Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tachykinin receptor 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04224 tachykinin receptor 3, putative | Get druggable targets OG5_137770 | All targets in OG5_137770 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0312 | 0.0185 | 1 |
Echinococcus granulosus | thymidylate synthase | 1.2726 | 0.9642 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.6054 | 0.456 | 0.4547 |
Mycobacterium tuberculosis | Hypothetical protein | 0.6054 | 0.456 | 0.4729 |
Mycobacterium ulcerans | folylpolyglutamate synthase protein FolC | 0.01 | 0.0024 | 0.0025 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1229 | 0.0884 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1229 | 0.0884 | 0.0916 |
Echinococcus granulosus | dihydrofolate reductase | 0.1229 | 0.0884 | 0.0894 |
Echinococcus multilocularis | thymidylate synthase | 1.2726 | 0.9642 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.1229 | 0.0884 | 0.0894 |
Onchocerca volvulus | 1.2726 | 0.9642 | 1 | |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1229 | 0.0884 | 0.0916 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 1.3195 | 1 | 1 |
Brugia malayi | thymidylate synthase | 1.2726 | 0.9642 | 1 |
Mycobacterium leprae | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) | 0.01 | 0.0024 | 0.0025 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 1.3195 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 1.2726 | 0.9642 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 1.2726 | 0.9642 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1229 | 0.0884 | 0.0894 |
Onchocerca volvulus | Putative folylpolyglutamate synthase | 0.01 | 0.0024 | 0.0025 |
Trichomonas vaginalis | conserved hypothetical protein | 0.6054 | 0.456 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 1.2726 | 0.9642 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 1.3195 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 1.3195 | 1 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 1.2726 | 0.9642 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1229 | 0.0884 | 0.0894 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0312 | 0.0185 | 0.0192 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 1.2726 | 0.9642 | 1 |
Treponema pallidum | folylpolyglutamate synthetase (folC) | 0.01 | 0.0024 | 0.5 |
Brugia malayi | hypothetical protein | 0.6054 | 0.456 | 0.4716 |
Mycobacterium tuberculosis | Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) | 0.01 | 0.0024 | 0.0025 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 1.3195 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1229 | 0.0884 | 0.0916 |
Schistosoma mansoni | dihydrofolate reductase | 0.1229 | 0.0884 | 0.0894 |
Brugia malayi | Dihydrofolate reductase | 0.1229 | 0.0884 | 0.0894 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0312 | 0.0185 | 0.0192 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 881 nM | Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells | ChEMBL. | No reference |
IC50 (binding) | = 881 nM | Binding affinity towards Neurokinin -1(NK-1) receptor of human by using [125I]- Tyr8 substance P as a radioligand in CHO cells | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.