Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0125 | 0.7181 | 0.7181 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0066 | 0.0769 | 0.0769 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.7181 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0125 | 0.7181 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0125 | 0.7181 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0125 | 0.7181 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0125 | 0.7181 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0125 | 0.7181 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0125 | 0.7181 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0125 | 0.7181 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0151 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.7181 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0769 | 0.1071 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0125 | 0.7181 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0125 | 0.7181 | 1 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0769 | 0.1071 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0125 | 0.7181 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0125 | 0.7181 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0125 | 0.7181 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0125 | 0.7181 | 0.7181 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0125 | 0.7181 | 0.7181 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0125 | 0.7181 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0125 | 0.7181 | 0.7181 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0125 | 0.7181 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0125 | 0.7181 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0125 | 0.7181 | 0.7181 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0125 | 0.7181 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0125 | 0.7181 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0125 | 0.7181 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0066 | 0.0769 | 0.1071 |
Brugia malayi | nuclear receptor RXR | 0.0066 | 0.0769 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0125 | 0.7181 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0125 | 0.7181 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.7181 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0125 | 0.7181 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0125 | 0.7181 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0125 | 0.7181 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0125 | 0.7181 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0125 | 0.7181 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0125 | 0.7181 | 0.7181 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0125 | 0.7181 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0125 | 0.7181 | 0.7181 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0125 | 0.7181 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.7181 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0125 | 0.7181 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0125 | 0.7181 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.7181 | 1 |
Brugia malayi | steroid hormone receptor | 0.0125 | 0.7181 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0125 | 0.7181 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0125 | 0.7181 | 0.7181 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0125 | 0.7181 | 0.7181 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0125 | 0.7181 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0125 | 0.7181 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.7181 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0769 | 0.1071 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0066 | 0.0769 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0125 | 0.7181 | 1 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0769 | 0.1071 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0125 | 0.7181 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.7181 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0066 | 0.0769 | 0.0769 |
Onchocerca volvulus | 0.0125 | 0.7181 | 1 | |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0066 | 0.0769 | 0.1071 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0125 | 0.7181 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0125 | 0.7181 | 0.7181 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0769 | 0.1071 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0125 | 0.7181 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0066 | 0.0769 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0125 | 0.7181 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0125 | 0.7181 | 0.7181 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0125 | 0.7181 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0125 | 0.7181 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0125 | 0.7181 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0125 | 0.7181 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0125 | 0.7181 | 0.7181 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0769 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0125 | 0.7181 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0125 | 0.7181 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0066 | 0.0769 | 0.1071 |
Brugia malayi | ecdysteroid receptor | 0.0125 | 0.7181 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0125 | 0.7181 | 0.7181 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0125 | 0.7181 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0125 | 0.7181 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0125 | 0.7181 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0125 | 0.7181 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0125 | 0.7181 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0769 | 0.1071 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
cLogP | = 6.654 | Calculated partition coefficient of the compound | ChEMBL. | 1635056 |
Log 1/MEC (functional) | = 0.79 | Minimum effective concentration for anti-coccidial activity against oocytes of coccidian parasite Eimeria tenella in chicks expressed as mmol/kg of feed | ChEMBL. | 1635056 |
MEC (functional) | = 60 p.p.m. | Minimum effective concentration in feed to protect chickens against infections caused by Eimeria tenella | ChEMBL. | 6895527 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.