Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | potassium voltage-gated channel, shaker-related subfamily, member 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel | potassium voltage-gated channel, shaker-related subfamily, member 3 | 528 aa | 448 aa | 36.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.1068 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0181 | 0.084 | 0.0797 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0181 | 0.084 | 0.0797 |
Onchocerca volvulus | 0.0181 | 0.084 | 0.5 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0181 | 0.084 | 0.0797 |
Brugia malayi | Carboxylesterase family protein | 0.0181 | 0.084 | 0.0797 |
Loa Loa (eye worm) | hypothetical protein | 0.1068 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1068 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1068 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1068 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1068 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1068 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.084 | 0.0797 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0104 | 0.0047 | 0.0047 |
Schistosoma mansoni | gliotactin | 0.0181 | 0.084 | 0.0797 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.084 | 0.0797 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1068 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0181 | 0.084 | 0.084 |
Onchocerca volvulus | 0.0181 | 0.084 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.1068 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1068 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0181 | 0.084 | 0.084 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0181 | 0.084 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1068 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0181 | 0.084 | 0.0797 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0181 | 0.084 | 0.0797 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.084 | 0.0797 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0181 | 0.084 | 0.084 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0181 | 0.084 | 0.0797 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0181 | 0.084 | 0.5 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0181 | 0.084 | 0.0797 |
Onchocerca volvulus | 0.0181 | 0.084 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.084 | 0.0797 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0181 | 0.084 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0181 | 0.084 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0181 | 0.084 | 0.0797 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.084 | 0.0797 |
Brugia malayi | Carboxylesterase family protein | 0.1068 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.084 | 0.0797 |
Loa Loa (eye worm) | carboxylesterase | 0.0181 | 0.084 | 0.0797 |
Brugia malayi | Carboxylesterase family protein | 0.0181 | 0.084 | 0.0797 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0181 | 0.084 | 0.5 |
Brugia malayi | hypothetical protein | 0.0181 | 0.084 | 0.0797 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0181 | 0.084 | 0.5 |
Schistosoma mansoni | acetylcholinesterase | 0.0181 | 0.084 | 0.0797 |
Echinococcus granulosus | neuroligin | 0.0181 | 0.084 | 0.0797 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0181 | 0.084 | 0.084 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.084 | 0.0797 |
Brugia malayi | Carboxylesterase family protein | 0.0181 | 0.084 | 0.0797 |
Onchocerca volvulus | 0.0181 | 0.084 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0185 | 0.0886 | 0.0844 |
Onchocerca volvulus | 0.0181 | 0.084 | 0.5 | |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0181 | 0.084 | 0.0797 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.