TDR Targets

Basic information

Technical information

TDR Targets ID: 354284
Name: N-[4-[[(2S)-4-(dimethylamino)-1-phenylsulfany lbutan-2-yl]amino]-3-nitrophenyl]sulfonyl-4-[ 2-methoxy-4-(3-morpholin-4-ylpropyl)phenyl]be nzamide
MW: 761.95 | Formula: C39H47N5O7S2
H donors: 2 H acceptors: 5 LogP: 7.24 Rotable bonds: 19
Rule of 5 violations (Lipinski): 2
SMILES: COc1cc(CCCN2CCOCC2)ccc1c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(c(c1)[N+](=O)[O-])N[C@H](CSc1ccccc1)CCN(C)C
InChi: 1S/C39H47N5O7S2/c1-42(2)21-19-32(28-52-33-9-5-4-6-10-33)40-36-18-16-34(27-37(36)44(46)47)53(48,49)41-39(45)31-14-12-30(13-15-31)35-17-11-29(26-38(35)50-3)8-7-20-43-22-24-51-25-23-43/h4-6,9-18,26-27,32,40H,7-8,19-25,28H2,1-3H3,(H,41,45)/t32-/m0/s1
InChiKey: ODNXRXAXPHKAQQ-YTTGMZPUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[4-[[(1S)-3-(dimethylamino)-1-(phenylsulfanylmethyl)propyl]amino]-3-nitro-phenyl]sulfonyl-4-[2-methoxy-4-(3-morpholinopropyl)phenyl]benzamide
N-[4-[[(1S)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl-4-[2-methoxy-4-(3-morpholinopropyl)phenyl]benzamide
N-[4-[[(2S)-4-(dimethylamino)-1-phenylsulfanyl-butan-2-yl]amino]-3-nitro-phenyl]sulfonyl-4-[2-methoxy-4-(3-morpholin-4-ylpropyl)phenyl]benzamide
N-[4-[[(1S)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitro-phenyl]sulfonyl-4-[2-methoxy-4-(3-morpholinopropyl)phenyl]benzamide
N-[4-[[(2S)-4-dimethylamino-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonyl-4-[2-methoxy-4-(3-morpholin-4-ylpropyl)phenyl]benzamide
N-[4-[[(1S)-3-dimethylamino-1-(phenylsulfanylmethyl)propyl]amino]-3-nitro-phenyl]sulfonyl-4-[2-methoxy-4-(3-morpholinopropyl)phenyl]benzamide
N-[4-[[(1S)-3-dimethylamino-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl-4-[2-methoxy-4-(3-morpholinopropyl)phenyl]benzamide
N-[4-[[(1S)-3-dimethylamino-1-[(phenylthio)methyl]propyl]amino]-3-nitro-phenyl]sulfonyl-4-[2-methoxy-4-(3-morpholinopropyl)phenyl]benzamide
N-[4-[[(2S)-4-dimethylamino-1-phenylsulfanyl-butan-2-yl]amino]-3-nitro-phenyl]sulfonyl-4-[2-methoxy-4-(3-morpholin-4-ylpropyl)phenyl]benzamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	BCL2-like 1	Starlite/ChEMBL	References
Homo sapiens	B-cell CLL/lymphoma 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	Get druggable targets OG5_139665	All targets in OG5_139665
Echinococcus granulosus	EGFP:Bcl2 fusion protein	Get druggable targets OG5_139665	All targets in OG5_139665

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	endonuclease IV APN	0.0087	0.0457	0.0409
Brugia malayi	6-phosphofructokinase	0.0109	0.0619	0.2062
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.0003	0.0003
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.005	0.0198	0.0658
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0051	0.015
Brugia malayi	hypothetical protein	0.0043	0.0146	0.0487
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0051	0.015
Brugia malayi	hypothetical protein	0.0238	0.1534	0.5106
Onchocerca volvulus		0.0154	0.0939	0.273
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0186	0.0621
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0035	0.0089	0.0154
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0545	0.3718	1
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0093	0.0503	0.1673
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0093	0.0503	0.1673
Onchocerca volvulus		0.0154	0.0939	0.273
Trypanosoma cruzi	2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative	0.0113	0.0644	0.1618
Loa Loa (eye worm)	ACC-1 protein	0.0093	0.0503	0.1673
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.005	0.0198	0.0658
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0093	0.0503	0.1673
Onchocerca volvulus		0.0154	0.0939	0.273
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0122	0.0708	0.0705
Brugia malayi	neuropeptide F receptor	0.0154	0.0939	0.3127
Mycobacterium ulcerans	6-phosphofructokinase	0.0109	0.0619	0.0619
Onchocerca volvulus		0.005	0.0198	0.0574
Brugia malayi	chromobox protein homolog 3	0.0044	0.0155	0.0517
Echinococcus granulosus	acetylcholinesterase	0.0132	0.0781	0.1351
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Schistosoma mansoni	amine GPCR	0.0154	0.0939	0.8019
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0154	0.0939	0.8019
Onchocerca volvulus		0.0043	0.0146	0.0425
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0093	0.0503	0.087
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0154	0.0939	0.1625
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0292	0.2489
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0044	0.0155	0.0451
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0047	0.0179	0.052
Loa Loa (eye worm)	hypothetical protein	0.0238	0.1534	0.5106
Brugia malayi	Calcitonin receptor-like protein seb-1	0.011	0.0624	0.2077
Entamoeba histolytica	phosphofructokinase, putative	0.0109	0.0619	0.9582
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.069	0.2297
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0043	0.0146	0.0253
Brugia malayi	excitatory GABA receptor EXP-1A	0.0093	0.0503	0.1673
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.0619	0.18
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.005	0.0198	0.0658
Plasmodium vivax	6-phosphofructokinase, putative	0.003	0.0051	0.0001
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0067	0.0315	0.105
Brugia malayi	RNA binding protein	0.0063	0.0292	0.0971
Entamoeba histolytica	phosphofructokinase, putative	0.0109	0.0619	0.9582
Echinococcus granulosus	g-protein coupled receptor	0.0154	0.0939	0.1625
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0154	0.0939	0.8019
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0067	0.0315	0.0546
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0043	0.0146	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Echinococcus multilocularis	g protein coupled receptor	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0457	0.1523
Brugia malayi	TAR-binding protein	0.0063	0.0292	0.0971
Loa Loa (eye worm)	G-protein coupled receptor	0.0154	0.0939	0.3127
Schistosoma mansoni	amine GPCR	0.0154	0.0939	0.8019
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0093	0.0503	0.1673
Onchocerca volvulus		0.0093	0.0503	0.1461
Trichomonas vaginalis	6-phosphofructokinase, putative	0.003	0.0051	0.015
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0487
Brugia malayi	Dopamine receptor protein 1	0.0154	0.0939	0.3127
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0154	0.0939	0.1625
Schistosoma mansoni	hypothetical protein	0.0067	0.0315	0.2693
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0154	0.0939	0.1625
Brugia malayi	AKH receptor	0.0154	0.0939	0.3127
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0487
Echinococcus granulosus	g protein coupled receptor	0.0154	0.0939	0.1625
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0035	0.0089	0.0154
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	0.1428	1	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0487
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0116	0.0664	0.5674
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0154	0.0939	0.8019
Schistosoma mansoni	nAChR subunit	0.0093	0.0503	0.4291
Entamoeba histolytica	hypothetical protein	0.005	0.0198	0.2476
Echinococcus granulosus	hypothetical protein	0.0154	0.0939	0.1625
Toxoplasma gondii	hypothetical protein	0.1428	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0154	0.0939	0.1625
Schistosoma mansoni	amine GPCR	0.0154	0.0939	0.8019
Echinococcus multilocularis	nAChR subunit	0.0093	0.0503	0.087
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0051	0.015
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0093	0.0503	0.087
Echinococcus granulosus	GPCR family 2	0.0035	0.0089	0.0154
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.003	0.0051	0.0001
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0154	0.0939	0.1625
Onchocerca volvulus	Putative nachr subunit	0.0093	0.0503	0.1461
Echinococcus granulosus	7TM GPCR rhodopsin	0.0154	0.0939	0.1625
Onchocerca volvulus		0.0506	0.344	1
Echinococcus granulosus	g protein coupled receptor	0.0154	0.0939	0.1625
Chlamydia trachomatis	endonuclease IV	0.0087	0.0457	0.0408
Brugia malayi	Cation transporter family protein	0.0093	0.0503	0.1673
Schistosoma mansoni	nAChR subunit	0.0093	0.0503	0.4291
Plasmodium vivax	peptide deformylase, putative	0.1428	1	1
Onchocerca volvulus		0.0154	0.0939	0.273
Loa Loa (eye worm)	hypothetical protein	0.005	0.0198	0.0658
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Echinococcus granulosus	histone lysine methyltransferase setb	0.0064	0.0295	0.051
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0109	0.0619	0.0619
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0154	0.0939	0.3127
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0487
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0064	0.0295	0.2518
Echinococcus multilocularis	fmrfamide receptor	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Onchocerca volvulus		0.0154	0.0939	0.273
Echinococcus multilocularis	neuropeptides capa receptor	0.0154	0.0939	0.1625
Echinococcus granulosus	chromobox protein 1	0.0079	0.0401	0.0694
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0093	0.0503	0.087
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0154	0.0939	0.8019
Schistosoma mansoni	neuropeptide F-like receptor	0.0154	0.0939	0.8019
Leishmania major	polypeptide deformylase-like protein, putative	0.0545	0.3718	1
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0093	0.0503	0.087
Onchocerca volvulus		0.0043	0.0146	0.0425
Schistosoma mansoni	biogenic amine receptor	0.0154	0.0939	0.8019
Echinococcus granulosus	rhodopsin orphan GPCR	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Brugia malayi	GnHR receptor homolog	0.0154	0.0939	0.3127
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0503	0.1673
Loa Loa (eye worm)	carboxylesterase	0.0132	0.0781	0.2599
Plasmodium falciparum	thioredoxin reductase	0.0053	0.0221	0.0172
Brugia malayi	G-protein coupled receptor	0.0154	0.0939	0.3127
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0292	0.2489
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0295	0.0982
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0503	0.1673
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	0.1428	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0151	0.0915	0.7812
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0154	0.0939	0.8019
Schistosoma mansoni	biogenic amine receptor	0.0154	0.0939	0.8019
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0093	0.0503	0.1673
Schistosoma mansoni	nAChR subunit	0.0093	0.0503	0.4291
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0315	0.105
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0487
Schistosoma mansoni	hypothetical protein	0.0075	0.0376	0.3212
Loa Loa (eye worm)	phosphofructokinase	0.0109	0.0619	0.2062
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0051	0.015
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0089	0.0296
Loa Loa (eye worm)	hypothetical protein	0.005	0.0198	0.0658
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0503	0.1673
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0503	0.1673
Loa Loa (eye worm)	apoptosis regulator protein	0.0067	0.0315	0.105
Trypanosoma cruzi	trypanothione reductase, putative	0.0053	0.0221	0.0466
Schistosoma mansoni	hypothetical protein	0.0035	0.0089	0.0759
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0077	0.039	0.3332
Loa Loa (eye worm)	hypothetical protein	0.005	0.0198	0.0658
Schistosoma mansoni	nAChR subunit	0.0093	0.0503	0.4291
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Trichomonas vaginalis	chromobox protein, putative	0.0079	0.0401	0.1166
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0093	0.0503	0.1673
Brugia malayi	hypothetical protein	0.0154	0.0939	0.3127
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0077	0.0386	0.33
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0154	0.0939	0.3127
Brugia malayi	glutathione reductase	0.0053	0.0221	0.0737
Echinococcus multilocularis	glycine receptor subunit beta	0.0093	0.0503	0.087
Brugia malayi	Melibiase family protein	0.0077	0.039	0.1299
Echinococcus granulosus	carboxylesterase 5A	0.0132	0.0781	0.1351
Schistosoma mansoni	nAChR subunit	0.0043	0.0146	0.1249
Echinococcus granulosus	neuropeptide Y receptor	0.0154	0.0939	0.1625
Brugia malayi	hypothetical protein	0.0154	0.0939	0.3127
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.005	0.0198	0.1687
Loa Loa (eye worm)	heterochromatin protein 1	0.0079	0.0401	0.1336
Brugia malayi	Serotonin receptor	0.0154	0.0939	0.3127
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0487
Brugia malayi	Hypothetical 29.7 kDa protein C05D11.5 in chromosome III	0.0023	0.0003	0.0011
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0093	0.0503	0.1673
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0154	0.0939	0.1625
Echinococcus granulosus	neuropeptides capa receptor	0.0154	0.0939	0.1625
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0154	0.0939	0.8019
Schistosoma mansoni	neuropeptide receptor	0.0154	0.0939	0.8019
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0109	0.0619	0.1551
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0154	0.0939	0.8019
Mycobacterium ulcerans	endonuclease IV	0.0087	0.0457	0.0457
Loa Loa (eye worm)	LGC-31 protein	0.0093	0.0503	0.1673
Schistosoma mansoni	hypothetical protein	0.0187	0.1171	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0154	0.0939	0.8019
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0154	0.0939	0.8019
Onchocerca volvulus		0.0035	0.0087	0.0254
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0035	0.0089	0.0296
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0043	0.0146	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0487
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	0.1428	1	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0064	0.0295	0.0246
Trichomonas vaginalis	set domain proteins, putative	0.0506	0.344	1
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Echinococcus granulosus	glycine receptor subunit beta	0.0093	0.0503	0.087
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0093	0.0503	0.4291
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0545	0.3718	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0154	0.0939	0.1625
Echinococcus multilocularis	neuropeptide receptor	0.0154	0.0939	0.1625
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0093	0.0503	0.4291
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0503	0.1673
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0035	0.0089	0.0154
Trypanosoma brucei	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	0.0113	0.0644	0.1618
Mycobacterium tuberculosis	Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase)	0.0087	0.0457	0.0457
Loa Loa (eye worm)	hypothetical protein	0.005	0.0198	0.0658
Schistosoma mansoni	nAChR subunit	0.0043	0.0146	0.1249
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0093	0.0503	0.1673
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0093	0.0503	0.1673
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0093	0.0503	0.1673
Schistosoma mansoni	hypothetical protein	0.0154	0.0939	0.8019
Onchocerca volvulus	Putative hydroxypyruvate isomerase	0.0023	0.0003	0.001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Trichomonas vaginalis	2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative	0.0113	0.0644	0.1872
Schistosoma mansoni	hypothetical protein	0.0049	0.0186	0.1592
Brugia malayi	putative neuropeptide receptor NPR1	0.0154	0.0939	0.3127
Onchocerca volvulus		0.0093	0.0503	0.1461
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0043	0.0146	0.0487
Echinococcus granulosus	neuropeptide receptor A26	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Onchocerca volvulus		0.0154	0.0939	0.273
Echinococcus granulosus	glycine receptor subunit beta	0.0093	0.0503	0.087
Loa Loa (eye worm)	acetylcholine receptor protein	0.0043	0.0146	0.0487
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0093	0.0503	0.087
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0154	0.0939	0.1625
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0292	0.0504
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0154	0.0939	0.273
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0154	0.0939	0.8019
Loa Loa (eye worm)	melatonin receptor type 1A	0.0154	0.0939	0.3127
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0122	0.0708	0.0708
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0043	0.0146	0.0487
Schistosoma mansoni	flap endonuclease-1	0.0027	0.003	0.026
Brugia malayi	Melatonin receptor type 1A	0.0154	0.0939	0.3127
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0155	0.0451
Loa Loa (eye worm)	hypothetical protein	0.005	0.0198	0.0658
Echinococcus multilocularis	serotonin receptor	0.0154	0.0939	0.1625
Schistosoma mansoni	6-phosphofructokinase	0.0109	0.0619	0.5287
Echinococcus multilocularis	neuropeptide Y receptor	0.0154	0.0939	0.1625
Onchocerca volvulus		0.0154	0.0939	0.273
Echinococcus multilocularis	acetylcholinesterase	0.0132	0.0781	0.1351
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0135	0.0805	0.0802
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0154	0.0939	0.8019
Echinococcus granulosus	survival motor neuron protein 1	0.0238	0.1534	0.2654
Schistosoma mansoni	opsin-like receptor	0.0154	0.0939	0.8019
Onchocerca volvulus		0.005	0.0198	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Loa Loa (eye worm)	hypothetical protein	0.005	0.0198	0.0658
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0154	0.0939	0.8019
Plasmodium vivax	6-phosphofructokinase, putative	0.003	0.0051	0.0001
Echinococcus multilocularis	orexin receptor type 2	0.0154	0.0939	0.1625
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0292	0.0504
Echinococcus multilocularis	6 phosphofructokinase	0.0109	0.0619	0.1071
Schistosoma mansoni	opsin-like receptor	0.0154	0.0939	0.8019
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0093	0.0503	0.087
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0093	0.0503	0.087
Schistosoma mansoni	hypothetical protein	0.0187	0.1171	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0154	0.0939	0.1625
Echinococcus multilocularis	chromobox protein 1	0.0079	0.0401	0.0694
Echinococcus multilocularis	g protein coupled receptor	0.0154	0.0939	0.1625
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0093	0.0503	0.087
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0154	0.0939	0.8019
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0093	0.0503	0.087
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0154	0.0939	0.3127
Brugia malayi	hypothetical protein	0.0043	0.0146	0.0487
Brugia malayi	Cation transporter family protein	0.0093	0.0503	0.1673
Brugia malayi	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	0.0069	0.0333	0.1109
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0545	0.3718	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0503	0.1673
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0064	0.0295	0.2518
Toxoplasma gondii	melibiase subfamily protein	0.0116	0.0664	0.0617
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0093	0.0503	0.1673
Schistosoma mansoni	hypothetical protein	0.0154	0.0939	0.8019
Plasmodium vivax	apurinic/apyrimidinic endonuclease Apn1, putative	0.0087	0.0457	0.0409
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0093	0.0503	0.087
Brugia malayi	G-protein coupled receptor	0.0154	0.0939	0.3127
Brugia malayi	Flap endonuclease-1	0.0029	0.0051	0.0168
Echinococcus granulosus	acetylcholinesterase	0.0132	0.0781	0.1351
Echinococcus multilocularis	carboxylesterase 5A	0.0132	0.0781	0.1351
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Echinococcus granulosus	g protein coupled receptor	0.0154	0.0939	0.1625
Giardia lamblia	Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit	0.003	0.0051	0.0015
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0154	0.0939	0.8019
Mycobacterium tuberculosis	Probable oxidoreductase	0.0135	0.0805	0.0805
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0093	0.0503	0.087
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0154	0.0939	0.3127
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0043	0.0146	0.0487
Schistosoma mansoni	hypothetical protein	0.0154	0.0939	0.8019
Brugia malayi	hypothetical protein	0.0154	0.0939	0.3127
Loa Loa (eye worm)	6-phosphofructokinase	0.0109	0.0619	0.2062
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0154	0.0939	0.273
Plasmodium vivax	SET domain protein, putative	0.0064	0.0295	0.0246
Echinococcus granulosus	tm gpcr rhodopsin	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0154	0.0939	0.1625
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.011	0.0624	0.2077
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0154	0.0939	0.1625
Trypanosoma brucei	Polypeptide deformylase 1	0.0545	0.3718	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0154	0.0939	0.1625
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0151	0.0915	0.1583
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0093	0.0503	0.4291
Echinococcus granulosus	neuropeptide s receptor	0.0154	0.0939	0.1625
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0116	0.0664	0.5674
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0154	0.0939	0.3127
Schistosoma mansoni	biogenic amine receptor	0.0154	0.0939	0.8019
Brugia malayi	Carboxylesterase family protein	0.0132	0.0781	0.2599
Brugia malayi	follicle stimulating hormone receptor	0.0386	0.2585	0.8608
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0781	0.2599
Brugia malayi	G protein-coupled receptor F59B2.13	0.0154	0.0939	0.3127
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0186	0.1592
Onchocerca volvulus		0.0093	0.0503	0.1461
Brugia malayi	larval opioid receptor	0.0154	0.0939	0.3127
Schistosoma mansoni	histamine h1 receptor	0.0154	0.0939	0.8019
Brugia malayi	hypothetical protein	0.0154	0.0939	0.3127
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Echinococcus multilocularis	flap endonuclease 1	0.0029	0.0051	0.0088
Schistosoma mansoni	adenoreceptor	0.0154	0.0939	0.8019
Brugia malayi	hypothetical protein	0.0043	0.0146	0.0487
Echinococcus multilocularis	survival motor neuron protein 1	0.0238	0.1534	0.2654
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0093	0.0503	0.087
Brugia malayi	Dopamine receptor	0.0154	0.0939	0.3127
Leishmania major	ATP-dependent phosphofructokinase	0.0109	0.0619	0.1551
Schistosoma mansoni	opsin-like receptor	0.0154	0.0939	0.8019
Brugia malayi	hypothetical protein	0.0154	0.0939	0.3127
Brugia malayi	Serotonin receptor	0.0154	0.0939	0.3127
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0154	0.0939	0.8019
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.0619	0.18
Brugia malayi	Cation transporter family protein	0.0093	0.0503	0.1673
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0154	0.0939	0.8019
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0154	0.0939	0.8019
Loa Loa (eye worm)	hypothetical protein	0.005	0.0198	0.0658
Echinococcus multilocularis	chromobox protein 1	0.0079	0.0401	0.0694
Schistosoma mansoni	hypothetical protein	0.0154	0.0939	0.8019
Echinococcus multilocularis	glycine receptor subunit beta	0.0093	0.0503	0.087
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0154	0.0939	0.3127
Echinococcus granulosus	nAChR subunit	0.005	0.0198	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0503	0.1673
Mycobacterium tuberculosis	Probable dehydrogenase	0.0122	0.0708	0.0708
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0292	0.0971
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0503	0.1673
Schistosoma mansoni	myosin xvIII	0.0154	0.0939	0.8019
Trypanosoma brucei	Peptide deformylase 2	0.0545	0.3718	1
Loa Loa (eye worm)	hypothetical protein	0.0319	0.2112	0.7031
Loa Loa (eye worm)	neuropeptide F receptor	0.0154	0.0939	0.3127
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0154	0.0939	0.1625
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0093	0.0503	0.087
Echinococcus granulosus	geminin	0.0187	0.1171	0.2026
Brugia malayi	Thioredoxin reductase	0.0053	0.0221	0.0737
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.0619	0.18
Loa Loa (eye worm)	hypothetical protein	0.0077	0.039	0.1299
Brugia malayi	sulfakinin receptor protein	0.0154	0.0939	0.3127
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0503	0.1673
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0155	0.0517
Trichomonas vaginalis	conserved hypothetical protein	0.0044	0.0155	0.0451
Echinococcus granulosus	neuropeptide Y receptor	0.0154	0.0939	0.1625
Echinococcus multilocularis	acetylcholinesterase	0.0132	0.0781	0.1351
Brugia malayi	hypothetical protein	0.0154	0.0939	0.3127
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0109	0.0619	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0487
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0064	0.0295	0.2518
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0154	0.0939	0.8019
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0151	0.0915	0.3046
Echinococcus multilocularis	neuropeptides capa receptor	0.0154	0.0939	0.1625
Echinococcus granulosus	fmrfamide receptor	0.0154	0.0939	0.1625
Brugia malayi	MH2 domain containing protein	0.0119	0.069	0.2297
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0035	0.0089	0.0296
Onchocerca volvulus		0.0093	0.0503	0.1461
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0503	0.1673
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0154	0.0939	0.3127
Brugia malayi	phosphofructokinase	0.0109	0.0619	0.2062
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0154	0.0939	0.1625
Onchocerca volvulus		0.0154	0.0939	0.273
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0067	0.0315	0.0546
Loa Loa (eye worm)	hypothetical protein	0.005	0.0198	0.0658
Echinococcus granulosus	neuropeptides capa receptor	0.0154	0.0939	0.1625
Toxoplasma gondii	phosphofructokinase PFKII	0.003	0.0051	0.0001
Echinococcus granulosus	somatostatin receptor	0.0154	0.0939	0.1625
Echinococcus multilocularis	fmrfamide receptor	0.0154	0.0939	0.1625
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0051	0.015
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0781	0.2599
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0487
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0093	0.0503	0.087
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0445	0.3003	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0154	0.0939	0.1625
Loa Loa (eye worm)	neuropeptide F receptor	0.0154	0.0939	0.3127
Entamoeba histolytica	2,3-bisphosphoglycerate-independent phosphoglycerate mutase, putative	0.0113	0.0644	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0043	0.0146	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0487
Trichomonas vaginalis	phosphofructokinase, putative	0.003	0.0051	0.015
Echinococcus multilocularis	G protein coupled receptor 139	0.0154	0.0939	0.1625
Onchocerca volvulus		0.0154	0.0939	0.273
Schistosoma mansoni	neurotransmitter gated ion channel	0.0043	0.0146	0.1249
Loa Loa (eye worm)	thioredoxin reductase	0.0053	0.0221	0.0737
Leishmania major	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	0.0113	0.0644	0.1618
Onchocerca volvulus		0.0093	0.0503	0.1461
Echinococcus granulosus	rhodopsin orphan GPCR	0.0154	0.0939	0.1625
Onchocerca volvulus		0.0154	0.0939	0.273
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Echinococcus granulosus	neuropeptide receptor	0.0154	0.0939	0.1625
Schistosoma mansoni	chromobox protein	0.0079	0.0401	0.3426
Brugia malayi	Pre-SET motif family protein	0.0064	0.0295	0.0982
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0109	0.0619	0.1551
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0292	0.2489
Echinococcus granulosus	rhodopsin orphan GPCR	0.0154	0.0939	0.1625
Schistosoma mansoni	neuropeptide receptor	0.0154	0.0939	0.8019
Toxoplasma gondii	thioredoxin reductase	0.0053	0.0221	0.0172
Plasmodium vivax	glutathione reductase, putative	0.0053	0.0221	0.0172
Echinococcus granulosus	allatostatin A receptor	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0503	0.1673
Echinococcus multilocularis	somatostatin receptor	0.0154	0.0939	0.1625
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.069	0.2297
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Echinococcus granulosus	sex peptide receptor	0.0154	0.0939	0.1625
Echinococcus granulosus	G protein coupled receptor 139	0.0154	0.0939	0.1625
Brugia malayi	neuropeptide F receptor	0.0154	0.0939	0.3127
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0093	0.0503	0.1673
Brugia malayi	ORL1-like opioid receptor	0.0154	0.0939	0.3127
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0135	0.0805	0.0805
Schistosoma mansoni	hypothetical protein	0.0067	0.0315	0.2693
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0154	0.0939	0.1625
Echinococcus granulosus	tm gpcr rhodopsin	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0503	0.1673
Mycobacterium ulcerans	epimerase	0.0023	0.0003	0.0003
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0154	0.0939	0.1625
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0292	0.2489
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0487
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0093	0.0503	0.1673
Echinococcus granulosus	6 phosphofructokinase	0.0109	0.0619	0.1071
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0151	0.0915	0.1583
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0154	0.0939	0.1625
Brugia malayi	hypothetical protein	0.0043	0.0146	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Trypanosoma brucei	trypanothione reductase	0.0053	0.0221	0.0466
Onchocerca volvulus		0.0154	0.0939	0.273
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0093	0.0503	0.087
Schistosoma mansoni	nAChR subunit	0.0093	0.0503	0.4291
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0093	0.0503	0.087
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0487
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0292	0.0971
Schistosoma mansoni	acetylcholine receptor-related	0.0043	0.0146	0.1249
Brugia malayi	hypothetical protein	0.0043	0.0146	0.0487
Brugia malayi	Heterochromatin protein 1	0.0079	0.0401	0.1336
Toxoplasma gondii	6-phosphofructokinase	0.003	0.0051	0.0001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0154	0.0939	0.1625
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0154	0.0939	0.1625
Schistosoma mansoni	chromobox protein	0.0079	0.0401	0.3426
Loa Loa (eye worm)	hypothetical protein	0.005	0.0198	0.0658
Echinococcus multilocularis	neuropeptide receptor A26	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Entamoeba histolytica	2,3-bisphosphoglycerate-independentphosphoglycerate mutase, putative	0.0062	0.0283	0.3924
Echinococcus multilocularis	neuropeptide receptor	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Echinococcus multilocularis	geminin	0.0187	0.1171	0.2026
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0835	0.578	1
Trichomonas vaginalis	chromobox protein, putative	0.0047	0.0179	0.052
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0154	0.0939	0.3127
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0064	0.0295	0.051
Echinococcus granulosus	thioredoxin glutathione reductase	0.0053	0.0221	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0503	0.1673
Mycobacterium leprae	PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE)	0.0087	0.0457	0.0454
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.003	0.0051	0.0001
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0035	0.0089	0.0154
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0151	0.0915	0.1583
Mycobacterium tuberculosis	Probable reductase	0.0122	0.0708	0.0708
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0386	0.2585	0.8608
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0067	0.0315	0.2693
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0043	0.0146	0.0487
Brugia malayi	G protein-coupled receptor	0.0154	0.0939	0.3127
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0154	0.0939	0.1625
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0093	0.0503	0.087
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0043	0.0146	0.0253
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.011	0.0624	0.2077
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0151	0.0915	0.1583
Brugia malayi	Dopamine receptor protein 2	0.0154	0.0939	0.3127
Loa Loa (eye worm)	TYRA-2 protein	0.0154	0.0939	0.3127
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0093	0.0503	0.1673
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0151	0.0915	0.7812
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0503	0.1673
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Loa Loa (eye worm)	hypothetical protein	0.011	0.0624	0.2077
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0064	0.0185
Brugia malayi	hypothetical protein	0.0154	0.0939	0.3127
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0154	0.0939	0.1625
Mycobacterium ulcerans	sugar phosphate isomerases/epimerases	0.0023	0.0003	0.0003
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0043	0.0146	0.0487
Brugia malayi	DNA-(Apurinic or apyrimidinic site) lyase	0.0087	0.0457	0.1523
Brugia malayi	hypothetical protein	0.0154	0.0939	0.3127
Echinococcus multilocularis	dro:myosuppressin receptor	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0376	0.1252
Echinococcus multilocularis	g protein coupled receptor	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0503	0.1673
Onchocerca volvulus		0.0077	0.0386	0.1123
Schistosoma mansoni	6-phosphofructokinase	0.0109	0.0619	0.5287
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0154	0.0939	0.1625
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0154	0.0939	0.1625
Schistosoma mansoni	apoptosis regulator bax	0.0067	0.0315	0.2693
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0064	0.0185
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0093	0.0503	0.1673
Brugia malayi	putative neuropeptide receptor	0.0154	0.0939	0.3127
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0503	0.1673
Brugia malayi	Latrophilin receptor protein 2	0.0035	0.0089	0.0296
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0077	0.039	0.1134
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0093	0.0503	0.4291
Echinococcus multilocularis	allatostatin A receptor	0.0154	0.0939	0.1625
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0116	0.0664	0.115
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0154	0.0939	0.8019
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0154	0.0939	0.3127
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0151	0.0915	0.3046
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0154	0.0939	0.1625
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0003	0.0003
Schistosoma mansoni	neuropeptide receptor	0.0154	0.0939	0.8019
Echinococcus granulosus	chromobox protein 1	0.0079	0.0401	0.0694
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0154	0.0939	0.8019
Echinococcus granulosus	neuropeptide receptor	0.0154	0.0939	0.1625
Loa Loa (eye worm)	independent phosphoglycerate mutase isoform 2	0.0113	0.0644	0.2144
Schistosoma mansoni	hypothetical protein	0.0067	0.0315	0.2693
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0093	0.0503	0.1673
Trichomonas vaginalis	flap endonuclease-1, putative	0.0029	0.0051	0.0147
Schistosoma mansoni	neuropeptide f receptor 76f	0.0154	0.0939	0.8019
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0487
Echinococcus multilocularis	neuropeptide Y receptor	0.0154	0.0939	0.1625
Loa Loa (eye worm)	flap endonuclease-1	0.0029	0.0051	0.0168
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0135	0.0805	0.0805
Onchocerca volvulus		0.0154	0.0939	0.273
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0093	0.0503	0.1673
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0122	0.0708	0.0708
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0487
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0053	0.0221	0.0383
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0292	0.0971
Schistosoma mansoni	neurotransmitter gated ion channel	0.005	0.0198	0.1687
Echinococcus multilocularis	nAChR subunit	0.005	0.0198	0.0342
Loa Loa (eye worm)	ACC-1 protein	0.0093	0.0503	0.1673
Schistosoma mansoni	neuropeptide receptor	0.0154	0.0939	0.8019
Brugia malayi	latrophilin 2 splice variant baaae	0.0075	0.0376	0.1252
Echinococcus granulosus	orexin receptor type 2	0.0154	0.0939	0.1625
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.003	0.0051	0.0001
Schistosoma mansoni	nAChR subunit	0.0093	0.0503	0.4291
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0154	0.0939	0.8019
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0093	0.0503	0.087
Onchocerca volvulus		0.0154	0.0939	0.273
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Echinococcus granulosus	nAChR subunit	0.0093	0.0503	0.087
Echinococcus granulosus	flap endonuclease 1	0.0029	0.0051	0.0088
Schistosoma mansoni	neurotransmitter gated ion channel	0.0043	0.0146	0.1249
Echinococcus multilocularis	g-protein coupled receptor	0.0154	0.0939	0.1625
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0093	0.0503	0.087
Plasmodium falciparum	apurinic/apyrimidinic endonuclease Apn1, putative	0.0087	0.0457	0.0409
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0154	0.0939	0.8019
Onchocerca volvulus		0.0049	0.0186	0.0542
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0077	0.039	0.3332
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.003	0.0051	0.0015
Onchocerca volvulus		0.0154	0.0939	0.273
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0087	0.0291
Brugia malayi	hypothetical protein	0.0122	0.0712	0.2372
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0061	0.0278	0.0481
Onchocerca volvulus		0.0093	0.0503	0.1461
Schistosoma mansoni	hypothetical protein	0.0035	0.0089	0.0759
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0116	0.0664	0.5674
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.005	0.0198	0.0658
Schistosoma mansoni	hypothetical protein	0.0035	0.0089	0.0759
Brugia malayi	hypothetical protein	0.0154	0.0939	0.3127
Trichomonas vaginalis	phosphofructokinase, putative	0.0109	0.0619	0.18
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Loa Loa (eye worm)	acetylcholinesterase 1	0.0132	0.0781	0.2599
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Brugia malayi	hypothetical protein	0.0154	0.0939	0.3127
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0545	0.3718	1
Schistosoma mansoni	amine GPCR	0.0154	0.0939	0.8019
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0053	0.0221	0.0221
Echinococcus multilocularis	serotonin receptor	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0093	0.0503	0.1673
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0116	0.0664	0.115
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0109	0.0619	0.0571
Schistosoma mansoni	growth hormone secretagogue receptor	0.0154	0.0939	0.8019
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0093	0.0503	0.1673
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0154	0.0939	0.1625
Echinococcus multilocularis	GPCR, family 2	0.0035	0.0089	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0503	0.1673
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0093	0.0503	0.1673
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0116	0.0664	0.5674
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0093	0.0503	0.1673
Brugia malayi	RE15519p	0.0154	0.0939	0.3127
Brugia malayi	Carboxylesterase family protein	0.0132	0.0781	0.2599
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0093	0.0503	0.4291
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0043	0.0146	0.0487
Echinococcus granulosus	dro:myosuppressin receptor	0.0154	0.0939	0.1625
Echinococcus granulosus	7tm_1 domain containing protein	0.0154	0.0939	0.1625
Schistosoma mansoni	neuropeptide F-like receptor	0.0154	0.0939	0.8019
Echinococcus granulosus	rhodopsin orphan GPCR	0.0154	0.0939	0.1625
Echinococcus granulosus	rhodopsin orphan GPCR	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0122	0.0708	0.0708
Echinococcus multilocularis	neuropeptide s receptor	0.0154	0.0939	0.1625
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0835	0.578	1
Loa Loa (eye worm)	glutathione reductase	0.0053	0.0221	0.0737
Trichomonas vaginalis	chromobox protein, putative	0.0079	0.0401	0.1166
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.005	0.0198	0.1687
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0503	0.1673
Plasmodium falciparum	peptide deformylase	0.1428	1	1
Schistosoma mansoni	nAChR subunit	0.0093	0.0503	0.4291
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0487
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0154	0.0939	0.1625
Plasmodium vivax	thioredoxin reductase, putative	0.0053	0.0221	0.0172
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0154	0.0939	0.8019
Treponema pallidum	polypeptide deformylase (def)	0.1428	1	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0154	0.0939	0.8019
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0154	0.0939	0.1625
Schistosoma mansoni	amine GPCR	0.0154	0.0939	0.8019
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0064	0.0295	0.051
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0154	0.0939	0.1625
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0122	0.0708	0.0708
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0093	0.0503	0.087
Echinococcus multilocularis	sex peptide receptor	0.0154	0.0939	0.1625
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0154	0.0939	0.3127
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0003	0.0011
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0116	0.0664	0.115
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0043	0.0146	0.0253
Loa Loa (eye worm)	G-protein coupled receptor	0.0154	0.0939	0.3127
Brugia malayi	6-phosphofructokinase	0.0109	0.0619	0.2062
Onchocerca volvulus		0.0154	0.0939	0.273
Giardia lamblia	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	0.0113	0.0644	1
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0503	0.1673
Schistosoma mansoni	hypothetical protein	0.0035	0.0089	0.0759
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0132	0.0781	0.6665
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0151	0.0915	0.7812
Plasmodium falciparum	glutathione reductase	0.0053	0.0221	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Echinococcus granulosus	serotonin receptor	0.0154	0.0939	0.1625
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0292	0.0971
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0292	0.2489
Brugia malayi	Pre-SET motif family protein	0.0445	0.3003	1
Trichomonas vaginalis	chromobox protein, putative	0.0047	0.0179	0.052
Onchocerca volvulus		0.0043	0.0146	0.0425
Onchocerca volvulus		0.0154	0.0939	0.273
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0093	0.0503	0.4291
Loa Loa (eye worm)	GABA receptor subunit	0.005	0.0198	0.0658
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0093	0.0503	0.1673
Leishmania major	trypanothione reductase	0.0053	0.0221	0.0466
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Onchocerca volvulus		0.0154	0.0939	0.273
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0093	0.0503	0.087
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0043	0.0146	0.0253
Loa Loa (eye worm)	6-phosphofructokinase	0.0109	0.0619	0.2062
Mycobacterium ulcerans	peptide deformylase	0.1428	1	1
Loa Loa (eye worm)	hypothetical protein	0.0154	0.0939	0.3127
Entamoeba histolytica	phosphofructokinase, putative	0.0109	0.0619	0.9582
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0154	0.0939	0.8019
Echinococcus granulosus	tm gpcr rhodopsin	0.0154	0.0939	0.1625
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0043	0.0146	0.1249
Echinococcus granulosus	biogenic amine 5HT receptor	0.0154	0.0939	0.1625

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 32.5 uM	Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of gelatin	ChEMBL.	16451081
EC50 (functional)	= 32.5 uM	Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of gelatin	ChEMBL.	16451081
EC50 (functional)	= 59.2 uM	Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of 3% fetal bovine serum	ChEMBL.	16451081
EC50 (functional)	= 59.2 uM	Activity towards mouse FL5.12 cell line transfected with Bcl-XL in presence of 3% fetal bovine serum	ChEMBL.	16451081
Ki (binding)	= 0.25 uM	Binding affinity to Bcl-XL by fluorescence polarization assay	ChEMBL.	16451081
Ki (binding)	= 0.25 uM	Binding affinity to Bcl-XL by fluorescence polarization assay	ChEMBL.	16451081
Ki (binding)	= 1.14 uM	Binding affinity to Bcl-XL in 1% human serum by fluorescence polarization assay	ChEMBL.	16451081
Ki (binding)	= 1.14 uM	Binding affinity to Bcl-XL in 1% human serum by fluorescence polarization assay	ChEMBL.	16451081
Ki (binding)	= 2.16 uM	Binding affinity to Bcl2 by fluorescence polarization assay	ChEMBL.	16451081
Ki (binding)	= 2.16 uM	Binding affinity to Bcl2 by fluorescence polarization assay	ChEMBL.	16451081

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL202964
PubChem: 11621908

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 354284