Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 5 | Starlite/ChEMBL | References |
Homo sapiens | glutamate receptor, metabotropic 5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidasin homolog | 0.0039 | 0 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0039 | 0 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0098 | 0.3306 | 0.7221 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0098 | 0.3306 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0111 | 0.4061 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0082 | 0.2412 | 0.5269 |
Onchocerca volvulus | 0.0039 | 0 | 0.5 | |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.012 | 0.4578 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0217 | 1 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0039 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.4578 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0039 | 0 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0082 | 0.2412 | 0.5269 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0048 | 0.0484 | 0.1192 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0082 | 0.2412 | 0.5941 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0048 | 0.0484 | 0.1464 |
Onchocerca volvulus | 0.0039 | 0 | 0.5 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0039 | 0 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0217 | 1 | 0.5 |
Onchocerca volvulus | 0.0039 | 0 | 0.5 | |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0217 | 1 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0039 | 0 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0217 | 1 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.012 | 0.4578 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0217 | 1 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0217 | 1 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0217 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0217 | 1 | 0.5 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0089 | 0.2788 | 0.8434 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.26 uM | Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR | ChEMBL. | 16380255 |
IC50 (functional) | = 0.26 uM | Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPR | ChEMBL. | 16380255 |
IC50 (binding) | = 1.2 uM | Displacement of [3H]MPEP from mGluR5d in rat brain membrane | ChEMBL. | 16380255 |
IC50 (binding) | = 1.2 uM | Displacement of [3H]MPEP from mGluR5d in rat brain membrane | ChEMBL. | 16380255 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.