Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Canis lupus familiaris | Cyclooxygenase-2 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 0.5 uM | Inhibition of COX2 by canine whole blood assay | ChEMBL. | 16380252 |
IC50 (binding) | > 0.5 uM | Inhibition of COX2 by canine whole blood assay | ChEMBL. | 16380252 |
Inhibition (binding) | = 39 % | Inhibition of COX2 at 0.5 uM by canine whole blood assay | ChEMBL. | 16380252 |
Inhibition (binding) | = 39 % | Inhibition of COX2 at 0.5 uM by canine whole blood assay | ChEMBL. | 16380252 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.