TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 416.264 | Formula: C18H15Cl2N7O
H donors: 2 H acceptors: 4 LogP: 3.41 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cn1cnc(c1c1nnc(o1)Nc1ccc(c(c1)Cl)Cl)NCc1ccncc1
InChi: 1S/C18H15Cl2N7O/c1-27-10-23-16(22-9-11-4-6-21-7-5-11)15(27)17-25-26-18(28-17)24-12-2-3-13(19)14(20)8-12/h2-8,10,22H,9H2,1H3,(H,24,26)
InChiKey: ZVOCXKULCIMARG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References
Homo sapiens	fms-related tyrosine kinase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0016	0.0021	0.0021
Echinococcus granulosus	Immunoglobulin	0.0025	0.0239	0.0684
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0016	0.0021	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0315	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0154	0.0154
Schistosoma mansoni	amine oxidase	0.0022	0.0154	0.044
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0315	0.0315
Mycobacterium ulcerans	carboxylesterase, LipT	0.0029	0.0315	0.0251
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0036	0.0103
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0016	0.0021	0.0021
Schistosoma mansoni	vesicular amine transporter	0.0025	0.0239	0.0684
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0507	0.1448
Onchocerca volvulus		0.0029	0.0315	0.0315
Brugia malayi	steroid hormone receptor	0.0016	0.0021	0.0021
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.1324	0.3782
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0022	0.0154	1
Echinococcus multilocularis	Immunoglobulin	0.0025	0.0239	0.0684
Loa Loa (eye worm)	carboxylesterase	0.0029	0.0315	0.0315
Onchocerca volvulus		0.0029	0.0315	0.0315
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0103	0.2001	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0016	0.0021	0.0021
Brugia malayi	SWIRM domain containing protein	0.0022	0.0154	0.0154
Brugia malayi	Carboxylesterase family protein	0.0029	0.0315	0.0315
Schistosoma mansoni	BC026374 protein (S09 family)	0.0029	0.0315	0.0901
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0016	0.0021	0.0061
Echinococcus multilocularis	Protein lozenge	0.0057	0.0964	0.2753
Echinococcus granulosus	roundabout 2	0.004	0.0572	0.1633
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0016	0.0021	0.0021
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0029	0.0315	0.0461
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0029	0.0315	0.0901
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0029	0.0315	0.0461
Loa Loa (eye worm)	RNA binding protein	0.0073	0.1324	0.1324
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0036	0.0036
Echinococcus granulosus	twitchin	0.0032	0.0397	0.1135
Onchocerca volvulus		0.0029	0.0315	0.0315
Brugia malayi	Steroid receptor seven-up type 2	0.0016	0.0021	0.0021
Brugia malayi	TAR-binding protein	0.0073	0.1324	0.1324
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0016	0.0021	0.0021
Schistosoma mansoni	cell adhesion molecule	0.0034	0.0426	0.1216
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0284	0.6089	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0016	0.0021	0.0021
Brugia malayi	Immunoglobulin I-set domain containing protein	0.041	0.893	0.893
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.1324	0.3782
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0016	0.0021	0.0061
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0029	0.0315	0.0901
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0029	0.0315	0.0461
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0305	0.6576	1
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0025	0.0239	0.0684
Toxoplasma gondii	histone lysine-specific demethylase	0.0022	0.0154	1
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0022	0.0154	1
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0103	0.2001	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0016	0.0021	0.0061
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.1324	0.3782
Onchocerca volvulus		0.0016	0.0021	0.0021
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0022	0.0154	0.044
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0016	0.0021	0.0061
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0036	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1989	0.1989
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0021	0.0021
Schistosoma mansoni	serine/threonine protein kinase	0.0103	0.2001	0.5717
Brugia malayi	hypothetical protein	0.0022	0.0154	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0021	0.0021
Schistosoma mansoni	lozenge	0.0057	0.0964	0.2753
Schistosoma mansoni	nuclear hormone receptor	0.0016	0.0021	0.0061
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0016	0.0021	0.0021
Echinococcus multilocularis	tar DNA binding protein	0.0073	0.1324	0.3782
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0239	0.0239
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0016	0.0021	0.0061
Echinococcus granulosus	carboxylesterase 5A	0.0169	0.3501	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0029	0.0315	0.0901
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0239	0.0239
Onchocerca volvulus		0.0029	0.0315	0.0315
Echinococcus granulosus	acetylcholinesterase	0.0169	0.3501	1
Echinococcus multilocularis	FTZ F1 alpha	0.0016	0.0021	0.0061
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0022	0.0154	0.044
Plasmodium vivax	hypothetical protein, conserved	0.0022	0.0154	1
Echinococcus granulosus	dual specificity	0.0103	0.2001	0.5717
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0507	0.1448
Schistosoma mansoni	nephrin	0.0032	0.0385	0.1101
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0016	0.0021	0.0021
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0016	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0315	0.0315
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0305	0.6576	1
Echinococcus multilocularis	roundabout 2	0.004	0.0572	0.1633
Loa Loa (eye worm)	hypothetical protein	0.0169	0.3501	0.3501
Onchocerca volvulus		0.0375	0.8148	0.8148
Loa Loa (eye worm)	hypothetical protein	0.0457	1	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0572	0.0572
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0016	0.0021	0.0061
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0016	0.0021	0.0061
Echinococcus granulosus	FTZ F1 alpha	0.0016	0.0021	0.0061
Brugia malayi	RNA recognition motif domain containing protein	0.0073	0.1324	0.1324
Brugia malayi	Carboxylesterase family protein	0.0029	0.0315	0.0315
Plasmodium falciparum	protoporphyrinogen oxidase	0.0022	0.0154	1
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0022	0.0154	0.06
Echinococcus granulosus	tar DNA binding protein	0.0073	0.1324	0.3782
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0426	0.0426
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0022	0.0154	0.044
Onchocerca volvulus	Protein ultraspiracle homolog	0.0016	0.0021	0.0021
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0022	0.0154	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0016	0.0021	0.0021
Schistosoma mansoni	retinoic acid receptor RXR	0.0016	0.0021	0.0061
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0016	0.0021	0.0021
Echinococcus multilocularis	para nitrobenzyl esterase	0.0029	0.0315	0.0901
Echinococcus multilocularis	acetylcholinesterase	0.0169	0.3501	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0154	0.0154
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0016	0.0021	0.0061
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0016	0.0021	0.0061
Loa Loa (eye worm)	steroid hormone receptor	0.0016	0.0021	0.0021
Brugia malayi	Carboxylesterase family protein	0.0169	0.3501	0.3501
Echinococcus multilocularis	neuroligin	0.0029	0.0315	0.0901
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0029	0.0315	0.0901
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0016	0.0021	0.0021
Brugia malayi	Fibronectin type III domain containing protein	0.0025	0.0239	0.0239
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0029	0.0315	0.0901
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0022	0.0154	0.044
Brugia malayi	Protein kinase domain containing protein	0.0103	0.2001	0.2001
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0154	0.0154
Brugia malayi	RNA binding protein	0.0073	0.1324	0.1324
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0016	0.0021	0.0021
Brugia malayi	nuclear receptor NHR-88	0.0016	0.0021	0.0021
Loa Loa (eye worm)	acetylcholinesterase 1	0.0169	0.3501	0.3501
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0021	0.0021
Schistosoma mansoni	gliotactin	0.0029	0.0315	0.0901
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0073	0.1324	0.1324
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0016	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0021	0.0021
Echinococcus multilocularis		0.0022	0.0154	0.044
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0239	0.0239
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0022	0.0154	0.5
Brugia malayi	hypothetical protein	0.0025	0.0239	0.0239
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0015	0.0012	0.0012
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0036	0.0103
Onchocerca volvulus		0.0457	1	1
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0025	0.0239	0.0684
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0025	0.0239	0.0684
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0016	0.0021	0.0021
Schistosoma mansoni	RAR-like nuclear receptor	0.0016	0.0021	0.0061
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0169	0.3501	1
Entamoeba histolytica	protein kinase domain containing protein	0.0103	0.2001	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0016	0.0021	0.0061
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0029	0.0315	0.5
Schistosoma mansoni	coup transcription factor	0.0016	0.0021	0.0061
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0029	0.0315	0.0901
Schistosoma mansoni	acetylcholinesterase	0.0029	0.0315	0.0901
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0016	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0021	0.0021
Brugia malayi	ecdysteroid receptor	0.0016	0.0021	0.0021
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0103	0.2001	0.2001
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0239	0.0239
Entamoeba histolytica	protein kinase, putative	0.0103	0.2001	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0016	0.0021	0.0061
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0029	0.0315	0.0901
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0036	0.0103
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0036	0.0103
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0025	0.0239	0.0239
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0016	0.0021	0.0021
Schistosoma mansoni	amine oxidase	0.0022	0.0154	0.044
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0154	0.0154
Schistosoma mansoni	tyrosine kinase	0.0016	0.0023	0.0066
Onchocerca volvulus		0.0022	0.0154	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0154	0.0154
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0016	0.0021	0.0061
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0034	0.0426	0.1216
Brugia malayi	hypothetical protein	0.0037	0.0507	0.0507
Echinococcus granulosus	neuroligin	0.0029	0.0315	0.0901
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.041	0.893	0.893
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0103	0.2001	1
Echinococcus multilocularis	acetylcholinesterase	0.0169	0.3501	1
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0036	0.0103
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.1324	0.3782
Echinococcus granulosus	acetylcholinesterase	0.0169	0.3501	1
Brugia malayi	amine oxidase, flavin-containing family protein	0.0022	0.0154	0.0154
Echinococcus multilocularis	Immunoglobulin	0.0025	0.0239	0.0684
Entamoeba histolytica	hypothetical protein	0.0103	0.2001	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0315	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0021	0.0021
Schistosoma mansoni	thyroid hormone receptor	0.0016	0.0021	0.0061
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0016	0.0021	0.0061
Echinococcus granulosus	para nitrobenzyl esterase	0.0029	0.0315	0.0901
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0021	0.0021
Echinococcus granulosus	defective proboscis extension response	0.0025	0.0239	0.0684
Schistosoma mansoni	hypothetical protein	0.0037	0.0507	0.1448
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0315	0.0315
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0507	0.1448
Loa Loa (eye worm)	carboxylesterase	0.0029	0.0315	0.0315
Entamoeba histolytica	protein kinase, putative	0.0103	0.2001	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0154	0.0154
Plasmodium vivax	hypothetical protein, conserved	0.0022	0.0154	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.0154	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0239	0.0239
Onchocerca volvulus	Bile acid receptor homolog	0.0016	0.0021	0.0021
Loa Loa (eye worm)	TAR-binding protein	0.0073	0.1324	0.1324
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0016	0.0021	0.0061
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0016	0.0021	0.0021
Echinococcus multilocularis	carboxylesterase 5A	0.0169	0.3501	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0016	0.0021	0.0061
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0016	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0315	0.0315
Brugia malayi	Carboxylesterase family protein	0.0029	0.0315	0.0315
Loa Loa (eye worm)	hypothetical protein	0.004	0.0572	0.0572
Mycobacterium tuberculosis	Possible oxidoreductase	0.0022	0.0154	0.0195
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0036	0.0036
Echinococcus multilocularis	neuroglian	0.0032	0.0385	0.1101
Schistosoma mansoni	thyroid hormone receptor	0.0016	0.0021	0.0061
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0016	0.0021	0.0061
Echinococcus granulosus	neuroglian	0.0032	0.0385	0.1101
Loa Loa (eye worm)	hypothetical protein	0.0457	1	1
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0022	0.0154	0.044
Brugia malayi	Nuclear hormone receptor-like 1	0.0016	0.0021	0.0021
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0016	0.0021	0.0061
Loa Loa (eye worm)	carboxylesterase	0.0169	0.3501	0.3501
Leishmania major	UDP-galactopyranose mutase	0.0022	0.0154	0.06
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1989	0.1989
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0036	0.0103
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0016	0.0021	0.0061
Echinococcus granulosus	BC026374 protein S09 family	0.0029	0.0315	0.0901
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0022	0.0154	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0016	0.0021	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0315	0.0315
Echinococcus multilocularis	dual specificity	0.0103	0.2001	0.5717
Loa Loa (eye worm)	hypothetical protein	0.0169	0.3501	0.3501
Brugia malayi	Carboxylesterase family protein	0.0169	0.3501	0.3501
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0022	0.0154	0.044
Brugia malayi	photoreceptor-specific nuclear receptor	0.0016	0.0021	0.0021
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0016	0.0021	0.0061
Brugia malayi	hypothetical protein	0.0029	0.0315	0.0315
Trichomonas vaginalis	spcc417.12 protein, putative	0.0029	0.0315	0.5
Onchocerca volvulus	Tyrosine kinase homolog	0.0382	0.8317	0.8317
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0016	0.0021	0.0021
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0022	0.0154	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0073	0.1324	0.3782
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0016	0.0021	0.0061
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0016	0.0021	0.0061
Loa Loa (eye worm)	runx1	0.0057	0.0964	0.0964
Onchocerca volvulus		0.0029	0.0315	0.0315
Brugia malayi	Carboxylesterase family protein	0.0029	0.0315	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0239	0.0239
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0036	0.0103
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0022	0.0154	0.06
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0022	0.0154	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0016	0.0021	0.0021
Brugia malayi	nuclear hormone receptor	0.0016	0.0021	0.0021
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0103	0.2001	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	< 30 %	Protective index against IGF1R at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against InR at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against FGFR1 at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against Flt3 at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against ErbB1 at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against ErbB2 at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against EphB4 at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against c-Met at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against PKA at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against GSK3beta at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against PKB/Akt at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against bcr-Abl at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against Cdk2 at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against Cdk5 at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against IGF1R at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against InR at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against FGFR1 at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against Flt3 at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against ErbB1 at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against ErbB2 at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against EphB4 at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against c-Met at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against PKA at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against GSK3beta at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against PKB/Akt at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against bcr-Abl at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against Cdk2 at 10 uM by HTRF method	ChEMBL.	16321531
Activity (binding)	< 30 %	Protective index against Cdk5 at 10 uM by HTRF method	ChEMBL.	16321531
IC50 (binding)	= 0.18 uM	Inhibition of VEGFR2 by enzymatic assay	ChEMBL.	16321531
IC50 (binding)	= 0.18 uM	Inhibition of VEGFR2 by enzymatic assay	ChEMBL.	16321531
IC50 (binding)	= 0.26 uM	Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assay	ChEMBL.	16321531
IC50 (binding)	= 0.26 uM	Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assay	ChEMBL.	16321531
IC50 (binding)	= 0.49 uM	Inhibition of VEGFR1 by enzymatic assay	ChEMBL.	16321531
IC50 (binding)	= 0.49 uM	Inhibition of VEGFR1 by enzymatic assay	ChEMBL.	16321531

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL204874

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 354513