kinase domain containing protein 0.0069 0.004 0.0097
Giardia lamblia Aurora kinase 0.0069 0.004 0.4293
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.4348 1 1
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.4348 1 1
Plasmodium falciparum serine/threonine protein kinase, putative 0.0069 0.004 0.0037
Entamoeba histolytica protein kinase, putative 0.0069 0.004 0.0097
Brugia malayi serine/threonine protein kinase 6 0.0069 0.004 0.0037
Trichomonas vaginalis cyclins, putative 0.009 0.0089 0.0227
Loa Loa (eye worm) AUR protein kinase 0.0069 0.004 0.4459
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.1698 0.3832 1
Leishmania major dihydroorotate dehydrogenase 0.4348 1 1
Trichomonas vaginalis cyclin B, putative 0.009 0.0089 0.0227
Brugia malayi Zinc finger, C2H2 type family protein 0.1698 0.3832 0.383
Trichomonas vaginalis AGC family protein kinase 0.0069 0.004 0.0097

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.12 uM Inhibitory activity against CDK2/Cyclin A ChEMBL. 16290148
IC50 (binding) = 0.12 uM Inhibitory activity against CDK2/Cyclin A ChEMBL. 16290148
IC50 (binding) = 0.39 uM Inhibitory activity against Aurora A kinase ChEMBL. 16290148
IC50 (binding) = 0.39 uM Inhibitory activity against Aurora A kinase ChEMBL. 16290148

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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