Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor E75 | 0.0114 | 0.0621 | 0.049 |
Echinococcus multilocularis | geminin | 0.0171 | 0.1975 | 0.4509 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.3624 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.3624 | 1 |
Echinococcus granulosus | geminin | 0.0171 | 0.1975 | 0.4509 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0241 | 0.3624 | 1 |
Brugia malayi | hypothetical protein | 0.0128 | 0.0943 | 0.1046 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0241 | 0.3624 | 0.5685 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0241 | 0.3624 | 0.5685 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0114 | 0.0621 | 0.1714 |
Brugia malayi | hypothetical protein | 0.0114 | 0.0621 | 0.049 |
Brugia malayi | hypothetical protein | 0.0128 | 0.0943 | 0.1046 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0943 | 0.2602 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0241 | 0.3624 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0241 | 0.3624 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0241 | 0.3624 | 1 |
Onchocerca volvulus | 0.0241 | 0.3624 | 1 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0621 | 0.1714 |
Echinococcus granulosus | FTZ F1 alpha | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0621 | 0.1714 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0621 | 0.1714 |
Schistosoma mansoni | nuclear receptor | 0.0114 | 0.0621 | 0.0862 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0114 | 0.0621 | 0.1714 |
Brugia malayi | ecdysone receptor | 0.0114 | 0.0621 | 0.049 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0241 | 0.3624 | 0.5685 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0241 | 0.3624 | 0.5685 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0943 | 0.2602 |
Brugia malayi | nuclear receptor RXR | 0.0128 | 0.0943 | 0.1046 |
Schistosoma mansoni | thyroid hormone receptor | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0241 | 0.3624 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0241 | 0.3624 | 0.5685 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0241 | 0.3624 | 0.5685 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0621 | 0.1714 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0114 | 0.0621 | 0.0862 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0621 | 0.1714 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0241 | 0.3624 | 0.5685 |
Onchocerca volvulus | 0.0114 | 0.0621 | 0.0862 | |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0241 | 0.3624 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0241 | 0.3624 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0128 | 0.0943 | 0.1046 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0241 | 0.3624 | 1 |
Brugia malayi | hypothetical protein | 0.0114 | 0.0621 | 0.049 |
Schistosoma mansoni | zinc finger protein | 0.0114 | 0.0621 | 0.0862 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0114 | 0.0621 | 0.049 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0241 | 0.3624 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0241 | 0.3624 | 0.5685 |
Schistosoma mansoni | nuclear hormone receptor | 0.0241 | 0.3624 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0114 | 0.0621 | 0.049 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0621 | 0.1714 |
Brugia malayi | nuclear receptor RXR | 0.0114 | 0.0621 | 0.049 |
Schistosoma mansoni | thyroid hormone receptor | 0.0241 | 0.3624 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0114 | 0.0621 | 0.0862 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0114 | 0.0621 | 0.049 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0241 | 0.3624 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0114 | 0.0621 | 0.049 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0241 | 0.3624 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0114 | 0.0621 | 0.0862 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0621 | 0.1714 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0621 | 0.1714 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0114 | 0.0621 | 0.0862 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0241 | 0.3624 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0621 | 0.1714 |
Brugia malayi | hypothetical protein | 0.0347 | 0.6118 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0114 | 0.0621 | 0.0862 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0241 | 0.3624 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0241 | 0.3624 | 1 |
Brugia malayi | steroid hormone receptor | 0.0241 | 0.3624 | 0.5685 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0128 | 0.0943 | 0.1046 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0241 | 0.3624 | 0.5685 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0241 | 0.3624 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0241 | 0.3624 | 0.5685 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0241 | 0.3624 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0114 | 0.0621 | 0.049 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0338 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.3624 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0241 | 0.3624 | 0.5685 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0128 | 0.0943 | 0.184 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0128 | 0.0943 | 0.184 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0241 | 0.3624 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0114 | 0.0621 | 0.0862 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0241 | 0.3624 | 0.5685 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0114 | 0.0621 | 0.1714 |
Schistosoma mansoni | coup transcription factor | 0.0241 | 0.3624 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0114 | 0.0621 | 0.0862 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0943 | 0.2602 |
Onchocerca volvulus | 0.0114 | 0.0621 | 0.0862 | |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.1975 | 0.4982 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.3624 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0241 | 0.3624 | 0.5685 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0241 | 0.3624 | 0.5685 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0621 | 0.1714 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.3624 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0114 | 0.0621 | 0.1714 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0943 | 0.2602 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.1975 | 0.4982 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0241 | 0.3624 | 0.5685 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0241 | 0.3624 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.3624 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0128 | 0.0943 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0241 | 0.3624 | 0.5685 |
Brugia malayi | nuclear receptor NHR-67 | 0.0114 | 0.0621 | 0.049 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0241 | 0.3624 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0114 | 0.0621 | 0.049 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0338 | 0.0933 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1402 | 0.3868 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0114 | 0.0621 | 0.0862 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0114 | 0.0621 | 0.049 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0114 | 0.0621 | 0.049 |
Brugia malayi | ecdysteroid receptor | 0.0241 | 0.3624 | 0.5685 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0943 | 0.2602 |
Brugia malayi | tailless protein | 0.0114 | 0.0621 | 0.049 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0621 | 0.1714 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0241 | 0.3624 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0621 | 0.1714 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0128 | 0.0943 | 0.2602 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0241 | 0.3624 | 0.5685 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0241 | 0.3624 | 0.5685 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0621 | 0.1714 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0128 | 0.0943 | 0.1071 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 50 uM | Inhibitory activity againist Estrone sulfatase from MCF-7 cells (placental microsomes) | ChEMBL. | 11992772 |
IC50 (binding) | = 50 uM | Inhibitory activity againist Estrone sulfatase from MCF-7 cells (placental microsomes) | ChEMBL. | 11992772 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.