Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0665 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0665 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0112 | 0 | 0.5 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0365 | 0.4571 | 0.4571 |
Echinococcus multilocularis | acetylcholinesterase | 0.0665 | 1 | 1 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0365 | 0.4571 | 0.4571 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0112 | 0 | 0.5 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0365 | 0.4571 | 0.4571 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0112 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0665 | 1 | 1 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0365 | 0.4571 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0665 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0665 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0665 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0112 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0665 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0665 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0365 | 0.4571 | 0.4571 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0112 | 0 | 0.5 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0365 | 0.4571 | 0.4571 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0365 | 0.4571 | 0.4571 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0112 | 0 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0365 | 0.4571 | 0.4571 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 100000 nM | Inhibition of the Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ha-Ras by 50% in bovine brain at a concentration of ca. 1 nM. | ChEMBL. | No reference |
IC50 (binding) | > 100000 nM | Inhibition of the Farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ha-Ras by 50% in bovine brain at a concentration of ca. 1 nM. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.