Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0593 | 0.0403 | 0.043 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1867 | 0.1516 | 0.1562 |
Brugia malayi | hypothetical protein | 0.5172 | 0.4401 | 0.4659 |
Onchocerca volvulus | Putative folylpolyglutamate synthase | 0.0201 | 0.0061 | 0.0065 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1867 | 0.1516 | 0.1562 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1867 | 0.1516 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.5172 | 0.4401 | 0.4693 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.5172 | 0.4401 | 0.4367 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 1.1587 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1867 | 0.1516 | 0.1617 |
Echinococcus granulosus | dihydrofolate reductase | 0.1867 | 0.1516 | 0.1562 |
Mycobacterium tuberculosis | Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) | 0.0201 | 0.0061 | 0.0065 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0593 | 0.0403 | 1 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0593 | 0.0403 | 0.043 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 1.0872 | 0.9377 | 1 |
Mycobacterium leprae | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) | 0.0201 | 0.0061 | 0.0065 |
Schistosoma mansoni | dihydrofolate reductase | 0.1867 | 0.1516 | 0.1562 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1867 | 0.1516 | 0.1617 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 1.1587 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1867 | 0.1516 | 0.1617 |
Echinococcus granulosus | thymidylate synthase | 1.0872 | 0.9377 | 1 |
Onchocerca volvulus | 1.0872 | 0.9377 | 1 | |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 1.0872 | 0.9377 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 1.1587 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 1.0872 | 0.9377 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 1.1587 | 1 | 1 |
Mycobacterium ulcerans | folylpolyglutamate synthase protein FolC | 0.0201 | 0.0061 | 0.0065 |
Trichomonas vaginalis | conserved hypothetical protein | 0.5172 | 0.4401 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 1.0872 | 0.9377 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1867 | 0.1516 | 0.1562 |
Brugia malayi | thymidylate synthase | 1.0872 | 0.9377 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 1.0872 | 0.9377 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.1867 | 0.1516 | 0.1562 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 1.1587 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 1.0872 | 0.9377 | 1 |
Treponema pallidum | folylpolyglutamate synthetase (folC) | 0.0201 | 0.0061 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kd (binding) | = 0.1 uM | Binding affinity of compound to P-glycoprotein recombinant domain of prenylated xanthones was evaluated | ChEMBL. | 10890160 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.