Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2994 | 1 | 0.5 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0024 | 0.0038 | 0.0038 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.0144 | 0.0107 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1145 | 0.3798 | 0.5 |
Loa Loa (eye worm) | glutamate receptor | 0.0019 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.016 | 0.016 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.0107 | 0.0107 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1145 | 0.3798 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.2994 | 1 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0049 | 0.0122 | 0.0122 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.006 | 0.016 | 0.0065 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.0095 | 0.0058 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2994 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2994 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1145 | 0.3798 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.2994 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1145 | 0.3798 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1145 | 0.3798 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1145 | 0.3798 | 0.5 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0339 | 0.1096 | 0.101 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2994 | 1 | 1 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.0122 | 0.0122 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 0.016 | 0.0065 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2994 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2994 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.2994 | 1 | 1 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0339 | 0.1096 | 0.101 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.