Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0276 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0276 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0276 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0276 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0276 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0276 | 0.5 | 0.5 | |
Onchocerca volvulus | Peroxidase homolog | 0.0276 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0276 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0276 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0276 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0276 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0276 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0276 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0276 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0276 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0276 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0276 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0276 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0276 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0276 | 0.5 | 0.5 | |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0276 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0276 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0276 | 0.5 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.0276 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0276 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 7.8 | Agonist activity at delta opioid receptor in mouse vas deferens | ChEMBL. | 16290934 |
Log D | = 1.3 | Distribution coefficient of the compound, log D at pH 7.4 | ChEMBL. | 16290934 |
Log IC50 (functional) | Agonist activity at kappa opioid receptor in myentric plexus muscle from guinea pig | ChEMBL. | 16290934 | |
Log IC50 (functional) | Agonist activity at mu opioid receptor in myentric plexus muscle from guinea pig | ChEMBL. | 16290934 | |
Log IC50 (functional) | 0 | Agonist activity at mu opioid receptor in myentric plexus muscle from guinea pig | ChEMBL. | 16290934 |
Log IC50 (functional) | 0 | Agonist activity at kappa opioid receptor in myentric plexus muscle from guinea pig | ChEMBL. | 16290934 |
Log IC50 (functional) | = 7.8 | Agonist activity at delta opioid receptor in mouse vas deferens | ChEMBL. | 16290934 |
permeability (ADMET) | 0 | Permeability from apical to basolateral side of the Caco2 cell membrane | ChEMBL. | 16290934 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.