Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | adenosine deaminase | 0.2035 | 1 | 1 |
Leishmania major | adenine aminohydrolase | 0.2035 | 1 | 1 |
Mycobacterium leprae | Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) | 0.2035 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.2035 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.2035 | 1 | 0.5 |
Trypanosoma brucei | adenosine monophosphate deaminase, putative | 0.1391 | 0.2517 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.2035 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1391 | 0.2517 | 0.5 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.2035 | 1 | 1 |
Echinococcus multilocularis | adenosine deaminase | 0.2035 | 1 | 1 |
Toxoplasma gondii | Adenosine/AMP deaminase domain-containing protein | 0.2035 | 1 | 1 |
Mycobacterium tuberculosis | Probable adenosine deaminase Add (adenosine aminohydrolase) | 0.2035 | 1 | 0.5 |
Plasmodium vivax | adenosine deaminase, putative | 0.2035 | 1 | 1 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.2035 | 1 | 0.5 |
Treponema pallidum | adenosine deaminase | 0.2035 | 1 | 0.5 |
Schistosoma mansoni | adenosine deaminase | 0.2035 | 1 | 1 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1391 | 0.2517 | 0.5 |
Echinococcus granulosus | adenosine deaminase | 0.2035 | 1 | 1 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.2035 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.1391 | 0.2517 | 0.5 |
Mycobacterium ulcerans | adenosine deaminase | 0.2035 | 1 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1391 | 0.2517 | 0.5 |
Trypanosoma cruzi | adenosine monophosphate deaminase-like protein, putative | 0.1391 | 0.2517 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1391 | 0.2517 | 0.5 |
Trypanosoma brucei | AMP deaminase, putative | 0.1391 | 0.2517 | 0.5 |
Entamoeba histolytica | adenosine deaminase, putative | 0.2035 | 1 | 1 |
Loa Loa (eye worm) | AMP deaminase | 0.1391 | 0.2517 | 0.2517 |
Trypanosoma cruzi | adenosine monophosphate deaminase, putative | 0.1391 | 0.2517 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2035 | 1 | 1 |
Trypanosoma brucei | AMP deaminase, putative | 0.1391 | 0.2517 | 0.5 |
Trypanosoma cruzi | AMP deaminase, putative | 0.1391 | 0.2517 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 30 uM | Inhibition of DPP4 by continuous fluorimetric assay | ChEMBL. | 16376544 |
IC50 (binding) | = 30 uM | Inhibition of DPP4 by continuous fluorimetric assay | ChEMBL. | 16376544 |
IC50 (binding) | = 33 uM | Inhibition of DPP4 by continuous fluorimetric assay | ChEMBL. | 16376544 |
IC50 (binding) | = 33 uM | Inhibition of DPP4 by continuous fluorimetric assay | ChEMBL. | 16376544 |
IC50 (binding) | = 40 uM | Inhibition of DPP4 | ChEMBL. | 16321524 |
IC50 (binding) | = 40 uM | Inhibition of DPP4 | ChEMBL. | 16321524 |
IC50 (binding) | = 40 uM | Binding affinity to DPP4 | ChEMBL. | 18457385 |
Inhibition (binding) | = 70 % | Inhibition of DPP4 at 100 uM | ChEMBL. | 16321524 |
Inhibition (binding) | = 70 % | Inhibition of DPP4 at 100 uM | ChEMBL. | 16321524 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.