Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0031 | 0.0438 | 0.2647 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0133 | 0.0283 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0133 | 0.0283 |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.0208 | 0.0154 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.1146 | 0.2068 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0022 | 0.0208 | 0.0443 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0677 | 0.144 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (large chain) | 0.0161 | 0.3677 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0133 | 0.0283 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1024 | 0.2178 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0133 | 0.0283 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.0599 | 0.4775 |
Schistosoma mansoni | DNA polymerase eta | 0.0053 | 0.0995 | 0.2116 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0238 | 0.1904 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0129 | 0.2886 | 0.6138 |
Echinococcus multilocularis | acetylcholinesterase | 0.0129 | 0.2886 | 0.6138 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0734 | 0.1226 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0031 | 0.0438 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1024 | 0.2178 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0734 | 0.0508 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0208 | 0.0154 |
Leishmania major | DNA polymerase eta, putative | 0.0053 | 0.0995 | 1 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.0065 | 0.1289 | 0.2121 |
Echinococcus granulosus | acetylcholinesterase | 0.0129 | 0.2886 | 0.6138 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0208 | 0.0154 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0142 | 0.3213 | 0.6289 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0734 | 0.156 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0238 | 0.1904 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.0238 | 0.0037 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0238 | 0.1904 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0161 | 0.3677 | 0.681 |
Schistosoma mansoni | hypothetical protein | 0.0202 | 0.4702 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0129 | 0.2886 | 0.6138 |
Plasmodium falciparum | flap endonuclease 1 | 0.0031 | 0.0438 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0022 | 0.0208 | 0.0154 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0342 | 0.8175 | 1 |
Echinococcus multilocularis | geminin | 0.0202 | 0.4702 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0053 | 0.0995 | 1 |
Entamoeba histolytica | Rad52/22 family double-strand break repair protein, putative | 0.0118 | 0.2605 | 0.2425 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0031 | 0.0438 | 0.0288 |
Mycobacterium ulcerans | carbon monoxide dehydrogenase | 0.0226 | 0.5302 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.1146 | 0.2068 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1024 | 0.2178 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.0238 | 0.0505 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1024 | 0.2178 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase small chain CoxS | 0.0065 | 0.1289 | 0.2121 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1024 | 0.2178 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0133 | 0.0283 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0734 | 0.0508 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0148 | 0.003 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0022 | 0.0208 | 0.0443 |
Brugia malayi | Carboxylesterase family protein | 0.0129 | 0.2886 | 0.562 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0133 | 0.0283 |
Echinococcus granulosus | carboxylesterase 5A | 0.0129 | 0.2886 | 0.6138 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0031 | 0.0438 | 0.1335 |
Brugia malayi | hypothetical protein | 0.0022 | 0.0208 | 0.0154 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0238 | 0.1904 |
Loa Loa (eye worm) | carboxylesterase | 0.0129 | 0.2886 | 0.562 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.0238 | 0.0085 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0053 | 0.0995 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.0208 | 0.0154 |
Schistosoma mansoni | gliotactin | 0.0022 | 0.0208 | 0.0443 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0238 | 0.1904 |
Brugia malayi | Carboxylesterase family protein | 0.0129 | 0.2886 | 0.562 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (small chain) | 0.0065 | 0.1289 | 0.3115 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.0238 | 0.0505 |
Echinococcus granulosus | flap endonuclease 1 | 0.0031 | 0.0438 | 0.0932 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0031 | 0.0438 | 0.4047 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0133 | 0.0283 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.0599 | 0.4775 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0734 | 0.156 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.0238 | 0.0214 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0208 | 0.0154 |
Echinococcus multilocularis | dna polymerase eta | 0.0053 | 0.0995 | 0.2116 |
Schistosoma mansoni | hypothetical protein | 0.0202 | 0.4702 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0734 | 0.156 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0238 | 0.1904 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0.0413 | 0.3781 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0129 | 0.2886 | 0.562 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.0238 | 0.1904 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0208 | 0.0154 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.0238 | 0.0505 |
Echinococcus granulosus | geminin | 0.0202 | 0.4702 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0215 | 0.5031 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0215 | 0.5031 | 1 |
Trichomonas vaginalis | xanthine dehydrogenase, putative | 0.0342 | 0.8175 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1024 | 0.1819 |
Schistosoma mansoni | acetylcholinesterase | 0.0022 | 0.0208 | 0.0443 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxM_2 | 0.0115 | 0.2537 | 0.4573 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0129 | 0.2886 | 0.6138 |
Echinococcus granulosus | neuroligin | 0.0022 | 0.0208 | 0.0443 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.0238 | 0.0037 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0133 | 0.0283 |
Echinococcus multilocularis | acetylcholinesterase | 0.0129 | 0.2886 | 0.6138 |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.0208 | 0.0154 |
Mycobacterium tuberculosis | Probable carbon monoxyde dehydrogenase (medium chain) | 0.0115 | 0.2537 | 0.6715 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1024 | 0.2178 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0053 | 0.0995 | 0.176 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0238 | 0.1904 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.2886 | 0.562 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0413 | 0.2319 |
Mycobacterium ulcerans | aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 | 0.0161 | 0.3677 | 0.681 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0022 | 0.0208 | 0.0443 |
Echinococcus granulosus | dna polymerase eta | 0.0053 | 0.0995 | 0.2116 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0022 | 0.0208 | 0.0443 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0031 | 0.0438 | 0.0932 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0022 | 0.0208 | 0.0443 |
Loa Loa (eye worm) | carboxylesterase | 0.0022 | 0.0208 | 0.0154 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.0238 | 0.0505 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.0599 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0677 | 0.1111 |
Brugia malayi | Carboxylesterase family protein | 0.0022 | 0.0208 | 0.0154 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.2886 | 0.562 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0238 | 0.1904 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.1146 | 0.2068 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0238 | 0.1904 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.1146 | 0.2068 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0734 | 0.156 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0031 | 0.0438 | 0.0205 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.0238 | 0.0214 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.0238 | 0.0085 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.0238 | 0.0505 |
Treponema pallidum | hypothetical protein | 0.0056 | 0.1047 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0995 | 0.176 |
Trichomonas vaginalis | aldehyde oxidase, putative | 0.0342 | 0.8175 | 1 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0413 | 0.2319 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0022 | 0.0208 | 0.0443 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0238 | 0.0058 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0208 | 0.0154 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0238 | 0.0058 |
Schistosoma mansoni | flap endonuclease-1 | 0.0028 | 0.0364 | 0.0774 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0031 | 0.0438 | 0.0623 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0238 | 0.1904 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0413 | 0.0573 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0.0413 | 0.2319 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.0238 | 0.0505 |
Brugia malayi | MH2 domain containing protein | 0.0142 | 0.3213 | 0.6289 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0734 | 0.0508 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0142 | 0.3213 | 0.6289 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0133 | 0.0283 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0734 | 0.0508 |
Giardia lamblia | DNA repair protein RAD52 | 0.0415 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0677 | 0.1111 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0022 | 0.0208 | 0.0443 |
Entamoeba histolytica | Flap nuclease, putative | 0.0031 | 0.0438 | 0.0205 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0208 | 0.0154 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase medium chain CoxM | 0.0115 | 0.2537 | 0.4573 |
Mycobacterium ulcerans | hypothetical protein | 0.0056 | 0.1047 | 0.1647 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0022 | 0.0208 | 0.0443 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0022 | 0.0208 | 0.0443 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0031 | 0.0438 | 0.2647 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0238 | 0.1904 |
Entamoeba histolytica | hypothetical protein | 0.0118 | 0.2605 | 0.2425 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0238 | 0.1904 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0022 | 0.0208 | 0.0443 |
Brugia malayi | Flap endonuclease-1 | 0.0031 | 0.0438 | 0.0623 |
Brugia malayi | hypothetical protein | 0.003 | 0.0413 | 0.0573 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0022 | 0.0208 | 0.0443 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1024 | 0.2178 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1024 | 0.1819 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0208 | 0.0154 |
Mycobacterium ulcerans | carbon monoxyde dehydrogenase large chain CoxL | 0.0101 | 0.2187 | 0.3884 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0238 | 0.1904 |
Brugia malayi | N-terminal motif family protein | 0.0215 | 0.5031 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0133 | 0.0283 |
Echinococcus multilocularis | neuroligin | 0.0022 | 0.0208 | 0.0443 |
Treponema pallidum | quinoline 2-oxidoreductase | 0.0054 | 0.1015 | 0.8682 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.06 ug ml-1 | Antibacterial activity against Streptococcus pneumoniae OC9132 | ChEMBL. | 16289812 |
MIC (functional) | = 0.06 ug ml-1 | Antibacterial activity against Mef(A) efflux pump containing Streptococcus pneumoniae OC4438 | ChEMBL. | 16289812 |
MIC (functional) | = 0.12 ug ml-1 | Antibacterial activity against erm(B) ribosomal methylase gene containing Streptococcus pneumoniae OC4051 | ChEMBL. | 16289812 |
MIC (functional) | = 0.5 ug ml-1 | Antibacterial activity against Staphylococcus aureus OC4172 | ChEMBL. | 16289812 |
MIC (functional) | = 2 ug ml-1 | Antibacterial activity against Haemophilus influenzae OC4882 | ChEMBL. | 16289812 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.