TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 418.442 | Formula: C23H20F2N6
H donors: 1 H acceptors: 3 LogP: 3.53 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1cccc2c1c1nc[nH]c(c1n2)N1CCN(CC1)CCc1ccc(c(c1)F)F
InChi: 1S/C23H20F2N6/c24-17-5-4-15(12-18(17)25)6-7-30-8-10-31(11-9-30)23-22-21(27-14-28-23)20-16(13-26)2-1-3-19(20)29-22/h1-5,12,14H,6-11H2,(H,27,28)
InChiKey: KSLIYXLLGYPJIR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Starlite/ChEMBL	References
Mus musculus	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Entamoeba histolytica	P-glycoprotein-5	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania major	pentamidine resistance protein 1	Get druggable targets OG5_126561	All targets in OG5_126561
Leishmania mexicana	multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Leishmania major	ATP-binding cassette protein subfamily C, member 6, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Schistosoma mansoni	smdr2	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania major	ATP-binding cassette protein subfamily C, member 1, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Leishmania infantum	pentamidine resistance protein 1	Get druggable targets OG5_126561	All targets in OG5_126561
Trichomonas vaginalis	ABC transporter, half transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Trypanosoma brucei	multidrug resistance protein E	Get druggable targets OG5_126561	All targets in OG5_126561
Plasmodium vivax	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Candida albicans	hypothetical protein	Get druggable targets OG5_126561	All targets in OG5_126561
Leishmania mexicana	p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein	Get druggable targets OG5_126596	All targets in OG5_126596
Candida albicans	vacuolar ABC transporter similar to multiple drug resistance-associated protein	Get druggable targets OG5_126561	All targets in OG5_126561
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_126561	All targets in OG5_126561
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trypanosoma cruzi	multidrug resistance-associated protein, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Leishmania major	ABC-thiol transporter	Get druggable targets OG5_126561	All targets in OG5_126561
Babesia bovis	ABC transporter family protein	Get druggable targets OG5_126561	All targets in OG5_126561
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126561	All targets in OG5_126561
Leishmania donovani	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	ATP-binding cassette sub-family B member 5, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance associated protein 1	Get druggable targets OG5_126561	All targets in OG5_126561
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania mexicana	p-glycoprotein e	Get druggable targets OG5_126561	All targets in OG5_126561
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	Get druggable targets OG5_126561	All targets in OG5_126561
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania mexicana	multidrug resistance protein, copy 1-like protein	Get druggable targets OG5_126561	All targets in OG5_126561
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	Get druggable targets OG5_126596	All targets in OG5_126596
Giardia lamblia	Multidrug resistance-associated protein 1	Get druggable targets OG5_126561	All targets in OG5_126561
Theileria parva	ABC transporter, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania major	ATP-binding cassette protein subfamily C, member 2, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Candida albicans	similar to vacuolar membrane ATP-dependant transporter, metal resistance protein	Get druggable targets OG5_126561	All targets in OG5_126561
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Neospora caninum	hypothetical protein	Get druggable targets OG5_126561	All targets in OG5_126561
Schistosoma japonicum	Multidrug resistance protein 3, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Candida albicans	one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W)	Get druggable targets OG5_126561	All targets in OG5_126561
Plasmodium yoelii	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance associated protein 7	Get druggable targets OG5_126561	All targets in OG5_126561
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania infantum	ATP-binding cassette protein subfamily C, member 6, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Theileria parva	ABC transporter, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Leishmania major	p-glycoprotein e	Get druggable targets OG5_126561	All targets in OG5_126561
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania braziliensis	p-glycoprotein e, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Leishmania braziliensis	multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	multidrug resistance protein, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance associated protein 1	Get druggable targets OG5_126561	All targets in OG5_126561
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	Get druggable targets OG5_126596	All targets in OG5_126596
Brugia malayi	multidrug resistance protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Brugia malayi	multidrug resistance related protein 1	Get druggable targets OG5_126561	All targets in OG5_126561
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance associated protein 4	Get druggable targets OG5_126561	All targets in OG5_126561
Neospora caninum	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trypanosoma cruzi	hypothetical protein	Get druggable targets OG5_126561	All targets in OG5_126561
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Plasmodium berghei	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania mexicana	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126561	All targets in OG5_126561
Leishmania braziliensis	ABC-thiol transporter	Get druggable targets OG5_126561	All targets in OG5_126561
Echinococcus multilocularis	multidrug resistance associated protein 4	Get druggable targets OG5_126561	All targets in OG5_126561
Leishmania infantum	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Cryptosporidium parvum	ATP-binding cassette protein	Get druggable targets OG5_126561	All targets in OG5_126561
Leishmania braziliensis	p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance-associated protein 4, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Leishmania donovani	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Theileria parva	ABC transporter, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trypanosoma brucei gambiense	multidrug resistance-associated protein, putative,p-glycoprotein	Get druggable targets OG5_126561	All targets in OG5_126561
Echinococcus multilocularis	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	ko:K05674 ATP-binding cassette, subfamily C (CFTR/MRP), member 10, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Trichomonas vaginalis	abcb9, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Theileria parva	ABC transporter, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Leishmania mexicana	p-glycoprotein e, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Plasmodium falciparum	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	multidrug resistance protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	Get druggable targets OG5_126596	All targets in OG5_126596
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	Get druggable targets OG5_126561	All targets in OG5_126561
Theileria parva	ABC transporter, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trypanosoma cruzi	multidrug resistance-associated protein, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Brugia malayi	ABC transporter transmembrane region family protein	Get druggable targets OG5_126561	All targets in OG5_126561
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Theileria parva	ABC transporter, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	Get druggable targets OG5_126596	All targets in OG5_126596
Trypanosoma congolense	multidrug resistance protein A	Get druggable targets OG5_126561	All targets in OG5_126561
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glyco protein 6, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trypanosoma cruzi	multidrug resistance protein E, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Giardia lamblia	ABC transporter, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Plasmodium knowlesi	multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania mexicana	p-glycoprotein-like protein	Get druggable targets OG5_126561	All targets in OG5_126561
Schistosoma japonicum	Canalicular multispecific organic anion transporter 2, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Leishmania major	p-glycoprotein	Get druggable targets OG5_126596	All targets in OG5_126596
Cryptosporidium hominis	SI:dZ52I16.4 (novel ABC transporter similar to human multidrug-resistance proteins (MRP))	Get druggable targets OG5_126561	All targets in OG5_126561
Entamoeba histolytica	P-glycoprotein-2	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein 5, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania infantum	ATP-binding cassette protein subfamily C, member 2, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Leishmania major	ATP-binding cassette protein subfamily C, member 5, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Leishmania mexicana	ATP-binding cassette protein subfamily C, member 1, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania infantum	ATP-binding cassette protein subfamily C, member 1, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Candida albicans	one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W)	Get druggable targets OG5_126561	All targets in OG5_126561
Cryptosporidium parvum	ABC ATpase (2 ABC domains) with 10 transmembrane domains, adjacent duplicated gene	Get druggable targets OG5_126561	All targets in OG5_126561
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	ATP-binding cassette protein, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126561	All targets in OG5_126561
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126561	All targets in OG5_126561
Schistosoma japonicum	Multidrug resistance protein 3, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance-associated protein 4, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Candida albicans	potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	multidrug resistance associated protein 7	Get druggable targets OG5_126561	All targets in OG5_126561
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	ABC transporter, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Schistosoma japonicum	Multidrug resistance-associated protein 4, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Trypanosoma brucei	multidrug resistance-associated protein, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Candida albicans	similar to vacuolar membrane ATP-dependant transporter, metal resistance protein	Get druggable targets OG5_126561	All targets in OG5_126561
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania braziliensis	multidrug resistance protein, putative,p-glycoprotein, putative,ABC transporter, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Bile salt export pump, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	ATP-binding cassette protein, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Theileria parva	ABC transporter, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Theileria parva	ABC transporter, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126561	All targets in OG5_126561
Schistosoma japonicum	Multidrug resistance protein 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Candida albicans	one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W)	Get druggable targets OG5_126561	All targets in OG5_126561
Schistosoma japonicum	Multidrug resistance-associated protein 7, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ATP-binding cassette transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Candida albicans	one of three genes similar to S. cerevisiae YCF1 (YDR135C) and BPT1 (YLL015W)	Get druggable targets OG5_126561	All targets in OG5_126561
Trypanosoma brucei	p-glycoprotein	Get druggable targets OG5_126561	All targets in OG5_126561
Theileria parva	ABC transporter, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Trypanosoma brucei	multidrug resistance-associated protein, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Neospora caninum	ATP-binding cassette, sub-family B (MDR/TAP), member 4, related	Get druggable targets OG5_126596	All targets in OG5_126596
Onchocerca volvulus		Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	ATP-binding cassette protein, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, half transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	ATP-binding cassette protein, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Leishmania infantum	ABC-thiol transporter	Get druggable targets OG5_126561	All targets in OG5_126561
Babesia bovis	ABC transporter family protein	Get druggable targets OG5_126561	All targets in OG5_126561
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania donovani	pentamidine resistance protein 1	Get druggable targets OG5_126561	All targets in OG5_126561
Schistosoma japonicum	ko:K05667 ATP-binding cassette, subfamily C (CFTR/MRP), member 3, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Schistosoma japonicum	Multidrug resistance-associated protein 1, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Leishmania infantum	p-glycoprotein e	Get druggable targets OG5_126561	All targets in OG5_126561
Trypanosoma congolense	multidrug resistance-associated protein, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Trichomonas vaginalis	taga, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus multilocularis	ATP binding cassette sub family B	Get druggable targets OG5_126596	All targets in OG5_126596
Brugia malayi	ABC transporter family protein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Cryptosporidium parvum	ATP-binding cassette transporter	Get druggable targets OG5_126596	All targets in OG5_126596
Trichomonas vaginalis	ABC transporter, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania infantum	ATP-binding cassette protein subfamily B, member 2, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Entamoeba histolytica	P-glycoprotein-2	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Giardia lamblia	Multidrug resistance-associated protein 1	Get druggable targets OG5_126561	All targets in OG5_126561
Loa Loa (eye worm)	multidrug resistance-associated protein	Get druggable targets OG5_126561	All targets in OG5_126561
Giardia lamblia	Multidrug resistance-associated protein 1	Get druggable targets OG5_126561	All targets in OG5_126561
Leishmania mexicana	ABC-thiol transporter	Get druggable targets OG5_126561	All targets in OG5_126561
Giardia lamblia	MRP-like ABC transporter	Get druggable targets OG5_126561	All targets in OG5_126561
Candida albicans	vacuolar ABC transporter similar to multiple drug resistance-associated protein	Get druggable targets OG5_126561	All targets in OG5_126561
Babesia bovis	ABC transporter family protein	Get druggable targets OG5_126561	All targets in OG5_126561
Leishmania infantum	ATP-binding cassette protein subfamily C, member 5, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Cryptosporidium hominis	ATP-binding cassette protein 3	Get druggable targets OG5_126596	All targets in OG5_126596
Theileria parva	ABC transporter, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	Get druggable targets OG5_126596	All targets in OG5_126596
Leishmania braziliensis	p-glycoprotein e	Get druggable targets OG5_126561	All targets in OG5_126561
Theileria parva	ABC transporter, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126561	All targets in OG5_126561
Babesia bovis	ABC transporter, ATP-binding protein domain containing protein	Get druggable targets OG5_126561	All targets in OG5_126561
Entamoeba histolytica	P-glycoprotein-1	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	Get druggable targets OG5_126596	All targets in OG5_126596
Theileria parva	ABC transporter, putative	Get druggable targets OG5_126561	All targets in OG5_126561
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Schistosoma japonicum	Multidrug resistance protein 1, putative	Get druggable targets OG5_126596	All targets in OG5_126596
Trypanosoma brucei gambiense	multidrug resistance protein E,p-glycoprotein	Get druggable targets OG5_126561	All targets in OG5_126561
Schistosoma mansoni	multidrug resistance protein	Get druggable targets OG5_126596	All targets in OG5_126596
Echinococcus granulosus	multidrug resistance protein 1	Get druggable targets OG5_126596	All targets in OG5_126596
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126561	All targets in OG5_126561
Theileria parva	ABC transporter, putative	Get druggable targets OG5_126561	All targets in OG5_126561

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	proteasome subunit alpha type-7, putative	0.0034	0.2155	0.1883
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0089	0.7733	0.7829
Leishmania major	ABC-thiol transporter	0.0021	0.0816	0.0477
Echinococcus granulosus	proteasome subunit beta type 6	0.0034	0.2155	0.2181
Plasmodium vivax	proteasome subunit beta type-5, putative	0.011	0.9878	1
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0034	0.2155	0.2181
Leishmania major	proteasome beta 2 subunit, putative	0.0061	0.4893	0.4761
Entamoeba histolytica	proteasome subunit alpha type 6, putative	0.0034	0.2155	0.1883
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0034	0.2155	0.1859
Entamoeba histolytica	calcineurin catalytic subunit A, putative	0.0085	0.7315	0.7307
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0034	0.2155	0.1859
Entamoeba histolytica	proteasome subunit beta type 6 precursor, putative	0.0034	0.2155	0.1883
Brugia malayi	proteasome subunit beta type 3	0.0034	0.2155	0.1883
Leishmania major	pentamidine resistance protein 1	0.0021	0.0816	0.0477
Echinococcus granulosus	multidrug resistance protein 1	0.0017	0.0363	0.0367
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0034	0.2155	0.1859
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0016	0.0334	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0788	0.0771
Plasmodium falciparum	proteasome subunit alpha type-5, putative	0.0034	0.2155	0.1883
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0034	0.2155	0.1859
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0061	0.4893	0.4954
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0034	0.2155	0.1883
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0034	0.2155	0.5
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0089	0.7733	0.7829
Entamoeba histolytica	proteasome subunit alpha type 1, putative	0.0034	0.2155	0.1883
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0089	0.7733	0.7747
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0034	0.2155	0.2181
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0034	0.2155	0.2181
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0034	0.2155	0.1477
Plasmodium vivax	proteasome subunit beta type-3, putative	0.0034	0.2155	0.1883
Entamoeba histolytica	calcineurin catalytic subunit A, putative	0.0085	0.7315	0.7307
Schistosoma mansoni	multidrug resistance protein	0.0021	0.0816	0.0471
Entamoeba histolytica	calcineurin catalytic subunit A, putative	0.0085	0.7315	0.7307
Leishmania major	proteasome alpha 7 subunit, putative	0.0034	0.2155	0.1883
Leishmania major	ATP-binding cassette protein subfamily C, member 6, putative	0.0021	0.0816	0.0477
Leishmania major	ATP-binding cassette protein subfamily C, member 5, putative	0.0021	0.0816	0.0477
Toxoplasma gondii	heat shock protein hslv, putative	0.0034	0.2155	0.1883
Toxoplasma gondii	protein phosphatase 2B catalytic subunit, calcineurin family phosphatse superfamily protein	0.0085	0.7315	0.7307
Giardia lamblia	20S proteasome alpha subunit 3	0.0034	0.2155	0.1504
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0034	0.2155	0.2159
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0034	0.2155	0.2181
Entamoeba histolytica	Ser/Thr protein phosphatase, putative	0.0085	0.7315	0.7307
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0034	0.2155	0.2181
Giardia lamblia	Proteasome subunit beta type 1	0.0089	0.7733	0.7641
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0061	0.4893	0.4761
Entamoeba histolytica	proteasome subunit beta type 3, putative	0.0034	0.2155	0.1883
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0017	0.0363	0.0367
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0089	0.7733	0.7648
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0089	0.7733	0.7823
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0034	0.2155	0.1859
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0034	0.2155	0.1477
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0021	0.0816	0.0477
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0034	0.2155	0.1883
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0034	0.2155	0.1859
Plasmodium falciparum	proteasome subunit beta type-7, putative	0.0034	0.2155	0.1883
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.011	0.9878	1
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0034	0.2155	0.1883
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0034	0.2155	0.1883
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0034	0.2155	0.1859
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0061	0.4893	0.4954
Giardia lamblia	20S proteasome alpha subunit 1	0.0034	0.2155	0.1504
Trypanosoma brucei	proteasome beta 6 subunit	0.0089	0.7733	0.7634
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0034	0.2155	0.2159
Entamoeba histolytica	proteasome subunit alpha type 2-A, putative	0.0034	0.2155	0.1883
Plasmodium falciparum	proteasome subunit beta type-3, putative	0.0034	0.2155	0.1883
Plasmodium falciparum	proteasome subunit alpha type-1, putative	0.0034	0.2155	0.1883
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0017	0.0363	0.0367
Toxoplasma gondii	proteasome subunit beta type, putative	0.011	0.9878	1
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0034	0.2155	0.1883
Brugia malayi	proteasome subunit alpha type 6	0.0034	0.2155	0.1883
Trypanosoma cruzi	serine/threonine protein phosphatase 2B catalytic subunit A2, putative	0.0085	0.7315	0.7406
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0034	0.2155	0.2159
Trypanosoma cruzi	multidrug resistance protein E, putative	0.0021	0.0816	0.0826
Echinococcus multilocularis	multidrug resistance associated protein 1	0.0021	0.0816	0.0826
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0034	0.2155	0.2181
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0034	0.2155	0.2181
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0816	0.08
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0034	0.2155	0.2159
Echinococcus granulosus	proteasome subunit beta type 7	0.0034	0.2155	0.2181
Trypanosoma cruzi	Enriched in surface-labeled proteome protein 12	0.0102	0.9056	0.9168
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0061	0.4893	0.4954
Loa Loa (eye worm)	PAS-3 protein	0.0034	0.2155	0.2159
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0034	0.2155	0.1883
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0021	0.0816	0.0477
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0034	0.2155	0.1883
Leishmania major	proteasome alpha 1 subunit, putative	0.0034	0.2155	0.1883
Plasmodium vivax	proteasome subunit alpha type-2, putative	0.0034	0.2155	0.1883
Trypanosoma cruzi	Enriched in surface-labeled proteome protein 12	0.0102	0.9056	0.9168
Plasmodium falciparum	proteasome subunit alpha type-6, putative	0.0034	0.2155	0.1883
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0034	0.2155	0.2181
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0034	0.2155	0.1859
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0034	0.2155	0.2181
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0034	0.2155	0.1859
Schistosoma mansoni	protein phosphatase-2b	0.0085	0.7315	0.7214
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0021	0.0816	0.0477
Trypanosoma brucei	hypothetical protein, conserved	0.0102	0.9056	0.9093
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0089	0.7733	0.7747
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0034	0.2155	0.1477
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0034	0.2155	0.1883
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0034	0.2155	0.1883
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0034	0.2155	0.1477
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0034	0.2155	0.1477
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0034	0.2155	0.2181
Echinococcus multilocularis	proteasome subunit beta type 6	0.0034	0.2155	0.2181
Plasmodium falciparum	proteasome subunit beta type-5	0.011	0.9878	1
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0034	0.2155	0.2181
Leishmania major	proteasome alpha 3 subunit, putative	0.0034	0.2155	0.1883
Echinococcus multilocularis	serine:threonine protein phosphatase 2B	0.0085	0.7315	0.7406
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0034	0.2155	0.2181
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0034	0.2155	0.2181
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0034	0.2155	0.1477
Giardia lamblia	20S proteasome alpha subunit 5	0.0034	0.2155	0.1504
Giardia lamblia	20S proteasome alpha subunit 6	0.0034	0.2155	0.1504
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0363	0.0339
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0034	0.2155	0.1477
Brugia malayi	ABC transporter transmembrane region family protein	0.0021	0.0816	0.0477
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.011	0.9878	1
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0034	0.2155	0.2181
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0034	0.2155	0.2181
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0034	0.2155	0.1859
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0034	0.2155	0.2181
Schistosoma mansoni	multidrug resistance protein	0.0021	0.0816	0.0471
Schistosoma mansoni	multidrug resistance protein	0.0021	0.0816	0.0471
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.2155	0.1883
Toxoplasma gondii	proteasome beta subunit	0.0034	0.2155	0.1883
Onchocerca volvulus	Notchless protein homolog	0.0034	0.2155	1
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0034	0.2155	0.2181
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.0021	0.0816	0.08
Echinococcus granulosus	multidrug resistance associated protein 7	0.0021	0.0816	0.0826
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0034	0.2155	0.1883
Loa Loa (eye worm)	hypothetical protein	0.0085	0.7315	0.7399
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0034	0.2155	0.1883
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0034	0.2155	0.2181
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.2155	0.1883
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0034	0.2155	0.1859
Trypanosoma brucei	proteasome beta 7 subunit	0.0034	0.2155	0.1477
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0034	0.2155	0.1477
Entamoeba histolytica	Ser/Thr protein phosphatase, putative	0.0085	0.7315	0.7307
Entamoeba histolytica	ABC transporter, putative	0.0021	0.0816	0.0477
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0034	0.2155	0.2181
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.2155	0.1883
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0089	0.7733	0.7747
Brugia malayi	Serine/threonine protein phosphatase 2B catalytic subunit 2	0.0085	0.7315	0.7307
Plasmodium falciparum	proteasome subunit alpha type-7, putative	0.0034	0.2155	0.1883
Entamoeba histolytica	calcineurin catalytic subunit A, putative	0.0085	0.7315	0.7307
Echinococcus granulosus	Proteasome subunit alpha beta	0.0034	0.2155	0.2181
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0034	0.2155	0.2181
Brugia malayi	20S proteasome alpha5 subunit	0.0034	0.2155	0.1883
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.011	0.9878	1
Plasmodium vivax	proteasome subunit alpha type-3, putative	0.0034	0.2155	0.1883
Giardia lamblia	20S proteasome alpha subunit 2	0.0034	0.2155	0.1504
Echinococcus granulosus	proteasome subunit alpha type 6	0.0034	0.2155	0.2181
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.011	0.9878	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0017	0.0363	0.0367
Plasmodium vivax	proteasome subunit alpha type-1, putative	0.0034	0.2155	0.1883
Echinococcus granulosus	multidrug resistance protein 1	0.0017	0.0363	0.0367
Leishmania major	proteasome alpha 1 subunit, putative	0.0034	0.2155	0.1883
Trypanosoma cruzi	20S proteasome subunit	0.0061	0.4893	0.4954
Brugia malayi	multidrug resistance related protein 1	0.0021	0.0816	0.0477
Echinococcus granulosus	proteasome subunit alpha type 2	0.0034	0.2155	0.2181
Loa Loa (eye worm)	multidrug resistance protein 3	0.0017	0.0363	0.0339
Echinococcus multilocularis	multidrug resistance associated protein 7	0.0021	0.0816	0.0826
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0363	0.0339
Plasmodium vivax	proteasome subunit beta type-7, putative	0.0034	0.2155	0.1883
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.2155	0.1883
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0034	0.2155	0.1883
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0021	0.0816	0.0477
Giardia lamblia	Proteasome subunit beta type 3	0.0034	0.2155	0.1504
Brugia malayi	proteasome subunit beta type 2	0.0061	0.4893	0.4761
Brugia malayi	proteasome subunit beta type 1	0.0089	0.7733	0.7747
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.0034	0.2155	0.1883
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0017	0.0363	0.0367
Brugia malayi	Proteasome A-type and B-type family protein	0.0034	0.2155	0.1883
Giardia lamblia	Multidrug resistance-associated protein 1	0.0021	0.0816	0.0031
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0034	0.2155	0.1883
Entamoeba histolytica	proteasome subunit beta type 7-B precursor, putative	0.0034	0.2155	0.1883
Leishmania major	proteasome beta 5 subunit, putative	0.011	0.9878	1
Trypanosoma brucei	Enriched in surface-labeled proteome protein 12	0.0102	0.9056	0.9093
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.2155	0.1883
Echinococcus multilocularis	multidrug resistance protein 1	0.0017	0.0363	0.0367
Plasmodium vivax	proteasome subunit alpha type-4, putative	0.0034	0.2155	0.1883
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.011	0.9878	1
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0034	0.2155	0.2181
Leishmania major	proteasome beta 3 subunit, putative	0.0034	0.2155	0.1883
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0034	0.2155	0.1883
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0034	0.2155	0.2181
Entamoeba histolytica	proteasome subunit alpha type 4, putative	0.0034	0.2155	0.1883
Entamoeba histolytica	proteasome subunit alpha type 3, putative	0.0034	0.2155	0.1883
Plasmodium falciparum	serine/threonine protein phosphatase 2B catalytic subunit A	0.0085	0.7315	0.7307
Entamoeba histolytica	hypothetical protein	0.0021	0.0816	0.0477
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0034	0.2155	0.2159
Brugia malayi	proteasome subunit alpha type 4	0.0034	0.2155	0.1883
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0034	0.2155	0.1859
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.011	0.9878	1
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0061	0.4893	0.4761
Giardia lamblia	Proteasome subunit beta type 9 precursor	0.0034	0.2155	0.1504
Giardia lamblia	ABC transporter, putative	0.0021	0.0816	0.0031
Leishmania major	serine/threonine protein phosphatase 2B catalytic subunit A2, putative	0.0085	0.7315	0.7307
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0021	0.0816	0.0826
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.2155	0.1883
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0034	0.2155	0.1477
Leishmania major	serine/threonine protein phosphatase, putative	0.0085	0.7315	0.7307
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0034	0.2155	0.1883
Plasmodium vivax	proteasome subunit beta type-4, putative	0.0034	0.2155	0.1883
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0034	0.2155	0.2181
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0034	0.2155	0.1883
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0034	0.2155	0.2181
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0089	0.7733	0.7829
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.011	0.9878	1
Toxoplasma gondii	peptidase, T1 family protein	0.0034	0.2155	0.1883
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0034	0.2155	0.1883
Echinococcus granulosus	multidrug resistance associated protein 1	0.0021	0.0816	0.0826
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0017	0.0363	0.0367
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0034	0.2155	0.2181
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0034	0.2155	0.1883
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.011	0.9878	1
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0034	0.2155	0.2181
Giardia lamblia	MRP-like ABC transporter	0.0021	0.0816	0.0031
Leishmania major	proteasome beta 2 subunit, putative	0.0034	0.2155	0.1883
Mycobacterium ulcerans	proteasome PrcB	0.011	0.9878	1
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0089	0.7733	0.7747
Echinococcus multilocularis	ATP binding cassette sub family B	0.0016	0.0334	0.0338
Trypanosoma cruzi	Enriched in surface-labeled proteome protein 12	0.0102	0.9056	0.9168
Entamoeba histolytica	probable proteasome subunit beta type 2, putative	0.0061	0.4893	0.4761
Plasmodium falciparum	proteasome subunit beta type-4	0.0034	0.2155	0.1883
Plasmodium vivax	proteasome subunit beta type-2, putative	0.0061	0.4893	0.4761
Echinococcus granulosus	multidrug resistance protein 1	0.0017	0.0363	0.0367
Echinococcus multilocularis	serine:threonine protein phosphatase 2B	0.0085	0.7315	0.7406
Plasmodium vivax	proteasome subunit alpha type-6, putative	0.0034	0.2155	0.1883
Giardia lamblia	Proteasome subunit beta type 7 precursor	0.0034	0.2155	0.1504
Leishmania major	proteasome alpha 2 subunit, putative	0.0034	0.2155	0.1883
Trypanosoma brucei	proteasome alpha 7 subunit	0.0034	0.2155	0.1477
Brugia malayi	proteasome subunit alpha type 1	0.0034	0.2155	0.1883
Leishmania major	proteasome beta-1 subunit, putative	0.0034	0.2155	0.1883
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0089	0.7733	0.7829
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0034	0.2155	0.2159
Brugia malayi	Proteasome A-type and B-type family protein	0.0034	0.2155	0.1883
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0017	0.0363	0.0339
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0034	0.2155	0.2181
Brugia malayi	Proteasome A-type and B-type family protein	0.0034	0.2155	0.1883
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0017	0.0363	0.0367
Plasmodium falciparum	ATP-dependent protease subunit ClpQ	0.0034	0.2155	0.1883
Plasmodium vivax	serine/threonine protein phosphatase 2B catalytic subunit A, putative	0.0085	0.7315	0.7307
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0061	0.4893	0.4701
Trypanosoma cruzi	Enriched in surface-labeled proteome protein 12	0.0102	0.9056	0.9168
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0034	0.2155	0.1883
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0034	0.2155	0.1883
Giardia lamblia	Proteasome subunit beta type 2	0.0061	0.4893	0.4516
Entamoeba histolytica	proteasome subunit alpha type 7, putative	0.0034	0.2155	0.1883
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0034	0.2155	0.2181
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0034	0.2155	0.2181
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0021	0.0816	0.0477
Entamoeba histolytica	proteasome subunit alpha type 5, putative	0.0034	0.2155	0.1883
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0034	0.2155	0.1859
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0034	0.2155	0.2159
Giardia lamblia	20S proteasome alpha subunit 4	0.0034	0.2155	0.1504
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0017	0.0363	0.0367
Echinococcus multilocularis	multidrug resistance protein 1	0.0017	0.0363	0.0367
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0017	0.0363	0.0367
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.2155	0.1883
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0034	0.2155	0.2181
Plasmodium falciparum	proteasome subunit alpha type-3, putative	0.0034	0.2155	0.1883
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0816	0.08
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0034	0.2155	0.2181
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0017	0.0363	0.0367
Echinococcus granulosus	serine:threonine protein phosphatase 2B	0.0085	0.7315	0.7406
Plasmodium falciparum	proteasome subunit alpha type-4, putative	0.0034	0.2155	0.1883
Plasmodium vivax	proteasome subunit alpha type-5, putative	0.0034	0.2155	0.1883
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0034	0.2155	0.2181
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0034	0.2155	0.2181
Echinococcus granulosus	proteasome prosome macropain	0.011	0.9878	1
Brugia malayi	proteasome subunit alpha type 3	0.0034	0.2155	0.1883
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0034	0.2155	0.1883
Schistosoma mansoni	protein phosphatase-2b	0.0085	0.7315	0.7214
Toxoplasma gondii	proteasome subunit	0.0034	0.2155	0.1883
Leishmania major	p-glycoprotein e	0.0021	0.0816	0.0477
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0061	0.4893	0.4701
Trypanosoma brucei	protein phosphatase 2B, putative	0.0085	0.7315	0.7172
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0034	0.2155	0.1859
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0034	0.2155	0.2181
Echinococcus granulosus	proteasome subunit beta t family	0.0034	0.2155	0.2181
Trypanosoma cruzi	Enriched in surface-labeled proteome protein 12	0.0102	0.9056	0.9168
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0061	0.4893	0.4939
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0034	0.2155	0.1477
Schistosoma mansoni	multidrug resistance protein	0.0021	0.0816	0.0471
Trypanosoma cruzi	serine/threonine protein phosphatase, putative	0.0085	0.7315	0.7406
Giardia lamblia	Multidrug resistance-associated protein 1	0.0021	0.0816	0.0031
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0034	0.2155	0.2181
Trypanosoma cruzi	serine/threonine protein phosphatase, putative	0.0085	0.7315	0.7406
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0034	0.2155	0.1883
Trichomonas vaginalis	Family T1, proteasome alpha subunit, threonine peptidase	0.0034	0.2155	0.1883
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0017	0.0363	0.5
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0034	0.2155	0.2181
Brugia malayi	Proteasome subunit alpha type 7-1	0.0034	0.2155	0.1883
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0021	0.0816	0.0826
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0034	0.2155	0.1859
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0034	0.2155	0.2181
Echinococcus multilocularis	proteasome (prosome, macropain)	0.011	0.9878	1
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0034	0.2155	0.2159
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0034	0.2155	0.2159
Leishmania major	proteasome beta 7 subunit, putative	0.0034	0.2155	0.1883
Trypanosoma brucei	hypothetical protein, conserved	0.0102	0.9056	0.9093
Entamoeba histolytica	proteasome subunit beta Type 4 precursor, putative	0.0034	0.2155	0.1883
Leishmania major	ATP-binding cassette protein subfamily C, member 2, putative	0.0021	0.0816	0.0477
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.011	0.9878	1
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0089	0.7733	0.7747
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0034	0.2155	0.1883
Brugia malayi	Proteasome subunit alpha type 1	0.0034	0.2155	0.1883
Plasmodium falciparum	proteasome subunit beta type-2, putative	0.0061	0.4893	0.4761
Plasmodium vivax	ATP-dependent protease subunit ClpQ, putative	0.0034	0.2155	0.1883
Plasmodium falciparum	proteasome subunit alpha type-2, putative	0.0034	0.2155	0.1883
Leishmania major	proteasome alpha 7 subunit, putative	0.0034	0.2155	0.1883
Echinococcus multilocularis	proteasome subunit beta type 7	0.0034	0.2155	0.2181
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0061	0.4893	0.4761
Loa Loa (eye worm)	hypothetical protein	0.0083	0.7193	0.7274
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0061	0.4893	0.4499
Leishmania major	ATP-binding cassette protein subfamily C, member 1, putative	0.0021	0.0816	0.0477
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0034	0.2155	0.2159
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0089	0.7733	0.7747
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0334	0.0311
Giardia lamblia	20S proteasome alpha subunit 7	0.0034	0.2155	0.1504
Giardia lamblia	Proteasome subunit beta type 4 precursor	0.0034	0.2155	0.1504
Plasmodium vivax	proteasome subunit beta type-6, putative	0.0034	0.2155	0.1883
Plasmodium falciparum	proteasome subunit beta type-6, putative	0.0034	0.2155	0.1883
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0034	0.2155	0.1883
Brugia malayi	Proteasome A-type and B-type family protein	0.011	0.9878	1
Echinococcus granulosus	serine:threonine protein phosphatase 2B	0.0085	0.7315	0.7406
Brugia malayi	proteasome subunit alpha type 2	0.0034	0.2155	0.1883
Entamoeba histolytica	multidrug resistance protein, putative	0.0021	0.0816	0.0477

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (ADMET)	uM	Inhibition of cytochrome P450 3A4 of human liver microsomes	ChEMBL.	14998324
IC50 (ADMET)	ND 0 uM	Inhibition of cytochrome P450 3A4 of human liver microsomes	ChEMBL.	14998324
IC50 (binding)	= 0.169 uM	Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assay	ChEMBL.	14998324
IC50 (binding)	= 0.169 uM	Inhibitory activity against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in single-dose potentiation assay	ChEMBL.	14998324
IC50 (binding)	>= 0.25 uM	Inhibitory concentration against multidrug resistance associated protein 1	ChEMBL.	16168641
IC50 (binding)	>= 0.25 uM	Inhibitory concentration against multidrug resistance associated protein 1	ChEMBL.	16168641
IC50 (binding)	= 0.277 uM	In vitro inhibitory activity of the compound against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in accumulation assay	ChEMBL.	14998324
IC50 (binding)	= 0.277 uM	In vitro inhibitory activity of the compound against MRP1 (Multidrug resistance associated protein 1) expressed in COR.L23/R cell line in accumulation assay	ChEMBL.	14998324
IC50 (binding)	> 1 uM	Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assay	ChEMBL.	14998324
IC50 (binding)	> 1 uM	Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assay	ChEMBL.	14998324
IC50 (binding)	= 11.6 uM	In vitro inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in accumulation assay	ChEMBL.	14998324
IC50 (binding)	= 11.6 uM	In vitro inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in accumulation assay	ChEMBL.	14998324

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL430925

Bibliographic References

2 literature references were collected for this gene.

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Detailed information for compound 35511