Detailed information for compound 35511

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 418.442 | Formula: C23H20F2N6
  • H donors: 1 H acceptors: 3 LogP: 3.53 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cccc2c1c1nc[nH]c(c1n2)N1CCN(CC1)CCc1ccc(c(c1)F)F
  • InChi: 1S/C23H20F2N6/c24-17-5-4-15(12-18(17)25)6-7-30-8-10-31(11-9-30)23-22-21(27-14-28-23)20-16(13-26)2-1-3-19(20)29-22/h1-5,12,14H,6-11H2,(H,27,28)
  • InChiKey: KSLIYXLLGYPJIR-UHFFFAOYSA-N  

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Starlite/ChEMBL References
Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 1A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major pentamidine resistance protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum pentamidine resistance protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei multidrug resistance protein E Get druggable targets OG5_126561 All targets in OG5_126561
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans vacuolar ABC transporter similar to multiple drug resistance-associated protein Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma cruzi multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Babesia bovis ABC transporter family protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) ABC transporter transmembrane region family protein Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana multidrug resistance protein, copy 1-like protein Get druggable targets OG5_126561 All targets in OG5_126561
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Giardia lamblia Multidrug resistance-associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans similar to vacuolar membrane ATP-dependant transporter, metal resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance associated protein 7 Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily C, member 6, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein e, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica multidrug resistance protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi multidrug resistance related protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance associated protein 4 Get druggable targets OG5_126561 All targets in OG5_126561
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis multidrug resistance associated protein 4 Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance-associated protein 4, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei gambiense multidrug resistance-associated protein, putative,p-glycoprotein Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05674 ATP-binding cassette, subfamily C (CFTR/MRP), member 10, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana p-glycoprotein e, putative Get druggable targets OG5_126561 All targets in OG5_126561
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma cruzi multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Brugia malayi ABC transporter transmembrane region family protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma congolense multidrug resistance protein A Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma cruzi multidrug resistance protein E, putative Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana p-glycoprotein-like protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Canalicular multispecific organic anion transporter 2, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis SI:dZ52I16.4 (novel ABC transporter similar to human multidrug-resistance proteins (MRP)) Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily C, member 2, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana ATP-binding cassette protein subfamily C, member 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily C, member 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Cryptosporidium parvum ABC ATpase (2 ABC domains) with 10 transmembrane domains, adjacent duplicated gene Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance-associated protein 4, putative Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance associated protein 7 Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance-associated protein 4, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans similar to vacuolar membrane ATP-dependant transporter, metal resistance protein Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance-associated protein 7, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W) Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei p-glycoprotein Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma brucei multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica ATP-binding cassette protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Babesia bovis ABC transporter family protein Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani pentamidine resistance protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum ko:K05667 ATP-binding cassette, subfamily C (CFTR/MRP), member 3, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma japonicum Multidrug resistance-associated protein 1, putative Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Trypanosoma congolense multidrug resistance-associated protein, putative Get druggable targets OG5_126561 All targets in OG5_126561
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Giardia lamblia Multidrug resistance-associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) multidrug resistance-associated protein Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia Multidrug resistance-associated protein 1 Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania mexicana ABC-thiol transporter Get druggable targets OG5_126561 All targets in OG5_126561
Giardia lamblia MRP-like ABC transporter Get druggable targets OG5_126561 All targets in OG5_126561
Candida albicans vacuolar ABC transporter similar to multiple drug resistance-associated protein Get druggable targets OG5_126561 All targets in OG5_126561
Babesia bovis ABC transporter family protein Get druggable targets OG5_126561 All targets in OG5_126561
Leishmania infantum ATP-binding cassette protein subfamily C, member 5, putative Get druggable targets OG5_126561 All targets in OG5_126561
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis p-glycoprotein e Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Babesia bovis ABC transporter, ATP-binding protein domain containing protein Get druggable targets OG5_126561 All targets in OG5_126561
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei gambiense multidrug resistance protein E,p-glycoprotein Get druggable targets OG5_126561 All targets in OG5_126561
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126561 All targets in OG5_126561
Theileria parva ABC transporter, putative Get druggable targets OG5_126561 All targets in OG5_126561

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0034 0.2155 0.1883
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0089 0.7733 0.7829
Leishmania major ABC-thiol transporter 0.0021 0.0816 0.0477
Echinococcus granulosus proteasome subunit beta type 6 0.0034 0.2155 0.2181
Plasmodium vivax proteasome subunit beta type-5, putative 0.011 0.9878 1
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0034 0.2155 0.2181
Leishmania major proteasome beta 2 subunit, putative 0.0061 0.4893 0.4761
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0034 0.2155 0.1883
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0034 0.2155 0.1859
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0085 0.7315 0.7307
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0034 0.2155 0.1859
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0034 0.2155 0.1883
Brugia malayi proteasome subunit beta type 3 0.0034 0.2155 0.1883
Leishmania major pentamidine resistance protein 1 0.0021 0.0816 0.0477
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.0363 0.0367
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0034 0.2155 0.1859
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0016 0.0334 0.0338
Loa Loa (eye worm) hypothetical protein 0.0021 0.0788 0.0771
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0034 0.2155 0.1883
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0034 0.2155 0.1859
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0061 0.4893 0.4954
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0034 0.2155 0.1883
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0034 0.2155 0.5
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0089 0.7733 0.7829
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0034 0.2155 0.1883
Plasmodium vivax proteasome subunit beta type-1, putative 0.0089 0.7733 0.7747
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0034 0.2155 0.2181
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0034 0.2155 0.2181
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0034 0.2155 0.1477
Plasmodium vivax proteasome subunit beta type-3, putative 0.0034 0.2155 0.1883
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0085 0.7315 0.7307
Schistosoma mansoni multidrug resistance protein 0.0021 0.0816 0.0471
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0085 0.7315 0.7307
Leishmania major proteasome alpha 7 subunit, putative 0.0034 0.2155 0.1883
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0021 0.0816 0.0477
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0021 0.0816 0.0477
Toxoplasma gondii heat shock protein hslv, putative 0.0034 0.2155 0.1883
Toxoplasma gondii protein phosphatase 2B catalytic subunit, calcineurin family phosphatse superfamily protein 0.0085 0.7315 0.7307
Giardia lamblia 20S proteasome alpha subunit 3 0.0034 0.2155 0.1504
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0034 0.2155 0.2159
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0034 0.2155 0.2181
Entamoeba histolytica Ser/Thr protein phosphatase, putative 0.0085 0.7315 0.7307
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0034 0.2155 0.2181
Giardia lamblia Proteasome subunit beta type 1 0.0089 0.7733 0.7641
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0061 0.4893 0.4761
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0034 0.2155 0.1883
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0017 0.0363 0.0367
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0089 0.7733 0.7648
Loa Loa (eye worm) proteasome subunit beta type 1 0.0089 0.7733 0.7823
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0034 0.2155 0.1859
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0034 0.2155 0.1477
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0816 0.0477
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0034 0.2155 0.1883
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0034 0.2155 0.1859
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0034 0.2155 0.1883
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.011 0.9878 1
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0034 0.2155 0.1883
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0034 0.2155 0.1883
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0034 0.2155 0.1859
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0061 0.4893 0.4954
Giardia lamblia 20S proteasome alpha subunit 1 0.0034 0.2155 0.1504
Trypanosoma brucei proteasome beta 6 subunit 0.0089 0.7733 0.7634
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0034 0.2155 0.2159
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0034 0.2155 0.1883
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0034 0.2155 0.1883
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0034 0.2155 0.1883
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0017 0.0363 0.0367
Toxoplasma gondii proteasome subunit beta type, putative 0.011 0.9878 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0034 0.2155 0.1883
Brugia malayi proteasome subunit alpha type 6 0.0034 0.2155 0.1883
Trypanosoma cruzi serine/threonine protein phosphatase 2B catalytic subunit A2, putative 0.0085 0.7315 0.7406
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0034 0.2155 0.2159
Trypanosoma cruzi multidrug resistance protein E, putative 0.0021 0.0816 0.0826
Echinococcus multilocularis multidrug resistance associated protein 1 0.0021 0.0816 0.0826
Echinococcus multilocularis proteasome subunit alpha type 2 0.0034 0.2155 0.2181
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0034 0.2155 0.2181
Loa Loa (eye worm) hypothetical protein 0.0021 0.0816 0.08
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0034 0.2155 0.2159
Echinococcus granulosus proteasome subunit beta type 7 0.0034 0.2155 0.2181
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0102 0.9056 0.9168
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0061 0.4893 0.4954
Loa Loa (eye worm) PAS-3 protein 0.0034 0.2155 0.2159
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0034 0.2155 0.1883
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0816 0.0477
Toxoplasma gondii proteasome subunit alpha type, putative 0.0034 0.2155 0.1883
Leishmania major proteasome alpha 1 subunit, putative 0.0034 0.2155 0.1883
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0034 0.2155 0.1883
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0102 0.9056 0.9168
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0034 0.2155 0.1883
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0034 0.2155 0.2181
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0034 0.2155 0.1859
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0034 0.2155 0.2181
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0034 0.2155 0.1859
Schistosoma mansoni protein phosphatase-2b 0.0085 0.7315 0.7214
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0021 0.0816 0.0477
Trypanosoma brucei hypothetical protein, conserved 0.0102 0.9056 0.9093
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0089 0.7733 0.7747
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0034 0.2155 0.1477
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0034 0.2155 0.1883
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0034 0.2155 0.1883
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0034 0.2155 0.1477
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0034 0.2155 0.1477
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0034 0.2155 0.2181
Echinococcus multilocularis proteasome subunit beta type 6 0.0034 0.2155 0.2181
Plasmodium falciparum proteasome subunit beta type-5 0.011 0.9878 1
Echinococcus multilocularis proteasome subunit alpha type 6 0.0034 0.2155 0.2181
Leishmania major proteasome alpha 3 subunit, putative 0.0034 0.2155 0.1883
Echinococcus multilocularis serine:threonine protein phosphatase 2B 0.0085 0.7315 0.7406
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0034 0.2155 0.2181
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0034 0.2155 0.2181
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0034 0.2155 0.1477
Giardia lamblia 20S proteasome alpha subunit 5 0.0034 0.2155 0.1504
Giardia lamblia 20S proteasome alpha subunit 6 0.0034 0.2155 0.1504
Loa Loa (eye worm) hypothetical protein 0.0017 0.0363 0.0339
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0034 0.2155 0.1477
Brugia malayi ABC transporter transmembrane region family protein 0.0021 0.0816 0.0477
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.011 0.9878 1
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0034 0.2155 0.2181
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0034 0.2155 0.2181
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0034 0.2155 0.1859
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0034 0.2155 0.2181
Schistosoma mansoni multidrug resistance protein 0.0021 0.0816 0.0471
Schistosoma mansoni multidrug resistance protein 0.0021 0.0816 0.0471
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0034 0.2155 0.1883
Toxoplasma gondii proteasome beta subunit 0.0034 0.2155 0.1883
Onchocerca volvulus Notchless protein homolog 0.0034 0.2155 1
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0034 0.2155 0.2181
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0021 0.0816 0.08
Echinococcus granulosus multidrug resistance associated protein 7 0.0021 0.0816 0.0826
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0034 0.2155 0.1883
Loa Loa (eye worm) hypothetical protein 0.0085 0.7315 0.7399
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0034 0.2155 0.1883
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0034 0.2155 0.2181
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0034 0.2155 0.1883
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0034 0.2155 0.1859
Trypanosoma brucei proteasome beta 7 subunit 0.0034 0.2155 0.1477
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0034 0.2155 0.1477
Entamoeba histolytica Ser/Thr protein phosphatase, putative 0.0085 0.7315 0.7307
Entamoeba histolytica ABC transporter, putative 0.0021 0.0816 0.0477
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0034 0.2155 0.2181
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0034 0.2155 0.1883
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0089 0.7733 0.7747
Brugia malayi Serine/threonine protein phosphatase 2B catalytic subunit 2 0.0085 0.7315 0.7307
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0034 0.2155 0.1883
Entamoeba histolytica calcineurin catalytic subunit A, putative 0.0085 0.7315 0.7307
Echinococcus granulosus Proteasome subunit alpha beta 0.0034 0.2155 0.2181
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0034 0.2155 0.2181
Brugia malayi 20S proteasome alpha5 subunit 0.0034 0.2155 0.1883
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.011 0.9878 1
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0034 0.2155 0.1883
Giardia lamblia 20S proteasome alpha subunit 2 0.0034 0.2155 0.1504
Echinococcus granulosus proteasome subunit alpha type 6 0.0034 0.2155 0.2181
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.011 0.9878 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0017 0.0363 0.0367
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0034 0.2155 0.1883
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.0363 0.0367
Leishmania major proteasome alpha 1 subunit, putative 0.0034 0.2155 0.1883
Trypanosoma cruzi 20S proteasome subunit 0.0061 0.4893 0.4954
Brugia malayi multidrug resistance related protein 1 0.0021 0.0816 0.0477
Echinococcus granulosus proteasome subunit alpha type 2 0.0034 0.2155 0.2181
Loa Loa (eye worm) multidrug resistance protein 3 0.0017 0.0363 0.0339
Echinococcus multilocularis multidrug resistance associated protein 7 0.0021 0.0816 0.0826
Loa Loa (eye worm) hypothetical protein 0.0017 0.0363 0.0339
Plasmodium vivax proteasome subunit beta type-7, putative 0.0034 0.2155 0.1883
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0034 0.2155 0.1883
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0034 0.2155 0.1883
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0816 0.0477
Giardia lamblia Proteasome subunit beta type 3 0.0034 0.2155 0.1504
Brugia malayi proteasome subunit beta type 2 0.0061 0.4893 0.4761
Brugia malayi proteasome subunit beta type 1 0.0089 0.7733 0.7747
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0034 0.2155 0.1883
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0017 0.0363 0.0367
Brugia malayi Proteasome A-type and B-type family protein 0.0034 0.2155 0.1883
Giardia lamblia Multidrug resistance-associated protein 1 0.0021 0.0816 0.0031
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0034 0.2155 0.1883
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0034 0.2155 0.1883
Leishmania major proteasome beta 5 subunit, putative 0.011 0.9878 1
Trypanosoma brucei Enriched in surface-labeled proteome protein 12 0.0102 0.9056 0.9093
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0034 0.2155 0.1883
Echinococcus multilocularis multidrug resistance protein 1 0.0017 0.0363 0.0367
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0034 0.2155 0.1883
Trypanosoma brucei proteasome subunit beta type-5, putative 0.011 0.9878 1
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0034 0.2155 0.2181
Leishmania major proteasome beta 3 subunit, putative 0.0034 0.2155 0.1883
Toxoplasma gondii proteasome subunit alpha1, putative 0.0034 0.2155 0.1883
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0034 0.2155 0.2181
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0034 0.2155 0.1883
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0034 0.2155 0.1883
Plasmodium falciparum serine/threonine protein phosphatase 2B catalytic subunit A 0.0085 0.7315 0.7307
Entamoeba histolytica hypothetical protein 0.0021 0.0816 0.0477
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0034 0.2155 0.2159
Brugia malayi proteasome subunit alpha type 4 0.0034 0.2155 0.1883
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0034 0.2155 0.1859
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.011 0.9878 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0061 0.4893 0.4761
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0034 0.2155 0.1504
Giardia lamblia ABC transporter, putative 0.0021 0.0816 0.0031
Leishmania major serine/threonine protein phosphatase 2B catalytic subunit A2, putative 0.0085 0.7315 0.7307
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0021 0.0816 0.0826
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0034 0.2155 0.1883
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0034 0.2155 0.1477
Leishmania major serine/threonine protein phosphatase, putative 0.0085 0.7315 0.7307
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0034 0.2155 0.1883
Plasmodium vivax proteasome subunit beta type-4, putative 0.0034 0.2155 0.1883
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0034 0.2155 0.2181
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0034 0.2155 0.1883
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0034 0.2155 0.2181
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0089 0.7733 0.7829
Giardia lamblia Proteasome subunit beta type 5 precursor 0.011 0.9878 1
Toxoplasma gondii peptidase, T1 family protein 0.0034 0.2155 0.1883
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0034 0.2155 0.1883
Echinococcus granulosus multidrug resistance associated protein 1 0.0021 0.0816 0.0826
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0017 0.0363 0.0367
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0034 0.2155 0.2181
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0034 0.2155 0.1883
Mycobacterium leprae proteasome (beta subunit) PrcB 0.011 0.9878 1
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0034 0.2155 0.2181
Giardia lamblia MRP-like ABC transporter 0.0021 0.0816 0.0031
Leishmania major proteasome beta 2 subunit, putative 0.0034 0.2155 0.1883
Mycobacterium ulcerans proteasome PrcB 0.011 0.9878 1
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0089 0.7733 0.7747
Echinococcus multilocularis ATP binding cassette sub family B 0.0016 0.0334 0.0338
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0102 0.9056 0.9168
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0061 0.4893 0.4761
Plasmodium falciparum proteasome subunit beta type-4 0.0034 0.2155 0.1883
Plasmodium vivax proteasome subunit beta type-2, putative 0.0061 0.4893 0.4761
Echinococcus granulosus multidrug resistance protein 1 0.0017 0.0363 0.0367
Echinococcus multilocularis serine:threonine protein phosphatase 2B 0.0085 0.7315 0.7406
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0034 0.2155 0.1883
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0034 0.2155 0.1504
Leishmania major proteasome alpha 2 subunit, putative 0.0034 0.2155 0.1883
Trypanosoma brucei proteasome alpha 7 subunit 0.0034 0.2155 0.1477
Brugia malayi proteasome subunit alpha type 1 0.0034 0.2155 0.1883
Leishmania major proteasome beta-1 subunit, putative 0.0034 0.2155 0.1883
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0089 0.7733 0.7829
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0034 0.2155 0.2159
Brugia malayi Proteasome A-type and B-type family protein 0.0034 0.2155 0.1883
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0017 0.0363 0.0339
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0034 0.2155 0.2181
Brugia malayi Proteasome A-type and B-type family protein 0.0034 0.2155 0.1883
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0017 0.0363 0.0367
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0034 0.2155 0.1883
Plasmodium vivax serine/threonine protein phosphatase 2B catalytic subunit A, putative 0.0085 0.7315 0.7307
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0061 0.4893 0.4701
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0102 0.9056 0.9168
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0034 0.2155 0.1883
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0034 0.2155 0.1883
Giardia lamblia Proteasome subunit beta type 2 0.0061 0.4893 0.4516
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0034 0.2155 0.1883
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0034 0.2155 0.2181
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0034 0.2155 0.2181
Entamoeba histolytica ATP-binding cassette protein, putative 0.0021 0.0816 0.0477
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0034 0.2155 0.1883
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0034 0.2155 0.1859
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0034 0.2155 0.2159
Giardia lamblia 20S proteasome alpha subunit 4 0.0034 0.2155 0.1504
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0017 0.0363 0.0367
Echinococcus multilocularis multidrug resistance protein 1 0.0017 0.0363 0.0367
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0017 0.0363 0.0367
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0034 0.2155 0.1883
Echinococcus granulosus Proteasome subunit alpha type 7 0.0034 0.2155 0.2181
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0034 0.2155 0.1883
Loa Loa (eye worm) hypothetical protein 0.0021 0.0816 0.08
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0034 0.2155 0.2181
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0017 0.0363 0.0367
Echinococcus granulosus serine:threonine protein phosphatase 2B 0.0085 0.7315 0.7406
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0034 0.2155 0.1883
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0034 0.2155 0.1883
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0034 0.2155 0.2181
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0034 0.2155 0.2181
Echinococcus granulosus proteasome prosome macropain 0.011 0.9878 1
Brugia malayi proteasome subunit alpha type 3 0.0034 0.2155 0.1883
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0034 0.2155 0.1883
Schistosoma mansoni protein phosphatase-2b 0.0085 0.7315 0.7214
Toxoplasma gondii proteasome subunit 0.0034 0.2155 0.1883
Leishmania major p-glycoprotein e 0.0021 0.0816 0.0477
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0061 0.4893 0.4701
Trypanosoma brucei protein phosphatase 2B, putative 0.0085 0.7315 0.7172
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0034 0.2155 0.1859
Echinococcus granulosus subfamily T1A non peptidase ue 0.0034 0.2155 0.2181
Echinococcus granulosus proteasome subunit beta t family 0.0034 0.2155 0.2181
Trypanosoma cruzi Enriched in surface-labeled proteome protein 12 0.0102 0.9056 0.9168
Loa Loa (eye worm) proteasome subunit beta type 2 0.0061 0.4893 0.4939
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0034 0.2155 0.1477
Schistosoma mansoni multidrug resistance protein 0.0021 0.0816 0.0471
Trypanosoma cruzi serine/threonine protein phosphatase, putative 0.0085 0.7315 0.7406
Giardia lamblia Multidrug resistance-associated protein 1 0.0021 0.0816 0.0031
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0034 0.2155 0.2181
Trypanosoma cruzi serine/threonine protein phosphatase, putative 0.0085 0.7315 0.7406
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0034 0.2155 0.1883
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0034 0.2155 0.1883
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0017 0.0363 0.5
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0034 0.2155 0.2181
Brugia malayi Proteasome subunit alpha type 7-1 0.0034 0.2155 0.1883
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0021 0.0816 0.0826
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0034 0.2155 0.1859
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0034 0.2155 0.2181
Echinococcus multilocularis proteasome (prosome, macropain) 0.011 0.9878 1
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0034 0.2155 0.2159
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0034 0.2155 0.2159
Leishmania major proteasome beta 7 subunit, putative 0.0034 0.2155 0.1883
Trypanosoma brucei hypothetical protein, conserved 0.0102 0.9056 0.9093
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0034 0.2155 0.1883
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0021 0.0816 0.0477
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.011 0.9878 1
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0089 0.7733 0.7747
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0034 0.2155 0.1883
Brugia malayi Proteasome subunit alpha type 1 0.0034 0.2155 0.1883
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0061 0.4893 0.4761
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0034 0.2155 0.1883
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0034 0.2155 0.1883
Leishmania major proteasome alpha 7 subunit, putative 0.0034 0.2155 0.1883
Echinococcus multilocularis proteasome subunit beta type 7 0.0034 0.2155 0.2181
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0061 0.4893 0.4761
Loa Loa (eye worm) hypothetical protein 0.0083 0.7193 0.7274
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0061 0.4893 0.4499
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0021 0.0816 0.0477
Loa Loa (eye worm) proteasome subunit beta type 3 0.0034 0.2155 0.2159
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0089 0.7733 0.7747
Loa Loa (eye worm) hypothetical protein 0.0016 0.0334 0.0311
Giardia lamblia 20S proteasome alpha subunit 7 0.0034 0.2155 0.1504
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0034 0.2155 0.1504
Plasmodium vivax proteasome subunit beta type-6, putative 0.0034 0.2155 0.1883
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0034 0.2155 0.1883
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0034 0.2155 0.1883
Brugia malayi Proteasome A-type and B-type family protein 0.011 0.9878 1
Echinococcus granulosus serine:threonine protein phosphatase 2B 0.0085 0.7315 0.7406
Brugia malayi proteasome subunit alpha type 2 0.0034 0.2155 0.1883
Entamoeba histolytica multidrug resistance protein, putative 0.0021 0.0816 0.0477

Activities

Activity type Activity value Assay description Source Reference
IC50 (ADMET) uM Inhibition of cytochrome P450 3A4 of human liver microsomes ChEMBL. 14998324
IC50 (ADMET) ND 0 uM Inhibition of cytochrome P450 3A4 of human liver microsomes ChEMBL. 14998324
IC50 (binding) = 0.169 uM Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assay ChEMBL. 14998324
IC50 (binding) = 0.169 uM Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assay ChEMBL. 14998324
IC50 (binding) >= 0.25 uM Inhibitory concentration against multidrug resistance associated protein 1 ChEMBL. 16168641
IC50 (binding) >= 0.25 uM Inhibitory concentration against multidrug resistance associated protein 1 ChEMBL. 16168641
IC50 (binding) = 0.277 uM In vitro inhibitory activity of the compound against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in accumulation assay ChEMBL. 14998324
IC50 (binding) = 0.277 uM In vitro inhibitory activity of the compound against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in accumulation assay ChEMBL. 14998324
IC50 (binding) > 1 uM Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assay ChEMBL. 14998324
IC50 (binding) > 1 uM Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assay ChEMBL. 14998324
IC50 (binding) = 11.6 uM In vitro inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in accumulation assay ChEMBL. 14998324
IC50 (binding) = 11.6 uM In vitro inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in accumulation assay ChEMBL. 14998324

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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